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80 Studies found from all possible combinations of your search terms. Select a protocol that you wish to review.
Protocol Number
Title
Protocol Status
Min-Max Age
Institute
Keywords
000957-HG
A Phase 1/2, Open-Label, Single Dose Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of SEL-302 (MMA-101 following administration of SEL-110) in Pediatric Subjects with Mut Subtype Isolated Methylmalonic Acidemia (MMA)
Participants currently recruited/enrolled
3-17 Years
NHGRI
Single
000954-C
A Phase 1/2 Single Arm Open-Label Clinical Trial of TC-510 In Patients with Advanced Mesothelin-Expressing Cancer
Participants currently recruited/enrolled
18-125 Years
NCI
Single
000923-H
Observational Study of Cardiac Arrhythmias in Subjects Treated with BTK Inhibitors
Participants currently recruited/enrolled
18-110 Years
NHLBI
Ventricular
000908-DK
Peripheral Blood and Urine Immune Cell Phenotyping in Membranous Nephropathy using FACS and Single Cell RNA-seq
Participants currently recruited/enrolled
18-125 Years
NIDDK
Single
000821-I
An Open-Label, Single-Arm, Phase 1/2 Dose-Escalation Trial of Long-Acting Recombinant Human IL-7 (NT-I7, Efineptakin Alfa) for Idiopathic CD4 Lymphopenia
Recruitment has not started
18-75 Years
NIAID
Single
000782-C
A Dose-Escalation and Expansion Study of the Safety and Pharmacokinetics of XL092 as Single-Agent and Combination Therapy in Subjects with Inoperable Locally Advanced or Metastatic Solid Tumors
Recruitment has not started
18-125 Years
NCI
Single
000560-N
Data Collection of Standard Care of Patients in the EMG Section
Participants currently recruited/enrolled
18-125 Years
NINDS
Single
000462-C
Phase 2, Open-label, Single-arm, Window of Opportunity Study of ASP-1929 Photoimmunotherapy with Fluorescence Imaging in Patients With Operable Primary or Recurrent Head and Neck or Cutaneous Squamous Cell Carcinoma
Participants currently recruited/enrolled
18-125 Years
NCI
Single
000288-C
A Phase II, Open-Label, Single-Arm Study of Berzosertib (M6620) in Combination with Topotecan in Participants with Relapsed Platinum-Resistant Small-Cell Lung Cancer
Completed Study; data analyses ongoing
18-125 Years
NCI
Single
000183-I
An open-label single-arm Phase IIb study of F901318 as treatment of invasive fungal infections due to Lomentospora prolificans, Scedosporium spp., Aspergillus spp., and other resistant fungi in patients lacking suitable alternative treatment options
Participants currently recruited/enrolled
16-125 Years
NIAID
Single
000108-EI
An Observational Prospective Natural History Study of Stargardt-like Macular Dystrophy (STDG3) Secondary to Mutations in ELOVL4
Participants currently recruited/enrolled
10-125 Years
NEI
Single
22-I-0008
A Single Arm Open Label Phase 2 Trial of Anti-CD4 Antibody UB-421 in Combination with Optimized Background Antiretroviral Therapy in Patients with Multi-Drug Resistant HIV-1 Infection
Recruitment has not started
18-125 Years
NIAID
Single
21-N-0016
Phase I/II Study of Teriflunomide in HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis
Participants currently recruited/enrolled
18-125 Years
NINDS
Single
21-C-0022
A Phase 2 Single Arm Open-Label Clinical Trial of ADP-A2M4 SPEAR(TM) T Cells in Subjects with Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma
Participants currently recruited/enrolled
10-75 Years
NCI
Single
20-NR-0003
A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue
Participants currently recruited/enrolled
18-70 Years
NINR
Single
20-N-0105
Layer-specific Contribution to Consolidation of Skill Learning in the Primary Motor Cortex
Participants currently recruited/enrolled
18-50 Years
NINDS
Single
20-I-0140
A Double-Blind, Randomized, Placebo-Controlled, Phase 1, Single-Dose, Dose-Escalating Trial of Long-Acting Recombinant Human IL-7 (NT-I7) for COVID-19
Participants currently recruited/enrolled
19-75 Years
NIAID
Single
20-H-0080
Red Cell Half Life Determination in Patients with and without Sickle Cell Disease
Completed Study; data analyses ongoing
18-100 Years
NHLBI
Single
20-H-0029
An Intravenous, Open-Label, Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Fx-5A in Healthy Volunteers
Participants currently recruited/enrolled
18-125 Years
NHLBI
Single
20-DK-0168
LYNC-LD Prospective Multicenter Natural History Study of Lipodystrophy Syndromes to Determine Prevalence, Incidence and Predictors of Diabetes and Severe Hypertriglyceridemia, and their Complications.
