This study is currently recruiting participants.
Number
000912-HG
Sponsoring Institute
National Human Genome Research Institute (NHGRI)
Recruitment Detail
Type: Participants currently recruited/enrolled Gender: Male & Female Min Age: 18 Years Max Age: N/A
Referral Letter Required
No
Population Exclusion(s)
Children
Keywords
Joint; Pain; Health Service Use; Immigrants; Natural History
Recruitment Keyword(s)
None
Condition(s)
Rheumatoid Arthritis
Investigational Drug(s)
Investigational Device(s)
Intervention(s)
Supporting Site
National Human Genome Research Institute
Rheumatoid arthritis (RA) is more severe in Hispanic people. Genetics plays a role. But social issues may also lead to more severe RA in Hispanics. Some Hispanics may not seek help for early symptoms. Support from family and friends may persuade people to seek treatment earlier. Researchers want to learn more about how social factors affect RA in Hispanics.
Objective:
This natural history study will explore genetic and social factors related to RA in Hispanic families.
Eligibility: People aged 18 years or older of Hispanic/Latino heritage. They may have RA or RA symptoms; they may also have a relative or partner with RA or RA symptoms.
Design:
Participants will receive an email or text with a link to a 30-minute online survey. They will answer questions about these things:
Physical and emotional health
How health problems affect their life
Family history of RA and other conditions
Cultural identity and language preference
Participants may also answer these questions in a phone call or an in-person interview.
Participants will be asked to list people in their social network. They will answer questions about those relationships. They will be asked if they want to invite their family and friends to participate in the study.
If more than 1 person from a participant s family takes part in the study, they may be invited for an interview. They will answer questions about how arthritis pain affects their mind and body.
Participants will give a sample of saliva. They will spit into a vial. They will mail it in using a prepaid label.
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INCLUSION CRITERIA: Consistent with the study objective, to be eligible to participate in this study, an individual must meet all of the following: -Age 18 and over; -Able to speak either English or Spanish; -Of Hispanic/Latino heritage (regardless of country of origin); -Meeting one of the following: (a) has RA or RA symptoms, (b) has at least one biological kin who has RA or RA symptoms, (c) has a spouse/partner who has RA or RA symptoms. It is not required to have an official diagnosis or records of symptoms. The screening questionnaire will screen prospective participants for either a confirmed diagnosis of RA or presence of inflammatory polyarthritis (pain, swelling and stiffness in three or more joints), which is the evaluation criterion for suspected RA in absence of laboratory testing, for themselves or their biological relatives or spouse/partner; -Able and willing to give written informed consent. EXCLUSION CRITERIA: This is a study being conducted at NHGRI s intramural research program. Therefore, NHGRI staff will be excluded from as a safeguard against the risk of ethical concerns.
Consistent with the study objective, to be eligible to participate in this study, an individual must meet all of the following:
-Age 18 and over;
-Able to speak either English or Spanish;
-Of Hispanic/Latino heritage (regardless of country of origin);
-Meeting one of the following: (a) has RA or RA symptoms, (b) has at least one biological kin who has RA or RA symptoms, (c) has a spouse/partner who has RA or RA symptoms. It is not required to have an official diagnosis or records of symptoms. The screening questionnaire will screen prospective participants for either a confirmed diagnosis of RA or presence of inflammatory polyarthritis (pain, swelling and stiffness in three or more joints), which is the evaluation criterion for suspected RA in absence of laboratory testing, for themselves or their biological relatives or spouse/partner;
-Able and willing to give written informed consent.
EXCLUSION CRITERIA:
This is a study being conducted at NHGRI s intramural research program. Therefore, NHGRI staff will be excluded from as a safeguard against the risk of ethical concerns.
Principal Investigator
Referral Contact
For more information: