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Protocol Number Title Protocol Status Min-Max Age Institute Keywords
20-C-0013Phase I/II Trial of PLX038 (PEGylated SN38) and Rucaparib in Solid Tumors and Small Cell CancersNo longer recruiting/follow-up only18-125 YearsNCI Lung Combined Type Carcinoma
16-C-0107A Phase I/II Trial of EP0057, a Nanoparticle Camptothecin with Olaparib in Patients with Relapsed/Refractory Small Cell Lung, Bladder and Prostate CancersParticipants currently recruited/enrolled18-125 YearsNCI Lung Combined Type Carcinoma
11-C-0140A Phase I Study of Gemcitabine, Carboplatin and Lenalidomide (GCL) for Treatment of Patients with Advanced/Metastatic Urothelial Carcinoma (UC) and Other Solid TumorsCompleted Study; data analyses ongoing18-125 YearsNCI Lung Combined Type Carcinoma
001004-CA Phase 1b/2 Basket Study of ACR-368 as Monotherapy and in Combination with Gemcitabine in Adult Subjects with Platinum-Resistant Ovarian Carcinoma, Endometrial Adenocarcinoma, and Urothelial Carcinoma Based on Acrivon Oncosignature (R) StatusParticipants currently recruited/enrolled18-120 YearsNCI Combined Type Carcinoma
000782-CA Dose-Escalation and Expansion Study of the Safety and Pharmacokinetics of XL092 as Single-Agent and Combination Therapy in Subjects with Inoperable Locally Advanced or Metastatic Solid TumorsRecruitment has not started18-125 YearsNCI Combined Type Carcinoma
000520-CPhase I/II Evaluation of a Cancer Lysate Vaccine and Montanide(R) ISA-51 VG with or without the IL-15 Super-Agonist N-803 as Adjuvant Therapy for PD-L1 Negative Non-Small Cell Lung CancerRecruitment has not started18-125 YearsNCI Lung Combined Carcinoma
000462-CPhase 2, Open-label, Single-arm, Window of Opportunity Study of ASP-1929 Photoimmunotherapy with Fluorescence Imaging in Patients With Operable Primary or Recurrent Head and Neck or Cutaneous Squamous Cell CarcinomaParticipants currently recruited/enrolled18-125 YearsNCI Combined Type Carcinoma
000045-CA Phase I Trial of T Cell Receptor Gene Therapy Targeting KK-LC-1 for Gastric, Breast, Cervical, Lung and other KK-LC-1 Positive Epithelial CancersParticipants currently recruited/enrolled18-120 YearsNCI Lung Type Carcinoma
20-C-0009Randomized Phase II Trial of Topotecan Plus M6620 (VX-970) vs. Topotecan Alone in Patients with Relapsed Small-Cell Lung CancerParticipants currently recruited/enrolled18-125 YearsNCI Lung Combined Carcinoma
18-C-0110Safety Run-In and Phase II Trial of M7824 and Topotecan or Temozolomide in Relapsed Small Cell CancersParticipants currently recruited/enrolled18-125 YearsNCI Lung Type Carcinoma
17-C-0140Phase I/II Evaluation of Oral Decitabine/Tetrahydrouridine as Epigenetic Priming for Pembrolizumab Immune Checkpoint Blockade in Inoperable Locally Advanced or Metastatic Non-Small Cell Lung Cancers, Esophageal Carcinomas, or Pleural MesotheliomasCompleted Study; data analyses ongoing18-99 YearsNCI Lung Type Carcinoma
14-C-0104A Phase II Study Using Autologous Young Tumor-Infiltrating Lymphocytes Derived from Patients with Non-Small Cell Lung Cancer Following Non-Myeloablative Lymphocyte Depleting Preparative RegimenParticipants currently recruited/enrolled18-70 YearsNCI Lung Type Carcinoma
001516-CPhase I Study of Aerosolized Antibiotics and Pembrolizumab in Advanced Non-Small Cell Lung CancerRecruitment has not started10-120 YearsNCI Lung Combined
001126-DCCollection of Clinical Data and Specimens for Research in Hearing, Balance and Communication DisordersParticipants currently recruited/enrolled2-125 YearsNIDCDLung Type
