This study is NOT currently recruiting participants.
Number
17-N-0055
Sponsoring Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Recruitment Detail
Type: Completed Study; data analyses ongoing Gender: Male & Female Min Age: 18 Years Max Age: N/A
Referral Letter Required
No
Population Exclusion(s)
Adults who are or may become unable to consent;Non-English Speaking;Pregnant Women;Children
Keywords
Explicit Memory; Implicit Memory; Memory Disorder
Recruitment Keyword(s)
None
Condition(s)
Traumatic Brain Injury
Investigational Drug(s)
Investigational Device(s)
Intervention(s)
Device: rTMS
Supporting Site
National Institute of Neurological Disorders and Stroke
Traumatic brain injury (TBI) damages the connections between brain cells. This can lead to problems like memory loss. Repetitive transcranial magnetic stimulation (rTMS) can help improve connections between brain areas in healthy people. Researchers want to see if it can be useful in patients with memory problems after TBI.
Objective:
To see how repetitive transcranial magnetic stimulation can be used to improve the connections between parts of the brain and whether this will lead to changes in memory.
Eligibility:
Adults 18-50 years old with TBI who can speak and write in English.
Healthy volunteers the same age and English ability.
Design:
Participants will be screened with a neurological exam and may have a urine pregnancy test.
Participants with TBI will have 7-15 visits. Healthy volunteers will have 2-8.
At the visits, participants will have all or some of the following:
-MRI for about 1 hour. They will lie in a machine that takes pictures in a magnetic field. They will do some memory tasks.
-Memory and attention tasks with pictures and with a computer
-Questions about their mental state and well-being
-TMS: A wire coil is held on the scalp and a short electrical current passes through it. Participants will hear a click and feel a pulling or twitch. They may be asked to make simple movements. rTMS is repeated magnetic pulses in short bursts. They will have this for about 20 minutes.
A week after the last visit, some participants will return for a memory test.
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INCLUSION CRITERIA: Experiments 1 and 2: Healthy individuals Age 18-50 (inclusive) -English speaking and writing Experiment 3 Age 18-50 (inclusive) -English speaking and writing History of mild to moderate TBI Performance 1 standard deviation below age-adjusted population norms on the CVLT-2 within the past year from the date of visit. EXCLUSION CRITERIA: Any current major neurological or psychiatric disorder such as (but not limited to) stroke, Parkinson disease, Alzheimer disease, schizophrenia or major depression History of seizure Medications acting on the central nervous system Ferromagnetic metal in the cranial cavity or eye, implanted neural stimulator, cochlear implant, or ocular foreign body Implanted cardiac pacemaker or auto-defibrillator or pump Non-removable body piercing -Claustrophobia Inability to lie supine for 1 hour Pregnancy, nursing, or plans to become pregnant during the study. Members of the NINDS Behavioral Neurology Unit (BNU) For Experiment 2: Participation in Experiment 1
Experiments 1 and 2:
Healthy individuals
Age 18-50 (inclusive)
-English speaking and writing
Experiment 3
History of mild to moderate TBI
Performance 1 standard deviation below age-adjusted population norms on the
CVLT-2 within the past year from the date of visit.
EXCLUSION CRITERIA:
Any current major neurological or psychiatric disorder such as (but not limited to) stroke, Parkinson disease, Alzheimer disease, schizophrenia or major depression
History of seizure
Medications acting on the central nervous system
Ferromagnetic metal in the cranial cavity or eye, implanted neural stimulator, cochlear implant, or ocular foreign body
Implanted cardiac pacemaker or auto-defibrillator or pump
Non-removable body piercing
-Claustrophobia
Inability to lie supine for 1 hour
Pregnancy, nursing, or plans to become pregnant during the study.
Members of the NINDS Behavioral Neurology Unit (BNU)
For Experiment 2: Participation in Experiment 1
Principal Investigator
Referral Contact
For more information: