NIH Clinical Center: Search the Studies

Search the Studies

127 Studies found from all possible combinations of your search terms. Select a protocol that you wish to review.

Protocol Number	Title	Protocol Status	Min-Max Age	Institute	Keywords
20-C-0070	A Phase II Study of Allogeneic Hematopoietic Stem Cell Transplant for Patients with Inborn Errors of Immunity	Participants currently recruited/enrolled	4-69 Years	NCI	T-Cell Immunodeficiency
20-C-0011	Phase 1 Study of Recombinant Human IL-15 (rhIL-15) and Mogamulizumab for Patients with Refractory or Relapsed Adult T-Cell Leukemia and Mycosis Fungoides/Sezary Syndrome	Completed Study; data analyses ongoing	18-125 Years	NCI	T-Cell Immunodeficiency
18-I-0041	Investigating the Mechanistic Biology of Primary Immunodeficiency Disorders	Participants currently recruited/enrolled	0-75 Years	NIAID	T-Cell Immunodeficiency
18-CC-0013	A Randomized, Double-Blind, Placebo-Controlled Study of a Single Dose of Pembrolizumab in HIV-Infected Patients	Participants currently recruited/enrolled	18-99 Years	CC	T-Cell Immunodeficiency
18-C-0135	Phase II Trial of Allogeneic Hematopoietic Cell Transplantation for Disorders of T-cell Proliferation and/or Dysregulation	Participants currently recruited/enrolled	4-125 Years	NCI	T-Cell Immunodeficiency
17-C-0048	Anti-CD30 CAR T Cells with Fully-human Binding Domains for Treating CD30-expressing Lymphomas Including Anaplastic Large Cell Lymphomas	Completed Study; data analyses ongoing	18-73 Years	NCI	T-Cell Immunodeficiency
16-C-0066	Phase I Study of MK-3475 (Pembrolizumab) in Patients with Human Immunodeficiency Virus (HIV) and Relapsed/Refractory or Disseminated Malignant Neoplasm	Participants currently recruited/enrolled	18-125 Years	NCI	T-Cell Immunodeficiency
16-C-0003	Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies	Participants currently recruited/enrolled	4-75 Years	NCI	T-Cell Immunodeficiency
14-I-0020	Hematopoietic Stem Cell Mobilization in Idiopathic CD4 Lymphocytopenia Patients and Healthy Controls for the Study of T Cell Maturation and Trafficking in Murine Models	Participants currently recruited/enrolled	18-65 Years	NIAID	Immunodeficiency Thymic
13-N-0135	Pilot Study of Raltegravir, an Integrase Inhibitor, in Human T-Cell Lymphotrophic Virus-1(HTLV-1) Associated Myelopathy, Tropical Spastic Paraparesis (HAM/TSP)	Completed Study; data analyses ongoing	18-125 Years	NINDS	T-Cell Immunodeficiency
10-H-0154	Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused with a Reduced Dose of Non-Mobilized Donor T-Cells	Participants currently recruited/enrolled	4-80 Years	NHLBI	T-Cell Aplasia
06-I-0015	Screening Protocol for Genetic Diseases of Lymphocyte Homeostasis and Programmed Cell Death	Participants currently recruited/enrolled	0-125 Years	NIAID	T-Cell Immunodeficiency
000821-I	An Open-Label, Single-Arm, Phase 1/2 Dose-Escalation Trial of Long-Acting Recombinant Human IL-7 (NT-I7, Efineptakin Alfa) for Idiopathic CD4 Lymphopenia	Recruitment has not started	18-75 Years	NIAID	T-Cell
000809-I	A Pilot Study of Fecal Microbiota Transplantation for Chronic Granulomatous Disease-Associated Colitis	Participants currently recruited/enrolled	10-60 Years	NIAID	Immunodeficiency
000792-C	A Multicenter Study to Evaluate Next-Generation Sequencing (NGS) Testing and Monitoring of B-Cell Recovery to Guide Management Following Chimeric Antigen Receptor T-cell (CART) Induced Remission in Children and Young Adults with B Lineage Acute Lymphobla	Recruitment has not started	1-25 Years	NCI	T-Cell
000633-C	Phase 1/2 Study of VIP152, Venetoclax, and Prednisone (VVIP) in Relapsed/Refractory Lymphoid Malignancies	Participants currently recruited/enrolled	18-125 Years	NCI	T-Cell
000631-C	Investigation of the Cognitive Aftereffects of Neurotoxicity in Children and Young Adults with Relapsed/Refractory Hematologic Malignancies who Receive CAR T-cell Therapy	Recruitment has not started	5-125 Years	NCI	T-Cell
000612-C	Phase 1 Study of NT-I7 (rhIL-7-hyFc) for the Treatment of Kaposi Sarcoma in Patients With or Without Infection with HIV	Participants currently recruited/enrolled	18-125 Years	NCI	Immunodeficiency
000478-C	A Phase I/II Trial of Allogeneic Reduced-Intensity, HLA-Haploidentical Bone Marrow Transplantation Followed by GVHD Prophylaxis with Cyclophosphamide, Bortezomib and Maraviroc for Hematologic Malignancies in People Living with HIV (PLWH)	Participants currently recruited/enrolled	12-125 Years	NCI	Immunodeficiency
000404-C	A Phase II Study of Allogeneic Hematopoietic Stem Cell Transplant for Subjects with VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome	Participants currently recruited/enrolled	18-75 Years	NCI	Immunodeficiency
000392-I	Metabolic Profiling of Immune Responses in Immune-Mediated Diseases	Participants currently recruited/enrolled	18-75 Years	NIAID	Immunodeficiency
000324-C	Phase 1/2 Dose Escalation Study of CD19/CD22 Bicistronic Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults with Recurrent or Refractory CD19/CD22-expressing B Cell Malignancies	Participants currently recruited/enrolled	3-35 Years	NCI	T-Cell
000317-C	A Phase II, Open-Label Trial of PT-112 in Subjects with Thymoma and Thymic Carcinoma	Participants currently recruited/enrolled	18-125 Years	NCI	Thymic
000277-C	Imaging and Biopsy of HIV-Infected Individuals Undergoing Analytic Treatment Interruption	Participants currently recruited/enrolled	18-125 Years	NCI	Immunodeficiency
000272-H	Defining the Genetic Etiology of Suppurative Lung Disease in Children and Adults	Participants currently recruited/enrolled	5-45 Years	NHLBI	Immunodeficiency
000193-C	Phase 1 Study of Copanlisib with Dose-adjusted EPOCH-R in Relapsed and Refractory Burkitt Lymphoma and other High-Grade B-cell Lymphomas	Clinical hold/Recruitment or enrollment suspended	18-125 Years	NCI	T-Cell
000114-C	A Phase II Study Evaluating T-Cell Clonality After Stereotactic Body Radiation Therapy Alone and in Combination with the Immunocytokine M9241 in Localized High and Intermediate Risk Prostate Cancer Treated with Androgen Deprivation Therapy	Participants currently recruited/enrolled	18-125 Years	NCI	T-Cell
000067-C	Understanding the Patient Experience: Symptom Burden in Pediatric Patients Receiving Chimeric Antigen Receptor (CAR) T-cell Therapy	Participants currently recruited/enrolled	2-125 Years	NCI	T-Cell
21-I-0003	A Phase 1/2 Study to Evaluate the Safety, Tolerability and Efficacy, of JSP191 for Hematopoietic Cell Transplantation Conditioning to Achieve Engraftment and Immune Reconstitution in Subjects with SCID	Participants currently recruited/enrolled	3-125 Years	NIAID	Immunodeficiency
21-C-0026	A Phase I/II Study of Abemaciclib in Patients with HIV-associated and HIV-negative Kaposi Sarcoma	Participants currently recruited/enrolled	18-125 Years	NCI	Immunodeficiency
20-I-0084	Sample Collection for Systems Evaluation of Patients with Unknown or Incompletely Characterized Immune Defects	Participants currently recruited/enrolled	2-125 Years	NIAID	Immunodeficiency
20-H-0044	Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Immune Activation in Psoriasis	Completed Study; data analyses ongoing	18-80 Years	NHLBI	T-Cell
20-H-0033	Early Initiation of Oral Therapy with Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA)	Participants currently recruited/enrolled	3-125 Years	NHLBI	T-Cell
20-H-0021	Treatment of Refractory Diamond-Blackfan Anemia with Eltrombopag	No longer recruiting/follow-up only	2-125 Years	NHLBI	Aplasia
20-C-0167	Close Assessment and Testing for Chronic Graft-vs-Host Disease (CATCH Study)	Participants currently recruited/enrolled	18-125 Years	NCI	Immunodeficiency
20-C-0127	A Phase 1 Study of Romidepsin, CC-486 (5-azacitidine), dexamethasone, and lenalidomide (RAdR) for relapsed/refractory T-cell malignancies	Participants currently recruited/enrolled	18-125 Years	NCI	T-Cell
20-C-0103	Investigation of the B- and T-cell Repertoire and Immune Response in Patients with Acute and Resolved COVID-19 Infection	Participants currently recruited/enrolled	18-125 Years	NCI	T-Cell
20-C-0098	A Phase 1/2, Open Label, Dose-Escalation, Safety and Tolerability Study of NC410 in Subjects with Advanced or Metastatic Solid Tumors	Completed Study; data analyses ongoing	18-125 Years	NCI	T-Cell
20-C-0097	A Phase II, Open-Label Trial of Bintrafusp Alfa (M7824) in Subjects with Thymoma and Thymic Carcinoma	Participants currently recruited/enrolled	18-125 Years	NCI	Thymic
20-C-0041	Protocol for a Research Database for Hematopoietic Cell Transplantation, Other Cellular Therapies and Marrow Toxic Injuries	Enrolling by Invitation	1-125 Years	NCI	T-Cell
19-I-0069	Phase I Open-Label Study of Safety and Immunogenicity of AD4-HIV Envelope Vaccine Vectors in Healthy Volunteers	Participants currently recruited/enrolled	18-65 Years	NIAID	Immunodeficiency
19-I-0015	Phase 1/2 Randomized, Double-Blind, Placebo-Controlled Study of Safety and Efficacy of Abatacept for Treating Chronic Cytopenia in Cytotoxic T-lymphocyte Antigen 4 (CTLA4) Haploinsufficiency	Participants currently recruited/enrolled	8-65 Years	NIAID	T-Cell
19-CC-0063	Impact of Steady State Cobicistat and Darunavir/Cobicistat on the Pharmacokinetics and Pharmacodynamics of Oral Anticoagulants (Rivaroxaban, Apixaban) in Healthy Volunteers	Participants currently recruited/enrolled	18-65 Years	CC	Immunodeficiency
19-C-0143	A Phase II Study Using the Administration of Autologous T-Cells Engineered using the Sleeping Beauty Transposon/Transposase System to Express T-Cell Receptors Reactive Against Mutated Neoantigens in Patients with Metastatic Cancer	Participants currently recruited/enrolled	18-70 Years	NCI	T-Cell
19-C-0117	A Phase 1 / 2 Single Arm Open-label Clinical Trial of Gavocabtagene Autoleucel (gavo-cel) in Patients with Advanced Mesothelin Expressing Cancer	Participants currently recruited/enrolled	18-120 Years	NCI	T-Cell
19-C-0102	A Phase I Clinical Trial of T-cells Expressing an anti-SLAMF7 CAR for Treating Multiple Myeloma	Completed Study; data analyses ongoing	18-73 Years	NCI	T-Cell
19-C-0085	Phase II Trial of Allogeneic Hematopoietic Cell Transplantation for Peripheral T cell Lymphoma	Clinical hold/Recruitment or enrollment suspended	12-125 Years	NCI	T-Cell
19-C-0076	A Phase 1 Study of Interleukin-15 in Combination with Avelumab (Bavencio) in Relapsed/Refractory Mature T-cell Malignancies	Completed Study; data analyses ongoing	18-125 Years	NCI	T-Cell
19-C-0017	A Phase I/II Study Administering Peripheral Blood Lymphocytes Transduced with a Murine T-Cell Receptor Recognizing the G12D Variant of Mutated RAS in HLA-A*11:01 Patients	Participants currently recruited/enrolled	18-70 Years	NCI	T-Cell
18-I-0128	Send-In Sample Collection to Achieve Genetic and Immunologic Characterization of Primary Immunodeficiencies	Participants currently recruited/enrolled	0-99 Years	NIAID	Immunodeficiency
18-I-0030	VRC 603: A Phase 1 Dose-Escalation Study of the Safety of AAV8-VRC07 (VRC-HIVAAV070-00-GT) Recombinant AAV Vector Expressing VRC07 HIV-1 Neutralizing Antibody in Antiretroviral-Treated, HIV-1 Infected Adults with Controlled Viremia	No longer recruiting/follow-up only	18-65 Years	NIAID	Immunodeficiency
18-CC-0117	PET Imaging of the Dopaminergic and Serotonergic Systems in Treated HIV Positive Subjects	Completed Study; data analyses ongoing	18-70 Years	CC	Immunodeficiency
18-CC-0087	Impact of Weekly Administration of Rifapentine and Isoniazid on Steady State Pharmacokinetics of Tenofovir Alafenamide in Healthy Volunteers	Completed Study; data analyses ongoing	18-65 Years	CC	Immunodeficiency
18-C-0049	A Phase II Study Using the Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in Patients with Metastatic Cancer	Participants currently recruited/enrolled	18-72 Years	NCI	T-Cell
17-I-0163	Natural History of Intestinal Inflammation in Patients with Primary Immune Dysregulations	Participants currently recruited/enrolled	3-125 Years	NIAID	Immunodeficiency
17-I-0122	NIAID Centralized Sequencing Protocol	Participants currently recruited/enrolled	0-125 Years	NIAID	Immunodeficiency
17-C-0174	Molecular Characterization of Viral-associated Tumors, Tumors Occurring in the Setting of HIV or Other Immune Disorders and Castleman Disease	Participants currently recruited/enrolled	18-125 Years	NCI	Immunodeficiency
17-C-0137	Leukapheresis for CAR or Adoptive Cell Therapy Manufacturing	Enrolling by Invitation	3-65 Years	NCI	T-Cell
17-C-0113	A Phase I/II Study Administering Peripheral Blood Lymphocytes Transduced with a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients	Participants currently recruited/enrolled	18-70 Years	NCI	T-Cell
17-C-0092	A Phase I/II Study of Pexa-Vec Oncolytic Virus in Combination with Immune Checkpoint Inhibition in Refractory Colorectal Cancer	Completed Study; data analyses ongoing	18-125 Years	NCI	T-Cell
17-C-0066	A Pilot Study to Investigate the Safety and Clinical Activity of Avelumab (MSB0010718C) in Thymoma and Thymic Carcinoma after Progression on Platinum-Based Chemotherapy	Participants currently recruited/enrolled	18-125 Years	NCI	Thymic
16-N-0072	A Pilot Study of Adoptive Cellular Immunotherapy for Progressive Multifocal Leukoencephalopathy with Ex Vivo Generated Polyomavirus-Specific T-cells	Completed Study; data analyses ongoing	18-125 Years	NINDS	T-Cell
16-I-0165	An open-label, non-randomized extension study to evaluate the long term safety, tolerability, efficacy and pharmacokinetics of CDZ173 (leniolisib) in patients with APDS/PASLI (Activated phosphoinositide 3-kinase delta syndrome/p110 delta-activating mutat	No longer recruiting/follow-up only	12-75 Years	NIAID	Immunodeficiency
16-H-0085	Pilot Study to Evaluate the Effect of Fasting and Refeeding on T-Cell Fate	Completed Study; data analyses ongoing	21-37 Years	NHLBI	T-Cell
16-CC-0112	Impact of Once-Weekly Rifapentine and Isoniazid on the Steady State Pharmacokinetics of Dolutegravir and Darunavir Boosted with Cobicistat in Healthy Volunteers	Completed Study; data analyses ongoing	18-65 Years	CC	Immunodeficiency
16-C-0131	A Phase I/II Study Administering Peripheral Blood Lymphocytes Transduced with a CD70-Binding Chimeric Antigen Receptor to Patients with CD70-Expressing Cancers	Participants currently recruited/enrolled	18-70 Years	NCI	T-Cell
16-C-0128	A Phase I/II Study of Mesothelin-Targeted Immunotoxin LMB-100 Alone or in Combination with Nab-Paclitaxel in Participants with Previously Treated Metastatic and/ or Locally Advanced Pancreatic Ductal Adenocarcinoma and Mesothelin Expressing Solid Tumors	Completed Study; data analyses ongoing	18-125 Years	NCI	Thymic
16-C-0062	A Phase I Study of Subcutaneous Recombinant Human IL-15 (S.C. Rhil-15) and Alemtuzumab for Patients with Refractory or Relapsed Chronic and Acute Adult T-Cell Leukemia (ATL)	Completed Study; data analyses ongoing	18-125 Years	NCI	T-Cell
