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Protocol Details

MRS (Magnetic Resonance Spectroscopy) Measurement of Glutamate and GABA Metabolism in Brain

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number

05-M-0144

Sponsoring Institute

National Institute of Mental Health (NIMH)

Recruitment Detail

Type: Participants currently recruited/enrolled
Gender: Male & Female
Min Age: 18 Years
Max Age: 65 Years

Referral Letter Required

No

Population Exclusion(s)

Children;
Fetuses;
Adults who are or may become unable to consent;
Pregnant Women;
Neonates

Keywords

Glutamate;
Excitatory Amino Acid;
Neurochemistry;
Brain;
Magnetic Resonance Spectroscopy

Recruitment Keyword(s)

None

Condition(s)

Normal Physiology

Investigational Drug(s)

None

Investigational Device(s)

None

Intervention(s)

Device: 3T and 7T device

Supporting Site

National Institute of Mental Health

This study will use magnetic resonance spectroscopy (MRS) to measure in the brain the transfer of [13]C as it is naturally metabolized from glucose to specific chemical transmitters. From this method, we can measure the rate of production of an important excitatory neurotransmitter (glutamate) as well as an inhibitory neurotransmitter (GABA).

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Eligibility

INCLUSION CRITERIA:

-18-65 years of age

-Able to give written informed consent

-Healthy based on medical history and physical exam

-Enrolled in Protocol 01-M-0254 or Protocol 17-M-0181

EXCLUSION CRITERIA:

-Any current Axis 1 diagnosis

-Clinically significant laboratory abnormalities

-Positive HIV test

-Metallic foreign bodies that would be affected by the magnetic resonance imaging (MRI) magnet, or fear of enclosed spaces likely to make the subject unable to undergo an MRI scan.

-History of neurological illness or injury with the potential to affect study data interpretation, such as multiple sclerosis, Parkinson s disease, seizure disorder or traumatic brain injury

-Prescription psychotropic medication; drug free less than 8 weeks (anticholinergics, benzodiazepine, fluoxetine, antipsychotics, and anticonvulsants)

-Serious medical illness as determined from H&P or laboratory testing including Diabetes

-Inability to lie flat on camera bed for about two and a half hours

-Pregnant or breastfeeding

-Current substance use disorder based on DSM-5

-NIMH employees and staff and their immediate family members will be excluded from the study per NIMH policy.


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Citations:

Not Provided

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Contacts:

Principal Investigator

Referral Contact

For more information:

Li An, Ph.D.
National Institute of Mental Health (NIMH)
National Institutes of Health
Building 10
Room B1D733
10 Center Drive
Bethesda, Maryland 20892
(301) 896-2882
anl@mail.nih.gov

Christopher Johnson
National Institute of Mental Health (NIMH)
National Institutes of Health
Building 10
Room 2D50
10 Center Drive
Bethesda, Maryland 20892
(301) 402-6695
johnsonchri@mail.nih.gov

Office of Patient Recruitment
National Institutes of Health Clinical Center (CC)
Building 61, 10 Cloister Court
Bethesda, Maryland 20892
Toll Free: 1-800-411-1222
Local Phone: 301-451-4383
TTY: TTY Users Dial 7-1-1
ccopr@nih.gov

Clinical Trials Number:

NCT00109174

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