001084-CHA Prospective Natural History Study of Lymphatic AnomaliesParticipants currently recruited/enrolled0-125 YearsNICHDLung Type
001032-CBAY 1895344 Plus Topoisomerase-1 (Top1) Inhibitors in Patients with Advanced Solid Tumors, Phase I Studies with Expansion Cohorts in Small Cell Lung Carcinoma (SCLC), Poorly Differentiated Neuroendocrine Carcinoma (PD-NEC) and Pancreatic Adenocarcinoma (Recruitment has not started18-125 YearsNCI Lung Carcinoma
000954-CA Phase 1/2 Single Arm Open-Label Clinical Trial of TC-510 In Patients with Advanced Mesothelin-Expressing CancerParticipants currently recruited/enrolled18-125 YearsNCI Lung Type
000862-CHPilot Study of the Use of Functional Near-Infrared Spectroscopy (fNIRS) Combined with Diffuse Correlation Spectroscopy (DCS) in Neurocognitive Disease as Compared to Healthy Neurotypical ControlsParticipants currently recruited/enrolled0-125 YearsNICHDCombined Type
000826-CAn Open Label, Randomised, Phase 2 Study to Evaluate the Safety and Efficacy of MTL-CEBPA Administered in Combination with Sorafenib or Sorafenib Alone, in TKI Naive Participants with Previously Treated Advanced Hepatocellular Carcinoma (HCC) and HepatitRecruitment has not started18-125 YearsNCI Combined Carcinoma
000644-CPhase 1/1b Trial of ATR Inhibitor BAY 1895344 in Combination with FOLFIRI in GI Malignancies with a Focus on Metastatic Colorectal and Gastric/Gastroesophageal CancersParticipants currently recruited/enrolled18-125 YearsNCI Combined Type
000613-CPhase I/II Trial to Determine the Lowest Effective Dose of Post-Transplantation Cyclophosphamide in Combination with Sirolimus and Mycophenolate Mofetil as Graft-Versus-Host Disease Prophylaxis after Reduced Intensity Conditioning and Peripheral Blood StParticipants currently recruited/enrolled12-125 YearsNCI Lung Type
000567-CPhase 1 Trial of Gemcitabine Combined with the BAY 1895344 ATR Inhibitor with Expansion Cohorts in Advanced Pancreatic and Ovarian CancerParticipants currently recruited/enrolled18-125 YearsNCI Combined Type
000491-CTissue Procurement and Natural History Study of Neuroendocrine Neoplasms (NENs) Including Adrenocortical Carcinoma (ACC)Participants currently recruited/enrolled18-125 YearsNCI Lung Carcinoma
000489-CPhase I/II Study Using Prophylactic Donor Lymphocyte Infusion Early Post-Transplant After Allogeneic Hematopoietic Cell Transplantation Using Post-Transplantation Cyclophosphamide for High-Risk Hematologic MalignanciesClinical hold/Recruitment or enrollment suspended12-125 YearsNCI Lung Type
000486-CA Phase 1 Trial of the ATR Inhibitor BAY 1895344 in Combination with Cisplatin and with Cisplatin Plus Gemcitabine in Advanced Solid Tumors with an Emphasis on Urothelial CarcinomaParticipants currently recruited/enrolled18-125 YearsNCI Lung Carcinoma
000473-CA Randomized Phase II Study of Systemic Chemotherapy with or without HAI FUDR-Dexamethasone in Patients with Unresectable Intrahepatic CholangiocarcinomaParticipants currently recruited/enrolled18-125 YearsNCI Combined Carcinoma
000418-CPhase 1/2a, Open-label, Multicenter Study of Intramuscular PRL-02 Depot in Patients with Advanced Prostate CancerParticipants currently recruited/enrolled18-120 YearsNCI Lung Type
000354-CPhase II Trial of Combination Anti-PD-1 and Aldesleukin for Metastatic Melanoma and Renal Cell CarcinomaParticipants currently recruited/enrolled18-125 YearsNCI Type Carcinoma
000337-CNatural History Study of KSHV-Associated Multicentric Castleman's DiseaseParticipants currently recruited/enrolled18-125 YearsNCI Lung Type