Participants currently recruited/enrolled
3-125 Years
NIDDK
Single
20-CC-0031
A single cohort study collecting interval timed incisional epidermal and dermal tissue samples during surgical procedures to profile temporal response of tissue after noxious stimuli.
Completed Study; data analyses ongoing
18-125 Years
CC
Single
20-C-0069
A First-In-Human Phase I Single-Agent Dose-Escalation, Food Effect and Dose Expansion Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms
Participants currently recruited/enrolled
18-125 Years
NCI
Single
20-C-0009
Randomized Phase II Trial of Topotecan Plus M6620 (VX-970) vs. Topotecan Alone in Patients with Relapsed Small-Cell Lung Cancer
Participants currently recruited/enrolled
18-125 Years
NCI
Single
19-H-0088
NHLBI DIR Transcatheter Mitral Cerclage Annuloplasty Early Feasibility Study
No longer recruiting/follow-up only
21-99 Years
NHLBI
Ventricular
19-C-0117
A Phase 1 / 2 Single Arm Open-label Clinical Trial of Gavocabtagene Autoleucel (gavo-cel) in Patients with Advanced Mesothelin Expressing Cancer
Participants currently recruited/enrolled
18-120 Years
NCI
Single
19-C-0023
A Phase II Study of Olaparib (AZD2281) in Patients with Metastatic/Advanced Urothelial Carcinoma and other genitourinary tumors with DNA-Repair Defects
Participants currently recruited/enrolled
18-125 Years
NCI
Single
18-I-0105
VRC 609: A Phase I, Open-Label, Dose-Escalation Study of the Safety and Pharmacokinetics of a Human Monoclonal Antibody, VRC-HIVMAB091-00-AB (N6LS), Administered Intravenously or Subcutaneously with or without Recombinant Human Hyaluronidase PH20 (rHuPH2
Completed Study; data analyses ongoing
18-50 Years
NIAID
Single
18-I-0039
Challenge Infection of Healthy Adult Volunteers with RSV A2
Completed Study; data analyses ongoing
18-50 Years
NIAID
Single
18-D-0114
An Open Label Pilot Study of Denosumab Treatment for Fibrous Dysplasia
No longer recruiting/follow-up only
18-125 Years
NIDCR
Single
18-CC-0013
A Randomized, Double-Blind, Placebo-Controlled Study of a Single Dose of Pembrolizumab in HIV-Infected Patients
Participants currently recruited/enrolled
18-99 Years
CC
Single
18-C-0110
Safety Run-In and Phase II Trial of M7824 and Topotecan or Temozolomide in Relapsed Small Cell Cancers
Participants currently recruited/enrolled
18-125 Years
NCI
Single
18-C-0058
A Pilot Study to Evaluate the Effects of Castration on the Pharmacokinetics of Zolpidem After Single Dose Administration in Men with Prostate Cancer Undergoing Androgen Deprivation Therapy Compared to Normal Healthy Females
Participants currently recruited/enrolled
18-125 Years
NCI
Single
18-C-0024
A Single-Arm Phase II Study of Hepatic Artery Infusion Pump Chemotherapy with Floxuridine and Dexamethasone in Combination with Systemic Chemotherapy for Patients with Colorectal Cancer Metastatic to the Liver
Participants currently recruited/enrolled
18-125 Years
NCI
Single
17-I-0016
Studies of the Natural History, Pathogenesis, and Outcome of Autoinflammatory Diseases (NOMID/CAPS, DIRA, CANDLE, SAVI, NLRC4-MAS, Still's-like Diseases, and Other Undifferentiated Autoinflammatory Diseases)
Participants currently recruited/enrolled
0-99 Years
NIAID
Single
17-H-0118
A Phase II Study Of Ibrutinib, Fludarabine, and Pembrolizumab in High-Risk or Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)
No longer recruiting/follow-up only
18-125 Years
NHLBI
Single
17-C-0157
A Phase I Single-Arm Study of the Combination of Durvalumab (MEDI4736) and Vicineum (oportuzumab monatox, VB4-845) in Subjects with High-Grade Non-Muscle-Invasive Bladder Cancer Previously Treated with Bacillus Calmette-Gu(SqrRoot)(Copyright)rin (BCG)
Participants currently recruited/enrolled
18-125 Years
NCI
Single
17-C-0156
Longitudinal Sample Collection and Tracking for the Developmental Therapeutics Clinic, National Cancer Institute
Participants currently recruited/enrolled
18-125 Years
NCI
Single
16-EI-0169
A Pilot Study to Investigate Ustekinumab (STELARA) for the Treatment of Active Sight-Threatening Uveitis
Completed Study; data analyses ongoing
18-125 Years
NEI
Single
16-DA-N140
Effects of a New Behavioral Intervention on Alcohol Craving and Drinking
Participants currently recruited/enrolled
21-65 Years
NIDA
Single
16-C-0066
Phase I Study of MK-3475 (Pembrolizumab) in Patients with Human Immunodeficiency Virus (HIV) and Relapsed/Refractory or Disseminated Malignant Neoplasm
Participants currently recruited/enrolled
18-125 Years
NCI
Single
15-D-0129
Open-Label, Dose-Escalation Study Evaluating the Safety of a Single Administration of an Adeno-Associated Virus Vector Encoding Human Aquaporin-1 to One Parotid Salivary Gland in Individuals with Irradiation-Induced Parotid Salivary Hypofunction.
