NIH Clinical Center: Search the Studies

Search the Studies

66 Studies found from all possible combinations of your search terms. Select a protocol that you wish to review.

Protocol Number	Title	Protocol Status	Min-Max Age	Institute	Keywords
000696-C	A Phase III, Multicenter, International Study with a Parallel, Randomized, Double-blind, Placebo-controlled, 2 Arm Design to Assess the Efficacy and Safety of Selumetinib in Adult Participants with NF1 who have Symptomatic, Inoperable Plexiform Neurofibr	Participants currently recruited/enrolled	18-120 Years	NCI	Autosomal Dominant
000413-H	Natural History study of CADASIL	Participants currently recruited/enrolled	18-100 Years	NHLBI	Autosomal Dominant
20-DC-0047	Natural History of Autosomal Dominant Hearing Loss	Participants currently recruited/enrolled	3-99 Years	NIDCD	Autosomal Dominant
20-D-0122	A Phase IIb, Open-label Dose-ranging Study Evaluating the Safety, Tolerability, Pharmacodynamics and Pharmacokinetics, and Efficacy of CLTX-305 (encaleret) in Autosomal Dominant Hypocalcemia Type 1 (ADH1)	No longer recruiting/follow-up only	16-125 Years	NIDCR	Autosomal Dominant
16-H-0132	CADASIL Disease Discovery	Completed Study; data analyses ongoing	18-100 Years	NHLBI	Autosomal Dominant
08-C-0130	A Phase II Trial of Peginterferon alfa-2b (PEG-Intron) for Neurofibromatosis Type 1 Related Unresectable, Symptomatic or Life-Threatening Plexiform Neurofibromas	Completed Study; data analyses ongoing	0-21 Years	NCI	Autosomal Dominant
00-I-0159	Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES)	Participants currently recruited/enrolled	0-125 Years	NIAID	Autosomal Dominant
000861-I	A Phase 2 Open-Label Study to Evaluate the Efficacy and Safety of Ruxolitinib on Hair Regrowth in Patients with Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED)-Associated Alopecia Areata	Participants currently recruited/enrolled	12-65 Years	NIAID	Hair
000827-AR	Natural History and Pathogenesis of Alopecia in Children and Adults	Participants currently recruited/enrolled	2-45 Years	NIAMS	Hair
000686-CH	Intrathecal 2-Hydroxypropyl-Beta-Cyclodextrin for Neurological Decline in Patients with Niemann-Pick Disease Type C1	Participants currently recruited/enrolled	18-125 Years	NICHD	Autosomal
000678-C	Rare Tumors and Cancer Predisposition in Individuals and Families	Participants currently recruited/enrolled	0-125 Years	NCI	Hair
000520-C	Phase I/II Evaluation of a Cancer Lysate Vaccine and Montanide(R) ISA-51 VG with or without the IL-15 Super-Agonist N-803 as Adjuvant Therapy for PD-L1 Negative Non-Small Cell Lung Cancer	Recruitment has not started	18-125 Years	NCI	Autosomal
000509-C	An Open Label, Multi-Center Roll-Over Study to Assess Long-Term Safety in Patients Who are Ongoing or Have Completed a Prior Global Novartis or GSK Sponsored Tafinlar (Dabrafenib) and/or Mekinist (Trametinib) Study and are Judged by the Investigator to B	Enrolling by Invitation	18-125 Years	NCI	Hair
000387-H	The Natural History of Acquired and Inherited Bone Marrow Failure Syndromes.	Participants currently recruited/enrolled	2-125 Years	NHLBI	Hair
000261-AA	Mechanisms Underlying Individual Variations of Taste and Smell in Obesity	Participants currently recruited/enrolled	18-65 Years	NIAAA	Hair
000176-C	A Phase I/II Trial of Lurbinectedin with Berzosertib, an ATR Kinase Inhibitor in Small Cell Cancers and High Grade Neuroendocrine Cancers	Participants currently recruited/enrolled	18-125 Years	NCI	Hair
000152-E	Natural History of The Human Biological Response to Environmental Exposure and Injury	Participants currently recruited/enrolled	18-125 Years	NIEHS	Hair
000144-C	A Phase I/II Study of Sacituzumab Govitecan plus Berzosertib in Small Cell Lung Cancer, Extra-Pulmonary Small Cell Neuroendocrine Cancer and Homologous Recombination-Deficient Cancers Resistant to PARP Inhibitors	Participants currently recruited/enrolled	18-125 Years	NCI	Hair
21-C-0019	Phase I Study of Anti-CD22 Chimeric Receptor T Cells in Patients with Relapsed/Refractory Hairy Cell Leukemia and Variant	Participants currently recruited/enrolled	18-125 Years	NCI	Hair
