NIH Clinical Center: Search the Studies

Search the Studies

447 Studies found from all possible combinations of your search terms. Select a protocol that you wish to review.

Protocol Number	Title	Protocol Status	Min-Max Age	Institute	Keywords
000975-C	Collection of Blood, Bone Marrow, Skin, Saliva, and Stool Samples from Healthy Volunteers Used for Comparative Analysis of Myeloid Malignancies	Participants currently recruited/enrolled	18-125 Years	NCI	Syndrome Type
000908-DK	Peripheral Blood and Urine Immune Cell Phenotyping in Membranous Nephropathy using FACS and Single Cell RNA-seq	Participants currently recruited/enrolled	18-125 Years	NIDDK	Syndrome Type
000862-CH	Pilot Study of the Use of Functional Near-Infrared Spectroscopy (fNIRS) Combined with Diffuse Correlation Spectroscopy (DCS) in Neurocognitive Disease as Compared to Healthy Neurotypical Controls	Participants currently recruited/enrolled	0-125 Years	NICHD	Syndrome Type
000821-I	An Open-Label, Single-Arm, Phase 1/2 Dose-Escalation Trial of Long-Acting Recombinant Human IL-7 (NT-I7, Efineptakin Alfa) for Idiopathic CD4 Lymphopenia	Recruitment has not started	18-75 Years	NIAID	Syndrome Type
000489-C	Phase I/II Study Using Prophylactic Donor Lymphocyte Infusion Early Post-Transplant After Allogeneic Hematopoietic Cell Transplantation Using Post-Transplantation Cyclophosphamide for High-Risk Hematologic Malignancies	Clinical hold/Recruitment or enrollment suspended	12-125 Years	NCI	Syndrome Type
000344-DK	Natural History Study of Parathyroid Disorders	Participants currently recruited/enrolled	0-125 Years	NIDDK	Syndrome Type
000137-CH	Implications of Maternal 45,X Mosaicism As A Secondary Genomic Finding Following Cell-free DNA Sequencing During Pregnancy: A Deep Phenotype Study	Recruitment has not started	18-99 Years	NICHD	Syndrome Type
20-N-0064	An observational study to assess clinical manifestations and biomarkers in amyotrophic lateral sclerosis type 4 and other inherited neurological disorders of RNA processing.	Participants currently recruited/enrolled	5-125 Years	NINDS	Syndrome Type
20-I-0132	A Multicentre, Randomised, Double-blind, Parallel-group, Placebo-controlled, 24-week Phase 3 Study with an Open-label Extension to Evaluate the Efficacy and Safety of Benralizumab in Patients with Hypereosinophilic Syndrome (HES)	Participants currently recruited/enrolled	12-130 Years	NIAID	Syndrome Type
20-I-0117	Surveillance of Individuals Following SARS-CoV-2 infection	Completed Study; data analyses ongoing	18-125 Years	NIAID	Syndrome Type
20-I-0111	COVID-19-associated Lymphopenia Pathogenesis Study in Blood	Participants currently recruited/enrolled	18-125 Years	NIAID	Syndrome Type
20-C-0011	Phase 1 Study of Recombinant Human IL-15 (rhIL-15) and Mogamulizumab for Patients with Refractory or Relapsed Adult T-Cell Leukemia and Mycosis Fungoides/Sezary Syndrome	Completed Study; data analyses ongoing	18-125 Years	NCI	Syndrome Type
19-NR-0098	Patient-Centered Assessment of Symptoms and Outcomes	Participants currently recruited/enrolled	18-125 Years	NINR	Syndrome Type
19-H-0139	Investigation of the Natural Progression of Clonal Hematopoiesis of Indeterminate Potential and Clonal Cytopenia of Undetermined Significance.	Participants currently recruited/enrolled	18-125 Years	NHLBI	Syndrome Type
19-C-0135	Evaluation of the Natural History and Management of Von Hippel-Lindau (VHL) Associated Pancreatic Neuroendocrine Tumors	Participants currently recruited/enrolled	12-125 Years	NCI	Syndrome Type
17-DK-0054	The Physiological Responses and Adaptation of Brown Adipose Tissue to Chronic Treatment with Beta3-Adrenergic Receptor Agonists	Participants currently recruited/enrolled	18-40 Years	NIDDK	Syndrome Type
15-DK-0108	Natural History of Noncirrhotic Portal Hypertension	Participants currently recruited/enrolled	12-125 Years	NIDDK	Syndrome Type
13-I-0157	The Natural History of GATA2 Deficiency and Related Disorders	Participants currently recruited/enrolled	2-100 Years	NIAID	Syndrome Type
13-C-0132	Allogeneic Hematopoietic Stem Cell Transplant for Patients with Mutations in GATA2 or the MonoMAC Syndrome	Participants currently recruited/enrolled	8-70 Years	NCI	Syndrome Type
12-EI-0042	NEI Intramural Biorepository for Retinal Diseases	Participants currently recruited/enrolled	2-125 Years	NEI	Syndrome Type
11-I-0187	The Natural History and Pathogenesis of Human Fungal Infections	Participants currently recruited/enrolled	0-99 Years	NIAID	Syndrome Type
11-E-0072	Environmental Risk Factors for the Anti-Synthetase Syndrome	Participants currently recruited/enrolled	2-100 Years	NIEHS	Syndrome Type
11-C-0255	Clinical, Epidemiologic, and Genetic Studies of Li-Fraumeni Syndrome	Participants currently recruited/enrolled	0-125 Years	NCI	Syndrome Type
11-C-0034	DICER1-Related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study	Participants currently recruited/enrolled	0-125 Years	NCI	Syndrome Type
10-E-0129	Study of the Effect of Innate Immunity on the Inflammatory Response to Endotoxin	Participants currently recruited/enrolled	18-125 Years	NIEHS	Syndrome Type
10-C-0066	A Study of Hairy Cell and other Leukemias with a Focus on Recombinant Immunotoxins for Cancer Treatment	Participants currently recruited/enrolled	18-125 Years	NCI	Syndrome Type
09-I-0102	Etiology, Pathogenesis, and Natural History of Idiopathic CD4+ Lymphocytopenia	Participants currently recruited/enrolled	18-125 Years	NIAID	Syndrome Type
08-H-0046	Co-Infusion of Umbilical Cord Blood and Haploidentical CD34+ Cells Following Nonmyeloablative Conditioning as Treatment for Severe Aplastic Anemia and MDS Associated with Severe Neutropenia Refractory to Immunosuppressive Therapy	Completed Study; data analyses ongoing	4-75 Years	NHLBI	Syndrome Type
06-I-0015	Screening Protocol for Genetic Diseases of Lymphocyte Homeostasis and Programmed Cell Death	Participants currently recruited/enrolled	0-125 Years	NIAID	Syndrome Type
05-C-0152	Variation in Gene Expression in Neurofibromatosis Type 1	Completed Study; data analyses ongoing	2-100 Years	NCI	Syndrome Type
04-I-0286	A Longitudinal Study of Familial Hypereosinophilia (FE): Natural History and Markers of Disease Progression	Participants currently recruited/enrolled	1-100 Years	NIAID	Syndrome Type
04-C-0102	Hematologic Malignancy Biology Study	Enrolling by Invitation	1-75 Years	NCI	Syndrome Type
02-C-0211	Clinical, Laboratory, and Epidemiologic Characterization of Individuals and Families at High Risk of Melanoma	Participants currently recruited/enrolled	2-125 Years	NCI	Syndrome Type
02-C-0159	Birt-Hogg-Dub(SqrRoot)(Copyright) Syndrome: Characterization of the FLCN Disease Gene and Predisposition to Renal Cancer, Cutaneous Fibrofolliculoma and Pulmonary Cysts	Participants currently recruited/enrolled	2-125 Years	NCI	Syndrome Type
02-C-0052	Etiologic Investigation of Cancer Susceptibility in Inherited Bone Marrow Failure Syndromes: A Natural History Study	Participants currently recruited/enrolled	0-125 Years	NCI	Syndrome Type
01-HG-0109	Natural History Study of the Clinical and Molecular Manifestations of Smith-Magenis Syndrome (SMS)	No longer recruiting/follow-up only	0-125 Years	NHGRI	Syndrome Type
00-CH-0160	Clinical and Molecular Analysis of ACTH-Independent Steroid Hormone Production in Adrenocortical Tissue	Completed Study; data analyses ongoing	3-70 Years	NICHD	Syndrome Type
001126-DC	Collection of Clinical Data and Specimens for Research in Hearing, Balance and Communication Disorders	Participants currently recruited/enrolled	2-125 Years	NIDCD	Type
001109-C	Defining the Natural History of Squamous Cell Carcinoma in Fanconi Anemia	Participants currently recruited/enrolled	8-125 Years	NCI	Syndrome
001084-CH	A Prospective Natural History Study of Lymphatic Anomalies	Participants currently recruited/enrolled	0-125 Years	NICHD	Type
001073-E	NIEHS Repository of Stored Biological Samples for Future Use	Recruitment has not started	18-125 Years	NIEHS	Type
001066-DA	Orexin's Role in The Neurobiology of Substance Use Disorder	Participants currently recruited/enrolled	18-60 Years	NIDA	Type
001061-H	Observational Study Investigating the Mechanistic Effects of Mitapivat in Subjects with Sickle Cell Disease	Enrolling by Invitation	16-125 Years	NHLBI	Syndrome
001058-DK	A Phase 1b/2a Open-label Multiple-ascending Dose Exploratory Study of CRN04894 in ACTH-dependent Cushing's Syndrome (Cushing's Disease or Ectopic ACTH Syndrome)	Recruitment has not started	18-75 Years	NIDDK	Syndrome
001043-I	Evaluating the Genetics and Immunology of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome and Other Tonsil Disorders	Recruitment has not started	0-125 Years	NIAID	Syndrome
001018-CH	Establishment of Genomic and Phenotypic Database for Niemann-Pick Disease, Type C	Participants currently recruited/enrolled	0-125 Years	NICHD	Type
001004-C	A Phase 1b/2 Basket Study of ACR-368 as Monotherapy and in Combination with Gemcitabine in Adult Subjects with Platinum-Resistant Ovarian Carcinoma, Endometrial Adenocarcinoma, and Urothelial Carcinoma Based on Acrivon Oncosignature (R) Status	Participants currently recruited/enrolled	18-120 Years	NCI	Type
000978-M	State-Dependent Interoception, Value-Based Decision-Making, and Introspection	Recruitment has not started	18-55 Years	NIMH	Type
000957-HG	A Phase 1/2, Open-Label, Single Dose Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of SEL-302 (MMA-101 following administration of SEL-110) in Pediatric Subjects with Mut Subtype Isolated Methylmalonic Acidemia (MMA)	Participants currently recruited/enrolled	3-17 Years	NHGRI	Type
000954-C	A Phase 1/2 Single Arm Open-Label Clinical Trial of TC-510 In Patients with Advanced Mesothelin-Expressing Cancer	Participants currently recruited/enrolled	18-125 Years	NCI	Type
000942-M	A Cognitive Test Battery for Intellectual Disabilities	Participants currently recruited/enrolled	4-125 Years	NIMH	Syndrome
000911-DK	Dinner Time for Obesity and Prediabetes (DTOP)	Recruitment has not started	18-50 Years	NIDDK	Type
000906-I	A Phase 2 Randomized, Double-Blinded Cross-Over Design Study of the Early Metabolic Effects of Dolutegravir or Tenofovir Alefenamide in Healthy Volunteers	Recruitment has not started	18-55 Years	NIAID	Type
000865-N	Natural History Protocol for Movement Disorders	Participants currently recruited/enrolled	2-125 Years	NINDS	Type
000861-I	A Phase 2 Open-Label Study to Evaluate the Efficacy and Safety of Ruxolitinib on Hair Regrowth in Patients with Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED)-Associated Alopecia Areata	Participants currently recruited/enrolled	12-65 Years	NIAID	Type