Participants currently recruited/enrolled
18-125 Years
NIDCR
Single
14-C-0156
A Phase II Single Arm Pilot Study of the Chk1/2 Inhibitor (LY2606368) In BRCA1/2 Mutation Associated Breast or Ovarian Cancer, Triple Negative Breast Cancer, and High Grade Serous Ovarian Cancer
Completed Study; data analyses ongoing
18-125 Years
NCI
Single
14-C-0037
A Phase 2 Study of the MET Kinase Inhibitor INC280 in Papillary Renal Cell Cancer
Completed Study; data analyses ongoing
18-125 Years
NCI
Single
14-C-0015
Pilot Trial of BMN 673, an Oral PARP Inhibitor, in Patients With Advanced Solid Tumors and Deleterious BRCA Mutations
Completed Study; data analyses ongoing
18-125 Years
NCI
Single
14-C-0004
A Multicenter Phase 2 Study of the Bruton's Tyrosine Kinase Inhibitor PCI-32765 (Ibrutinib) for Treatment of Relapsed Hairy Cell Leukemia
No longer recruiting/follow-up only
18-125 Years
NCI
Single
13-N-0149
An Evaluation of HIV-associated Neurocognitive Disorders (HAND) in Virologically Controlled Patients
Participants currently recruited/enrolled
18-125 Years
NINDS
Single
13-CC-0210
Evaluating an Extension Assist Knee Ankle Foot Orthosis to Improve Gait in Children with Movement Disorders
Participants currently recruited/enrolled
5-125 Years
CC
Single
13-CC-0012
A Natural History Study of Novel Biomarkers in Pulmonary Arterial Hypertension
Participants currently recruited/enrolled
18-125 Years
CC
Ventricular
13-C-0153
A Phase II Trial of Enzalutamide in Combination with PSA-TRICOM in Patients with Non-Metastatic Castration Sensitive Prostate Cancer
Completed Study; data analyses ongoing
18-125 Years
NCI
Single
13-C-0146
A Randomized Phase II Trial Combining Vaccine Therapy with PROSTVAC /TRICOM and Enzalutamide vs. Enzalutamide Alone in Men with Metastatic Castration Resistant Prostate Cancer
Completed Study; data analyses ongoing
18-125 Years
NCI
Single
13-C-0006
Phase I/II Trial Evaluating the Safety and Efficacy of Ruxolitinib in Patients with Smoldering and Chronic Adult T-cell Leukemia (ATL)
Completed Study; data analyses ongoing
18-125 Years
NCI
Single
13-AG-0034
Phase I, Double-Blind, Placebo-Controlled, Ascending, Single-Dose, Safety, Tolerability and Pharmacokinetic Study of Bisnorcymserine (BNC), a Highly Selective Inhibitor of Butyrylcholinesterase, in Healthy Adult Volunteers
Completed Study; data analyses ongoing
55-125 Years
NIA
Single
12-HG-0181
The Clinical Study of Patients with Sex Chromosome Variants
Completed Study; data analyses ongoing
18-125 Years
NHGRI
Single
12-H-0110
An Open-label, Non-Randomized, Single-Arm Pilot Study to Evaluate the Effectiveness of Etidronate Treatment for Arterial Calcifications due to Deficiency in CD73 (ACDC)
Completed Study; data analyses ongoing
18-80 Years
NHLBI
Single
12-H-0092
An Intravenous, Open-Label, Single-Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of rhLCAT in Patients with Stable Coronary Artery Disease
Completed Study; data analyses ongoing
30-75 Years
NHLBI
Single
12-E-0190
The Role of Functionally Relevant Cyclooxygenase-2 (COX-2) Gene Single Nucleotide Polymorphisms - 765G>C and 8473T>C in Lymphocyte Differentiation
Completed Study; data analyses ongoing
18-150 Years
NIEHS
Single
12-E-0061
The Role of the Functionally Relevant Single Nucleotide Polymorphisms CYP2J2 -50G>T (CYP2J2 7) and EPHX2 9846A>G (EPHX2 K55R) in Human Endothelial Function
Completed Study; data analyses ongoing
18-65 Years
NIEHS
Single
12-DC-0152
Normative Values in Audiovestibular Testing
Participants currently recruited/enrolled
5-80 Years
NIDCD
Single
12-C-0197
A Randomized Phase 2 Single-Center Study of Pomalidomide for Chronic GvHD
Completed Study; data analyses ongoing
18-75 Years
NCI
Single
11-CH-0078
Evaluation of Cortisol Resistance in Young Endurance-Trained and Elderly Men
