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66 Studies found from all possible combinations of your search terms. Select a protocol that you wish to review.
Protocol Number Title Protocol Status Min-Max Age Institute Keywords
000696-CA Phase III, Multicenter, International Study with a Parallel, Randomized, Double-blind, Placebo-controlled, 2 Arm Design to Assess the Efficacy and Safety of Selumetinib in Adult Participants with NF1 who have Symptomatic, Inoperable Plexiform NeurofibrParticipants currently recruited/enrolled18-120 YearsNCI Autosomal Dominant
000413-HNatural History study of CADASILParticipants currently recruited/enrolled18-100 YearsNHLBIAutosomal Dominant
20-DC-0047Natural History of Autosomal Dominant Hearing LossParticipants currently recruited/enrolled3-99 YearsNIDCDAutosomal Dominant
20-D-0122A Phase IIb, Open-label Dose-ranging Study Evaluating the Safety, Tolerability, Pharmacodynamics and Pharmacokinetics, and Efficacy of CLTX-305 (encaleret) in Autosomal Dominant Hypocalcemia Type 1 (ADH1)No longer recruiting/follow-up only16-125 YearsNIDCRAutosomal Dominant
16-H-0132CADASIL Disease DiscoveryCompleted Study; data analyses ongoing18-100 YearsNHLBIAutosomal Dominant
08-C-0130A Phase II Trial of Peginterferon alfa-2b (PEG-Intron) for Neurofibromatosis Type 1 Related Unresectable, Symptomatic or Life-Threatening Plexiform NeurofibromasCompleted Study; data analyses ongoing0-21 YearsNCI Autosomal Dominant
00-I-0159Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES)Participants currently recruited/enrolled0-125 YearsNIAIDAutosomal Dominant
000861-IA Phase 2 Open-Label Study to Evaluate the Efficacy and Safety of Ruxolitinib on Hair Regrowth in Patients with Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED)-Associated Alopecia AreataParticipants currently recruited/enrolled12-65 YearsNIAIDHair
000827-ARNatural History and Pathogenesis of Alopecia in Children and AdultsParticipants currently recruited/enrolled2-45 YearsNIAMSHair
000686-CHIntrathecal 2-Hydroxypropyl-Beta-Cyclodextrin for Neurological Decline in Patients with Niemann-Pick Disease Type C1Participants currently recruited/enrolled18-125 YearsNICHDAutosomal
000678-CRare Tumors and Cancer Predisposition in Individuals and FamiliesParticipants currently recruited/enrolled0-125 YearsNCI Hair
000520-CPhase I/II Evaluation of a Cancer Lysate Vaccine and Montanide(R) ISA-51 VG with or without the IL-15 Super-Agonist N-803 as Adjuvant Therapy for PD-L1 Negative Non-Small Cell Lung CancerRecruitment has not started18-125 YearsNCI Autosomal
000509-CAn Open Label, Multi-Center Roll-Over Study to Assess Long-Term Safety in Patients Who are Ongoing or Have Completed a Prior Global Novartis or GSK Sponsored Tafinlar (Dabrafenib) and/or Mekinist (Trametinib) Study and are Judged by the Investigator to BEnrolling by Invitation18-125 YearsNCI Hair
000387-HThe Natural History of Acquired and Inherited Bone Marrow Failure Syndromes.Participants currently recruited/enrolled2-125 YearsNHLBIHair
000261-AAMechanisms Underlying Individual Variations of Taste and Smell in ObesityParticipants currently recruited/enrolled18-65 YearsNIAAAHair
000176-CA Phase I/II Trial of Lurbinectedin with Berzosertib, an ATR Kinase Inhibitor in Small Cell Cancers and High Grade Neuroendocrine CancersParticipants currently recruited/enrolled18-125 YearsNCI Hair
000152-ENatural History of The Human Biological Response to Environmental Exposure and InjuryParticipants currently recruited/enrolled18-125 YearsNIEHSHair
000144-CA Phase I/II Study of Sacituzumab Govitecan plus Berzosertib in Small Cell Lung Cancer, Extra-Pulmonary Small Cell Neuroendocrine Cancer and Homologous Recombination-Deficient Cancers Resistant to PARP InhibitorsParticipants currently recruited/enrolled18-125 YearsNCI Hair
21-C-0019Phase I Study of Anti-CD22 Chimeric Receptor T Cells in Patients with Relapsed/Refractory Hairy Cell Leukemia and VariantParticipants currently recruited/enrolled18-125 YearsNCI Hair
