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Protocol Details

Perception, Sensation, Cognition and Action in Humans

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts




Sponsoring Institute

National Eye Institute (NEI)

Recruitment Detail

Type: Participants currently recruited/enrolled
Gender: Male & Female
Min Age: 18 Years
Max Age: 65 Years

Referral Letter Required


Population Exclusion(s)

Adults who are or may become unable to consent;


Magnetic Resonance Imaging (MRI);
Color Vision;
Natural History

Recruitment Keyword(s)



Normal Physiology

Investigational Drug(s)


Investigational Device(s)




Supporting Site

National Eye Institute


When people see and hear, the brain changes signals from the eyes and ears into perceptions and thoughts. No one fully understands how this happens. Researchers want to explore how healthy brains process sights and sounds.


To explore how people understand what they see and hear when the brain processes sights and sounds.


Adults ages 18-65 who have at least 20/40 vision in at least one eye and do not use a hearing aid.


Some participants will take tests online anonymously. They will do computer tasks related to colors and behavior.

In-person participants will be screened with medical history and physical exam. They will complete questionnaires and vision and hearing tests.

Participants will plan how many testing sessions they will have and when. Sessions last 2-5 hours. They may include:

Magnetic Resonance Imaging: Magnets and radio waves to take pictures of the brain. Participants will lie on a table that slides in and out of a tube. They will do a task during the scan.

Magnetoencephalography: Records magnetic field changes from brain activity. Participants will sit or lie down. A cone will be lowered onto their head. They may do a task during the test.

Electromyography: Electrodes attached to the skin will measure the electrical activity of muscles.

Electroencephalogram: Electrodes on the scalp will record brain waves.

Electrocardiography: Electrodes on the chest will record heart electrical activity.

Tests of memory, attention, thinking, vision, and hearing.

Eye Tracking: Cameras will follow participants eye movements. They may wear a cap with infrared cameras in front of their eyes.

During the sessions, participants vital signs may be monitored.

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A subject can be included in this study if he/she:

-is in good general health;

-is between 18 and 65 years old;

-is capable of understanding the procedures and requirements of this study;

-is willing and able to provide his/her own informed consent;


-has visual acuity of 20/40 in at least one eye (corrected with contact lenses is okay);

-has no hearing impairment requiring a hearing aid.


A participant is not eligible for participation in the in-lab portion of this study if any of the following exclusion criteria are present, as self-reported by the prospective participant or determined during clinical testing following consent:

-Participant has serious vision or hearing problems; for some sub-studies focused on color vision, subjects who are colorblind will also be excluded;

-Participants without consent capacity will not be enrolled;

-Participant has a neurological disorder (examples include, but are not limited to: epilepsy, schizophrenia, Alzheimer s Disease, Parkinson s Disease, multiple sclerosis) or a psychiatric disorder (examples include, but are not limited to: clinical anxiety, depression, attention deficit hyperactivity disorder (ADHD), schizophrenia);

-Participant has had a serious head injury or has a history of brain surgery. Head injury is defined as an injury to the brain from some external force resulting in loss of consciousness of 30 minutes or more;

-Participant has psychoactive drug or alcohol abuse or dependence in the past three months, as determined by the Drug Abuse Screening Test (DAST), except nicotine and caffeine. A score of 6 or greater on the DAST will be considered exclusionary. The effects of nicotine and caffeine in neuroimaging are attenuated if participants do not smoke or consume caffeine 2-3 hours before the scan session; Over-the-counter medication/herbals will not be a criterion for exclusion;

-Participant is an NEI employee within the Sensation, Cognition and Action section.


Contraindication to MR scanning include the following: pregnancy; metallic tattoos or metallic eyeliner; claustrophobia; inability to lie still on their back for ~2 hours; implanted cardiac pacemaker or auto-defibrillator; surgical aneurysm clips; implanted neural stimulator; artificial heart valves or pumps; metal fragments in cranial cavity, body or eyes (e.g., history as a metal worker); nitroglycerin patch (foil backer); cochlear implants (tubes are okay); weight > 450 lbs; metal rods, plates, screws in body; shrapnel or bullet wound; intrauterine device (IUD) not approved on (most IUDs are okay); vestibular or inner ear abnormality such as Meniere s disease; metallic braces; hair extensions attached with metallic wires; transdermal patches; movement disorders; dental implants; consumed of nicotine or caffeine in the two hours prior to the experimental session. Subjects may participate in this study, but will not be allowed to have a 7.0 T MRI scan if they have metallic dental crowns or a bridge.


Subjects may not participate in the on-line portion of the study if they:

-Do not have access to compatible equipment. For example, smartphone screens are too small to be used. Amazon MTurk will outline which devices may be used.

-Are unwilling to allow permission for JavaScript to run on the site and disable any script blockers.

-Are unwilling to agree to Amazon MTurk's terms and conditions.

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Not Provided

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Principal Investigator

Referral Contact

For more information:

Bevil Conway, Ph.D.
National Eye Institute (NEI)
National Institutes of Health
Building 49
Room 2A72
49 Convent Drive
Bethesda, Maryland 20892
(301) 594-3238

Marianne F. Duyck, Ph.D.
National Eye Institute (NEI)
National Institutes of Health
Building 49
Room 2A50
49 Convent Drive
Bethesda, Maryland 20892
(301) 402-4956

Office of Patient Recruitment
National Institutes of Health Clinical Center (CC)
Building 61, 10 Cloister Court
Bethesda, Maryland 20892
Toll Free: 1-800-411-1222
Local Phone: 301-451-4383
TTY: TTY Users Dial 7-1-1

Clinical Trials Number:


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