000829-H	Controls and Healthy Vasculature Initiative	Participants currently recruited/enrolled	18-125 Years	NHLBI	Type
000798-D	A Phase 2 Study of Burosumab for Fibroblast Growth Factor-23 Mediated Hypophosphatemia in Fibrous Dysplasia	Participants currently recruited/enrolled	1-125 Years	NIDCR	Syndrome
000782-C	A Dose-Escalation and Expansion Study of the Safety and Pharmacokinetics of XL092 as Single-Agent and Combination Therapy in Subjects with Inoperable Locally Advanced or Metastatic Solid Tumors	Recruitment has not started	18-125 Years	NCI	Type
000780-D	A Phase 2 Study of Denosumab for Prevention of Skeletal Disease Progression in Children with Fibrous Dysplasia	Participants currently recruited/enrolled	4-14 Years	NIDCR	Syndrome
000760-H	Extension Study (extended access) of Syk-inhibition Using Fostamatinib to Treat Post-Transplant Immune-mediated Cytopenias	Enrolling by Invitation	18-75 Years	NHLBI	Type
000758-H	A Phase II Study Using Fostamatinib to Treat Post-Hematopoietic Stem Cell Transplant Immune-Mediated Cytopenias	Participants currently recruited/enrolled	18-75 Years	NHLBI	Type
000756-DK	Phase II Study of Growth Hormone Inhibition Using Pegvisomant In Severe Insulin Resistance	Participants currently recruited/enrolled	18-65 Years	NIDDK	Syndrome
000748-DK	Analysis of the Utility of Polygenic Scores for Prediction of Incident Type 2 Diabetes Across Multiple Ancestry Groups	No longer recruiting/follow-up only	0-125 Years	NIDDK	Type
000732-C	A Long-Term Follow-Up Study of Patients Who Received VOR33	Recruitment has not started	18-125 Years	NCI	Type
000726-C	A Randomized Phase 2 Study of Atezolizumab with or without Selinexor in Alveolar Soft Part Sarcoma (AXIOM)	Participants currently recruited/enrolled	18-125 Years	NCI	Type
000696-C	A Phase III, Multicenter, International Study with a Parallel, Randomized, Double-blind, Placebo-controlled, 2 Arm Design to Assess the Efficacy and Safety of Selumetinib in Adult Participants with NF1 who have Symptomatic, Inoperable Plexiform Neurofibr	Participants currently recruited/enrolled	18-120 Years	NCI	Type
000686-CH	Intrathecal 2-Hydroxypropyl-Beta-Cyclodextrin for Neurological Decline in Patients with Niemann-Pick Disease Type C1	Participants currently recruited/enrolled	18-125 Years	NICHD	Type
000678-C	Rare Tumors and Cancer Predisposition in Individuals and Families	Participants currently recruited/enrolled	0-125 Years	NCI	Type
000661-C	Comprehensive Molecular and Clinical Evaluation of Pediatric and Adult Myelodysplastic Syndromes (MDS)	Participants currently recruited/enrolled	0-125 Years	NCI	Syndrome
000647-C	An Open-label, Multicenter Follow-up Study to Collect Long-term Data on Participants from Multiple Bintrafusp alfa (M7824) Clinical Studies	Recruitment has not started	18-125 Years	NCI	Type
000644-C	Phase 1/1b Trial of ATR Inhibitor BAY 1895344 in Combination with FOLFIRI in GI Malignancies with a Focus on Metastatic Colorectal and Gastric/Gastroesophageal Cancers	Participants currently recruited/enrolled	18-125 Years	NCI	Type
000613-C	Phase I/II Trial to Determine the Lowest Effective Dose of Post-Transplantation Cyclophosphamide in Combination with Sirolimus and Mycophenolate Mofetil as Graft-Versus-Host Disease Prophylaxis after Reduced Intensity Conditioning and Peripheral Blood St	Participants currently recruited/enrolled	12-125 Years	NCI	Type
000612-C	Phase 1 Study of NT-I7 (rhIL-7-hyFc) for the Treatment of Kaposi Sarcoma in Patients With or Without Infection with HIV	Participants currently recruited/enrolled	18-125 Years	NCI	Type
000611-C	A Phase II Trial of Focal Ultrahypofractionated Stereotactic Radiation Therapy for the Treatment of Unifocal Prostate Cancer	Recruitment has not started	18-125 Years	NCI	Type
000567-C	Phase 1 Trial of Gemcitabine Combined with the BAY 1895344 ATR Inhibitor with Expansion Cohorts in Advanced Pancreatic and Ovarian Cancer	Participants currently recruited/enrolled	18-125 Years	NCI	Type
000547-HG	Observational Study of Advanced Data Analytics in Genetic Conditions	Recruitment has not started	0-125 Years	NHGRI	Syndrome
000519-EI	Phase II, Multicenter, Open-label Safety Study of Bilateral NT-501 in Participants with Macular Telangiectasia Type 2	No longer recruiting/follow-up only	18-125 Years	NEI	Type
000488-I	Natural History of Systemic and Nasal Mucosal Immunity after Influenza Vaccination in a Pediatric Population	No longer recruiting/follow-up only	2-17 Years	NIAID	Type
000487-CH	Natural History Investigation into Biochemical and Phenotypical Aspects of Smith-Lemli-Opitz Syndrome and Related Disorders of Cholesterol Metabolism	Participants currently recruited/enrolled	0-125 Years	NICHD	Syndrome
000475-C	Phase 2 Study of Rogaratinib (BAY 1163877) in the Treatment of Patients with Sarcoma Harboring Alterations in Fibroblast Growth Factor Receptor (FGFR) 1-4 and SDH-deficient Gastrointestinal Stromal Tumor (GIST)	Participants currently recruited/enrolled	18-125 Years	NCI	Type
000462-C	Phase 2, Open-label, Single-arm, Window of Opportunity Study of ASP-1929 Photoimmunotherapy with Fluorescence Imaging in Patients With Operable Primary or Recurrent Head and Neck or Cutaneous Squamous Cell Carcinoma	Participants currently recruited/enrolled	18-125 Years	NCI	Type
000444-H	Vaccine Responses in Patients with B Cell Malignancies	Participants currently recruited/enrolled	18-125 Years	NHLBI	Type
000423-C	Feasibility and Preliminary Efficacy of Acceptance and Commitment Therapy (ACT) for Sleep Disturbances in Adults with Sickle Cell Disease (SCD): A Pilot Randomized Controlled Trial	Participants currently recruited/enrolled	18-55 Years	NCI	Type
000421-AA	Individual Variations of Taste and Smell Perception in Alcohol Use Disorder (AUD)	Recruitment has not started	18-65 Years	NIAAA	Type
000418-C	Phase 1/2a, Open-label, Multicenter Study of Intramuscular PRL-02 Depot in Patients with Advanced Prostate Cancer	Participants currently recruited/enrolled	18-120 Years	NCI	Type
000414-CH	Pilot Study of an Optic-to-Audio Device in a Pediatric Cohort with CLN3-related Conditions or Low Vision	Participants currently recruited/enrolled	6-18 Years	NICHD	Type
000411-CC	A Feasibility Pilot Study of a Virtual Education-Based Transition Intervention to Improve Transition Readiness in Adolescent and Young Adults with Congenital Adrenal Hyperplasia.	Recruitment has not started	16-22 Years	CC	Type
000404-C	A Phase II Study of Allogeneic Hematopoietic Stem Cell Transplant for Subjects with VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome	Participants currently recruited/enrolled	18-75 Years	NCI	Syndrome
000393-DK	Diabetic Kidney Disease and Related Complications in American Indians with Type 2 Diabetes	Participants currently recruited/enrolled	18-125 Years	NIDDK	Type
000387-H	The Natural History of Acquired and Inherited Bone Marrow Failure Syndromes.	Participants currently recruited/enrolled	2-125 Years	NHLBI	Syndrome
000384-I	Analysis of the Immune Response to COVID-19 Vaccination and Outcomes in Individuals With and Without Immune Deficiencies and Dysregulations	Participants currently recruited/enrolled	3-125 Years	NIAID	Type
000356-C	A Phase I/II Trial of BMS-986253 in Myelodysplastic Syndromes	Participants currently recruited/enrolled	18-125 Years	NCI	Syndrome
000354-C	Phase II Trial of Combination Anti-PD-1 and Aldesleukin for Metastatic Melanoma and Renal Cell Carcinoma	Participants currently recruited/enrolled	18-125 Years	NCI	Type
000350-D	Use of Clear Aligners for the Treatment of Dental Malocclusion In Individuals with Osteogenesis Imperfecta Types III and IV	Participants currently recruited/enrolled	12-40 Years	NIDCR	Type
000343-H	Detection of T cell Somatic Mutations in Bone Marrow Failure Using Whole Exome or Targeted Sequencing	Enrolling by Invitation	18-125 Years	NHLBI	Syndrome
000337-C	Natural History Study of KSHV-Associated Multicentric Castleman's Disease	Participants currently recruited/enrolled	18-125 Years	NCI	Type
000328-C	Bicalutamide Implants (Biolen ) with Radiation Therapy in Patients with Localized Prostate Cancer	Participants currently recruited/enrolled	18-125 Years	NCI	Type
000326-H	A Phase 1, Dose Escalation, Safety and Tolerability Study of NX- 2127, a Bruton's Tyrosine Kinase (BTK) Degrader, in Adults with Relapsed/Refractory B-cell Malignancies	Participants currently recruited/enrolled	18-125 Years	NHLBI	Type
000324-C	Phase 1/2 Dose Escalation Study of CD19/CD22 Bicistronic Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults with Recurrent or Refractory CD19/CD22-expressing B Cell Malignancies	Participants currently recruited/enrolled	3-35 Years	NCI	Type
000305-C	Exploratory Phase II Study of LAnreotide in Unresectable or Metastatic Pheochromocytoma / PARAganglioma	Participants currently recruited/enrolled	18-125 Years	NCI	Type
000293-C	Managing Cancer and Living Meaningfully (CALM) Therapy in Individuals Diagnosed with a Primary Central Nervous System Tumor	Enrolling by Invitation	18-125 Years	NCI	Type
000264-C	A Pharmacodynamics-Driven Trial of Talazoparib, an Oral PARP Inhibitor, in Patients With Advanced Solid Tumors and Aberrations in Genes Involved in DNA Damage Response	Participants currently recruited/enrolled	18-125 Years	NCI	Type
000254-C	A Phase II Trial of the Superenhancer Inhibitor Minnelide in Advanced Refractory Adenosquamous Carcinoma of the Pancreas (ASCP)	Participants currently recruited/enrolled	18-125 Years	NCI	Type
000226-I	Efficacy of Belimumab and Rituximab Compared to Rituximab Alone for the Treatment of Primary Membranous Nephropathy	Participants currently recruited/enrolled	18-75 Years	NIAID	Syndrome
000213-HG	Clinical and Laboratory Study of Rare Skeletal Disorders	Participants currently recruited/enrolled	0-125 Years	NHGRI	Type
000212-I	Induced Blood-Stage Plasmodium Vivax Infection with HMPBS02-Pv Challenge Agent in Healthy Malaria-Naive Adults to Produce a Plasmodium Vivax Parasite Cell Bank for Future Studies	No longer recruiting/follow-up only	18-50 Years	NIAID	Type
000194-C	A Phase I Trial of ProAgio, an anti- alpha-v-beta3 Integrin Cytotoxin, for Previously Treated Advanced Pancreatic Cancer and Other Solid Tumor Malignancies	Participants currently recruited/enrolled	18-125 Years	NCI	Type
000193-C	Phase 1 Study of Copanlisib with Dose-adjusted EPOCH-R in Relapsed and Refractory Burkitt Lymphoma and other High-Grade B-cell Lymphomas	Clinical hold/Recruitment or enrollment suspended	18-125 Years	NCI	Type
000187-EI	Adaptive Optics Imaging of Outer Retinal Diseases	Participants currently recruited/enrolled	21-125 Years	NEI	Type