16-C-0061	Biospecimen Procurement for Center for Immuno-Oncology Immunotherapy Protocols	Participants currently recruited/enrolled	18-125 Years	NCI	T-Cell
16-C-0054	T Cells Expressing a Fully-human Anti- CD19 Chimeric Antigen Receptor for Treating B-cell Malignancies	No longer recruiting/follow-up only	18-73 Years	NCI	T-Cell
15-I-0135	An open-label, non-randomized, within-patient dose-finding study followed by a randomized, subject, investigator and sponsor-blinded placebo controlled study to assess the efficacy and safety of CDZ173 (leniolisib) in patients with APDS/PASLI (Activated	Completed Study; data analyses ongoing	12-75 Years	NIAID	Immunodeficiency
15-H-0172	A Pilot Phase II Study Using Ibrutinib and Short-Course Fludarabine in Previously Untreated Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)	No longer recruiting/follow-up only	18-125 Years	NHLBI	T-Cell
15-DK-0079	Observational Study of Hepatitis B Virus (HBV) in Patients Coinfected with Human Immunodeficiency Virus (HIV)	Completed Study; data analyses ongoing	18-125 Years	NIDDK	Immunodeficiency
15-C-0141	Gene Therapy Follow up Protocol for Subjects Previously Enrolled in CAR T-Cell Studies	Enrolling by Invitation	18-125 Years	NCI	T-Cell
15-C-0076	A Pilot Study of Long Term TARP Vaccination Using A Multi-Epitope TARP Peptide Autologous Dendritic Cell Vaccination in Previously Vaccinated Men on NCI 09-C-0139	Completed Study; data analyses ongoing	18-125 Years	NCI	T-Cell
14-I-0185	A Phase III Double-Blind Randomized Crossover Study of Plerixafor Versus G-CSF in the Treatment of Patients with WHIM Syndrome.	Completed Study; data analyses ongoing	10-75 Years	NIAID	Immunodeficiency
14-I-0146	The Pathogenesis and Genetics of Disseminated or Refractory Coccidioidomycosis	Participants currently recruited/enrolled	2-100 Years	NIAID	Immunodeficiency
14-I-0089	A Retrospective and Cross-Sectional Analysis of Patients Treated for Severe Combined Immunodeficiency (SCID) Since January 1, 1968	Enrolling by Invitation	2-125 Years	NIAID	Immunodeficiency
14-I-0072	A Prospective Natural History Study of Diagnosis, Treatment and Outcomes of Children with SCID Disorders	Completed Study; data analyses ongoing	2-125 Years	NIAID	Immunodeficiency
14-I-0039	Elite Controller and ART-Treated HIV+ Statin Versus ASA Treatment Intervention Study	Completed Study; data analyses ongoing	18-125 Years	NIAID	Immunodeficiency
14-I-0009	Characterization and Management of Patients with HIV-1 Infection Who Experience Virologic Failure Despite Combination Antiretroviral Therapy	Completed Study; data analyses ongoing	18-100 Years	NIAID	Immunodeficiency
14-HG-0048	Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)	Participants currently recruited/enrolled	21-125 Years	NHGRI	T-Cell
14-C-0105	Tissue Procurement and Natural History Study of Patients with Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors	Participants currently recruited/enrolled	18-125 Years	NCI	Thymic
14-C-0056	Collection of Blood from Patients with Ovarian, Primary Peritoneal or Fallopian Tube Cancer	Completed Study; data analyses ongoing	18-125 Years	NCI	T-Cell
13-N-0149	An Evaluation of HIV-associated Neurocognitive Disorders (HAND) in Virologically Controlled Patients	Participants currently recruited/enrolled	18-125 Years	NINDS	Immunodeficiency
13-N-0017	Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)	Participants currently recruited/enrolled	2-125 Years	NINDS	Immunodeficiency
13-I-0062	A Double Blind Randomized Placebo Controlled Study Examining the Effects of a Non-Absorbable (Rifaximin) Antibiotic on the Chronic Immune Activation Observed In HIV-infected Subjects	Completed Study; data analyses ongoing	18-65 Years	NIAID	Immunodeficiency