20-H-0158	Natural History Study: Gene First Approach to Connective Tissue Disease	Enrolling by Invitation	2-100 Years	NHLBI	Hair
20-C-0076	Phase 2 Trial of Encorafenib plus Binimetinib for Patients with BRAF V600 Mutated Relapsed/Refractory HCL	Participants currently recruited/enrolled	18-125 Years	NCI	Hair
20-C-0075	Phase 2 Trial for Binimetinib for Patients with Relapsed/Refractory BRAF Wild Type Hairy Cell Leukemia and Variant	Participants currently recruited/enrolled	18-125 Years	NCI	Hair
20-C-0013	Phase I/II Trial of PLX038 (PEGylated SN38) and Rucaparib in Solid Tumors and Small Cell Cancers	No longer recruiting/follow-up only	18-125 Years	NCI	Hair
19-N-0036	Exploring the Relationship Between Brain Asymmetry and Attention	Completed Study; data analyses ongoing	18-35 Years	NINDS	Dominant
19-E-0110	Reproductive Axis Maturation in the Early Post-Menarchal Years: A Pilot Study	Participants currently recruited/enrolled	8-34 Years	NIEHS	Hair
19-C-0042	A Phase I Study of Moxetumomab Pasudotox-tdfk (Lumoxiti (TM)) and either Rituximab (Rituxan (R)) or Ruxience for Relapsed Hairy Cell Leukemia	No longer recruiting/follow-up only	18-125 Years	NCI	Hair
19-C-0033	Phase II Study of Nivolumab (anti-PD1), Tadalafil and Oral Vancomycin in Patients with Refractory Primary Hepatocellular Carcinoma or Liver Dominant Metastatic Cancer from Colorectal or Pancreatic Cancers	No longer recruiting/follow-up only	18-125 Years	NCI	Dominant
18-I-0022	Use of Ustekinumab (Anti-IL-12/23p40 Monoclonal Antibody) in Patients with Leukocyte Adhesion Deficiency Type 1 (LAD1) who have Inflammatory Pathology	Participants currently recruited/enrolled	12-65 Years	NIAID	Autosomal
18-HG-0064	A Natural History Study of Patients with Generalized Arterial Calcification of Infancy (GACI) or Autosomal Recessive Hypophosphatemic Rickets Type 2 (ARHR2)	Completed Study; data analyses ongoing	0-125 Years	NHGRI	Autosomal
18-CH-0031	Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks	Participants currently recruited/enrolled	7-70 Years	NICHD	Hair
18-CC-0052	Near-infrared Spectroscopy and Electroencephalography to Assess Cortical Activation During Motor Tasks in Infants and Toddlers with or at high-risk for Cerebral Palsy and Autism Spectrum Disorder Compared to Infants and Toddlers with Typical Development	Participants currently recruited/enrolled	0-5 Years	CC	Hair
17-CH-0020	Observational Study of Males with Creatine Transporter Deficiency (CTD)	No longer recruiting/follow-up only	2-40 Years	NICHD	Hair
17-C-0117	A Phase 1/2a, Open-Label, Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Anti-Tumor Activity of PEN-866 in Advanced Solid Malignancies	Completed Study; data analyses ongoing	18-125 Years	NCI	Hair
17-C-0012	A Phase I Study of a Combination of MM-398 and Veliparib in solid tumors	Completed Study; data analyses ongoing	18-125 Years	NCI	Hair
16-EI-0134	Studies of the Natural History, Pathogenesis and Outcome of Ocular Disorders	Participants currently recruited/enrolled	0-125 Years	NEI	Hair
16-EI-0046	Uveitis/Intraocular Inflammatory Disease Biobank (iBank)	No longer recruiting/follow-up only	8-125 Years	NEI	Hair
16-C-0107	A Phase I/II Trial of EP0057, a Nanoparticle Camptothecin with Olaparib in Patients with Relapsed/Refractory Small Cell Lung, Bladder and Prostate Cancers	Participants currently recruited/enrolled	18-125 Years	NCI	Hair
15-H-0155	Hereditary Parkinson Disease Natural History Protocol	Completed Study; data analyses ongoing	18-80 Years	NHLBI	Autosomal
15-EI-0128	The Genetics of Inherited Eye Disease	Participants currently recruited/enrolled	0-125 Years	NEI	Hair
15-C-0150	A Phase I/II Trial of Topotecan with VX-970 (M6620), an ATR Kinase Inhibitor in Small Cell Cancers	No longer recruiting/follow-up only	18-125 Years	NCI	Hair
14-I-0206	Novel Genetic Disorders of the Immune System	Participants currently recruited/enrolled	0-99 Years	NIAID	Hair
14-HG-0125	Insights Into Microbiome and Environmental Contributions to Sickle Cell Disease and Leg Ulcers	Participants currently recruited/enrolled	18-125 Years	NHGRI	Hair