000173-C	Systematically Assessing Changes in Plexiform Neurofibroma Related Disfigurement from Photographs of Subjects with Neurofibromatosis Type 1 on a Phase 2 Clinical Trial	Completed Study; data analyses ongoing	7-125 Years	NCI	Type
000141-DC	Deep Phenotyping of Hearing Instability Disorders: Cohort Establishment, Biomarker Identification, Development of Novel Phenotyping Measures, and Discovery of Therapeutic Targets	Participants currently recruited/enrolled	18-80 Years	NIDCD	Syndrome
000134-I	A Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Trial of Intravenous Zotatifin in Adults with Mild or Moderate Coronavirus Disease 2019 (COVID-19)	Participants currently recruited/enrolled	18-125 Years	NIAID	Syndrome
000106-CH	Gonadal Tissue Freezing for Fertility Preservation in Individuals at risk for Ovarian Dysfunction and Premature Ovarian Insufficiency	Participants currently recruited/enrolled	4-21 Years	NICHD	Syndrome
000081-C	A Phase 2 Study of Anti-PD-L1 Antibody (Atezolizumab) in Chondrosarcoma and Clear Cell Sarcoma	Completed Study; data analyses ongoing	2-125 Years	NCI	Type
000059-C	Phase I Study of Intratumor Injection of anti-Mesothelin Immunotoxin LMB-100 with Ipilimumab in Malignant Mesothelioma	Participants currently recruited/enrolled	18-125 Years	NCI	Type
000057-C	A Phase 1 Study of AZD8186 in Combination with Docetaxel in Patients with PTEN Mutated or PIK3CB Mutated Advanced Solid Tumors, Potentially Amenable to Docetaxel	Completed Study; data analyses ongoing	18-125 Years	NCI	Type
000045-C	A Phase I Trial of T Cell Receptor Gene Therapy Targeting KK-LC-1 for Gastric, Breast, Cervical, Lung and other KK-LC-1 Positive Epithelial Cancers	Participants currently recruited/enrolled	18-120 Years	NCI	Type
21-N-0010	A Phase 2 Clinical Trial of Tolebrutinib, a Brain-penetrant Bruton's Tyrosine Kinase Inhibitor, for the Modulation of Chronically Inflamed White Matter Lesions in Multiple Sclerosis	No longer recruiting/follow-up only	18-125 Years	NINDS	Type
21-M-0018	Characterization of an Optically Pumped Magnetometer (OPM) Magnetoencephalography (MEG) Array	Participants currently recruited/enrolled	18-65 Years	NIMH	Type
21-I-0005	Phase 1 Study of the Safety and Immunogenicity of an Epstein-Barr virus (EBV) gp350- Ferritin Nanoparticle Vaccine in Healthy Adults With or Without EBV Infection	Participants currently recruited/enrolled	18-29 Years	NIAID	Type
21-I-0003	A Phase 1/2 Study to Evaluate the Safety, Tolerability and Efficacy, of JSP191 for Hematopoietic Cell Transplantation Conditioning to Achieve Engraftment and Immune Reconstitution in Subjects with SCID	Participants currently recruited/enrolled	3-125 Years	NIAID	Type
21-H-0027	Characterization of Tissue-Specific Immune Responses to Bronchoscopic Instillation of Mycobacterial Antigens into the Human Lung	Participants currently recruited/enrolled	18-64 Years	NHLBI	Type
21-C-0030	Phase I Study of GPC3 Targeted CAR-T Cell Therapy in Advanced GPC3 Expressing Hepatocellular Carcinoma (HCC)	Participants currently recruited/enrolled	18-125 Years	NCI	Type
21-C-0026	A Phase I/II Study of Abemaciclib in Patients with HIV-associated and HIV-negative Kaposi Sarcoma	Participants currently recruited/enrolled	18-125 Years	NCI	Type
21-C-0021	SARC037: A Phase I/II Study to Evaluate the Safety of Trabectedin Administered as a 1-Hour Infusion in Ewing Sarcoma Patients in Combination with Low Dose Irinotecan and 3'-Deoxy-3'-18F Fluorothymidine (18F-FLT) Imaging	Participants currently recruited/enrolled	6-125 Years	NCI	Type
21-C-0019	Phase I Study of Anti-CD22 Chimeric Receptor T Cells in Patients with Relapsed/Refractory Hairy Cell Leukemia and Variant	Participants currently recruited/enrolled	18-125 Years	NCI	Type
21-C-0015	Phase II Trial Evaluating the Association of Peripheral Blood Immunologic Response to Therapeutic Response to Adjuvant Treatment with Immune Checkpoint Inhibition (ICI) in Patients with Newly Diagnosed Glioblastoma or Gliosarcoma	Participants currently recruited/enrolled	18-125 Years	NCI	Type
21-C-0011	A Phase I/II Study of the Cyclin-Dependent Kinase(CDK)4/6 Inhibitor Abemaciclib for Neurofibromatosis Type 1 (NF1) Related Atypical Neurofibromas	Participants currently recruited/enrolled	12-125 Years	NCI	Type
21-C-0007	A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon Cancers	Participants currently recruited/enrolled	18-125 Years	NCI	Type
21-C-0006	Phase I/II Study Evaluating Safety and Efficacy of Tivozanib (AV-951) in Cholangiocarcinoma	Clinical hold/Recruitment or enrollment suspended	18-125 Years	NCI	Type
20-NR-0003	A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue	Participants currently recruited/enrolled	18-70 Years	NINR	Syndrome
20-N-0060	Mechanisms Underlying the Beneficial Effects of Naps on Motor Learning	Participants currently recruited/enrolled	18-80 Years	NINDS	Type
20-N-0019	The Effect of Vorinostat on ACTH Producing Pituitary Adenomas in Cushing's Disease	Participants currently recruited/enrolled	18-125 Years	NINDS	Type
20-M-0166	Electrophysiologic Sleep Phenotyping and Sleep-Dependent Neuro-maturation in Clinical and Healthy Pediatric Populations	Participants currently recruited/enrolled	0-8 Years	NIMH	Syndrome
20-M-0159	Role of GABAergic Transmission in Auditory Processing in Autism Spectrum Disorder	Participants currently recruited/enrolled	14-25 Years	NIMH	Syndrome
20-M-0082	Phase 1 Study: PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease	Participants currently recruited/enrolled	18-99 Years	NIMH	Syndrome
20-I-0002	Pilot Study of Mepolizumab in Episodic Angioedema with Eosinophilia	Completed Study; data analyses ongoing	18-125 Years	NIAID	Syndrome
20-HG-0034	A Multi-Cohort Phase 2 Dose-Escalation Study of MK-7075 (Miransertib) in Proteus Syndrome	Participants currently recruited/enrolled	3-125 Years	NHGRI	Syndrome
20-DK-0168	LYNC-LD Prospective Multicenter Natural History Study of Lipodystrophy Syndromes to Determine Prevalence, Incidence and Predictors of Diabetes and Severe Hypertriglyceridemia, and their Complications.	Participants currently recruited/enrolled	3-125 Years	NIDDK	Syndrome
20-DK-0018	Prebiotics and Metformin Influences Gut and Hormones in Type 2 Diabetes Youth	Completed Study; data analyses ongoing	10-25 Years	NIDDK	Type
20-D-0131	Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sj(SqrRoot)(Delta)gren's Syndrome; a Phase Ib-IIa Placebo-controlled Clinical Trial and Associated Mechanistic Studies	Participants currently recruited/enrolled	18-75 Years	NIDCR	Syndrome
20-D-0122	A Phase IIb, Open-label Dose-ranging Study Evaluating the Safety, Tolerability, Pharmacodynamics and Pharmacokinetics, and Efficacy of CLTX-305 (encaleret) in Autosomal Dominant Hypocalcemia Type 1 (ADH1)	No longer recruiting/follow-up only	16-125 Years	NIDCR	Type
20-D-0094	Transmissibility and Viral Load of SARS-CoV-2 Through Oral Secretions	Completed Study; data analyses ongoing	18-125 Years	NIDCR	Type
20-CH-0165	Androgen Receptor, Implications for Health and Wellbeing: Natural History Study of Individuals with Androgen Insensitivity	Participants currently recruited/enrolled	0-99 Years	NICHD	Syndrome
20-C-0155	Phase I/II Trial Investigating the Safety, Tolerability, Pharmacokinetics, Immune and Clinical Activity of SX-682 in Combination with BinTrafusp Alfa (M7824 or TGF-beta "Trap"/PD-L1) with CV301 TRICOM in Advanced Solid Tumors (STAT)	No longer recruiting/follow-up only	18-125 Years	NCI	Type
20-C-0130	A Feasibility Study Investigating the Use of Machine Learning to Analyze Facial Imaging, Voice and Spoken Language for the Capture and Classification of Cancer/Tumor Pain	Enrolling by Invitation	12-125 Years	NCI	Type
20-C-0107	Clinical, Genetic, and Epidemiologic Study of Children and Adults with RASopathies	Participants currently recruited/enrolled	0-125 Years	NCI	Syndrome
20-C-0106	Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients with BAP1 Tumor Predisposition Syndrome	Participants currently recruited/enrolled	30-125 Years	NCI	Syndrome
20-C-0075	Phase 2 Trial for Binimetinib for Patients with Relapsed/Refractory BRAF Wild Type Hairy Cell Leukemia and Variant	Participants currently recruited/enrolled	18-125 Years	NCI	Type
20-C-0062	A phase 1b Study of Nivolumab in Patients with Autoimmune Disorders and Advanced Malignancies (AIM-NIVO)	Participants currently recruited/enrolled	18-125 Years	NCI	Syndrome
20-C-0028	Phase 1/2 Study of Anti-CD33 Chimeric Antigen Receptor-Expressing T Cells (CD33CART) in Children and Young Adults with Relapsed/Refractory Acute Myeloid Leukemia	Participants currently recruited/enrolled	3-35 Years	NCI	Type
20-C-0027	A Phase I Clinical Trial of Selinexor (KPT-330) in Combination with Temozolomide and Radiation Therapy in Patients with Newly Diagnosed Glioblastoma	Participants currently recruited/enrolled	18-125 Years	NCI	Type
20-C-0013	Phase I/II Trial of PLX038 (PEGylated SN38) and Rucaparib in Solid Tumors and Small Cell Cancers	No longer recruiting/follow-up only	18-125 Years	NCI	Type
20-C-0012	A Phase I Study of Bintrafusp alfa (M7824) and NHS-IL12 (M9241) Alone and in Combination with Stereotactic Body Radiation Therapy (SBRT) in Adults with Metastatic Non-Prostate Genitourinary Malignancies	Participants currently recruited/enrolled	18-125 Years	NCI	Type
20-AG-0087	Ketone ester effects on biomarkers of brain metabolism and cognitive performance in cognitively intact adults (Bullet) 55 years old. A double-blinded randomized controlled clinical trial	Participants currently recruited/enrolled	55-125 Years	NIA	Syndrome
19-M-0054	Mapping the Phenotype in Adults with Phelan-McDermid Syndrome	Completed Study; data analyses ongoing	0-125 Years	NIMH	Syndrome
19-I-0140	A Phase 1 Evaluation of the Safety of Belimumab in People with Idiopathic CD4 Lymphopenia and Autoantibodies (Phoebe)	Participants currently recruited/enrolled	18-70 Years	NIAID	Type
19-I-0133	Paradoxical Tuberculosis Reactions in Patients without HIV Infection	Participants currently recruited/enrolled	18-125 Years	NIAID	Syndrome
19-I-0084	Skin Immunity Sample Collection Involving Blisters and Biopsies	Recruitment has not started	7-65 Years	NIAID	Syndrome
19-I-0022	A Prospective, Multicenter Study to Compare and Validate Endoscopic, Histologic, Molecular, and Patient-Reported Outcomes in Pediatric and Adult Patients with Eosinophilic Esophagitis (EoE), Gastritis (EG) and Colitis (EC)	Participants currently recruited/enrolled	3-125 Years	NIAID	Type
19-HG-0101	A Phase 1/2 Study of Intravenous Gene Transfer with an AAV9 Vector Expressing Human Beta-galactosidase in Type I and Type II GM1 Gangliosidosis	No longer recruiting/follow-up only	0-12 Years	NHGRI	Type