000324-CPhase 1/2 Dose Escalation Study of CD19/CD22 Bicistronic Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults with Recurrent or Refractory CD19/CD22-expressing B Cell MalignanciesParticipants currently recruited/enrolled3-35 YearsNCI Lung Type
000254-CA Phase II Trial of the Superenhancer Inhibitor Minnelide in Advanced Refractory Adenosquamous Carcinoma of the Pancreas (ASCP)Participants currently recruited/enrolled18-125 YearsNCI Type Carcinoma
000059-CPhase I Study of Intratumor Injection of anti-Mesothelin Immunotoxin LMB-100 with Ipilimumab in Malignant MesotheliomaParticipants currently recruited/enrolled18-125 YearsNCI Lung Type
000057-CA Phase 1 Study of AZD8186 in Combination with Docetaxel in Patients with PTEN Mutated or PIK3CB Mutated Advanced Solid Tumors, Potentially Amenable to DocetaxelCompleted Study; data analyses ongoing18-125 YearsNCI Lung Type
22-C-0005Phase I Dose Escalation and Expansion Study of Tazemetostat in Combination with Topotecan and Pembrolizumab in Recurrent Small Cell Lung CancerParticipants currently recruited/enrolled18-125 YearsNCI Lung Carcinoma
21-I-0003A Phase 1/2 Study to Evaluate the Safety, Tolerability and Efficacy, of JSP191 for Hematopoietic Cell Transplantation Conditioning to Achieve Engraftment and Immune Reconstitution in Subjects with SCIDParticipants currently recruited/enrolled3-125 YearsNIAIDCombined Type
21-H-0027Characterization of Tissue-Specific Immune Responses to Bronchoscopic Instillation of Mycobacterial Antigens into the Human LungParticipants currently recruited/enrolled18-64 YearsNHLBILung Type
21-C-0030Phase I Study of GPC3 Targeted CAR-T Cell Therapy in Advanced GPC3 Expressing Hepatocellular Carcinoma (HCC)Participants currently recruited/enrolled18-125 YearsNCI Type Carcinoma
21-C-0026A Phase I/II Study of Abemaciclib in Patients with HIV-associated and HIV-negative Kaposi SarcomaParticipants currently recruited/enrolled18-125 YearsNCI Lung Type
21-C-0019Phase I Study of Anti-CD22 Chimeric Receptor T Cells in Patients with Relapsed/Refractory Hairy Cell Leukemia and VariantParticipants currently recruited/enrolled18-125 YearsNCI Lung Type
20-I-0132A Multicentre, Randomised, Double-blind, Parallel-group, Placebo-controlled, 24-week Phase 3 Study with an Open-label Extension to Evaluate the Efficacy and Safety of Benralizumab in Patients with Hypereosinophilic Syndrome (HES)Participants currently recruited/enrolled12-130 YearsNIAIDLung Type
20-I-0037Matched Related and Unrelated Donor Stem Cell Transplantation for Severe Combined Immune Deficiency (SCID): Busulfan-based Conditioning with h-ATG, Radiation, and SirolimusEnrolling by Invitation3-40 YearsNIAIDLung Combined
20-C-0155Phase I/II Trial Investigating the Safety, Tolerability, Pharmacokinetics, Immune and Clinical Activity of SX-682 in Combination with BinTrafusp Alfa (M7824 or TGF-beta "Trap"/PD-L1) with CV301 TRICOM in Advanced Solid Tumors (STAT)No longer recruiting/follow-up only18-125 YearsNCI Combined Type
20-C-0149Phase II Trial of Olaparib (LYNPARZA) plus Durvalumab (IMFINZI) in EGFR-Mutated Adenocarcinomas that Transform to Small Cell Lung Cancer (SCLC) and Other Neuroendocrine TumorsParticipants currently recruited/enrolled18-125 YearsNCI Lung Carcinoma
20-C-0098A Phase 1/2, Open Label, Dose-Escalation, Safety and Tolerability Study of NC410 in Subjects with Advanced or Metastatic Solid TumorsCompleted Study; data analyses ongoing18-125 YearsNCI Lung Carcinoma
20-C-0097A Phase II, Open-Label Trial of Bintrafusp Alfa (M7824) in Subjects with Thymoma and Thymic CarcinomaParticipants currently recruited/enrolled18-125 YearsNCI Lung Carcinoma
20-C-0028Phase 1/2 Study of Anti-CD33 Chimeric Antigen Receptor-Expressing T Cells (CD33CART) in Children and Young Adults with Relapsed/Refractory Acute Myeloid LeukemiaParticipants currently recruited/enrolled3-35 YearsNCI Lung Type
20-C-0027A Phase I Clinical Trial of Selinexor (KPT-330) in Combination with Temozolomide and Radiation Therapy in Patients with Newly Diagnosed GlioblastomaParticipants currently recruited/enrolled18-125 YearsNCI Combined Type
20-C-0012A Phase I Study of Bintrafusp alfa (M7824) and NHS-IL12 (M9241) Alone and in Combination with Stereotactic Body Radiation Therapy (SBRT) in Adults with Metastatic Non-Prostate Genitourinary MalignanciesParticipants currently recruited/enrolled18-125 YearsNCI Type Carcinoma
20-C-0011Phase 1 Study of Recombinant Human IL-15 (rhIL-15) and Mogamulizumab for Patients with Refractory or Relapsed Adult T-Cell Leukemia and Mycosis Fungoides/Sezary SyndromeCompleted Study; data analyses ongoing18-125 YearsNCI Lung Type
19-NR-0098Patient-Centered Assessment of Symptoms and OutcomesParticipants currently recruited/enrolled18-125 YearsNINR Lung Type
19-H-0139Investigation of the Natural Progression of Clonal Hematopoiesis of Indeterminate Potential and Clonal Cytopenia of Undetermined Significance.Participants currently recruited/enrolled18-125 YearsNHLBILung Type
19-C-0137A Phase II Study of Ipilimumab, Cabozantinib, and NIvolumab in Rare Genitourinary Cancers (ICONIC)Participants currently recruited/enrolled18-125 YearsNCI Type Carcinoma
19-C-0094A Phase II Study of Combined Treatment of Durvalumab, Bevacizumab, Tremelimumab and Transarterial Chemoembolization (TACE) in Subjects with Hepatocellular Carcinoma (HCC) or Biliary Tract Carcinoma (BTC)Participants currently recruited/enrolled18-125 YearsNCI Combined Carcinoma
19-C-0076A Phase 1 Study of Interleukin-15 in Combination with Avelumab (Bavencio) in Relapsed/Refractory Mature T-cell MalignanciesCompleted Study; data analyses ongoing18-125 YearsNCI Lung Combined
18-H-0012A Phase I Study of HERV-E TCR Transduced Autologous T Cells in Patients with Metastatic Clear Cell Renal Cell CarcinomaParticipants currently recruited/enrolled18-75 YearsNHLBILung Carcinoma
18-C-0138An Open-Label Phase 2 Study to Evaluate PT2977 for the Treatment of Von Hippel-Lindau Disease-Associated Renal Cell Carcinoma.No longer recruiting/follow-up only18-125 YearsNCI Type Carcinoma
18-C-0078A Phase I/II Study of Immunotherapy Combination BN-Brachyury vaccine, M7824, N-803 and Epacadostat (QuEST1)Participants currently recruited/enrolled18-125 YearsNCI Combined Type
18-C-0062Phase 2 Trial of XL184 (Cabozantinib) an Oral Small-Molecule Inhibitor of Multiple Kinases, in Children and Young Adults with Refractory Sarcomas, Wilms Tumor, and Other Rare TumorsCompleted Study; data analyses ongoing2-30 YearsNCI Lung Carcinoma
18-C-0049A Phase II Study Using the Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in Patients with Metastatic CancerParticipants currently recruited/enrolled18-72 YearsNCI Lung Type
17-C-0117A Phase 1/2a, Open-Label, Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Anti-Tumor Activity of PEN-866 in Advanced Solid MalignanciesCompleted Study; data analyses ongoing18-125 YearsNCI Lung Carcinoma
17-C-0092A Phase I/II Study of Pexa-Vec Oncolytic Virus in Combination with Immune Checkpoint Inhibition in Refractory Colorectal CancerCompleted Study; data analyses ongoing18-125 YearsNCI Type Carcinoma