20-H-0158Natural History Study: Gene First Approach to Connective Tissue DiseaseEnrolling by Invitation2-100 YearsNHLBIHair
20-C-0076Phase 2 Trial of Encorafenib plus Binimetinib for Patients with BRAF V600 Mutated Relapsed/Refractory HCLParticipants currently recruited/enrolled18-125 YearsNCI Hair
20-C-0075Phase 2 Trial for Binimetinib for Patients with Relapsed/Refractory BRAF Wild Type Hairy Cell Leukemia and VariantParticipants currently recruited/enrolled18-125 YearsNCI Hair
20-C-0013Phase I/II Trial of PLX038 (PEGylated SN38) and Rucaparib in Solid Tumors and Small Cell CancersNo longer recruiting/follow-up only18-125 YearsNCI Hair
19-N-0036Exploring the Relationship Between Brain Asymmetry and AttentionCompleted Study; data analyses ongoing18-35 YearsNINDSDominant
19-E-0110Reproductive Axis Maturation in the Early Post-Menarchal Years: A Pilot StudyParticipants currently recruited/enrolled8-34 YearsNIEHSHair
19-C-0042A Phase I Study of Moxetumomab Pasudotox-tdfk (Lumoxiti (TM)) and either Rituximab (Rituxan (R)) or Ruxience for Relapsed Hairy Cell LeukemiaNo longer recruiting/follow-up only18-125 YearsNCI Hair
19-C-0033Phase II Study of Nivolumab (anti-PD1), Tadalafil and Oral Vancomycin in Patients with Refractory Primary Hepatocellular Carcinoma or Liver Dominant Metastatic Cancer from Colorectal or Pancreatic CancersNo longer recruiting/follow-up only18-125 YearsNCI Dominant
18-I-0022Use of Ustekinumab (Anti-IL-12/23p40 Monoclonal Antibody) in Patients with Leukocyte Adhesion Deficiency Type 1 (LAD1) who have Inflammatory PathologyParticipants currently recruited/enrolled12-65 YearsNIAIDAutosomal
18-HG-0064A Natural History Study of Patients with Generalized Arterial Calcification of Infancy (GACI) or Autosomal Recessive Hypophosphatemic Rickets Type 2 (ARHR2)Completed Study; data analyses ongoing0-125 YearsNHGRIAutosomal
18-CH-0031Clinical and Molecular Characteristics of Primary Aldosteronism in BlacksParticipants currently recruited/enrolled7-70 YearsNICHDHair
18-CC-0052Near-infrared Spectroscopy and Electroencephalography to Assess Cortical Activation During Motor Tasks in Infants and Toddlers with or at high-risk for Cerebral Palsy and Autism Spectrum Disorder Compared to Infants and Toddlers with Typical DevelopmentParticipants currently recruited/enrolled0-5 YearsCC Hair
17-CH-0020Observational Study of Males with Creatine Transporter Deficiency (CTD)No longer recruiting/follow-up only2-40 YearsNICHDHair
17-C-0117A Phase 1/2a, Open-Label, Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Anti-Tumor Activity of PEN-866 in Advanced Solid MalignanciesCompleted Study; data analyses ongoing18-125 YearsNCI Hair
17-C-0012A Phase I Study of a Combination of MM-398 and Veliparib in solid tumorsCompleted Study; data analyses ongoing18-125 YearsNCI Hair
16-EI-0134Studies of the Natural History, Pathogenesis and Outcome of Ocular DisordersParticipants currently recruited/enrolled0-125 YearsNEI Hair
16-EI-0046Uveitis/Intraocular Inflammatory Disease Biobank (iBank)No longer recruiting/follow-up only8-125 YearsNEI Hair
16-C-0107A Phase I/II Trial of EP0057, a Nanoparticle Camptothecin with Olaparib in Patients with Relapsed/Refractory Small Cell Lung, Bladder and Prostate CancersParticipants currently recruited/enrolled18-125 YearsNCI Hair
15-H-0155Hereditary Parkinson Disease Natural History ProtocolCompleted Study; data analyses ongoing18-80 YearsNHLBIAutosomal
15-EI-0128The Genetics of Inherited Eye DiseaseParticipants currently recruited/enrolled0-125 YearsNEI Hair
15-C-0150A Phase I/II Trial of Topotecan with VX-970 (M6620), an ATR Kinase Inhibitor in Small Cell CancersNo longer recruiting/follow-up only18-125 YearsNCI Hair
14-I-0206Novel Genetic Disorders of the Immune SystemParticipants currently recruited/enrolled0-99 YearsNIAIDHair
14-HG-0125Insights Into Microbiome and Environmental Contributions to Sickle Cell Disease and Leg UlcersParticipants currently recruited/enrolled18-125 YearsNHGRIHair
