Search the Studies

59 Studies found from all possible combinations of your search terms. Select a protocol that you wish to review.
Protocol Number Title Protocol Status Min-Max Age Institute Keywords
001061-HObservational Study Investigating the Mechanistic Effects of Mitapivat in Subjects with Sickle Cell DiseaseEnrolling by Invitation16-125 YearsNHLBISickle Anemia
000539-HAddition of JSP191 (c-kit antibody) to Non-myeloablative Hematopoietic Cell Transplantation For Sickle Cell Disease and Beta-ThalassemiaParticipants currently recruited/enrolled4-100 YearsNHLBISickle Anemia
000464-HEvaluation of Clonal Hematopoiesis in Patients with Sickle Cell Disease Receiving Curative TherapiesEnrolling by Invitation4-125 YearsNHLBISickle Anemia
000423-CFeasibility and Preliminary Efficacy of Acceptance and Commitment Therapy (ACT) for Sleep Disturbances in Adults with Sickle Cell Disease (SCD): A Pilot Randomized Controlled TrialParticipants currently recruited/enrolled18-55 YearsNCI Sickle Anemia
000049-HEvaluation of the Safety,Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects with Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of MitapivatNo longer recruiting/follow-up only18-70 YearsNHLBISickle Anemia
20-H-0080Red Cell Half Life Determination in Patients with and without Sickle Cell DiseaseNo longer recruiting/follow-up only18-100 YearsNHLBISickle Anemia
16-I-0065Screening for Alpha Globin DeletionsParticipants currently recruited/enrolled18-39 YearsNIAIDSickle Anemia
09-H-0225Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Severe Congenital Anemias Including Sickle Cell Disease and Beta-ThalassemiaNo longer recruiting/follow-up only2-125 YearsNHLBISickle Anemia
08-DK-0004High Sensitivity Screening of Compound Libraries to Discover a Drug for the Treatment of Sickle Cell DiseaseParticipants currently recruited/enrolled18-100 YearsNIDDKSickle Anemia
03-H-0170Nonmyeloablative Allogeneic Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation For Severe Congenital Anemias Including Sickle Cell Disease (SCD) and Beta-ThalassemiaParticipants currently recruited/enrolled2-125 YearsNHLBISickle Anemia
01-H-0088Determining the Prevalence and Prognosis of Secondary Pulmonary Hypertension in Adult Patients with Sickle Cell AnemiaCompleted Study; data analyses ongoing18-125 YearsNHLBISickle Anemia
001109-CDefining the Natural History of Squamous Cell Carcinoma in Fanconi AnemiaParticipants currently recruited/enrolled8-125 YearsNCI Anemia
000844-HExploring Near Infrared Spectroscopy (NIRS) Technologies for Assessment of Muscle Physiology, Tissue Oxygenation, and Blood Flow in Patients with Sickle Cell Disease (SCD)Participants currently recruited/enrolled18-125 YearsNHLBISickle
000760-HExtension Study (extended access) of Syk-inhibition Using Fostamatinib to Treat Post-Transplant Immune-mediated CytopeniasEnrolling by Invitation18-75 YearsNHLBIAnemia
000758-HA Phase II Study Using Fostamatinib to Treat Post-Hematopoietic Stem Cell Transplant Immune-Mediated CytopeniasParticipants currently recruited/enrolled18-75 YearsNHLBIAnemia
000697-HU01 Cooperative Assessment of Late Effects for SCD Curative Therapies (COALESCE)Participants currently recruited/enrolled18-65 YearsNHLBISickle
000518-CCObservational Study of Dietary Intake and Dietary Behaviors in Adults with Sickle Cell DiseaseParticipants currently recruited/enrolled18-125 YearsCC Sickle
000479-HObservational Study to Deeply Phenotype Major Organs in Sickle Cell Disease After Curative TherapiesParticipants currently recruited/enrolled18-125 YearsNHLBISickle
000387-HThe Natural History of Acquired and Inherited Bone Marrow Failure Syndromes.Participants currently recruited/enrolled2-125 YearsNHLBIAnemia
20-H-0141Long-term Follow-up of Subjects With Sickle Cell Disease Treated With Ex Vivo Gene Therapy Using Autologous Hematopoietic Stem Cells Transduced With a Lentiviral VectorEnrolling by Invitation18-125 YearsNHLBISickle
20-H-0137A Study to Evaluate the Effects of Fixed Dose Flavonoid Isoquercetin on Thrombo-Inflammatory Biomarkers in Subjects with Stable Sickle Cell DiseaseCompleted Study; data analyses ongoing18-46 YearsNHLBISickle
20-H-0068Venous Thrombosis Biomarkers in Sickle Cell Disease and Sickle Cell TraitParticipants currently recruited/enrolled18-80 YearsNHLBISickle
20-H-0033Early Initiation of Oral Therapy with Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA)Participants currently recruited/enrolled3-125 YearsNHLBIAnemia
20-H-0021Treatment of Refractory Diamond-Blackfan Anemia with EltrombopagNo longer recruiting/follow-up only2-125 YearsNHLBIAnemia
19-I-0093Collection of Human Biospecimens for Basic and Clinical Research into Globin VariantsParticipants currently recruited/enrolled18-70 YearsNIAIDSickle
19-H-0118Repeat Peripheral Blood Stem Cell Transplantation for Patients with Sickle Cell Disease or Beta-Thalassemia and Falling Donor Myeloid Chimerism LevelsParticipants currently recruited/enrolled2-80 YearsNHLBISickle
19-H-0100Best Noninvasive Predictor of Renal Function in Assessing Adult Sickle NephropathyCompleted Study; data analyses ongoing18-125 YearsNHLBISickle
19-H-0097A Pilot Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Escalating Multiple Oral Doses of AG-348 in Subjects with Stable Sickle Cell DiseaseCompleted Study; data analyses ongoing18-70 YearsNHLBISickle
18-H-0146Genotype -Phenotype Correlation of PKLR Variants with Pyruvate Kinase, 2,3-Diphosphglycerate and ATP Activities in Red Blood Cells of Patients with Sickle Cell DiseaseParticipants currently recruited/enrolled18-80 YearsNHLBISickle
18-H-0090Haplo-identical Transplantation for Severe Aplastic Anemia, Hypo-plastic MDS and PNH using Peripheral Blood Stem Cells and post-transplant Cyclophosphamide for GVHD prophylaxisParticipants currently recruited/enrolled4-75 YearsNHLBIAnemia
18-H-0004Low Dose Danazol for the Treatment of Telomere Related DiseasesParticipants currently recruited/enrolled3-125 YearsNHLBIAnemia
17-H-0124Peripheral Blood Stem Cell Collection for Sickle Cell Disease (SCD) Patients Using PlerixaforCompleted Study; data analyses ongoing18-125 YearsNHLBISickle
17-H-0121Eltrombopag for Patients with Fanconi AnemiaParticipants currently recruited/enrolled2-125 YearsNHLBIAnemia
17-H-0091Unrelated Umbilical Cord Blood Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS using CordIn, Umbilical Cord Blood-Derived Ex Vivo Expanded Stem and Progenitor Cells, to Expedite Engraftment and Improve Transplant OutcomeParticipants currently recruited/enrolled4-75 YearsNHLBIAnemia
17-H-0069Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell DiseaseParticipants currently recruited/enrolled2-125 YearsNHLBISickle
17-H-0056Pathophysiology of Acute Pain in Patients with Sickle Cell DiseaseCompleted Study; data analyses ongoing18-80 YearsNHLBISickle
17-H-0019A Randomized Trial of Sirolimus (Rapamune(R)) for Relapse Prevention in Patients with Severe Aplastic Anemia Responsive to Immunosuppressive TherapyParticipants currently recruited/enrolled2-125 YearsNHLBIAnemia
14-HG-0125Insights Into Microbiome and Environmental Contributions to Sickle Cell Disease and Leg UlcersParticipants currently recruited/enrolled18-125 YearsNHGRISickle
14-H-0155A Phase 1/2 Study Evaluating Gene Therapy by Transplantation of Autologous CD34+ Stem Cells Transduced Ex Vivo with the LentiGlobin BB305 Lentiviral Vector in Subjects with Severe Sickle Cell DiseaseNo longer recruiting/follow-up only18-50 YearsNHLBISickle