17-C-0049A Phase I/II Trial of the Insulin-Like Growth Factor 1 Receptor (IGF-1R) Antibody AMG479 (Ganitumab) in Combination with the Src Family Kinase (SFK) Inhibitor Dasatinib in Patients with Embryonal and Alveolar RhabdomyosarcomaCompleted Study; data analyses ongoing2-125 YearsNCI Combined Type
17-C-0011Phase 1 Study of Intraperitoneal Infusion of Autologous Monocytes with Sylatron (Peginterferon alfa-2b) and Actimmune (Interferon gamma-1b) in Women with Recurrent or Refractory Ovarian Cancer, Fallopian Tube Cancer or Primary Peritoneal CancerCompleted Study; data analyses ongoing18-125 YearsNCI Combined Carcinoma
16-C-0171Phase I/II Study of Lenalidomide Combined with Modified DA-EPOCH and Rituximab (EPOCH-R2) in Primary Effusion Lymphoma or KSHV-Associated Large Cell LymphomaParticipants currently recruited/enrolled18-125 YearsNCI Lung Combined
16-C-0154A Phase I/II Trial of T Cell Receptor Gene Therapy Targeting HPV-16 E7 for HPV-Associated CancersParticipants currently recruited/enrolled18-125 YearsNCI Lung Carcinoma
16-C-0135A Pilot Study of Combined Immune Checkpoint Inhibition in combination with Ablative Therapies in Subjects with Hepatocellular Carcinoma (HCC) or Biliary Tract Carcinomas (BTC)No longer recruiting/follow-up only18-125 YearsNCI Combined Carcinoma
16-C-0128A Phase I/II Study of Mesothelin-Targeted Immunotoxin LMB-100 Alone or in Combination with Nab-Paclitaxel in Participants with Previously Treated Metastatic and/ or Locally Advanced Pancreatic Ductal Adenocarcinoma and Mesothelin Expressing Solid TumorsCompleted Study; data analyses ongoing18-125 YearsNCI Lung Carcinoma
16-C-0092A Pilot Study of Local Ablative Therapy for Treatment of Oligoprogressive, EGFR-mutated, Non-Small Cell Lung Cancer (NSCLC) After Treatment with Osimertinib (AZD9291, Tagrisso)Completed Study; data analyses ongoing18-125 YearsNCI Lung Type
16-C-0034A Phase II Trial of Oral Pazopanib plus Oral Topotecan Metronomic Antiangiogenic Therapy for Recurrent Glioblastoma Multiforme (A) without Prior Bevacizumab Exposure and (B) after Failing Prior BevacizumabCompleted Study; data analyses ongoing18-125 YearsNCI Lung Type
15-C-0150A Phase I/II Trial of Topotecan with VX-970 (M6620), an ATR Kinase Inhibitor in Small Cell CancersNo longer recruiting/follow-up only18-125 YearsNCI Lung Carcinoma
15-C-0099A Phase 1, Open-Label, Dose-Escalation Study of SNX-5422 and Everolimus in Subjects with Neuroendocrine TumorsCompleted Study; data analyses ongoing18-100 YearsNCI Type Carcinoma
15-AR-0144Studies of Dermatologic Diseases-Biospecimen Acquisition ProtocolParticipants currently recruited/enrolled2-125 YearsNIAMSType Carcinoma
14-I-0146The Pathogenesis and Genetics of Disseminated or Refractory CoccidioidomycosisParticipants currently recruited/enrolled2-100 YearsNIAIDLung Type
14-H-0127Characterization of the Pathogenesis of Primary and Secondary Lymphatic DisordersParticipants currently recruited/enrolled2-90 YearsNHLBILung Type
14-C-0157Phase 1 Study of Ibrutinib and Immuno-Chemotherapy Using Temozolomide, Etoposide, Doxil, Dexamethasone, Ibrutinib, Rituximab (TEDDI-R) in Primary CNS LymphomaParticipants currently recruited/enrolled18-125 YearsNCI Combined Type
14-C-0037A Phase 2 Study of the MET Kinase Inhibitor INC280 in Papillary Renal Cell CancerCompleted Study; data analyses ongoing18-125 YearsNCI Type Carcinoma
