NIH Clinical Center Search the Studies: Study Number, Study Title

Protocol Details

Development of Functional and Structural Magnetic Resonance Imaging Techniques for the Study of Mood and Anxiety Disorders

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number

07-M-0021

Sponsoring Institute

National Institute of Mental Health (NIMH)

Recruitment Detail

Type: Participants currently recruited/enrolled
Gender: Male & Female
Min Age: 18 Years
Max Age: 65 Years

Referral Letter Required

No

Population Exclusion(s)

Children;
Pregnant Women;
Non-English Speaking

Keywords

Morphometry;
BOLD;
fMRI;
Spectrometry;
Relaxometry;
Natural History

Recruitment Keyword(s)

Healthy Volunteer;
HV

Condition(s)

Mood Disorders;
Anxiety Disorders

Investigational Drug(s)

None

Investigational Device(s)

None

Intervention(s)

None

Supporting Site

National Institute of Mental Health

This study is intended to help develop new MRI imaging techniques for studying mood and anxiety disorders. Researchers believe that depression and anxiety disorders may cause structural and functional changes in the brain. This study will optimize the way MRI scans are collected to look at brain structure and examine how the brain behaves while subjects perform particular tasks.

Healthy normal subjects between 18 and 50 years of age who have never had a major psychiatric disorder and who have no first-degree relatives with mood disorders may be eligible for this study. Candidates are screened by phone with questions about their psychiatric and medical history, current emotional state and sleep pattern, and family history of psychiatric disorders. Candidates who pass the preliminary screening then undergo additional screening interviews and laboratory tests.

Participants undergo magnetic resonance imaging (MRI) and neuropsychological testing, as follows:

"<TAB>MRI scans: Subjects are asked to participate in an MRI study on one of several scanners to measure blood flow in the brain, concentrations of certain chemicals in the brain, or magnetic properties of the brain. MRI uses a strong magnet and radio waves to obtain pictures of the brain. The subject lies still on a narrow bed with a metal coil close to the head. For this study, subjects may be asked to wear a special coil on the neck to help measure blood flow. They may be asked to watch a screen presenting images or to do a task in which they respond to pictures or sounds and may be asked to return for additional scans.

"<TAB>Neuropsychological testing: Subjects may undergo tests of cognitive performance. Often, people with mood disorders have subtle changes in performance on these tests that allow researchers to pinpoint where brain abnormalities occur. Before the tests can be used in patients, they must be validated by using healthy subjects. These tests are presented either orally, in written form, or on a computer.

--Back to Top--

Eligibility

INCLUSION CRITERIA:

Healthy Control:

-Male and female subjects between 18 and 65 years of age

-Subjects must be able to give written informed consent prior to participation in this study.

-Subjects who do not currently meet and have never met criteria for any major psychiatric disorder, and who have no known first degree relatives with mood disorders.

-For cognitive experiments utilizing language stimuli only native English speakers will be enrolled.

Major Depressive Disorder:

-Male and female subjects between 18 and 65 years of age.

-Subjects have been found eligible for other ETPB research protocols according to 01-M-0254.

-Subjects must fulfill DSM-IV criteria for Major Depression based on clinical assessment and confirmed by a structured diagnostic interview (SCID-P).

-Subjects must be able to give written informed consent prior to participation in this study.

-For cognitive experiments utilizing language stimuli, only native English speakers will be enrolled.

EXCLUSION CRITERIA:

Healthy Control:

-Subjects with major medical or neurological disorders expected to influence cerebral blood flow or morphology, or taking any medication that is likely to influence the imaging parameters-of-interest within 3 weeks of scanning.

-Women who are pregnant or breastfeeding. Subjects will undergo pregnancy testing no more than 24 hours prior to scanning.

-Subjects with contraindication to MRI scanning such as aneurysm clips, implanted neural stimulator, implanted cardiac pacemaker or auto-defibrillator, cochlear implant, or ocular foreign body.

-A history of drug or alcohol abuse within 1 year or a lifetime history of drug or alcohol dependence (DSM-IV) or alcohol use disorder (DSM-V equivalent).

-A current NIMH employee/staff or their immediate family member.

Major Depressive Disorder:

-Presence of Axis 1 psychiatric diagnosis other than Major Depression or an Axis 2 disorder

-Subjects with major medical or neurological disorders expected to influence cognitive function or are taking any drugs likely to affect mood or cognitive function within 2 weeks of study participation. Depressed subjects will not be tapered/withdrawn from medications under this study.

-A history of drug or alcohol abuse within 1 year or a lifetime history of drug or alcohol dependence (DSM-IV) or alcohol use disorder (DSM-V equivalent).

-A current NIMH employee/staff or their immediate family member

-Subjects with major medical or neurological disorders expected to influence cerebral blood flow or morphology.

-Women who are pregnant or breastfeeding. Subjects will undergo pregnancy testing no more than 24 hours prior to scanning.

-Subjects with contraindication to MRI scanning such as aneurysm clips, implanted neural stimulator, implanted cardiac pacemaker or auto-defibrillator, cochlear implant, or ocular foreign body.


--Back to Top--

Citations:

Drevets WC, Price JL, Simpson JR Jr, Todd RD, Reich T, Vannier M, Raichle ME. Subgenual prefrontal cortex abnormalities in mood disorders. Nature. 1997 Apr 24;386(6627):824-7.

Drevets WC, Ongur D, Price JL. Neuroimaging abnormalities in the subgenual prefrontal cortex: implications for the pathophysiology of familial mood disorders. Mol Psychiatry. 1998 May;3(3):220-6, 190-1.

Drevets WC. Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders. Curr Opin Neurobiol. 2001 Apr;11(2):240-9.

--Back to Top--

Contacts:

Principal Investigator

Referral Contact

For more information:

Allison Nugent, Ph.D.
National Institute of Mental Health (NIMH)
National Institutes of Health
Building 10
Room 4N242
10 Center Drive
Bethesda, Maryland 20892
(301) 451-8863
nugenta@mail.nih.gov

Allison Nugent, Ph.D.
National Institute of Mental Health (NIMH)
National Institutes of Health
Building 10
Room 4N242
10 Center Drive
Bethesda, Maryland 20892
(301) 451-8863
moodresearch@mail.nih.gov

Office of Patient Recruitment
National Institutes of Health Clinical Center (CC)
Building 61, 10 Cloister Court
Bethesda, Maryland 20892
Toll Free: 1-800-411-1222
Local Phone: 301-451-4383
TTY: TTY Users Dial 7-1-1
ccopr@nih.gov

Clinical Trials Number:

NCT00397111

--Back to Top--