This study is currently recruiting participants.
Number
07-M-0021
Sponsoring Institute
National Institute of Mental Health (NIMH)
Recruitment Detail
Type: Participants currently recruited/enrolled Gender: Male & Female Min Age: 18 Years Max Age: 65 Years
Referral Letter Required
No
Population Exclusion(s)
Children;Pregnant Women;Non-English Speaking
Keywords
Morphometry; BOLD; fMRI; Spectrometry; Relaxometry; Natural History
Recruitment Keyword(s)
Healthy Volunteer; HV
Condition(s)
Mood Disorders; Anxiety Disorders
Investigational Drug(s)
None
Investigational Device(s)
Intervention(s)
Supporting Site
National Institute of Mental Health
Healthy normal subjects between 18 and 50 years of age who have never had a major psychiatric disorder and who have no first-degree relatives with mood disorders may be eligible for this study. Candidates are screened by phone with questions about their psychiatric and medical history, current emotional state and sleep pattern, and family history of psychiatric disorders. Candidates who pass the preliminary screening then undergo additional screening interviews and laboratory tests.
Participants undergo magnetic resonance imaging (MRI) and neuropsychological testing, as follows:
"<TAB>MRI scans: Subjects are asked to participate in an MRI study on one of several scanners to measure blood flow in the brain, concentrations of certain chemicals in the brain, or magnetic properties of the brain. MRI uses a strong magnet and radio waves to obtain pictures of the brain. The subject lies still on a narrow bed with a metal coil close to the head. For this study, subjects may be asked to wear a special coil on the neck to help measure blood flow. They may be asked to watch a screen presenting images or to do a task in which they respond to pictures or sounds and may be asked to return for additional scans.
"<TAB>Neuropsychological testing: Subjects may undergo tests of cognitive performance. Often, people with mood disorders have subtle changes in performance on these tests that allow researchers to pinpoint where brain abnormalities occur. Before the tests can be used in patients, they must be validated by using healthy subjects. These tests are presented either orally, in written form, or on a computer.
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INCLUSION CRITERIA: Healthy Control: -Male and female subjects between 18 and 65 years of age -Subjects must be able to give written informed consent prior to participation in this study. -Subjects who do not currently meet and have never met criteria for any major psychiatric disorder, and who have no known first degree relatives with mood disorders. -For cognitive experiments utilizing language stimuli only native English speakers will be enrolled. Major Depressive Disorder: -Male and female subjects between 18 and 65 years of age. -Subjects have been found eligible for other ETPB research protocols according to 01-M-0254. -Subjects must fulfill DSM-IV criteria for Major Depression based on clinical assessment and confirmed by a structured diagnostic interview (SCID-P). -Subjects must be able to give written informed consent prior to participation in this study. -For cognitive experiments utilizing language stimuli, only native English speakers will be enrolled. EXCLUSION CRITERIA: Healthy Control: -Subjects with major medical or neurological disorders expected to influence cerebral blood flow or morphology, or taking any medication that is likely to influence the imaging parameters-of-interest within 3 weeks of scanning. -Women who are pregnant or breastfeeding. Subjects will undergo pregnancy testing no more than 24 hours prior to scanning. -Subjects with contraindication to MRI scanning such as aneurysm clips, implanted neural stimulator, implanted cardiac pacemaker or auto-defibrillator, cochlear implant, or ocular foreign body. -A history of drug or alcohol abuse within 1 year or a lifetime history of drug or alcohol dependence (DSM-IV) or alcohol use disorder (DSM-V equivalent). -A current NIMH employee/staff or their immediate family member. Major Depressive Disorder: -Presence of Axis 1 psychiatric diagnosis other than Major Depression or an Axis 2 disorder -Subjects with major medical or neurological disorders expected to influence cognitive function or are taking any drugs likely to affect mood or cognitive function within 2 weeks of study participation. Depressed subjects will not be tapered/withdrawn from medications under this study. -A history of drug or alcohol abuse within 1 year or a lifetime history of drug or alcohol dependence (DSM-IV) or alcohol use disorder (DSM-V equivalent). -A current NIMH employee/staff or their immediate family member -Subjects with major medical or neurological disorders expected to influence cerebral blood flow or morphology. -Women who are pregnant or breastfeeding. Subjects will undergo pregnancy testing no more than 24 hours prior to scanning. -Subjects with contraindication to MRI scanning such as aneurysm clips, implanted neural stimulator, implanted cardiac pacemaker or auto-defibrillator, cochlear implant, or ocular foreign body.
Healthy Control:
-Male and female subjects between 18 and 65 years of age
-Subjects must be able to give written informed consent prior to participation in this study.
-Subjects who do not currently meet and have never met criteria for any major psychiatric disorder, and who have no known first degree relatives with mood disorders.
-For cognitive experiments utilizing language stimuli only native English speakers will be enrolled.
Major Depressive Disorder:
-Male and female subjects between 18 and 65 years of age.
-Subjects have been found eligible for other ETPB research protocols according to 01-M-0254.
-Subjects must fulfill DSM-IV criteria for Major Depression based on clinical assessment and confirmed by a structured diagnostic interview (SCID-P).
-For cognitive experiments utilizing language stimuli, only native English speakers will be enrolled.
EXCLUSION CRITERIA:
-Subjects with major medical or neurological disorders expected to influence cerebral blood flow or morphology, or taking any medication that is likely to influence the imaging parameters-of-interest within 3 weeks of scanning.
-Women who are pregnant or breastfeeding. Subjects will undergo pregnancy testing no more than 24 hours prior to scanning.
-Subjects with contraindication to MRI scanning such as aneurysm clips, implanted neural stimulator, implanted cardiac pacemaker or auto-defibrillator, cochlear implant, or ocular foreign body.
-A history of drug or alcohol abuse within 1 year or a lifetime history of drug or alcohol dependence (DSM-IV) or alcohol use disorder (DSM-V equivalent).
-A current NIMH employee/staff or their immediate family member.
-Presence of Axis 1 psychiatric diagnosis other than Major Depression or an Axis 2 disorder
-Subjects with major medical or neurological disorders expected to influence cognitive function or are taking any drugs likely to affect mood or cognitive function within 2 weeks of study participation. Depressed subjects will not be tapered/withdrawn from medications under this study.
-A current NIMH employee/staff or their immediate family member
-Subjects with major medical or neurological disorders expected to influence cerebral blood flow or morphology.
Principal Investigator
Referral Contact
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