14-C-0131A Phase II, Open-Label Study in Patients With BRAF V600E-Mutated Rare Cancers With Several Histologies to Investigate the Clinical Efficacy and Safety of the Combination Therapy of Dabrafenib and TrametinibCompleted Study; data analyses ongoing18-125 YearsNCI Hair
14-C-0004A Multicenter Phase 2 Study of the Bruton's Tyrosine Kinase Inhibitor PCI-32765 (Ibrutinib) for Treatment of Relapsed Hairy Cell LeukemiaNo longer recruiting/follow-up only18-125 YearsNCI Hair
12-EI-0042NEI Intramural Biorepository for Retinal DiseasesParticipants currently recruited/enrolled2-125 YearsNEI Hair
11-EI-0245Generation of Induced Pluripotent Stem (iPS) Cell Lines from Somatic Cells of Participants with Eye Diseases and from Somatic Cells of Matched ControlsParticipants currently recruited/enrolled1-125 YearsNEI Hair
10-E-0063Sample Collection Registry for Quality Control of Biological and Environmental Specimens and Assay Development and TestingCompleted Study; data analyses ongoing18-125 YearsNIEHSHair
10-C-0066A Study of Hairy Cell and other Leukemias with a Focus on Recombinant Immunotoxins for Cancer TreatmentParticipants currently recruited/enrolled18-125 YearsNCI Hair
10-C-0056A Phase I Study of Indenoisoquinolines LMP400 and LMP776 in Adults With Relapsed Solid Tumors and LymphomasCompleted Study; data analyses ongoing18-125 YearsNCI Hair
10-C-0025Randomized Phase II Trial of Rituximab with Either Pentostatin or Bendamustine for Multiply Relapsed or Refractory Hairy Cell LeukemiaParticipants currently recruited/enrolled18-125 YearsNCI Hair
09-I-0086Screening Protocol for Genetic Diseases of Allergic InflammationParticipants currently recruited/enrolled0-99 YearsNIAIDHair
09-C-0005Randomized Trial of Cladribine (CdA) with Simultaneous or Delayed Rituximab to Eliminate Hairy Cell Leukemia Minimal Residual DiseaseParticipants currently recruited/enrolled18-125 YearsNCI Hair
06-H-0217Genetic Disorders of Mucociliary ClearanceCompleted Study; data analyses ongoing2-65 YearsNHLBIHair
06-DA-N415Screening Protocol for the Evaluation of Potential Research SubjectsParticipants currently recruited/enrolled18-125 YearsNIDA Hair
06-CH-0011Natural History Study of Patients with Excess AndrogenParticipants currently recruited/enrolled0-99 YearsNICHDHair
06-C-0213Tissue Procurement Protocol for the Developmental Therapeutics Clinic, National Cancer Institute (NCI)Participants currently recruited/enrolled0-125 YearsNCI Hair
06-C-0150A Phase II Clinical Trial of Anti-Tac(Fv)-PE38 (LMB-2) Immunotoxin for CD25 Positive Hairy Cell LeukemiaNo longer recruiting/follow-up only18-125 YearsNCI Hair
02-CH-0311Investigations into Inborn Errors of Cholesterol Synthesis and Related DisordersParticipants currently recruited/enrolled0-125 YearsNICHDDominant
02-C-0313Cancer Risk in Xeroderma Pigmentosum HeterozygotesParticipants currently recruited/enrolled0-99 YearsNCI Hair
02-C-0210Clinical, Laboratory, and Epidemiologic Characterization of Individuals and Families at High Risk of Blood and Lymph Node MalignancyParticipants currently recruited/enrolled0-125 YearsNCI Hair
02-C-0159Birt-Hogg-Dub(SqrRoot)(Copyright) Syndrome: Characterization of the FLCN Disease Gene and Predisposition to Renal Cancer, Cutaneous Fibrofolliculoma and Pulmonary CystsParticipants currently recruited/enrolled2-125 YearsNCI Hair
01-DC-0229Genetic Analysis of Hereditary Disorders of Hearing and BalanceCompleted Study; data analyses ongoing0-99 YearsNIDCDHair
00-HG-0153Investigations into Chediak-Higashi Syndrome and Related DisordersParticipants currently recruited/enrolled0-70 YearsNHGRIAutosomal
99-C-0099Examination of Clinical and Laboratory Abnormalities in Patients with Defective DNA Repair: Xeroderma Pigmentosum, Cockayne Syndrome, or TrichothiodystrophyParticipants currently recruited/enrolled0-125 YearsNCI Hair
98-CH-0081Clinical and Basic Investigations into Smith-Lemli-Opitz SyndromeCompleted Study; data analyses ongoing0-125 YearsNICHDAutosomal
94-C-0074Treatment and Natural History Study of Lymphomatoid GranulomatosisParticipants currently recruited/enrolled12-125 YearsNCI Hair