13-HG-0199	NIH Participation to USIDNET Registry	Participants currently recruited/enrolled	0-125 Years	NHGRI	Immunodeficiency
13-C-0132	Allogeneic Hematopoietic Stem Cell Transplant for Patients with Mutations in GATA2 or the MonoMAC Syndrome	Participants currently recruited/enrolled	8-70 Years	NCI	Immunodeficiency
13-C-0095	A Phase 2 Study of GI-6207 in Patients with Recurrent Medullary Thyroid Cancer	Completed Study; data analyses ongoing	18-125 Years	NCI	T-Cell
13-C-0006	Phase I/II Trial Evaluating the Safety and Efficacy of Ruxolitinib in Patients with Smoldering and Chronic Adult T-cell Leukemia (ATL)	Completed Study; data analyses ongoing	18-125 Years	NCI	T-Cell
12-C-0193	Lymphoid Malignancies and Precursors: Tissue Acquisition Protocol	Participants currently recruited/enrolled	18-125 Years	NCI	T-Cell
12-C-0118	A Phase II Study of Sunitinib in Patients with Advanced Relapsed or Refractory Thymoma or Thymic Carcinoma with at Least One Prior Line of Platinum-Based Systemic Chemotherapy	No longer recruiting/follow-up only	18-100 Years	NCI	Thymic
12-C-0047	A Phase I/II Study of the Safety, Pharmacokinetics and Efficacy of Pomalidomide (CC-4047) in the Treatment of Kaposi Sarcoma in Individuals With or Without HIV	Completed Study; data analyses ongoing	18-125 Years	NCI	Immunodeficiency
11-I-0057	Effect of Interferon Alpha 2b Intensification on HIV-1 Residual Viremia in Individuals Suppressed on Antiretroviral Therapy	Completed Study; data analyses ongoing	18-65 Years	NIAID	Immunodeficiency
11-I-0007	Lentiviral Gene Transfer for Treatment of Children Older Than 2 Years of Age with X-Linked Severe Combined Immunodeficiency	Clinical hold/Recruitment or enrollment suspended	2-40 Years	NIAID	Immunodeficiency
11-CC-0152	The Natural History of Liver Disease in a Cohort of Participants with Hepatitis B and/or Hepatitis C with or without HIV Infection	Completed Study; data analyses ongoing	18-99 Years	CC	Immunodeficiency
11-C-0136	Multi-Institutional Prospective Pilot Study of Lupron to Enhance Lymphocyte Immune Reconstitution Following Allogeneic Bone Marrow Transplantation in Post-Pubertal Children and Adults with Molecular Imaging Evaluation	Completed Study; data analyses ongoing	2-55 Years	NCI	Thymic
11-C-0096	Pilot Trial of Molecular Profiling and Targeted Therapy for Advanced Non-Small Cell Lung Cancer, Small Cell Lung Cancer, and Thymic Malignancies	No longer recruiting/follow-up only	18-125 Years	NCI	Thymic
10-I-0014	The Natural History of Severe Viral Infections and Characterization of Immune Defects	Participants currently recruited/enrolled	2-125 Years	NIAID	Immunodeficiency
10-CC-0053	Collection of Bone Marrow from Healthy Volunteers and Patients for the Production of Clinical Bone Marrow Stromal Cell (BMSC) Products	Completed Study; data analyses ongoing	18-125 Years	CC	Immunodeficiency
10-C-0201	Apheresis and CD34+ Selection of Mobilized Peripheral Blood CD34+ Cells from Patients with DOCK8 Deficiency, LAD-1, and GATA2 Deficiency	Participants currently recruited/enrolled	18-40 Years	NCI	Immunodeficiency
10-C-0174	Related and Unrelated Donor Hematopoietic Stem Cell Transplant for DOCK8 Deficiency	Participants currently recruited/enrolled	4-125 Years	NCI	Immunodeficiency
09-I-0200	A Phase I Study of MozobilTM in the Treatment of Patients with WHIMS	Participants currently recruited/enrolled	18-75 Years	NIAID	Immunodeficiency
09-I-0133	Establishing Fibroblast-derived Cell Lines from Skin/Tissue Biopsies of Patients with Immunodeficiency or Immunodysregulation Disorders	Enrolling by Invitation	2-85 Years	NIAID	Immunodeficiency