13-H-0051Bronchodilator Effects of Nebulized versus Inhaled Albuterol in Subjects with LymphangioleiomyomatosisParticipants currently recruited/enrolled18-125 YearsNHLBILung Type
13-C-0105Molecular Profiling-based Assignment of Cancer Therapy for Patients With Advanced Solid TumorsCompleted Study; data analyses ongoing18-120 YearsNCI Lung Type
13-C-0016A Phase I Study of an Adenoviral Transduced Autologous Dendritic Cell Vaccine Expressing Human HER2/neu ECTM in Adults with Tumors with 1-3+ HER2/neu ExpressionCompleted Study; data analyses ongoing18-125 YearsNCI Lung Type
12-M-0128TMS Investigations of the Human Visual SystemParticipants currently recruited/enrolled18-50 YearsNIMH Combined Type
12-C-0118A Phase II Study of Sunitinib in Patients with Advanced Relapsed or Refractory Thymoma or Thymic Carcinoma with at Least One Prior Line of Platinum-Based Systemic ChemotherapyNo longer recruiting/follow-up only18-100 YearsNCI Type Carcinoma
11-I-0007Lentiviral Gene Transfer for Treatment of Children Older Than 2 Years of Age with X-Linked Severe Combined ImmunodeficiencyClinical hold/Recruitment or enrollment suspended2-40 YearsNIAIDCombined Type
11-H-0046Cross-Sectional Characterization of Idiopathic BronchiectasisCompleted Study; data analyses ongoing18-125 YearsNHLBILung Type
11-E-0072Environmental Risk Factors for the Anti-Synthetase SyndromeParticipants currently recruited/enrolled2-100 YearsNIEHSLung Type
11-C-0247A Randomized Phase II Study of Tecemotide in Combination with Standard Androgen Deprivation Therapy and Radiation Therapy for untreated, intermediate and High Risk Prostate Cancer PatientsCompleted Study; data analyses ongoing18-100 YearsNCI Lung Combined
11-C-0096Pilot Trial of Molecular Profiling and Targeted Therapy for Advanced Non-Small Cell Lung Cancer, Small Cell Lung Cancer, and Thymic MalignanciesNo longer recruiting/follow-up only18-125 YearsNCI Lung Carcinoma
11-C-0034DICER1-Related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History StudyParticipants currently recruited/enrolled0-125 YearsNCI Lung Type
10-C-0166A Phase II Study Using Short-Term Cultured, Autologous Tumor-Infiltrating Lymphocytes Following a Lymphodepleting Regimen in Metastatic Cancers Plus the Administration of PembrolizumabParticipants currently recruited/enrolled18-72 YearsNCI Type Carcinoma
10-C-0114A Phase II Study of Bevacizumab and Erlotinib in Subjects with Advanced Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) or Sporadic Papillary Renal Cell CancerCompleted Study; data analyses ongoing18-125 YearsNCI Type Carcinoma
08-H-0186Safety and the Anti- Tumor Effects of Escalating Doses of Adoptively Infused Ex Vivo Expanded Autologous Natural Killer (NK) Cells Against Metastatic Cancers or Hematological Malignancies Sensitized to NK-TRAIL Cytotoxicity with BortezomibCompleted Study; data analyses ongoing18-70 YearsNHLBILung Carcinoma
08-C-0079Natural History Study and Longitudinal Assessment of Children, Adolescents, and Adults with Neurofibromatosis Type 1No longer recruiting/follow-up only0-125 YearsNCI Lung Type
07-C-0121Phase 2 Study of the C-Met RTK Inhibitor Foretinib (Formerly GSK 1363089) in Subjects with Papillary Renal Cell Carcinoma (PRC)Completed Study; data analyses ongoing18-125 YearsNCI Type Carcinoma
05-I-0213Screening and Baseline Assessment of Patients with Abnormalities of Immune FunctionParticipants currently recruited/enrolled0-125 YearsNIAIDLung Combined
05-H-0242A Pilot Study of Alemtuzumab (Campath) in Patients with Relapsed or Refractory Severe Aplastic AnemiaCompleted Study; data analyses ongoing2-110 YearsNHLBILung Type
04-CC-0119Biomarkers and Protein Mass Expression Profiles in Bronchoalveolar Lavage from Patients with Lung InfiltratesParticipants currently recruited/enrolled3-99 YearsCC Lung Type
04-C-0274Follow-Up Study of Subjects Previously Enrolled in Immunotherapy Studies Utilizing Gene Transfer or Other Immunotherapeutic AgentsParticipants currently recruited/enrolled18-125 YearsNCI Lung Type
03-H-0170Nonmyeloablative Allogeneic Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation For Severe Congenital Anemias Including Sickle Cell Disease (SCD) and Beta-ThalassemiaParticipants currently recruited/enrolled2-125 YearsNHLBICombined Type
02-C-0159Birt-Hogg-Dub(SqrRoot)(Copyright) Syndrome: Characterization of the FLCN Disease Gene and Predisposition to Renal Cancer, Cutaneous Fibrofolliculoma and Pulmonary CystsParticipants currently recruited/enrolled2-125 YearsNCI Lung Type
00-I-0159Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES)Participants currently recruited/enrolled0-125 YearsNIAIDLung Combined
00-HG-0141Clinical, Biochemical, and Molecular Investigations into AlkaptonuriaParticipants currently recruited/enrolled2-125 YearsNHGRILung Type
00-CH-0136A Trial of Pamidronate in Children with Osteogenesis ImperfectaCompleted Study; data analyses ongoing2-17 YearsNICHDLung Type
00-C-0078Collection of Blood, Fluid, Bone Marrow, Tumor, or Tissue Samples from Patients with Cancer or Normal VolunteersParticipants currently recruited/enrolled18-125 YearsNCI Lung Carcinoma
94-I-0079Eosinophil Activation and Function in Parasitic Infections and Other Conditions with Increased Tissue or Peripheral Blood Eosinophilia in HumansParticipants currently recruited/enrolled1-100 YearsNIAIDLung Type
88-I-0083Host Response to Infection and Treatment in the Filarial Diseases of HumansParticipants currently recruited/enrolled3-100 YearsNIAIDLung Type
001109-CDefining the Natural History of Squamous Cell Carcinoma in Fanconi AnemiaParticipants currently recruited/enrolled8-125 YearsNCI Carcinoma
001099-CA Phase 1/2, First-in-Human, Open-Label, Dose Escalation and Expansion Study of STAR0602, a Selective T Cell Receptor (TCR)-Targeting, Bifunctional Antibody-Fusion Molecule, in Subjects with Unresectable, Locally Advanced, or Metastatic Solid Tumors thatParticipants currently recruited/enrolled18-125 YearsNCI Carcinoma
001073-ENIEHS Repository of Stored Biological Samples for Future UseRecruitment has not started18-125 YearsNIEHSType
001066-DAOrexin's Role in The Neurobiology of Substance Use DisorderParticipants currently recruited/enrolled18-60 YearsNIDA Type
001061-HObservational Study Investigating the Mechanistic Effects of Mitapivat in Subjects with Sickle Cell DiseaseEnrolling by Invitation16-125 YearsNHLBILung
001018-CHEstablishment of Genomic and Phenotypic Database for Niemann-Pick Disease, Type CParticipants currently recruited/enrolled0-125 YearsNICHDType
000978-MState-Dependent Interoception, Value-Based Decision-Making, and IntrospectionRecruitment has not started18-55 YearsNIMH Type
000977-IPhase I/II Study using Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease with an Alemtuzumab, Busulfan and TBI-based Conditioning Regimen Combined with Cytokine (IL-6, +/- IFN-gamma) AntagonistsParticipants currently recruited/enrolled4-65 YearsNIAIDCombined
000975-CCollection of Blood, Bone Marrow, Skin, Saliva, and Stool Samples from Healthy Volunteers Used for Comparative Analysis of Myeloid MalignanciesParticipants currently recruited/enrolled18-125 YearsNCI Type
