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Protocol Details

Detailed Evaluation of the Neurophysiology of Surround Inhibition in the Human Motor Cortex

This study is NOT currently recruiting participants.

Summary | Eligibility | Citations | Contacts




Sponsoring Institute

National Institute of Neurological Disorders and Stroke (NINDS)

Recruitment Detail

Type: Completed Study; data analyses ongoing
Gender: Male & Female
Min Age: 18 Years
Max Age: 70 Years

Referral Letter Required


Population Exclusion(s)


Special Instructions

Currently Not Provided


Surround Inhibition;
Motor Control;
Transcranial Magnetic Stimulation (TMS);
TMS-Evoked Potential

Recruitment Keyword(s)



Normal Physiology

Investigational Drug(s)


Investigational Device(s)




Supporting Site

National Institute of Neurological Disorders and Stroke


Movement disorders have many different causes and symptoms. Researchers still do not fully understand which parts of the brain are involved in fine movement. They want to learn about which brain regions could be abnormal in people with movement disorders.


To better understand how the brain controls movement.


Healthy, right-handed adults age 18-70 years old.


Participants will be screened with a physical exam and questions about their handedness. They may have a urine test.

Participants will have 1 or 2 clinic visits. The first visit will last about 1.5 hours. The second will last about 3 hours.

Participants will have structural magnetic resonance imaging (MRI). A strong magnetic field and radio waves take pictures of the brain. Participants will lie on a table that slides in and out of a metal cylinder.

Participants may have transcranial magnetic stimulation. A wire coil is held on the scalp. A brief electrical current is passed through the coil and creates a magnetic pulse that stimulates the brain. Participants will wear a pair of glasses or a headband with small sensors so researchers can track head position.

Participants will perform a simple index finger movement task.

Participants may have surface electromyography from at least two hand muscles. Small metal disk or adhesive pad electrodes will be taped to the skin. Participants will be seated in a comfortable chair with their hands placed on a pillow.

Participants may have an electroencephalography. A cap with small disc electrodes will be placed on the scalp.

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-Age between 18 - 70 years.

-Right-handed (tested by the Edinburg handedness inventory).

-Able to give informed consent.

-Able to comply with all study procedures.

-Abstain from alcohol for at least 48 hrs prior to the study and caffeine on the day of the study (based on oral interview).


-Illegal drug use within the past 6 months based on history alone. The intent is to exclude those with drug use that may affect study results.

-Self-reported consumption of >14 alcoholic drinks/week for a man and >7 alcoholic drinks/week for a woman.

-Abnormal findings on neurological examination.

-History of or current brain tumor, stroke, head trauma with loss of consciousness, epilepsy or seizures.

-Current episode of major depression or any major psychiatric illness.

-Taking medications that act directly on the central nervous system such as anti-epileptics, anti-histamines, anti-parkinsonian medication, muscle relaxants, medication for insomnia, anti-depressants, anti-anxiety medication.

-Presence of any metal in the eye or skull area such as a brain stimulator, shrapnel, surgical metal, clips in the brain, cochlear implants, metal fragments in the eye.

-Presence of pacemaker, intracardiac lines, implanted pumps or stimulators or metal objects inside the eye or skull.

-Known hearing loss.

-NIH employees and/or staff.


EXCLUSION CRITERIA for MRI (sub-study 2 only):

We will follow the Clinical Radiology/NMR Center guidelines for MR safety.

Some of the exclusions are:

-Have non-MRI compatible metal in the body, such as a cardiac pacemaker, brain stimulator, shrapnel, surgical metal, clips in the brain or on blood vessels, cochlear implants, artificial heart valves or metal fragments in the eye as these make having an MRI unsafe.

-Have metallic dental fillings which are likely to cause MRI artifacts

-Unable to lie flat on the back for the expected length of the experiment,

-up to 30 mins.

-Uncomfortable being in a small space for the expected length of the experiment, up to 30 mins.


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Not Provided

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Principal Investigator

Referral Contact

For more information:

Mark Hallett, M.D.
National Institute of Neurological Disorders and Stroke (NINDS)

Elaine P. Considine, R.N.
National Institute of Neurological Disorders and Stroke (NINDS)
National Institutes of Health
Building 10
Room 7D36
10 Center Drive
Bethesda, Maryland 20892
(301) 435-8518

Office of Patient Recruitment
National Institutes of Health Clinical Center (CC)
Building 61, 10 Cloister Court
Bethesda, Maryland 20892
Toll Free: 1-800-411-1222
Local Phone: 301-451-4383
TTY: 1-866-411-1010

Clinical Trials Number:


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