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Protocol Details

Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number

11-M-0045

Sponsoring Institute

National Institute of Mental Health (NIMH)

Recruitment Detail

Type: Participants currently recruited/enrolled
Gender: Male & Female
Min Age: 18 Years
Max Age: 65 Years

Referral Letter Required

No

Population Exclusion(s)

Children;
Pregnant Women;
Fetuses

Keywords

Brain Metabolism;
Neurochemistry;
Magnetic Resonance Imaging;
Mental Illness;
Magnetic Resonance Spectroscopy

Recruitment Keyword(s)

None

Condition(s)

Brain Mapping;
Healthy Volunteer

Investigational Drug(s)

None

Investigational Device(s)

None

Intervention(s)

Other: NSR MAGNETOM 7T
Other: 1Tx x 32Rx Head Coil

Supporting Site

National Institute of Mental Health

Background:

- Magnetic resonance imaging (MRI) is a widely used scanning technique to obtain images of the human body and evaluate activity in the brain. A particular MRI method called magnetic resonance spectroscopy (MRS) can be used to study brain chemistry as well, which may help researchers who are studying new treatments for psychiatric illnesses. Researchers are interested in improving current MRI and MRS techniques, as well as developing new MRI and MRS techniques to view and measure brain chemicals and brain activity.

Objectives:

- To implement, develop, and optimize brain chemistry imaging techniques using magnetic resonance imaging and magnetic resonance spectroscopy.

Eligibility:

- Healthy individuals between 18 and 65 years of age.

Design:

- This study will involve a screening visit and a scanning visit at the National Institutes of Health Clinical Center.

- Participants will be screened with a full medical and physical examination, blood and urine tests, and neurological testing.

- During the second visit, participants will have an MRI scan of the brain. (Participants who have received an MRI within the past year will not need to have a second one; the images of the previous scan will be used for this study.) All participants will then have an MRS scan using the same scanning equipment.

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Eligibility

INCLUSION CRITERIA:

-18-65 years of age

-able to give written informed consent

-healthy based on medical history and physical exam

-enrolled in Protocol 01-M-0254 or Protocol 17-M-0181

EXCLUSION CRITERIA:

-Any current Axis 1 diagnosis

-Clinically significant laboratory abnormalities

-Positive HIV test

-Metallic foreign bodies that would be affected by the magnetic resonance imaging (MRI) magnet, or fear of enclosed spaces likely to make the subject unable to undergo an MRI scan.

-History of neurological illness or injury with the potential to affect study data interpretation, such as multiple sclerosis, Parkinson s disease, seizure disorder or traumatic brain injury

-Inability to lie flat on camera bed for about two and a half hours

-Pregnant or breastfeeding

-Current substance use disorder based on DSM-5

-NIMH employees and staff and their immediate family members will be excluded from the study per NIMH policy.


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Citations:

Not Provided

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Contacts:

Principal Investigator

Referral Contact

For more information:

Li An, Ph.D.
National Institute of Mental Health (NIMH)
National Institutes of Health
Building 10
Room B1D733
10 Center Drive
Bethesda, Maryland 20892
(301) 896-2882
anl@mail.nih.gov

Christopher Johnson
National Institute of Mental Health (NIMH)
National Institutes of Health
Building 10
Room 2D50
10 Center Drive
Bethesda, Maryland 20892
(301) 402-6695
johnsonchri@mail.nih.gov

Office of Patient Recruitment
National Institutes of Health Clinical Center (CC)
Building 61, 10 Cloister Court
Bethesda, Maryland 20892
Toll Free: 1-800-411-1222
Local Phone: 301-451-4383
TTY: TTY Users Dial 7-1-1
ccopr@nih.gov

Clinical Trials Number:

NCT01266577

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