Completed Study; data analyses ongoing
18-30 Years
NICHD
Single
11-C-0200
A Phase II Trial In Which Patients With Metastatic Alveolar Soft Part Sarcoma Are Randomized to Either Sunitinib or Cediranib Monotherapy, with Cross-Over at Disease Progression
No longer recruiting/follow-up only
16-125 Years
NCI
Single
10-N-0012
Screening Protocol for Patients with Stroke
Participants currently recruited/enrolled
18-90 Years
NINDS
Single
10-I-0195
Natural History of Tuberculosis
Participants currently recruited/enrolled
2-125 Years
NIAID
Single
10-H-0154
Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused with a Reduced Dose of Non-Mobilized Donor T-Cells
Participants currently recruited/enrolled
4-80 Years
NHLBI
Single
10-E-0134
Effect of SNPs in p53 and p53 Response Elements on the Inflammatory Response to DNA Damage
Completed Study; data analyses ongoing
18-100 Years
NIEHS
Single
10-CC-0149
Comparing Expectorated and Induced Sputum and Pharyngeal Swabs for Cultures, AFB Smears, and Cytokines in Pulmonary Nontuberculous Mycobacterial Infection
Completed Study; data analyses ongoing
18-80 Years
CC
Single
10-C-0201
Apheresis and CD34+ Selection of Mobilized Peripheral Blood CD34+ Cells from Patients with DOCK8 Deficiency, LAD-1, and GATA2 Deficiency
Participants currently recruited/enrolled
18-40 Years
NCI
Single
10-C-0174
Related and Unrelated Donor Hematopoietic Stem Cell Transplant for DOCK8 Deficiency
Participants currently recruited/enrolled
4-125 Years
NCI
Single
07-N-0122
Modulation of Motor Function by Stimulation of the Central and Peripheral Nervous System
Completed Study; data analyses ongoing
18-125 Years
NINDS
Single
07-HG-0002
ClinSeq: A Large-Scale Medical Sequencing Clinical Research Pilot Study
No longer recruiting/follow-up only
6-95 Years
NHGRI
Single
06-I-0153
A Pilot Study of Hepatic Fibrosis in HIV/AIDS Patients with Chronically Elevated Transaminases on Antiretroviral Therapy
No longer recruiting/follow-up only
18-100 Years
NIAID
Single
04-E-0053
Personalized Environment and Genes Study
Participants currently recruited/enrolled
18-130 Years
NIEHS
Single
04-DK-0021
Urinary Vitamin C Loss in Subjects with and without Diabetes
Participants currently recruited/enrolled
18-65 Years
NIDDK
Single
03-H-0170
Nonmyeloablative Allogeneic Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation For Severe Congenital Anemias Including Sickle Cell Disease (SCD) and Beta-Thalassemia
Participants currently recruited/enrolled
2-125 Years
NHLBI
Single
03-AR-0173
Studies of Natural History, Pathogenesis, and Outcomes in Autoimmune and Inflammatory Diseases Including Juvenile Dermatomyositis
Participants currently recruited/enrolled
2-125 Years
NIAMS
Single
02-I-0080
The Gemini Study: Study of the Long-Term Safety and Persistence of Cells Following Cell Transfers or Gene Therapy in Identical Twins Discordant for HIV Infection
No longer recruiting/follow-up only
18-125 Years
NIAID
Single
01-M-0232
Positron Emission Tomography (PET) Scanning in Dopamine Disorders: Parkinson's Disease and Schizophrenia
Participants currently recruited/enrolled
18-90 Years
NIMH
Single
95-I-0027
Virologic and Immunologic Evaluation of Lymph Node, Tonsillar and Intestinal Biopsies, and Bronchoalveolar Lavage Fluid
Participants currently recruited/enrolled
18-125 Years
NIAID
Single
83-C-0022
Psychological Benefits of a Normalized Camping Experience for Children with Cancer
Participants currently recruited/enrolled
7-25 Years
NCI
Single
79-C-0111
The Treatment of Stage I and II Carcinoma of the Breast with Mastectomy and Axillary Dissection vs. Excisional Biopsy Axillary Dissection, and Definitive Irradiation
Completed Study; data analyses ongoing
18-125 Years
NCI
Single