19-H-0034	Exploratory Study of Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome	Completed Study; data analyses ongoing	18-70 Years	NHLBI	Syndrome
19-DA-N019	Outcome Inference in the Sensory Preconditioning Task in Opioid-use Disorder	Participants currently recruited/enrolled	21-60 Years	NIDA	Type
19-CH-0051	Long-Term Follow-UP of Survivors of Pediatric Cushing Disease	Participants currently recruited/enrolled	2-90 Years	NICHD	Syndrome
19-CH-0026	Randomized, Double-Blind, Placebo-Controlled Study Plus Open Label Extension with a Double-Blind, Placebo-Controlled, Randomized Withdrawal Period of Diazoxide Choline Extended-Release Tablets (DCCR, Soleno Therapeutics, Inc.) in Participants with Prader	No longer recruiting/follow-up only	4-125 Years	NICHD	Syndrome
19-CH-0020	A Phase 1-2 Multi-Center Study to Assess the Efficacy and Safety of Abiraterone Acetate as Adjunctive Therapy in Pre-Pubescent Children with Classic 21-Hydroxylase Deficiency	Recruitment has not started	2-9 Years	NICHD	Syndrome
19-CC-0070	Translational Development of Photon-Counting CT Imaging	Completed Study; data analyses ongoing	18-125 Years	CC	Type
19-C-0138	Phase I/II Study of Lu-177-DOTATATE (Lutathera) in Combination with Olaparib in Inoperable Gastroenteropancreatico Neuroendocrine Tumors (GEP-NET)	Participants currently recruited/enrolled	18-125 Years	NCI	Type
19-C-0137	A Phase II Study of Ipilimumab, Cabozantinib, and NIvolumab in Rare Genitourinary Cancers (ICONIC)	Participants currently recruited/enrolled	18-125 Years	NCI	Type
19-C-0116	A Phase 2 Study of Acalabrutinib with DA-EPOCH-R or R-CHOP for Patients with Untreated Diffuse Large B-cell Lymphoma	Participants currently recruited/enrolled	18-125 Years	NCI	Type
19-C-0096	Studying the Biology of IDH-mutant Gliomas via Longitudinal Observation of 2-Hydroxyglutarate (2-HG) Using MR Spectroscopy	Participants currently recruited/enrolled	18-125 Years	NCI	Type
19-C-0085	Phase II Trial of Allogeneic Hematopoietic Cell Transplantation for Peripheral T cell Lymphoma	Clinical hold/Recruitment or enrollment suspended	12-125 Years	NCI	Type
19-C-0082	Natural History Study of Children and Adults with Chordoma	Participants currently recruited/enrolled	2-125 Years	NCI	Type
19-C-0076	A Phase 1 Study of Interleukin-15 in Combination with Avelumab (Bavencio) in Relapsed/Refractory Mature T-cell Malignancies	Completed Study; data analyses ongoing	18-125 Years	NCI	Syndrome
19-C-0061	A Phase 2 Trial of the MEK Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in Combination with the mTOR Inhibitor Sirolimus for Patients with Unresectable or Metastatic Malignant Peripheral Nerve Sheath Tumors	Participants currently recruited/enrolled	12-125 Years	NCI	Type
19-C-0040	Natural History Study of Men at High Genetic Risk for Prostate Cancer	Participants currently recruited/enrolled	30-75 Years	NCI	Syndrome
19-C-0016	Natural History and Biospecimen Acquisition Study for Children and Adults with Rare Solid Tumors	Participants currently recruited/enrolled	0-125 Years	NCI	Syndrome
19-C-0010	A Phase 1 Trial of MK-3475 Plus Ziv-Aflibercept in Patients with Advanced Solid Tumors	Completed Study; data analyses ongoing	18-125 Years	NCI	Type
18-M-0144	The effects of an ER beta agonist (Lilly Compound LY500307) on estradiol-withdrawal-induced mood symptoms in women with past perimenopausal depression.	Participants currently recruited/enrolled	45-65 Years	NIMH	Type
18-I-0022	Use of Ustekinumab (Anti-IL-12/23p40 Monoclonal Antibody) in Patients with Leukocyte Adhesion Deficiency Type 1 (LAD1) who have Inflammatory Pathology	Participants currently recruited/enrolled	12-65 Years	NIAID	Type
18-HG-0064	A Natural History Study of Patients with Generalized Arterial Calcification of Infancy (GACI) or Autosomal Recessive Hypophosphatemic Rickets Type 2 (ARHR2)	Completed Study; data analyses ongoing	0-125 Years	NHGRI	Type
18-H-0090	Haplo-identical Transplantation for Severe Aplastic Anemia, Hypo-plastic MDS and PNH using Peripheral Blood Stem Cells and post-transplant Cyclophosphamide for GVHD prophylaxis	Participants currently recruited/enrolled	4-75 Years	NHLBI	Syndrome
18-EI-0055	A Phase III Multicenter Randomized Sham Controlled Study to Determine the Safety and Efficacy of NT-501 in Macular Telangiectasia Type 2	Completed Study; data analyses ongoing	21-80 Years	NEI	Type
18-CH-0120	A Natural History of the Collagen-Related Disorder Osteogenesis Imperfecta and the Genotype-Phenotype Correlation	No longer recruiting/follow-up only	0-125 Years	NICHD	Type
18-C-0138	An Open-Label Phase 2 Study to Evaluate PT2977 for the Treatment of Von Hippel-Lindau Disease-Associated Renal Cell Carcinoma.	No longer recruiting/follow-up only	18-125 Years	NCI	Type
18-C-0110	Safety Run-In and Phase II Trial of M7824 and Topotecan or Temozolomide in Relapsed Small Cell Cancers	Participants currently recruited/enrolled	18-125 Years	NCI	Type
18-C-0102	Pilot Study of the MEK1/2 Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) for Adults with Neurofibromatosis Type 1 (NF1) and Cutaneous Neurofibromas (cNF)	Completed Study; data analyses ongoing	18-125 Years	NCI	Type
18-C-0093	Pilot Study of Medication Adherence in Children, Adolescents, and Adults with Neurofibromatosis Type 1 (NF1) on Clinical Treatment Trials	No longer recruiting/follow-up only	3-125 Years	NCI	Type
18-C-0078	A Phase I/II Study of Immunotherapy Combination BN-Brachyury vaccine, M7824, N-803 and Epacadostat (QuEST1)	Participants currently recruited/enrolled	18-125 Years	NCI	Type
18-C-0049	A Phase II Study Using the Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in Patients with Metastatic Cancer	Participants currently recruited/enrolled	18-72 Years	NCI	Type
18-AR-0081	Investigation of the Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease and Related Inflammatory Conditions	Participants currently recruited/enrolled	0-125 Years	NIAMS	Syndrome
17-N-0131	Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia	Participants currently recruited/enrolled	18-125 Years	NINDS	Syndrome
17-N-0035	Clinical and Physiological Studies of Tremor Syndromes	Completed Study; data analyses ongoing	18-125 Years	NINDS	Syndrome
17-I-0072	Herpesviruses Reactivation In Hiv-Infected Women Initiating ART (HERA)	Completed Study; data analyses ongoing	18-99 Years	NIAID	Type
17-H-0091	Unrelated Umbilical Cord Blood Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS using CordIn, Umbilical Cord Blood-Derived Ex Vivo Expanded Stem and Progenitor Cells, to Expedite Engraftment and Improve Transplant Outcome	Participants currently recruited/enrolled	4-75 Years	NHLBI	Syndrome
17-DK-0013	Therapeutic Targets in African-American Youth with Type 2 Diabetes	Participants currently recruited/enrolled	12-25 Years	NIDDK	Type
17-CH-0078	Setmelanotide (RM-493; Rhythm Pharmaceuticals, Inc.) Phase 2 Open-Label Treatment Trials in Patients with Rare Genetic Disorders of Obesity	No longer recruiting/follow-up only	6-100 Years	NICHD	Syndrome
17-CC-0148	Obtaining Samples from Human Subjects to Facilitate Basic, Translational and Clinical Research	Participants currently recruited/enrolled	18-125 Years	CC	Type
17-C-0175	CC-4047-BRN-001: A Phase 2 Clinical Study of Pomalidomide (CC-4047) Monotherapy for Children and Young Adults with Recurrent or Progressive Primary Brain Tumors	Completed Study; data analyses ongoing	3-20 Years	NCI	Type
17-C-0174	Molecular Characterization of Viral-associated Tumors, Tumors Occurring in the Setting of HIV or Other Immune Disorders and Castleman Disease	Participants currently recruited/enrolled	18-125 Years	NCI	Type
17-C-0153	Phase I Trial of Image Guided Focally Dose Escalated Prostate SBRT for Locally Recurrent Prostate Cancer after Prior Radiotherapy	Participants currently recruited/enrolled	18-125 Years	NCI	Type
17-C-0149	Phase 2 Trial of Pembrolizumab in Relapsed and Refractory Gray-Zone Lymphoma (GZL), Primary Central Nervous System Lymphoma (PCNSL),and Other Extranodal Diffuse Large B-cell Lymphomas	No longer recruiting/follow-up only	18-125 Years	NCI	Type
17-C-0140	Phase I/II Evaluation of Oral Decitabine/Tetrahydrouridine as Epigenetic Priming for Pembrolizumab Immune Checkpoint Blockade in Inoperable Locally Advanced or Metastatic Non-Small Cell Lung Cancers, Esophageal Carcinomas, or Pleural Mesotheliomas	Completed Study; data analyses ongoing	18-99 Years	NCI	Type
17-C-0125	Phase 2 Trial of Nivolumab in Epstein-Barr Virus (EBV)-Positive Lymphoproliferative Disorders and EBV-Positive Non-Hodgkin Lymphomas	Participants currently recruited/enrolled	12-125 Years	NCI	Type
17-C-0105	Prospective Study of Clonal Evolution in Follicular Lymphoma	Participants currently recruited/enrolled	18-125 Years	NCI	Type
17-C-0092	A Phase I/II Study of Pexa-Vec Oncolytic Virus in Combination with Immune Checkpoint Inhibition in Refractory Colorectal Cancer	Completed Study; data analyses ongoing	18-125 Years	NCI	Type
17-C-0089	Evaluation of 18F-DCFPyL PSMA- versus 18F-NaF-PET imaging for Detection of Metastatic Prostate Cancer	Enrolling by Invitation	18-125 Years	NCI	Type
17-C-0087	Lu-177-DOTATATE (Lutathera) in Therapy of Inoperable Pheochromocytoma/ Paraganglioma	Participants currently recruited/enrolled	18-125 Years	NCI	Syndrome
17-C-0061	Phase II Trial of Pembrolizumab in Recurrent or Metastatic Medullary Thyroid Cancer	Completed Study; data analyses ongoing	18-125 Years	NCI	Type
17-C-0049	A Phase I/II Trial of the Insulin-Like Growth Factor 1 Receptor (IGF-1R) Antibody AMG479 (Ganitumab) in Combination with the Src Family Kinase (SFK) Inhibitor Dasatinib in Patients with Embryonal and Alveolar Rhabdomyosarcoma	Completed Study; data analyses ongoing	2-125 Years	NCI	Type
17-C-0048	Anti-CD30 CAR T Cells with Fully-human Binding Domains for Treating CD30-expressing Lymphomas Including Anaplastic Large Cell Lymphomas	Completed Study; data analyses ongoing	18-73 Years	NCI	Type
17-C-0043	Hereditary Gastric Cancer Syndromes: An Integrated Genomic and Clinicopathologic Study of the Predisposition to Gastric Cancer	Participants currently recruited/enrolled	2-125 Years	NCI	Syndrome
17-AT-0075	Sensory and Opioid Mechanisms of Affective Touch	Completed Study; data analyses ongoing	18-50 Years	NCCIH	Type
16-N-0114	The Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques: An Investigator-Blinded Study	Participants currently recruited/enrolled	18-125 Years	NINDS	Type
16-N-0058	Myalgic Encephalomyelitis/Chronic Fatigue Syndrome	Completed Study; data analyses ongoing	18-60 Years	NINDS	Syndrome