14-H-0077Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-Thalassemia in Individuals with Higher Risk of Transplant FailureParticipants currently recruited/enrolled4-125 YearsNHLBISickle
13-H-0133Extended Dosing with Eltrombopag in Refractory Severe Aplastic AnemiaCompleted Study; data analyses ongoing2-125 YearsNHLBIAnemia
13-H-0116A Multicenter Safety Study of Unlicensed, Investigational Cryopreserved Cord Blood Units (CBUs) Manufactured by the National Cord Blood Program (NCBP) and Provided for Unrelated Hematopoietic Stem Cell Transplantation of Pediatric and Adult PatientsParticipants currently recruited/enrolled4-125 YearsNHLBIAnemia
12-H-0150Eltrombopag Added to Standard Immunosuppression in Treatment-Naive Severe Aplastic AnemiaParticipants currently recruited/enrolled2-125 YearsNHLBIAnemia
12-H-0064A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients with Hematologic Malignancies and Other IndicationsParticipants currently recruited/enrolled4-75 YearsNHLBIAnemia
12-C-0160Validation of the English Version of the Pain Interference Index and the Pain Rating Scale in Children, Adolescents, and Adults with Chronic Illness and their ParentsParticipants currently recruited/enrolled18-125 YearsNCI Sickle
11-H-0209Male Hormones for Telomere Related DiseasesCompleted Study; data analyses ongoing2-125 YearsNHLBIAnemia
11-H-0134A Pilot Study of a Thrombopoietin-Receptor Agonist (TPO-R Agonist), Eltrombopag, in Moderate Aplastic Anemia PatientsNo longer recruiting/follow-up only2-125 YearsNHLBIAnemia
10-H-0154Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused with a Reduced Dose of Non-Mobilized Donor T-CellsParticipants currently recruited/enrolled4-80 YearsNHLBIAnemia
09-H-0199A Pilot Study of a Thrombopoietin-Receptor Agonist (TPO-R agonist), Eltrombopag, in Patients with Low to Int-2 Risk Myelodysplastic Syndrome (MDS)Completed Study; data analyses ongoing18-125 YearsNHLBIAnemia
08-H-0046Co-Infusion of Umbilical Cord Blood and Haploidentical CD34+ Cells Following Nonmyeloablative Conditioning as Treatment for Severe Aplastic Anemia and MDS Associated with Severe Neutropenia Refractory to Immunosuppressive TherapyCompleted Study; data analyses ongoing4-75 YearsNHLBIAnemia
07-H-0113Procurement and Analysis of Blood, Bone Marrow, and Buccal Mucosa Samples from Healthy Volunteers to Support Clinical and Translational Research Projects in the NHLBIParticipants currently recruited/enrolled8-125 YearsNHLBIAnemia
06-H-0190Treatment of T-Large Granular Lymphocyte (T-LGL) Lymphoproliferative Disorders with Alemtuzumab (Campath)Completed Study; data analyses ongoing18-85 YearsNHLBIAnemia
05-H-0242A Pilot Study of Alemtuzumab (Campath) in Patients with Relapsed or Refractory Severe Aplastic AnemiaCompleted Study; data analyses ongoing2-110 YearsNHLBIAnemia
04-H-0161Studies of the Natural History of Sickle Cell DiseaseParticipants currently recruited/enrolled2-125 YearsNHLBISickle
03-H-0015Human Specimen Collection to Support Basic and Clinical ResearchParticipants currently recruited/enrolled18-125 YearsNHLBISickle
02-C-0052Etiologic Investigation of Cancer Susceptibility in Inherited Bone Marrow Failure Syndromes: A Natural History StudyParticipants currently recruited/enrolled0-125 YearsNCI Anemia
01-H-0122Collection and Storage of Umbilical Cord Hematopoietic Stem Cells for Sickle Cell Disease TherapyParticipants currently recruited/enrolled18-45 YearsNHLBISickle
99-CH-0103Evaluation of Women and Men with Endocrine and Reproductive-Related ConditionsClinical hold/Recruitment or enrollment suspended1-85 YearsNICHDSickle
97-H-0041Screening Protocol for Subjects Being Evaluated for National Heart, Lung and Blood Institute (NHLBI) ProtocolsEnrolling by Invitation2-125 YearsNHLBIAnemia
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