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Protocol Number Title Protocol Status Min-Max Age Institute Keywords
98-D-0145Screening and Natural History of Patients with Polyostotic Fibrous Dysplasia and the McCune-Albright SyndromeParticipants currently recruited/enrolled0-125 YearsNIDCRAbsence of
97-HG-0192Genetic Studies in the Amish and MennonitesCompleted Study; data analyses ongoing18-125 YearsNHGRIHypoplasia of
001092-CExploring the Role of Palliative Care in Phase 1 Enrolled Pediatric Oncology PatientsEnrolling by Invitation18-125 YearsNCI of
000911-DKDinner Time for Obesity and Prediabetes (DTOP)Recruitment has not started18-50 YearsNIDDKof
000889-IVRC 615: A Phase I, Open-Label, Dose-Escalation Study of the Safety and Pharmacokinetics of a Human Monoclonal Antibody, VRC-HIVMAB-0115-AB (VRC01.23LS), Administered Intravenously or Subcutaneously to Healthy AdultsParticipants currently recruited/enrolled18-60 YearsNIAIDof
000776-MAn Open Trial of Transcranial Magnetic Stimulation for Youth with Treatment-Resistant Major Depressive DisorderRecruitment has not started13-17 YearsNIMH of
000757-DKNatural History of Pregnancy and Pregnancy Outcomes in Metreleptin-Treated vs Untreated Subjects with LipodystrophyParticipants currently recruited/enrolled0-125 YearsNIDDKof
000726-CA Randomized Phase 2 Study of Atezolizumab with or without Selinexor in Alveolar Soft Part Sarcoma (AXIOM)Participants currently recruited/enrolled18-125 YearsNCI of
000488-INatural History of Systemic and Nasal Mucosal Immunity after Influenza Vaccination in a Pediatric PopulationNo longer recruiting/follow-up only2-17 YearsNIAIDof
000384-IAnalysis of the Immune Response to COVID-19 Vaccination and Outcomes in Individuals With and Without Immune Deficiencies and DysregulationsParticipants currently recruited/enrolled3-125 YearsNIAIDof
000344-DKNatural History Study of Parathyroid DisordersParticipants currently recruited/enrolled0-125 YearsNIDDKof
000268-CCNIH Intramural Research Program's Pregnancy Registry Protocol for Subjects and Their PartnersEnrolling by Invitation0-100 YearsCC of
000251-CThe Effect of Diet and Exercise on ImmuNotherapy and the Microbiome (EDEN)Participants currently recruited/enrolled18-125 YearsNCI of
000247-DKEvaluation of Patients with Gastrointestinal DiseaseParticipants currently recruited/enrolled18-125 YearsNIDDKof
000106-CHGonadal Tissue Freezing for Fertility Preservation in Individuals at risk for Ovarian Dysfunction and Premature Ovarian InsufficiencyParticipants currently recruited/enrolled4-21 YearsNICHDof
000101-MAn Investigation of the Antidepressant Effects of the mGlu2/3 receptor antagonist TS-161 in Treatment-Resistant DepressionParticipants currently recruited/enrolled18-65 YearsNIMH of
000079-DKThe Role of 68-Gallium-DOTATATE-PET/CT in the Imaging of Metastatic Thyroid CancerParticipants currently recruited/enrolled18-125 YearsNIDDKof
000057-CA Phase 1 Study of AZD8186 in Combination with Docetaxel in Patients with PTEN Mutated or PIK3CB Mutated Advanced Solid Tumors, Potentially Amenable to DocetaxelCompleted Study; data analyses ongoing18-125 YearsNCI of
000049-HEvaluation of the Safety,Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects with Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of MitapivatNo longer recruiting/follow-up only18-70 YearsNHLBIof
000045-CA Phase I Trial of T Cell Receptor Gene Therapy Targeting KK-LC-1 for Gastric, Breast, Cervical, Lung and other KK-LC-1 Positive Epithelial CancersParticipants currently recruited/enrolled18-125 YearsNCI of
21-M-0018Characterization of an Optically Pumped Magnetometer (OPM) Magnetoencephalography (MEG) ArrayParticipants currently recruited/enrolled18-65 YearsNIMH of
20-M-0157PET Imaging of Cyclooxygenase in Participants with Major Depressive Disorder (MDD)Participants currently recruited/enrolled18-70 YearsNIMH of
20-C-0106Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients with BAP1 Tumor Predisposition SyndromeParticipants currently recruited/enrolled30-125 YearsNCI of
20-C-0103Investigation of the B- and T-cell Repertoire and Immune Response in Patients with Acute and Resolved COVID-19 InfectionParticipants currently recruited/enrolled18-125 YearsNCI of
20-C-0097A Phase II, Open-Label Trial of Bintrafusp Alfa (M7824) in Subjects with Thymoma and Thymic CarcinomaParticipants currently recruited/enrolled18-125 YearsNCI of
19-M-0107The Mechanism of Action Underlying Ketamine's Antidepressant Effects: An Investigation of the AMPA Throughput Theory in Patients with Treatment-Resistant Major DepressionParticipants currently recruited/enrolled18-70 YearsNIMH of
19-I-0053Prospective Study to Identify Food-Specific and Component IgE Threshold Levels that Predict Food Allergy in Patients with Elevated Total Serum IgE Levels and Atopic DermatitisParticipants currently recruited/enrolled3-21 YearsNIAIDof
19-H-0097A Pilot Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Escalating Multiple Oral Doses of AG-348 in Subjects with Stable Sickle Cell DiseaseCompleted Study; data analyses ongoing18-70 YearsNHLBIof
19-CH-0071An Open-Label Phase 3 Study of the Safety and Efficacy of Pegvisomant in Children with Growth Hormone ExcessParticipants currently recruited/enrolled2-18 YearsNICHDof
18-I-0139Defining Skin Immunity of a Bite of Key Insect Vectors in HumansCompleted Study; data analyses ongoing18-64 YearsNIAIDof
18-HG-0064A Natural History Study of Patients with Generalized Arterial Calcification of Infancy (GACI) or Autosomal Recessive Hypophosphatemic Rickets Type 2 (ARHR2)Completed Study; data analyses ongoing0-125 YearsNHGRIof
18-H-0090Haplo-identical Transplantation for Severe Aplastic Anemia, Hypo-plastic MDS and PNH using Peripheral Blood Stem Cells and post-transplant Cyclophosphamide for GVHD prophylaxisParticipants currently recruited/enrolled4-75 YearsNHLBIof
18-CH-0031Clinical and Molecular Characteristics of Primary Aldosteronism in BlacksParticipants currently recruited/enrolled7-70 YearsNICHDof
18-C-0014Phase I Trial of 5-aza-4'-thio-2'-Deoxycytidine (Aza-TdC) in Patients with Advanced Solid TumorsParticipants currently recruited/enrolled18-120 YearsNCI of
18-AR-0081Investigation of the Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease and Related Inflammatory ConditionsParticipants currently recruited/enrolled0-125 YearsNIAMSof
17-M-0060Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive DisorderParticipants currently recruited/enrolled18-65 YearsNIMH of
17-I-0067Sanaria PfSPZ Challenge with Pyrimethamine Chemoprophylaxis (PfSPZ-CVac Approach): Phase 1 Dose Escalation Trial to Determine Safety and Development of Protective Efficacy after Exposure to Only Pre-erythrocytic Stages of Plasmodium falciparumCompleted Study; data analyses ongoing18-50 YearsNIAIDof
17-EI-0112A Long-term Follow-up Study of Participants Enrolled in 11-EI-0147: Longitudinal Investigation of Dark Adaptation in Participants with Age-Related Macular Degeneration (DA_AMD)Participants currently recruited/enrolled50-125 YearsNEI of
17-C-0137Leukapheresis for CAR or Adoptive Cell Therapy ManufacturingEnrolling by Invitation3-65 YearsNCI of
17-C-0105Prospective Study of Clonal Evolution in Follicular LymphomaParticipants currently recruited/enrolled18-125 YearsNCI of
17-C-0066A Pilot Study to Investigate the Safety and Clinical Activity of Avelumab (MSB0010718C) in Thymoma and Thymic Carcinoma after Progression on Platinum-Based ChemotherapyParticipants currently recruited/enrolled18-125 YearsNCI of
17-C-0061Phase II Trial of Pembrolizumab in Recurrent or Metastatic Medullary Thyroid CancerCompleted Study; data analyses ongoing18-125 YearsNCI of
17-C-0009Phase I Trial of Zotiraciclib (TG02) Plus Dose-Dense or Metronomic Temozolomide Followed by Randomized Phase II Trial of Zotiraciclib (TG02) plus Temozolomide versus Temozolomide alone in Adults with Recurrent Anaplastic Astrocytoma and GlioblastomaCompleted Study; data analyses ongoing18-125 YearsNCI of
16-N-0058Myalgic Encephalomyelitis/Chronic Fatigue SyndromeCompleted Study; data analyses ongoing18-60 YearsNINDSof
16-N-0041Tumor Related EpilepsyParticipants currently recruited/enrolled8-125 YearsNINDSof
16-H-0144Impact of Elastin Mediated Vascular Stiffness on End OrgansParticipants currently recruited/enrolled3-85 YearsNHLBIof
16-D-0040Natural History of Craniofacial Anomalies and Developmental Growth VariantsParticipants currently recruited/enrolled2-125 YearsNIDCRof
16-CH-0113Evaluation of Children with Endocrine and Metabolic-Related ConditionsParticipants currently recruited/enrolled0-100 YearsNICHDof
16-C-0135A Pilot Study of Combined Immune Checkpoint Inhibition in combination with Ablative Therapies in Subjects with Hepatocellular Carcinoma (HCC) or Biliary Tract Carcinomas (BTC)No longer recruiting/follow-up only18-125 YearsNCI of
16-C-0097Phase 1 Trial of Panobinostat in Children with Diffuse Intrinsic Pontine GliomaCompleted Study; data analyses ongoing2-21 YearsNCI of
16-C-0073A Phase 2 Study of Olaparib and Cediranib for the Treatment of Recurrent Ovarian CancerCompleted Study; data analyses ongoing18-125 YearsNCI of
15-I-0162Natural History and Genetics of Food Allergy and Related ConditionsParticipants currently recruited/enrolled0-99 YearsNIAIDof
15-I-0131Xenodiagnosis after Antibiotic Treatment for Lyme Disease - Phase II StudyCompleted Study; data analyses ongoing18-125 YearsNIAIDAbsence
15-H-0190Human Biospecimen Procurement and Analysis to Support Translational Research to Identify Genetic Etiology and Disease Mechanism(s) in Rare Genetic Vascular/Cardiovascular DiseasesParticipants currently recruited/enrolled0-125 YearsNHLBIof
15-C-0141Gene Therapy Follow up Protocol for Subjects Previously Enrolled in CAR T-Cell StudiesEnrolling by Invitation18-125 YearsNCI of
15-C-0116Phase I Trial of 4'-thio-2'-deoxycytidine (TdCyd) in Patients With Advanced Solid TumorsClinical hold/Recruitment or enrollment suspended18-125 YearsNCI of
14-I-0146The Pathogenesis and Genetics of Disseminated or Refractory CoccidioidomycosisParticipants currently recruited/enrolled2-100 YearsNIAIDof
14-HG-0055Study on Moebius Syndrome and Other Congenital Facial Weakness DisordersCompleted Study; data analyses ongoing2-80 YearsNHGRIof
14-EI-0064Whole Exome and Whole Genome Sequencing for Genotyping of Inherited and Congenital Eye ConditionsParticipants currently recruited/enrolled1-125 YearsNEI of
14-C-0161Phase I Trial of the Combination of Bortezomib and Clofarabine in Adults with Refractory Solid Tumors, Lymphomas, or Myelodysplastic SyndromesParticipants currently recruited/enrolled18-125 YearsNCI of
14-AA-0181NIAAA Natural History ProtocolParticipants currently recruited/enrolled18-100 YearsNIAAAof
13-HG-0053The NIH Mini Study: Metabolism, INfection and Immunity in Inborn Errors of Mitochondrial MetabolismParticipants currently recruited/enrolled2-125 YearsNHGRIof
13-H-0060Analysis of Samples Collected from a Subject who Received ACP- 501 (Human Recombinant Lecithin:Cholesterol Acyltransferase [rhLCAT])Completed Study; data analyses ongoing18-100 YearsNHLBIAbsence
13-C-0105Molecular Profiling-based Assignment of Cancer Therapy for Patients With Advanced Solid TumorsCompleted Study; data analyses ongoing18-120 YearsNCI of
12-HG-0181The Clinical Study of Patients with Sex Chromosome VariantsCompleted Study; data analyses ongoing18-125 YearsNHGRIof
12-DK-0097Energy Expenditure Responses to Different TemperaturesParticipants currently recruited/enrolled18-75 YearsNIDDKof
11-I-0109Viral Infections in Healthy and Immunocompromised HostsParticipants currently recruited/enrolled0-125 YearsNIAIDof
11-HG-0238Weight Management Interactions in a Virtual Clinical EnvironmentCompleted Study; data analyses ongoing20-50 YearsNHGRIof
11-CH-0078Evaluation of Cortisol Resistance in Young Endurance-Trained and Elderly MenCompleted Study; data analyses ongoing18-30 YearsNICHDof
11-C-0096Pilot Trial of Molecular Profiling and Targeted Therapy for Advanced Non-Small Cell Lung Cancer, Small Cell Lung Cancer, and Thymic MalignanciesNo longer recruiting/follow-up only18-125 YearsNCI of
10-HG-0065Whole Genome Medical Sequencing for Gene DiscoveryParticipants currently recruited/enrolled0-125 YearsNHGRIof
10-H-0141A Phase II Study of Ofatumumab-Based Induction Chemoimmunotherapy Followed by Consolidation Ofatumumab Immunotherapy in Previously Untreated Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma.No longer recruiting/follow-up only18-99 YearsNHLBIof
10-H-0083A Phase I Trial of Safety and Immunogenicity of Gardasil Vaccination Post Stem Cell Transplantation in Patients with and without ImmunosuppressionCompleted Study; data analyses ongoing18-50 YearsNHLBIof
10-C-0201Apheresis and CD34+ Selection of Mobilized Peripheral Blood CD34+ Cells from Patients with DOCK8 Deficiency, LAD-1, and GATA2 DeficiencyParticipants currently recruited/enrolled18-40 YearsNCI of
10-C-0025Randomized Phase II Trial of Rituximab with Either Pentostatin or Bendamustine for Multiply Relapsed or Refractory Hairy Cell LeukemiaParticipants currently recruited/enrolled18-125 YearsNCI of
09-I-0200A Phase I Study of MozobilTM in the Treatment of Patients with WHIMSParticipants currently recruited/enrolled18-75 YearsNIAIDof
09-I-0184Studies in the Pathogenesis of Systemic Capillary Leak SyndromeParticipants currently recruited/enrolled0-125 YearsNIAIDof
09-I-0032Comprehensive Multimodal Analysis of Patients with Neuroimmunological Diseases of the CNSParticipants currently recruited/enrolled0-99 YearsNIAIDof
09-I-0030Clinical and Immunologic Monitoring of Patients with Known or Suspected HIV InfectionParticipants currently recruited/enrolled18-125 YearsNIAIDof
09-DK-0097Vitamin E Pharmacokinetics and Biomarkers in Normal and Obese WomenCompleted Study; data analyses ongoing18-55 YearsNIDDKof
08-H-0046Co-Infusion of Umbilical Cord Blood and Haploidentical CD34+ Cells Following Nonmyeloablative Conditioning as Treatment for Severe Aplastic Anemia and MDS Associated with Severe Neutropenia Refractory to Immunosuppressive TherapyCompleted Study; data analyses ongoing4-75 YearsNHLBIof
08-EI-0102Screening Protocol for the Evaluation and Diagnosis of Potential Research ParticipantsParticipants currently recruited/enrolled2-125 YearsNEI of
08-DK-0098Natural History of Familial Carcinoid TumorParticipants currently recruited/enrolled18-125 YearsNIDDKof
07-H-0142Research Respiratory Tract ProceduresParticipants currently recruited/enrolled10-125 YearsNHLBIof
07-C-0121Phase 2 Study of the C-Met RTK Inhibitor Foretinib (Formerly GSK 1363089) in Subjects with Papillary Renal Cell Carcinoma (PRC)Completed Study; data analyses ongoing18-125 YearsNCI of
06-I-0153A Pilot Study of Hepatic Fibrosis in HIV/AIDS Patients with Chronically Elevated Transaminases on Antiretroviral TherapyNo longer recruiting/follow-up only18-100 YearsNIAIDof
06-C-0014Prospective Evaluation of Genetic and Epigenetic Alterations in Patients with Thoracic MalignanciesParticipants currently recruited/enrolled2-125 YearsNCI of
05-H-0130Long-Term Evaluation and Follow Up Care of Patients Treated with Allogeneic Stem Cell TransplantsParticipants currently recruited/enrolled7-80 YearsNHLBIof
05-C-0252Phase III Randomized Study of R-CHOP v. Dose-Adjusted EPOCH-R with Molecular Profiling in Untreated de Novo Diffuse Large B-Cell LymphomasCompleted Study; data analyses ongoing18-125 YearsNCI of
05-C-0170Randomized Phase II Study of Dose-Adjusted EPOCH-Rituximab-Bortezomib Induction Followed by Bortezomib Maintenance versus Observation in Untreated Mantle Cell Lymphoma with Microarray Profiling and ProteomicsCompleted Study; data analyses ongoing18-125 YearsNCI of
04-N-0056The Neural Immune Mechanisms and Genetic Influences on Chronic Pelvic Pain in Women with EndometriosisCompleted Study; data analyses ongoing18-50 YearsNINDSof
04-CH-0077Investigations of Bone-Related Connective Tissue DisordersCompleted Study; data analyses ongoing0-70 YearsNICHDof
04-C-0165Data Collection, Clinical Care and Interventions in CCR, NCIEnrolling by Invitation0-125 YearsNCI of
02-I-0110Natural History of Anthrax: A Study of Primary Infected, Recovered, and Exposed (SPoRE) Individuals and Evaluation of AVA Vaccinated RecipientsParticipants currently recruited/enrolled3-125 YearsNIAIDof
02-I-0055Evaluation, Treatment, and Follow-up of Patients with Lyme DiseaseParticipants currently recruited/enrolled2-125 YearsNIAIDof
02-C-0212Clinical, Genetic, Behavioral, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Breast/Ovarian CancerCompleted Study; data analyses ongoing18-100 YearsNCI of
01-M-0254The Evaluation of Patients with Mood and Anxiety Disorders and Healthy VolunteersParticipants currently recruited/enrolled3-99 YearsNIMH of
01-HG-0109Natural History Study of the Clinical and Molecular Manifestations of Smith-Magenis Syndrome (SMS)No longer recruiting/follow-up only0-125 YearsNHGRIof
01-D-0184A Natural History Study of Bone and Mineral DisordersParticipants currently recruited/enrolled0-125 YearsNIDCRof
01-CC-0045Studies of Phlebotomy Therapy in Hereditary HemochromatosisParticipants currently recruited/enrolled18-125 YearsCC of