16-I-0165	An open-label, non-randomized extension study to evaluate the long term safety, tolerability, efficacy and pharmacokinetics of CDZ173 (leniolisib) in patients with APDS/PASLI (Activated phosphoinositide 3-kinase delta syndrome/p110 delta-activating mutat	No longer recruiting/follow-up only	12-75 Years	NIAID	Syndrome
16-HG-0026	New Technology and Child Health	Participants currently recruited/enrolled	18-125 Years	NHGRI	Type
16-H-0144	Impact of Elastin Mediated Vascular Stiffness on End Organs	Participants currently recruited/enrolled	3-85 Years	NHLBI	Syndrome
16-H-0074	Williams Syndrome (WS) and Supravalvular Aortic Stenosis (SVAS) DNA and Tissue Bank	Participants currently recruited/enrolled	0-85 Years	NHLBI	Syndrome
16-H-0063	Williams Syndrome Skin and Vascular Elasticity Study (WS-SAVE Study)	Completed Study; data analyses ongoing	1-70 Years	NHLBI	Syndrome
16-EI-0090	Natural History of Spinocerebellar Ataxia Type 7 (SCA7)	Participants currently recruited/enrolled	12-125 Years	NEI	Type
16-CH-0103	Evaluation of Patients with Genetic Disorders	Participants currently recruited/enrolled	0-125 Years	NICHD	Syndrome
16-C-0107	A Phase I/II Trial of EP0057, a Nanoparticle Camptothecin with Olaparib in Patients with Relapsed/Refractory Small Cell Lung, Bladder and Prostate Cancers	Participants currently recruited/enrolled	18-125 Years	NCI	Type
16-C-0092	A Pilot Study of Local Ablative Therapy for Treatment of Oligoprogressive, EGFR-mutated, Non-Small Cell Lung Cancer (NSCLC) After Treatment with Osimertinib (AZD9291, Tagrisso)	Completed Study; data analyses ongoing	18-125 Years	NCI	Type
16-C-0060	A Phase 1b/2 Study of alvelestat (MPH966), an Oral Neutrophil Elastase Inhibitor, in Bronchiolitis Obliterans Syndrome after Allogeneic Hematopoietic Stem Cell Transplantation	Participants currently recruited/enrolled	18-125 Years	NCI	Syndrome
16-C-0043	Phase II Trial of the MEK1/2 Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate in Adults with Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas	No longer recruiting/follow-up only	18-125 Years	NCI	Type
16-C-0035	Prostvac in Patients with Biochemically Recurrent Prostate Cancer	No longer recruiting/follow-up only	18-125 Years	NCI	Type
16-C-0034	A Phase II Trial of Oral Pazopanib plus Oral Topotecan Metronomic Antiangiogenic Therapy for Recurrent Glioblastoma Multiforme (A) without Prior Bevacizumab Exposure and (B) after Failing Prior Bevacizumab	Completed Study; data analyses ongoing	18-125 Years	NCI	Type
15-M-0139	Mapping the Genotype, Phenotype, and Natural History of Phelan McDermid Syndrome	Participants currently recruited/enrolled	1-125 Years	NIMH	Syndrome
15-I-0162	Natural History and Genetics of Food Allergy and Related Conditions	Participants currently recruited/enrolled	0-99 Years	NIAID	Syndrome
15-I-0135	An open-label, non-randomized, within-patient dose-finding study followed by a randomized, subject, investigator and sponsor-blinded placebo controlled study to assess the efficacy and safety of CDZ173 (leniolisib) in patients with APDS/PASLI (Activated	Completed Study; data analyses ongoing	12-75 Years	NIAID	Syndrome
15-I-0056	Collection of Plasma from Subjects that Recovered From or Were Vaccinated To Emerging Infectious Diseases	Enrolling by Invitation	18-70 Years	NIAID	Syndrome
15-DK-0174	Dynamic Post-Prandial Metabolism in Patients with Non-Alcoholic Fatty Liver Disease	Completed Study; data analyses ongoing	18-125 Years	NIDDK	Syndrome
15-D-0051	Characterization of Diseases with Salivary Gland Involvement	Participants currently recruited/enrolled	4-125 Years	NIDCR	Syndrome
15-C-0200	Molecular Analysis for Therapy Choice (MATCH) (EAY131)	Completed Study; data analyses ongoing	18-125 Years	NCI	Type
15-C-0157	Phase I/II Trial of Vandetanib in Combination with Metformin in Subjects with HLRCC or SDH-Associated Kidney Cancer or Sporadic Papillary Renal Cell Carcinoma	Completed Study; data analyses ongoing	18-125 Years	NCI	Syndrome
15-C-0142	Acceptance and Commitment Training for Adolescents and Adults with Neurofibromatosis Type 1, Plexiform Neurofibromas, and Chronic Pain: A Phase III Clinical Trial	Completed Study; data analyses ongoing	16-59 Years	NCI	Type
15-C-0138	Phase I Study of Ipilimumab, Nivolumab, and the Combination in Patients with Newly Diagnosed Glioblastoma	Completed Study; data analyses ongoing	18-125 Years	NCI	Type
15-C-0099	A Phase 1, Open-Label, Dose-Escalation Study of SNX-5422 and Everolimus in Subjects with Neuroendocrine Tumors	Completed Study; data analyses ongoing	18-100 Years	NCI	Type
15-C-0093	Phase I Trial of Turalio(R) (pexidartinib, PLX3397) in Children and Young Adults with Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN)	Participants currently recruited/enrolled	3-35 Years	NCI	Type
15-C-0076	A Pilot Study of Long Term TARP Vaccination Using A Multi-Epitope TARP Peptide Autologous Dendritic Cell Vaccination in Previously Vaccinated Men on NCI 09-C-0139	Completed Study; data analyses ongoing	18-125 Years	NCI	Type
15-C-0067	A Phase I/II Open Label, Dose Escalation Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation	Participants currently recruited/enrolled	18-125 Years	NCI	Syndrome
15-C-0029	Phase I Dose Escalation Study of Anti-CD22 Chimeric Receptor T Cells in Pediatric and Young Adults with Recurrent or Refractory CD22-expressing B Cell Malignancies	Participants currently recruited/enrolled	3-39 Years	NCI	Type
15-C-0019	The Impact of Ras/MAPK Signaling Pathway-Targeted Therapies on Neurocognitive Functioning in Individuals with NF1	Completed Study; data analyses ongoing	4-99 Years	NCI	Type
15-AR-0144	Studies of Dermatologic Diseases-Biospecimen Acquisition Protocol	Participants currently recruited/enrolled	2-125 Years	NIAMS	Type
15-AG-0123	Intermittent Calorie Restriction, Insulin Resistance, and Biomarkers of Brain Function	Completed Study; data analyses ongoing	55-70 Years	NIA	Type
14-N-0086	Deep Brain Stimulation Therapy in Movement Disorders	Participants currently recruited/enrolled	18-125 Years	NINDS	Syndrome
14-I-0206	Novel Genetic Disorders of the Immune System	Participants currently recruited/enrolled	0-99 Years	NIAID	Type
14-I-0185	A Phase III Double-Blind Randomized Crossover Study of Plerixafor Versus G-CSF in the Treatment of Patients with WHIM Syndrome.	Completed Study; data analyses ongoing	10-75 Years	NIAID	Syndrome
14-I-0146	The Pathogenesis and Genetics of Disseminated or Refractory Coccidioidomycosis	Participants currently recruited/enrolled	2-100 Years	NIAID	Type
14-I-0124	PET Imaging and Lymph Node Assessment of IRIS in Persons With AIDS	Participants currently recruited/enrolled	18-125 Years	NIAID	Syndrome
14-I-0091	Analysis of Patients Treated for Chronic Granulomatous Disease Since January 1, 1995	Completed Study; data analyses ongoing	3-125 Years	NIAID	Type
14-I-0081	A Phase 2a Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Subcutaneous Benralizumab (MEDI-563) in Reducing Eosinophilia in Subjects with Hypereosinophilic Syndrome (HES)	No longer recruiting/follow-up only	18-75 Years	NIAID	Syndrome
14-I-0063	An Open-Label, Proof-of-Concept Study to Evaluate the Safety and Efficacy of Dexpramipexole (KNS-760704) in Subjects with Hypereosinophilic Syndrome	No longer recruiting/follow-up only	18-125 Years	NIAID	Syndrome
14-I-0020	Hematopoietic Stem Cell Mobilization in Idiopathic CD4 Lymphocytopenia Patients and Healthy Controls for the Study of T Cell Maturation and Trafficking in Murine Models	Participants currently recruited/enrolled	18-65 Years	NIAID	Syndrome
14-I-0009	Characterization and Management of Patients with HIV-1 Infection Who Experience Virologic Failure Despite Combination Antiretroviral Therapy	Completed Study; data analyses ongoing	18-100 Years	NIAID	Syndrome
14-HG-0055	Study on Moebius Syndrome and Other Congenital Facial Weakness Disorders	Completed Study; data analyses ongoing	2-80 Years	NHGRI	Syndrome
14-H-0127	Characterization of the Pathogenesis of Primary and Secondary Lymphatic Disorders	Participants currently recruited/enrolled	2-90 Years	NHLBI	Type
14-DK-0060	Famine from Feast: Linking Vitamin C, Red Blood Cell Fragility, and Diabetes	Participants currently recruited/enrolled	18-65 Years	NIDDK	Type
14-CH-0028	Evaluation of 68Ga-DOTATATE PET/CT, Octreotide and F-DOPA PET Imaging in Patients with Ectopic Cushing Syndrome	Participants currently recruited/enrolled	18-80 Years	NICHD	Syndrome
14-C-0163	Transformation of Plexiform Neurofibromas to Malignant Peripheral Nerve Sheath Tumors in Neurofibromatosis Type 1: Clinical, Histopathologic, and Genomic Analysis	Completed Study; data analyses ongoing	10-125 Years	NCI	Type
14-C-0161	Phase I Trial of the Combination of Bortezomib and Clofarabine in Adults with Refractory Solid Tumors, Lymphomas, or Myelodysplastic Syndromes	Participants currently recruited/enrolled	18-125 Years	NCI	Syndrome
14-C-0157	Phase 1 Study of Ibrutinib and Immuno-Chemotherapy Using Temozolomide, Etoposide, Doxil, Dexamethasone, Ibrutinib, Rituximab (TEDDI-R) in Primary CNS Lymphoma	Participants currently recruited/enrolled	18-125 Years	NCI	Type
14-C-0156	A Phase II Single Arm Pilot Study of the Chk1/2 Inhibitor (LY2606368) In BRCA1/2 Mutation Associated Breast or Ovarian Cancer, Triple Negative Breast Cancer, and High Grade Serous Ovarian Cancer	Completed Study; data analyses ongoing	18-125 Years	NCI	Syndrome
14-C-0104	A Phase II Study Using Autologous Young Tumor-Infiltrating Lymphocytes Derived from Patients with Non-Small Cell Lung Cancer Following Non-Myeloablative Lymphocyte Depleting Preparative Regimen	Participants currently recruited/enrolled	18-70 Years	NCI	Type
14-C-0056	Collection of Blood from Patients with Ovarian, Primary Peritoneal or Fallopian Tube Cancer	Completed Study; data analyses ongoing	18-125 Years	NCI	Type
14-C-0052	A Phase I/II Study of the Treatment of Metastatic Cancer that Expresses MAGE-A3 Using Lymphodepleting Conditioning Followed by Infusion of HLA-DP0401/0402 Restricted Anti-MAGE-A3 TCR-Gene Engineered Lymphocytes and Aldesleukin	Completed Study; data analyses ongoing	18-70 Years	NCI	Type
14-C-0037	A Phase 2 Study of the MET Kinase Inhibitor INC280 in Papillary Renal Cell Cancer	Completed Study; data analyses ongoing	18-125 Years	NCI	Type
14-C-0022	A Phase II Study for Metastatic Melanoma Using High-Dose Chemotherapy Preparative Regimen Followed by Cell Transfer Therapy Using Tumor-Infiltrating Lymphocytes Plus IL-2 with the Administration of Pembrolizumab in the Retreatment Arm	Completed Study; data analyses ongoing	18-70 Years	NCI	Type