09-I-0126	Pathogenesis and Genetic Basis of Physical Induced Urticarial Syndromes	Participants currently recruited/enrolled	2-90 Years	NIAID	Immunodeficiency
09-I-0102	Etiology, Pathogenesis, and Natural History of Idiopathic CD4+ Lymphocytopenia	Participants currently recruited/enrolled	18-125 Years	NIAID	Immunodeficiency
09-I-0086	Screening Protocol for Genetic Diseases of Allergic Inflammation	Participants currently recruited/enrolled	0-99 Years	NIAID	Immunodeficiency
09-H-0172	Natural History of Bronchiectasis	Participants currently recruited/enrolled	5-125 Years	NHLBI	Immunodeficiency
09-C-0025	Phase II Trial of LMB-2, Fludarabine and Cyclophosphamide for Adult T-Cell Leukemia	No longer recruiting/follow-up only	18-125 Years	NCI	T-Cell
09-C-0024	A Phase I Study of Quadrivalent Human Papilloma Virus (HPV) (Types 6, 11, 16, 18) Recombinant Vaccine in HIV-Infected and HIV-Negative Pre-Adolescents, Adolescents and Young Adults	Completed Study; data analyses ongoing	12-26 Years	NCI	Immunodeficiency
08-HG-0059	Studies of Skin Microflora in Healthy Individuals and Atopic Dermatitis Patients	Participants currently recruited/enrolled	2-125 Years	NHGRI	Immunodeficiency
05-I-0213	Screening and Baseline Assessment of Patients with Abnormalities of Immune Function	Participants currently recruited/enrolled	0-125 Years	NIAID	Immunodeficiency
05-H-0242	A Pilot Study of Alemtuzumab (Campath) in Patients with Relapsed or Refractory Severe Aplastic Anemia	Completed Study; data analyses ongoing	2-110 Years	NHLBI	T-Cell
05-C-0252	Phase III Randomized Study of R-CHOP v. Dose-Adjusted EPOCH-R with Molecular Profiling in Untreated de Novo Diffuse Large B-Cell Lymphomas	Completed Study; data analyses ongoing	18-125 Years	NCI	Thymic
04-C-0281	Natural History Study of Clinical and Biological Factors Determining Outcomes in Chronic Graft-Versus-Host Disease	Participants currently recruited/enrolled	1-125 Years	NCI	Immunodeficiency
03-H-0105	The Determination of Genetic Basis Of Immunodeficiency	Participants currently recruited/enrolled	0-125 Years	NHLBI	Immunodeficiency
02-C-0179	Biospecimen Acquisition from Human Subjects	Participants currently recruited/enrolled	18-125 Years	NCI	T-Cell
02-C-0052	Etiologic Investigation of Cancer Susceptibility in Inherited Bone Marrow Failure Syndromes: A Natural History Study	Participants currently recruited/enrolled	0-125 Years	NCI	Aplasia
01-C-0129	Eligibility Screening for the NIH Intramural Research Program Clinical Protocols	Enrolling by Invitation	0-125 Years	NCI	Immunodeficiency
01-C-0030	Short-Course EPOCH - Rituximab in Untreated CD-20+ HIV-Associated Lymphomas	No longer recruiting/follow-up only	18-125 Years	NCI	Immunodeficiency
00-I-0159	Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES)	Participants currently recruited/enrolled	0-125 Years	NIAID	Immunodeficiency
00-HG-0209	Molecular and Clinical Studies of Primary Immunodeficiency Diseases	No longer recruiting/follow-up only	3-125 Years	NHGRI	Immunodeficiency
95-I-0066	Genetic Analysis of Immune Disorders	Participants currently recruited/enrolled	0-125 Years	NIAID	Immunodeficiency
94-DK-0133	Genetic Markers for Focal Segmental Glomerulosclerosis	Completed Study; data analyses ongoing	1-125 Years	NIDDK	Immunodeficiency
92-I-0125	A Study of Viral Burden in Peripheral Blood Versus Lymphoid and Bone Marrow Tissue in HIV-Infected Individuals	Participants currently recruited/enrolled	18-125 Years	NIAID	Immunodeficiency
89-I-0158	Studies of Immune Regulation in Patients with Common Variable Immunodeficiency and Related Humoral Immunodeficiency Syndromes	Participants currently recruited/enrolled	2-125 Years	NIAID	Immunodeficiency