01-AR-0227Studies of the Natural History of Rheumatic Disease in Minority CommunitiesParticipants currently recruited/enrolled18-100 YearsNIAMSof
00-CH-0160Clinical and Molecular Analysis of ACTH-Independent Steroid Hormone Production in Adrenocortical TissueCompleted Study; data analyses ongoing3-70 YearsNICHDof
00-CH-0136A Trial of Pamidronate in Children with Osteogenesis ImperfectaCompleted Study; data analyses ongoing2-17 YearsNICHDof
00-CH-0093Diagnosis, Pathophysiology, and Molecular Biology of Pheochromocytoma and ParagangliomaParticipants currently recruited/enrolled3-125 YearsNICHDof
99-H-0050Non-Myeloablative Allogeneic Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Hematologic Malignancies in High Risk Patients and in Patients with Debilitating Hematologic DiseasesCompleted Study; data analyses ongoing2-80 YearsNHLBIof
99-C-0099Examination of Clinical and Laboratory Abnormalities in Patients with Defective DNA Repair: Xeroderma Pigmentosum, Cockayne Syndrome, or TrichothiodystrophyParticipants currently recruited/enrolled0-125 YearsNCI of
97-I-0096Evaluation, Treatment, and Monitoring of Patients With Known or Suspected Parasitic InfectionParticipants currently recruited/enrolled3-125 YearsNIAIDof
97-H-0041Screening Protocol for Subjects Being Evaluated for National Heart, Lung and Blood Institute (NHLBI) ProtocolsEnrolling by Invitation2-125 YearsNHLBIof
96-I-0052A Comprehensive Clinical, Microbiological and Immunological Assessment of Patients with Suspected Post Treatment Lyme Disease Syndrome and Selected Control PopulationsParticipants currently recruited/enrolled13-125 YearsNIAIDof
96-H-0100Role of Genetic Factors in the Pathogenesis of Lung DiseaseParticipants currently recruited/enrolled2-90 YearsNHLBIof
95-I-0066Genetic Analysis of Immune DisordersParticipants currently recruited/enrolled0-125 YearsNIAIDof
94-I-0079Eosinophil Activation and Function in Parasitic Infections and Other Conditions with Increased Tissue or Peripheral Blood Eosinophilia in HumansParticipants currently recruited/enrolled1-100 YearsNIAIDof
94-AR-0066Studies of the Pathogenesis and Natural History of Systemic Lupus Erythematosus (SLE)Participants currently recruited/enrolled9-125 YearsNIAMSof
91-DK-0214Evaluation of Patients with Liver DiseaseParticipants currently recruited/enrolled2-125 YearsNIDDKof
91-AR-0196Studies on the Natural History and Pathogenesis of Polymyositis, Dermatomyositis, and Related DiseasesParticipants currently recruited/enrolled16-125 YearsNIAMSof
89-M-0160Inpatient Evaluation of Neuropsychiatric PatientsParticipants currently recruited/enrolled18-125 YearsNIMH of
81-M-0126The Evaluation of Women with Menstrually Regulated Mood and Behavioral DisordersParticipants currently recruited/enrolled18-50 YearsNIMH of
79-C-0111The Treatment of Stage I and II Carcinoma of the Breast with Mastectomy and Axillary Dissection vs. Excisional Biopsy Axillary Dissection, and Definitive IrradiationCompleted Study; data analyses ongoing18-125 YearsNCI of
78-C-0039Clinical, Laboratory, and Epidemiologic Characterization of Individuals and Families at High Risk of CancerNo longer recruiting/follow-up only0-125 YearsNCI of
77-DK-0096Studies on Thyroid Nodules and Thyroid CancerParticipants currently recruited/enrolled0-125 YearsNIDDKof
77-DK-0002Evaluation of Patients with Thyroid Function DisordersParticipants currently recruited/enrolled0-125 YearsNIDDKof