13-N-0135	Pilot Study of Raltegravir, an Integrase Inhibitor, in Human T-Cell Lymphotrophic Virus-1(HTLV-1) Associated Myelopathy, Tropical Spastic Paraparesis (HAM/TSP)	Completed Study; data analyses ongoing	18-125 Years	NINDS	Type
13-N-0085	Clinical Manifestations and Biorepository for Focal Dystonia	Completed Study; data analyses ongoing	18-125 Years	NINDS	Type
13-N-0017	Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)	Participants currently recruited/enrolled	2-125 Years	NINDS	Syndrome
13-I-0177	Natural History Study of the Complications Associated with Allogeneic Hematopoietic Stem Cell Transplantations	Completed Study; data analyses ongoing	2-125 Years	NIAID	Type
13-I-0172	Phase I Study of the Safety of a Replication-Defective Herpes Simplex Virus-2 Vaccine, HSV529, in Adults Aged 18 to 40 Years With or Without HSV Infection	Completed Study; data analyses ongoing	18-40 Years	NIAID	Type
13-I-0082	Rituximab (Anti-CD20) for the Treatment of Subjects With Anticytokine Autoantibody-Associated Diseases	Completed Study; data analyses ongoing	18-125 Years	NIAID	Type
13-HG-0199	NIH Participation to USIDNET Registry	Participants currently recruited/enrolled	0-125 Years	NHGRI	Syndrome
13-H-0133	Extended Dosing with Eltrombopag in Refractory Severe Aplastic Anemia	Completed Study; data analyses ongoing	2-125 Years	NHLBI	Type
13-H-0116	A Multicenter Safety Study of Unlicensed, Investigational Cryopreserved Cord Blood Units (CBUs) Manufactured by the National Cord Blood Program (NCBP) and Provided for Unrelated Hematopoietic Stem Cell Transplantation of Pediatric and Adult Patients	Participants currently recruited/enrolled	4-125 Years	NHLBI	Syndrome
13-H-0051	Bronchodilator Effects of Nebulized versus Inhaled Albuterol in Subjects with Lymphangioleiomyomatosis	Participants currently recruited/enrolled	18-125 Years	NHLBI	Type
13-DK-0200	The Mechanism of Human Non-Shivering Thermogenesis and Basal Metabolic Rate	Participants currently recruited/enrolled	18-35 Years	NIDDK	Type
13-D-0014	Bacterial Arrangement in Supragingival Biofilms	Completed Study; data analyses ongoing	18-999 Years	NIDCR	Type
13-CH-0001	Intrathecal 2-Hydroxypropyl-B-Cyclodextrin in Patients with Niemann-Pick Disease, Type C1	Completed Study; data analyses ongoing	2-125 Years	NICHD	Type
13-CC-0210	Evaluating an Extension Assist Knee Ankle Foot Orthosis to Improve Gait in Children with Movement Disorders	Participants currently recruited/enrolled	5-125 Years	CC	Type
13-CC-0099	Vasti Control of Patellofemoral Kinematics in Patients with Chronic Patellofemoral Pain.	Participants currently recruited/enrolled	18-55 Years	CC	Syndrome
13-C-0175	A Phase II Protocol for Subjects with Stage T1 Bladder Cancer to Evaluate Selective Bladder Preserving Treatment by Radiation Therapy Concurrent with Radio-sensitizing Chemotherapy following a Thorough Transurethral Surgical Re-Staging	Completed Study; data analyses ongoing	18-125 Years	NCI	Type
13-C-0105	Molecular Profiling-based Assignment of Cancer Therapy for Patients With Advanced Solid Tumors	Completed Study; data analyses ongoing	18-120 Years	NCI	Type
13-C-0044	A Phase 2 Study of Cabozantinib (XL184), a Dual Inhibitor of MET and VEGFR, in Patients With Metastatic Refractory Soft Tissue Sarcoma	No longer recruiting/follow-up only	18-120 Years	NCI	Type
13-C-0016	A Phase I Study of an Adenoviral Transduced Autologous Dendritic Cell Vaccine Expressing Human HER2/neu ECTM in Adults with Tumors with 1-3+ HER2/neu Expression	Completed Study; data analyses ongoing	18-125 Years	NCI	Type
13-C-0006	Phase I/II Trial Evaluating the Safety and Efficacy of Ruxolitinib in Patients with Smoldering and Chronic Adult T-cell Leukemia (ATL)	Completed Study; data analyses ongoing	18-125 Years	NCI	Type
13-AR-0056	Stopping Tumor Necrosis Factor-Alpha Inhibitors in Rheumatoid Arthritis	Completed Study; data analyses ongoing	18-125 Years	NIAMS	Type
12-M-0128	TMS Investigations of the Human Visual System	Participants currently recruited/enrolled	18-50 Years	NIMH	Type
12-I-0103	Characterization of Innate Immune Responses to AS03 Adjuvanted H5N1 Vaccine Compared to Non-adjuvanted H5N1 Vaccine	Completed Study; data analyses ongoing	21-45 Years	NIAID	Type
12-HG-0181	The Clinical Study of Patients with Sex Chromosome Variants	Completed Study; data analyses ongoing	18-125 Years	NHGRI	Syndrome
12-HG-0022	Inherited Diseases, Caregiving, and Social Networks	Completed Study; data analyses ongoing	18-125 Years	NHGRI	Type
12-H-0064	A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients with Hematologic Malignancies and Other Indications	Participants currently recruited/enrolled	4-75 Years	NHLBI	Syndrome
12-H-0035	A Phase II study of Ibrutinib for Patients with Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) Who Need Therapy and are Older than 65 or have a 17p Deletion	No longer recruiting/follow-up only	18-125 Years	NHLBI	Type
12-E-0190	The Role of Functionally Relevant Cyclooxygenase-2 (COX-2) Gene Single Nucleotide Polymorphisms - 765G>C and 8473T>C in Lymphocyte Differentiation	Completed Study; data analyses ongoing	18-150 Years	NIEHS	Type
12-E-0050	The Role of Gonadotropin Pulsations in the Regulation of Puberty and Fertility	Participants currently recruited/enrolled	14-125 Years	NIEHS	Syndrome
12-E-0049	The Molecular Basis of Inherited Reproductive Disorders	Participants currently recruited/enrolled	0-125 Years	NIEHS	Syndrome
12-DC-0152	Normative Values in Audiovestibular Testing	Participants currently recruited/enrolled	5-80 Years	NIDCD	Type
12-C-0206	Understanding the Perceived Influence of Childhood Cancer and NF1 on the Parents' Marital/Partner Relationship: A Descriptive Study	Completed Study; data analyses ongoing	18-125 Years	NCI	Type
12-C-0193	Lymphoid Malignancies and Precursors: Tissue Acquisition Protocol	Participants currently recruited/enrolled	18-125 Years	NCI	Type
12-C-0118	A Phase II Study of Sunitinib in Patients with Advanced Relapsed or Refractory Thymoma or Thymic Carcinoma with at Least One Prior Line of Platinum-Based Systemic Chemotherapy	No longer recruiting/follow-up only	18-100 Years	NCI	Type
12-C-0112	Phase I Study of T Cells Expressing an Anti-CD19 Chimeric Receptor in Children and Young Adults with B Cell Malignancies	Completed Study; data analyses ongoing	1-30 Years	NCI	Type
12-C-0079	A Phase II Multicenter Study of AMG 386 and Abiraterone in Metastatic Castration Resistant Prostate Cancer	Completed Study; data analyses ongoing	18-125 Years	NCI	Type
12-AR-8001	Compassionate Use Treatment Protocol I4V-MC-JAGA; Treatment of Autoinflammatory Syndromes Expected to Benefit from JAK Inhibition	Completed Study; data analyses ongoing	1-125 Years	NIAMS	Syndrome
12-AR-0159	Effects of Treatments on the Microbiome in Healthy Volunteers and Patients with Atopic Dermatitis	Participants currently recruited/enrolled	2-50 Years	NIAMS	Type
11-N-0084	Evaluation and Diagnosis of Potential Research Subjects with Traumatic Brain Injury (TBI)	Completed Study; data analyses ongoing	18-125 Years	NINDS	Syndrome
11-I-0057	Effect of Interferon Alpha 2b Intensification on HIV-1 Residual Viremia in Individuals Suppressed on Antiretroviral Therapy	Completed Study; data analyses ongoing	18-65 Years	NIAID	Type
11-I-0007	Lentiviral Gene Transfer for Treatment of Children Older Than 2 Years of Age with X-Linked Severe Combined Immunodeficiency	Clinical hold/Recruitment or enrollment suspended	2-40 Years	NIAID	Type
11-HG-0110	Genetics of Obesity, Diabetes, and Heart Disease in African Diaspora Populations	Enrolling by Invitation	18-125 Years	NHGRI	Type
11-H-0046	Cross-Sectional Characterization of Idiopathic Bronchiectasis	Completed Study; data analyses ongoing	18-125 Years	NHLBI	Type
11-D-0172	The Pathogenesis and Natural History of Sjogren's Syndrome	Participants currently recruited/enrolled	16-125 Years	NIDCR	Syndrome
11-CC-0152	The Natural History of Liver Disease in a Cohort of Participants with Hepatitis B and/or Hepatitis C with or without HIV Infection	Completed Study; data analyses ongoing	18-99 Years	CC	Syndrome
11-CC-0120	Stereophotogrammetry of the Torso in Healthy Individuals and Patients with Scoliosis, Chest Wall Deformations, or Obesity	Completed Study; data analyses ongoing	2-125 Years	CC	Type
11-C-0242	Collection of Blood from Patients with Cancer, Other Tumors, or Tumor Predisposition Syndromes for Analysis of Genetic Differences in Drug Disposition	Participants currently recruited/enrolled	3-125 Years	NCI	Syndrome
11-C-0220	Natural History Study of the KSHV Inflammatory Cytokine Syndrome (KICS) Incorporating Pilot Evaluation of KSHV Targeted Therapies	Participants currently recruited/enrolled	18-125 Years	NCI	Syndrome
11-C-0190	Collection of Tissue Blocks or Slides from Patients with Cancer	Participants currently recruited/enrolled	18-125 Years	NCI	Type
11-C-0161	A Phase I/II Study of the Mitogen Activated Protein Kinase Kinase (MEK) 1 Inhibitor Selumetinib (AZD6244; Hydrogen Sulfate in Children with Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas (PN)	No longer recruiting/follow-up only	2-18 Years	NCI	Type
11-C-0140	A Phase I Study of Gemcitabine, Carboplatin and Lenalidomide (GCL) for Treatment of Patients with Advanced/Metastatic Urothelial Carcinoma (UC) and Other Solid Tumors	Completed Study; data analyses ongoing	18-125 Years	NCI	Type
11-C-0136	Multi-Institutional Prospective Pilot Study of Lupron to Enhance Lymphocyte Immune Reconstitution Following Allogeneic Bone Marrow Transplantation in Post-Pubertal Children and Adults with Molecular Imaging Evaluation	Completed Study; data analyses ongoing	2-55 Years	NCI	Syndrome
11-C-0132	Understanding the Psychosocial Needs of Parents Who Have Lost a Child to Cancer	Completed Study; data analyses ongoing	18-99 Years	NCI	Type
11-C-0061	Phase I Trial of Z-Endoxifen in Adults with Refractory Hormone Receptor-Positive Breast Cancer, Desmoid Tumors, Gynecologic Tumors, or other Hormone Receptor-Positive Solid Tumors	No longer recruiting/follow-up only	18-125 Years	NCI	Type
10-N-0122	Evaluation, Pathogenesis, and Outcome of Subjects with or Suspected Traumatic Brain Injury	Completed Study; data analyses ongoing	18-125 Years	NINDS	Type
10-N-0009	Physiological Investigations of Movement Disorders	Completed Study; data analyses ongoing	18-125 Years	NINDS	Syndrome
10-M-0112	Defining the Brain Phenotype of Children with Williams Syndrome	Participants currently recruited/enrolled	5-125 Years	NIMH	Syndrome
10-M-0047	Top-Down Attentional Control of Visual-Processing	Participants currently recruited/enrolled	18-125 Years	NIMH	Type
10-I-0216	Studies of Disorders with Increased Susceptibility to Fungal Infections	Participants currently recruited/enrolled	0-125 Years	NIAID	Type
10-I-0197	Admission and Management of Occupational or Other Exposures to Biodefense/Bioterrorism Agents or to Epidemic/Emerging Infectious Diseases	Participants currently recruited/enrolled	2-99 Years	NIAID	Syndrome
10-H-0154	Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused with a Reduced Dose of Non-Mobilized Donor T-Cells	Participants currently recruited/enrolled	4-80 Years	NHLBI	Syndrome
10-H-0141	A Phase II Study of Ofatumumab-Based Induction Chemoimmunotherapy Followed by Consolidation Ofatumumab Immunotherapy in Previously Untreated Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma.	No longer recruiting/follow-up only	18-99 Years	NHLBI	Type
10-H-0126	Cardiovascular Disease Discovery Protocol	Participants currently recruited/enrolled	1-100 Years	NHLBI	Syndrome
10-H-0083	A Phase I Trial of Safety and Immunogenicity of Gardasil Vaccination Post Stem Cell Transplantation in Patients with and without Immunosuppression	Completed Study; data analyses ongoing	18-50 Years	NHLBI	Type
10-DK-N091	Molecular and Clinical Profile of Diabetes Mellitus and its Complications	Participants currently recruited/enrolled	18-125 Years	NIDDK	Type
10-DK-0102	Clinical and Genetic Studies in Familial Non-Medullary Thyroid Cancer	Participants currently recruited/enrolled	7-125 Years	NIDDK	Type
10-CC-0118	Long Term Clinical Correlates of TBI: Imaging, Biomarkers, and Clinical Phenotyping Parameters	Participants currently recruited/enrolled	18-125 Years	CC	Type
10-C-0174	Related and Unrelated Donor Hematopoietic Stem Cell Transplant for DOCK8 Deficiency	Participants currently recruited/enrolled	4-125 Years	NCI	Type
10-C-0166	A Phase II Study Using Short-Term Cultured, Autologous Tumor-Infiltrating Lymphocytes Following a Lymphodepleting Regimen in Metastatic Cancers Plus the Administration of Pembrolizumab	Participants currently recruited/enrolled	18-72 Years	NCI	Type
10-C-0114	A Phase II Study of Bevacizumab and Erlotinib in Subjects with Advanced Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) or Sporadic Papillary Renal Cell Cancer	Completed Study; data analyses ongoing	18-125 Years	NCI	Type
10-C-0086	Comprehensive Omics Analysis of Pediatric Solid Tumors and Establishment of a Repository for Related Biological Studies	Participants currently recruited/enrolled	0-125 Years	NCI	Type
10-C-0056	A Phase I Study of Indenoisoquinolines LMP400 and LMP776 in Adults With Relapsed Solid Tumors and Lymphomas	Completed Study; data analyses ongoing	18-125 Years	NCI	Type
09-N-0010	Biomarkers of Risk of Parkinson Disease	Completed Study; data analyses ongoing	18-70 Years	NINDS	Type
09-M-0176	Functional Relevance of Dopamine Receptors in Healthy Controls and Patients with Schizophrenia: Characterization through [11C]NNC-112 and [18F]Fallypride Positron Emission Tomography	Participants currently recruited/enrolled	18-90 Years	NIMH	Type
09-I-0232	FLU 003 Plus: An International Observational Study to Characterize Adults Who Are Hospitalized with Influenza or Other Targeted Respiratory Viruses	Participants currently recruited/enrolled	18-125 Years	NIAID	Type
09-I-0200	A Phase I Study of MozobilTM in the Treatment of Patients with WHIMS	Participants currently recruited/enrolled	18-75 Years	NIAID	Syndrome
09-I-0184	Studies in the Pathogenesis of Systemic Capillary Leak Syndrome	Participants currently recruited/enrolled	0-125 Years	NIAID	Syndrome
09-I-0126	Pathogenesis and Genetic Basis of Physical Induced Urticarial Syndromes	Participants currently recruited/enrolled	2-90 Years	NIAID	Syndrome
09-H-0199	A Pilot Study of a Thrombopoietin-Receptor Agonist (TPO-R agonist), Eltrombopag, in Patients with Low to Int-2 Risk Myelodysplastic Syndrome (MDS)	Completed Study; data analyses ongoing	18-125 Years	NHLBI	Syndrome
09-DK-0223	Rituximab Plus Cyclosporine in Idiopathic Membranous Nephropathy	Participants currently recruited/enrolled	18-125 Years	NIDDK	Syndrome
09-DK-0097	Vitamin E Pharmacokinetics and Biomarkers in Normal and Obese Women	Completed Study; data analyses ongoing	18-55 Years	NIDDK	Type
09-CC-0217	Vasti Control of Patellofemoral Kinematics in Asymptomatic Volunteers	Completed Study; data analyses ongoing	18-55 Years	CC	Syndrome
09-C-0192	Phase II Study of Cediranib (AZD2171) in Patients With Alveolar Soft Part Sarcoma	No longer recruiting/follow-up only	0-125 Years	NCI	Type
09-C-0100	A Pilot Study of High Dose Rate Brachytherapy in The Radiation Oncology Branch	Participants currently recruited/enrolled	18-125 Years	NCI	Type
09-C-0025	Phase II Trial of LMB-2, Fludarabine and Cyclophosphamide for Adult T-Cell Leukemia	No longer recruiting/follow-up only	18-125 Years	NCI	Type
09-C-0024	A Phase I Study of Quadrivalent Human Papilloma Virus (HPV) (Types 6, 11, 16, 18) Recombinant Vaccine in HIV-Infected and HIV-Negative Pre-Adolescents, Adolescents and Young Adults	Completed Study; data analyses ongoing	12-26 Years	NCI	Type
09-C-0019	A Phase I Study of Dasatinib in Combination with Bevacizumab in Advanced Solid Tumors	Completed Study; data analyses ongoing	18-125 Years	NCI	Type
08-N-0044	A Prospective Natural History Study of Patients with Neurofibromatosis Type 2 (NF2).	Participants currently recruited/enrolled	8-75 Years	NINDS	Type
08-HG-0059	Studies of Skin Microflora in Healthy Individuals and Atopic Dermatitis Patients	Participants currently recruited/enrolled	2-125 Years	NHGRI	Syndrome
08-DK-0138	A New Method for Determining Gastric Acid Output Using a Wireless Capsule	Completed Study; data analyses ongoing	18-125 Years	NIDDK	Syndrome
08-C-0130	A Phase II Trial of Peginterferon alfa-2b (PEG-Intron) for Neurofibromatosis Type 1 Related Unresectable, Symptomatic or Life-Threatening Plexiform Neurofibromas	Completed Study; data analyses ongoing	0-21 Years	NCI	Type
08-C-0079	Natural History Study and Longitudinal Assessment of Children, Adolescents, and Adults with Neurofibromatosis Type 1	No longer recruiting/follow-up only	0-125 Years	NCI	Type
07-N-0122	Modulation of Motor Function by Stimulation of the Central and Peripheral Nervous System	Completed Study; data analyses ongoing	18-125 Years	NINDS	Type
07-DK-0115	Natural History of Type 2 Diabetes Mellitus in Children and Young Adults	Completed Study; data analyses ongoing	8-25 Years	NIDDK	Type
07-DK-0077	Study of the Phenotype of Overweight and Obese Adults	Participants currently recruited/enrolled	18-100 Years	NIDDK	Type
07-D-0016	Effects of PTH Replacement on Bone in Hypoparathyroidism	Completed Study; data analyses ongoing	18-70 Years	NIDCR	Syndrome
07-CH-0008	Prospective, Open-Label, Multicenter, International Study of Mifepristone for Symptomatic Treatment of Cushing's Syndrome Caused by Ectopic Adrenal Corticotrophin Hormone (ACTH) Secretion	Completed Study; data analyses ongoing	18-85 Years	NICHD	Syndrome
07-C-0195	Phase II Trial of Targeted Immune-Depleting Chemotherapy and Reduced-Intensity Allogeneic Hematopoietic Stem Cell Transplantation Using 8/8 and 7/8 HLA-matched Unrelated Donors and Utilizing Two Graft-versus-Host Disease Prophylaxis Regimens for the Trea	Completed Study; data analyses ongoing	18-74 Years	NCI	Syndrome
07-C-0121	Phase 2 Study of the C-Met RTK Inhibitor Foretinib (Formerly GSK 1363089) in Subjects with Papillary Renal Cell Carcinoma (PRC)	Completed Study; data analyses ongoing	18-125 Years	NCI	Type
07-C-0110	Analysis of Stored Data Collected from Individuals Administered Neurobehavioral Assessments on IRB-Approved Protocols	Enrolling by Invitation	0-125 Years	NCI	Type
06-M-0214	PET Measurement of Regional Rates of Cerebral Protein Synthesis in Subjects with Fragile X Syndrome	Completed Study; data analyses ongoing	18-24 Years	NIMH	Syndrome
06-CH-0186	Evaluation of Biochemical Markers and Clinical Investigation of Niemann-Pick Disease, Type C	Participants currently recruited/enrolled	0-125 Years	NICHD	Type
06-CH-0011	Natural History Study of Patients with Excess Androgen	Participants currently recruited/enrolled	0-99 Years	NICHD	Type
06-C-0213	Tissue Procurement Protocol for the Developmental Therapeutics Clinic, National Cancer Institute (NCI)	Participants currently recruited/enrolled	0-125 Years	NCI	Syndrome
06-C-0134	Natural History and Biology of Dermal Neurofibromas in Neurofibromatosis Type 1	Completed Study; data analyses ongoing	20-99 Years	NCI	Type
06-AR-0198	A Pilot Pediatric/Adult Study of Gene Expression Profiling and Clinical Characterization of Phototoxicity	Completed Study; data analyses ongoing	8-100 Years	NIAMS	Type
05-H-0242	A Pilot Study of Alemtuzumab (Campath) in Patients with Relapsed or Refractory Severe Aplastic Anemia	Completed Study; data analyses ongoing	2-110 Years	NHLBI	Type
05-CC-0216	Prospective Assessment of Functional Status, Psychosocial Adjustment, Health Related Quality of Life and the Symptom Experience in Patients Treated with Allogeneic Hematopoietic Stem Cell Transplantation	Completed Study; data analyses ongoing	18-125 Years	CC	Type
04-HG-0211	Analysis of Specimens from Individuals with Pulmonary Fibrosis	Participants currently recruited/enrolled	18-125 Years	NHGRI	Syndrome
04-H-0161	Studies of the Natural History of Sickle Cell Disease	Participants currently recruited/enrolled	2-125 Years	NHLBI	Syndrome
04-DK-0021	Urinary Vitamin C Loss in Subjects with and without Diabetes	Participants currently recruited/enrolled	18-65 Years	NIDDK	Type
04-CC-0119	Biomarkers and Protein Mass Expression Profiles in Bronchoalveolar Lavage from Patients with Lung Infiltrates	Participants currently recruited/enrolled	3-99 Years	CC	Type
04-C-0274	Follow-Up Study of Subjects Previously Enrolled in Immunotherapy Studies Utilizing Gene Transfer or Other Immunotherapeutic Agents	Participants currently recruited/enrolled	18-125 Years	NCI	Type
04-C-0238	A Phase 2 Study of 17-Allylamino-17-Demethoxygeldanamycin in Patients with Von Hippel Lindau Disease and Renal Tumors	Completed Study; data analyses ongoing	18-125 Years	NCI	Syndrome
04-C-0232	A Multi-Institutional Study of Proteomic Evaluation of Epithelial Ovarian Cancer, Primary Peritoneal Cancer, and Fallopian Tube Cancer Patients in First Clinical Remission: Development of a Protein Fingerprint Profile of Relapse	Completed Study; data analyses ongoing	18-125 Years	NCI	Type
04-C-0200	Urinary and Serum VEGF and MMP Levels in Patients Receiving Radiation Therapy for Glioblastoma Multiforme: Prospective Determination of a Predictive Value for Recurrence	Participants currently recruited/enrolled	18-125 Years	NCI	Type
03-M-0211	Family Study of Affective and Anxiety Spectrum Disorders	Participants currently recruited/enrolled	7-120 Years	NIMH	Syndrome
03-I-0263	VRC 200: A Multicenter Specimen Collection Protocol to Obtain Human Biological Samples for Research Studies	Participants currently recruited/enrolled	18-125 Years	NIAID	Type
03-H-0280	Disease Pathogenesis and Natural History of Lipid Disorders	Participants currently recruited/enrolled	2-100 Years	NHLBI	Type
03-H-0170	Nonmyeloablative Allogeneic Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation For Severe Congenital Anemias Including Sickle Cell Disease (SCD) and Beta-Thalassemia	Participants currently recruited/enrolled	2-125 Years	NHLBI	Type
03-E-0099	Pathogenic Studies In Families With Twins Or Siblings Discordant For Systemic Rheumatic Disorders	Completed Study; data analyses ongoing	2-125 Years	NIEHS	Type
03-DK-0257	Phase II Trial of Effect of Metreleptin Therapy in Severe Insulin Resistance	No longer recruiting/follow-up only	5-125 Years	NIDDK	Type
03-DK-0256	Inhibition of Intestinal Glucose Absorption by the Bioflavonoid Quercetin in the Obese and in Obese Type 2 Diabetics	Completed Study; data analyses ongoing	18-65 Years	NIDDK	Type
03-CC-0060	Virtual Function Anatomy (VFA)	Participants currently recruited/enrolled	5-95 Years	CC	Syndrome
03-C-0278	A Comparative Study of Pediatric CNS Tumor Activity as Assessed by 18F-FDG PET Imaging and Proton Magnetic Resonance Spectroscopic Imaging (1H-MRSI)	Completed Study; data analyses ongoing	1-21 Years	NCI	Type
03-C-0066	Hereditary Leiomyomatosis Renal Cell Cancer (HLRCC): Identification of the Disease Gene, and Characterization of the Predisposition to Renal Cancer	Participants currently recruited/enrolled	2-125 Years	NCI	Type
03-AR-0173	Studies of Natural History, Pathogenesis, and Outcomes in Autoimmune and Inflammatory Diseases Including Juvenile Dermatomyositis	Participants currently recruited/enrolled	2-125 Years	NIAMS	Syndrome
02-I-0286	Efficacy of Tyrosine Kinase Inhibition in Reducing Eosinophilia in Patients with Myeloid and/or Steroid-Refractory Hypereosinophilic Syndrome	Participants currently recruited/enrolled	2-125 Years	NIAID	Syndrome
02-I-0086	Evaluation of Viral Factors and Immune Parameters to Study HIV-Specific Immunity	Participants currently recruited/enrolled	18-125 Years	NIAID	Type
02-H-0250	A Phase I/II Study of HLA-matched Mobilized Peripheral Blood Hematopoietic Stem Cell Transplantation for Advanced Mycosis Fungoides/Sezary Syndrome Using Nonmyeloablative Conditioning with Campath-1H	Completed Study; data analyses ongoing	18-125 Years	NHLBI	Syndrome
02-DK-N304	Diabetes Prevention Program Outcomes Study (DPPOS)	No longer recruiting/follow-up only	25-125 Years	NIDDK	Type
02-CH-0311	Investigations into Inborn Errors of Cholesterol Synthesis and Related Disorders	Participants currently recruited/enrolled	0-125 Years	NICHD	Syndrome
02-C-0212	Clinical, Genetic, Behavioral, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Breast/Ovarian Cancer	Completed Study; data analyses ongoing	18-100 Years	NCI	Syndrome
01-M-0185	Effects of Arousal and Stress on Classical Conditioning	Completed Study; data analyses ongoing	18-50 Years	NIMH	Type
01-I-0238	Host Response to Infection and Treatment in Leishmania Infection of Humans	Participants currently recruited/enrolled	3-100 Years	NIAID	Type
01-I-0202	Natural History, Genetics, Phenotype, and Treatment of Mycobacterial Infections	Participants currently recruited/enrolled	0-100 Years	NIAID	Syndrome
01-H-0122	Collection and Storage of Umbilical Cord Hematopoietic Stem Cells for Sickle Cell Disease Therapy	Participants currently recruited/enrolled	18-45 Years	NHLBI	Type
01-DK-N117	Family Investigation of Nephropathy and Diabetes (F.I.N.D.)	Clinical hold/Recruitment or enrollment suspended	18-125 Years	NIDDK	Type
01-DC-0228	Clinical and Molecular Analysis of Enlarged Vestibular Aqueducts	Completed Study; data analyses ongoing	0-99 Years	NIDCD	Syndrome
00-N-0089	Genetic Analysis of the Chiari I Malformation	Completed Study; data analyses ongoing	1-125 Years	NINDS	Type
00-I-0159	Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES)	Participants currently recruited/enrolled	0-125 Years	NIAID	Syndrome
00-HG-0209	Molecular and Clinical Studies of Primary Immunodeficiency Diseases	No longer recruiting/follow-up only	3-125 Years	NHGRI	Syndrome
00-HG-0153	Investigations into Chediak-Higashi Syndrome and Related Disorders	Participants currently recruited/enrolled	0-70 Years	NHGRI	Syndrome
00-HG-0141	Clinical, Biochemical, and Molecular Investigations into Alkaptonuria	Participants currently recruited/enrolled	2-125 Years	NHGRI	Type
00-H-0051	Cutaneous Tumorigenesis in Patients with Tuberous Sclerosis	Participants currently recruited/enrolled	18-90 Years	NHLBI	Syndrome
00-CH-0136	A Trial of Pamidronate in Children with Osteogenesis Imperfecta	Completed Study; data analyses ongoing	2-17 Years	NICHD	Type
99-H-0050	Non-Myeloablative Allogeneic Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Hematologic Malignancies in High Risk Patients and in Patients with Debilitating Hematologic Diseases	Completed Study; data analyses ongoing	2-80 Years	NHLBI	Syndrome
99-C-0099	Examination of Clinical and Laboratory Abnormalities in Patients with Defective DNA Repair: Xeroderma Pigmentosum, Cockayne Syndrome, or Trichothiodystrophy	Participants currently recruited/enrolled	0-125 Years	NCI	Syndrome
98-N-0047	Immuno-Virological Evaluation of Human T Cell Leukemia Virus Type-1 Associated Myelopathy (HAM/TSP)	Participants currently recruited/enrolled	18-125 Years	NINDS	Type
98-D-0145	Screening and Natural History of Patients with Polyostotic Fibrous Dysplasia and the McCune-Albright Syndrome	Participants currently recruited/enrolled	0-100 Years	NIDCR	Syndrome
98-CH-0081	Clinical and Basic Investigations into Smith-Lemli-Opitz Syndrome	Completed Study; data analyses ongoing	0-125 Years	NICHD	Syndrome
97-HG-0192	Genetic Studies in the Amish and Mennonites	Completed Study; data analyses ongoing	18-125 Years	NHGRI	Syndrome
97-CH-0064	Evaluation and Intervention for Ambulation, Growth, and Basilar Invagination in Osteogenesis Imperfecta	Completed Study; data analyses ongoing	0-10 Years	NICHD	Type
97-C-0147	Collection of Serum and Tissue Samples from Patients with Biopsy-Proved or Suspected Malignant Diseases	Participants currently recruited/enrolled	2-125 Years	NCI	Syndrome
96-I-0052	A Comprehensive Clinical, Microbiological and Immunological Assessment of Patients with Suspected Post Treatment Lyme Disease Syndrome and Selected Control Populations	Participants currently recruited/enrolled	13-125 Years	NIAID	Syndrome
95-I-0066	Genetic Analysis of Immune Disorders	Participants currently recruited/enrolled	0-125 Years	NIAID	Type
95-HG-0193	Clinical and Basic Investigations into Hermansky-Pudlak Syndrome	Participants currently recruited/enrolled	0-125 Years	NHGRI	Syndrome
95-CH-0059	Definition of the Genotype and Clinical Phenotype of Primary Pigmented Nodular Adrenocortical Disease (PPNAD), Carney Complex, Peutz-Jeghers Syndrome and Related Conditions	Completed Study; data analyses ongoing	3-70 Years	NICHD	Syndrome
94-I-0079	Eosinophil Activation and Function in Parasitic Infections and Other Conditions with Increased Tissue or Peripheral Blood Eosinophilia in Humans	Participants currently recruited/enrolled	1-100 Years	NIAID	Type
94-HG-0132	The Phenotype and Etiology of Proteus Syndrome	Participants currently recruited/enrolled	0-125 Years	NHGRI	Syndrome
94-HG-0105	An Exploratory Study of the Genetics, Pathophysiology, and Natural History of Autoinflammatory Diseases	Participants currently recruited/enrolled	0-125 Years	NHGRI	Syndrome
93-I-0086	Evaluation and Long-Term Follow-Up of Patients with Acute or Chronic Inflammatory Disorders	Enrolling by Invitation	2-125 Years	NIAID	Syndrome
93-I-0063	Study of the Immunopathogenesis, Natural History, and Genetics of Autoimmune Lymphoproliferative Syndrome (ALPS) Associated with an Expansion of CD4-8-/TCR alpha/beta+ T Cells	Participants currently recruited/enrolled	0-99 Years	NIAID	Syndrome
92-DK-0156	Studies of Immunologically-Mediated Kidney Diseases	Participants currently recruited/enrolled	10-125 Years	NIDDK	Syndrome
92-CH-0034	Studies of Growth Deficiency and Growth Hormone Treatment in Children with Osteogenesis Imperfecta Types III and IV	Completed Study; data analyses ongoing	3-16 Years	NICHD	Type
91-I-0140	Studies of the Pathogenesis of HIV Infection in Human Peripheral Blood Cells and/or Body Fluids in HIV-Infected and HIV-Uninfected Volunteers	Participants currently recruited/enrolled	18-125 Years	NIAID	Type
90-M-0088	The Treatment of Menstrually-Related Mood Disorders with the Gonadotropin Releasing Hormone (GnRH) Agonist, Depot Leuprolide Acetate (Lupron)	Completed Study; data analyses ongoing	18-45 Years	NIMH	Syndrome
90-DK-0137	Evaluation of the Gastrinoma in Patients with Zollinger-Ellison Syndrome	Completed Study; data analyses ongoing	18-100 Years	NIDDK	Syndrome
89-M-0006	Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Volunteers	Participants currently recruited/enrolled	3-125 Years	NIMH	Syndrome
89-I-0158	Studies of Immune Regulation in Patients with Common Variable Immunodeficiency and Related Humoral Immunodeficiency Syndromes	Participants currently recruited/enrolled	2-125 Years	NIAID	Syndrome
88-I-0083	Host Response to Infection and Treatment in the Filarial Diseases of Humans	Participants currently recruited/enrolled	3-100 Years	NIAID	Type
88-CH-0032	Specificity of Mother-Infant Interaction: The Influence of Maternal Age, Employment Status, and Parenthood Status	Completed Study; data analyses ongoing	0-23 Years	NICHD	Type
82-I-0183	A Natural History Study of the Immune Regulation of Idiopathic Inflammatory Bowel Diseases: Crohn's Disease, Ulcerative Colitis, and Other Inflammatory Conditions of the Gut	Participants currently recruited/enrolled	0-75 Years	NIAID	Type
81-M-0126	The Evaluation of Women with Menstrually Regulated Mood and Behavioral Disorders	Participants currently recruited/enrolled	18-50 Years	NIMH	Syndrome
81-I-0164	Procedures to Obtain Plasma, Lymphocytes, or Other Specimens for Research Studies	Participants currently recruited/enrolled	18-125 Years	NIAID	Type
79-H-0100	Teaching Protocol for the Evaluation of Plasma Lipoproteins	No longer recruiting/follow-up only	2-99 Years	NHLBI	Type
78-C-0039	Clinical, Laboratory, and Epidemiologic Characterization of Individuals and Families at High Risk of Cancer	No longer recruiting/follow-up only	0-125 Years	NCI	Type
76-DK-0006	Natural History of Disorders of Insulin Resistance	Participants currently recruited/enrolled	0-125 Years	NIDDK	Type