14-C-0131	A Phase II, Open-Label Study in Patients With BRAF V600E-Mutated Rare Cancers With Several Histologies to Investigate the Clinical Efficacy and Safety of the Combination Therapy of Dabrafenib and Trametinib	Completed Study; data analyses ongoing	18-125 Years	NCI	Hair
14-C-0004	A Multicenter Phase 2 Study of the Bruton's Tyrosine Kinase Inhibitor PCI-32765 (Ibrutinib) for Treatment of Relapsed Hairy Cell Leukemia	No longer recruiting/follow-up only	18-125 Years	NCI	Hair
12-EI-0042	NEI Intramural Biorepository for Retinal Diseases	Participants currently recruited/enrolled	2-125 Years	NEI	Hair
11-EI-0245	Generation of Induced Pluripotent Stem (iPS) Cell Lines from Somatic Cells of Participants with Eye Diseases and from Somatic Cells of Matched Controls	Participants currently recruited/enrolled	1-125 Years	NEI	Hair
10-E-0063	Sample Collection Registry for Quality Control of Biological and Environmental Specimens and Assay Development and Testing	Completed Study; data analyses ongoing	18-125 Years	NIEHS	Hair
10-C-0066	A Study of Hairy Cell and other Leukemias with a Focus on Recombinant Immunotoxins for Cancer Treatment	Participants currently recruited/enrolled	18-125 Years	NCI	Hair
10-C-0056	A Phase I Study of Indenoisoquinolines LMP400 and LMP776 in Adults With Relapsed Solid Tumors and Lymphomas	Completed Study; data analyses ongoing	18-125 Years	NCI	Hair
10-C-0025	Randomized Phase II Trial of Rituximab with Either Pentostatin or Bendamustine for Multiply Relapsed or Refractory Hairy Cell Leukemia	Participants currently recruited/enrolled	18-125 Years	NCI	Hair
09-I-0086	Screening Protocol for Genetic Diseases of Allergic Inflammation	Participants currently recruited/enrolled	0-99 Years	NIAID	Hair
09-C-0005	Randomized Trial of Cladribine (CdA) with Simultaneous or Delayed Rituximab to Eliminate Hairy Cell Leukemia Minimal Residual Disease	Participants currently recruited/enrolled	18-125 Years	NCI	Hair
06-H-0217	Genetic Disorders of Mucociliary Clearance	Completed Study; data analyses ongoing	2-65 Years	NHLBI	Hair
06-DA-N415	Screening Protocol for the Evaluation of Potential Research Subjects	Participants currently recruited/enrolled	18-125 Years	NIDA	Hair
06-CH-0011	Natural History Study of Patients with Excess Androgen	Participants currently recruited/enrolled	0-99 Years	NICHD	Hair
06-C-0213	Tissue Procurement Protocol for the Developmental Therapeutics Clinic, National Cancer Institute (NCI)	Participants currently recruited/enrolled	0-125 Years	NCI	Hair
06-C-0150	A Phase II Clinical Trial of Anti-Tac(Fv)-PE38 (LMB-2) Immunotoxin for CD25 Positive Hairy Cell Leukemia	No longer recruiting/follow-up only	18-125 Years	NCI	Hair
02-CH-0311	Investigations into Inborn Errors of Cholesterol Synthesis and Related Disorders	Participants currently recruited/enrolled	0-125 Years	NICHD	Dominant
02-C-0313	Cancer Risk in Xeroderma Pigmentosum Heterozygotes	Participants currently recruited/enrolled	0-99 Years	NCI	Hair
02-C-0210	Clinical, Laboratory, and Epidemiologic Characterization of Individuals and Families at High Risk of Blood and Lymph Node Malignancy	Participants currently recruited/enrolled	0-125 Years	NCI	Hair
02-C-0159	Birt-Hogg-Dub(SqrRoot)(Copyright) Syndrome: Characterization of the FLCN Disease Gene and Predisposition to Renal Cancer, Cutaneous Fibrofolliculoma and Pulmonary Cysts	Participants currently recruited/enrolled	2-125 Years	NCI	Hair
01-DC-0229	Genetic Analysis of Hereditary Disorders of Hearing and Balance	Completed Study; data analyses ongoing	0-99 Years	NIDCD	Hair
00-HG-0153	Investigations into Chediak-Higashi Syndrome and Related Disorders	Participants currently recruited/enrolled	0-70 Years	NHGRI	Autosomal
99-C-0099	Examination of Clinical and Laboratory Abnormalities in Patients with Defective DNA Repair: Xeroderma Pigmentosum, Cockayne Syndrome, or Trichothiodystrophy	Participants currently recruited/enrolled	0-125 Years	NCI	Hair
98-CH-0081	Clinical and Basic Investigations into Smith-Lemli-Opitz Syndrome	Completed Study; data analyses ongoing	0-125 Years	NICHD	Autosomal
94-C-0074	Treatment and Natural History Study of Lymphomatoid Granulomatosis	Participants currently recruited/enrolled	12-125 Years	NCI	Hair