000958-CProspective Procurement of Tumor Tissue to Identify Novel Therapeutic Targets and Study the Tumor MicroenvironmentEnrolling by Invitation18-125 YearsNCI Lung
000957-HGA Phase 1/2, Open-Label, Single Dose Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of SEL-302 (MMA-101 following administration of SEL-110) in Pediatric Subjects with Mut Subtype Isolated Methylmalonic Acidemia (MMA)Participants currently recruited/enrolled3-17 YearsNHGRIType
000930-CA Phase 1b/2 Study of HCW9218, a Bifunctional TGF-Beta Antagonist/IL-15 Protein Complex, for Advanced Pancreatic CancerParticipants currently recruited/enrolled18-125 YearsNCI Carcinoma
000911-DKDinner Time for Obesity and Prediabetes (DTOP)Recruitment has not started18-50 YearsNIDDKType
000908-DKPeripheral Blood and Urine Immune Cell Phenotyping in Membranous Nephropathy using FACS and Single Cell RNA-seqParticipants currently recruited/enrolled18-125 YearsNIDDKType
000906-IA Phase 2 Randomized, Double-Blinded Cross-Over Design Study of the Early Metabolic Effects of Dolutegravir or Tenofovir Alefenamide in Healthy VolunteersRecruitment has not started18-55 YearsNIAIDType
000865-NNatural History Protocol for Movement DisordersParticipants currently recruited/enrolled2-125 YearsNINDSType
000861-IA Phase 2 Open-Label Study to Evaluate the Efficacy and Safety of Ruxolitinib on Hair Regrowth in Patients with Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED)-Associated Alopecia AreataParticipants currently recruited/enrolled12-65 YearsNIAIDType
000829-HControls and Healthy Vasculature InitiativeParticipants currently recruited/enrolled18-125 YearsNHLBIType
000821-IAn Open-Label, Single-Arm, Phase 1/2 Dose-Escalation Trial of Long-Acting Recombinant Human IL-7 (NT-I7, Efineptakin Alfa) for Idiopathic CD4 LymphopeniaRecruitment has not started18-75 YearsNIAIDType
000792-CA Multicenter Study to Evaluate Next-Generation Sequencing (NGS) Testing and Monitoring of B-Cell Recovery to Guide Management Following Chimeric Antigen Receptor T-cell (CART) Induced Remission in Children and Young Adults with B Lineage Acute LymphoblaRecruitment has not started1-25 YearsNCI Combined
000783-CPhase I/Ib Trial Evaluating the Safety and Efficacy of BET Inhibitor, ZEN003694 with PD-1 Inhibitor, Nivolumab with or without CTLA-4 Inhibitor, Ipilumumab in Solid TumorsParticipants currently recruited/enrolled18-125 YearsNCI Combined
000776-MAn Open Trial of Transcranial Magnetic Stimulation for Youth with Treatment-Resistant Major Depressive DisorderRecruitment has not started13-17 YearsNIMH Combined
000760-HExtension Study (extended access) of Syk-inhibition Using Fostamatinib to Treat Post-Transplant Immune-mediated CytopeniasEnrolling by Invitation18-75 YearsNHLBIType
000758-HA Phase II Study Using Fostamatinib to Treat Post-Hematopoietic Stem Cell Transplant Immune-Mediated CytopeniasParticipants currently recruited/enrolled18-75 YearsNHLBIType
000748-DKAnalysis of the Utility of Polygenic Scores for Prediction of Incident Type 2 Diabetes Across Multiple Ancestry GroupsNo longer recruiting/follow-up only0-125 YearsNIDDKType
000732-CA Long-Term Follow-Up Study of Patients Who Received VOR33Recruitment has not started18-125 YearsNCI Type
000731-CA First-In-Human, Open-Label, Multicenter Study of VOR33 in Patients with Acute Myeloid Leukemia who are at High-Risk for Leukemia Relapse following Hematopoietic Cell TransplantationParticipants currently recruited/enrolled18-70 YearsNCI Lung
000726-CA Randomized Phase 2 Study of Atezolizumab with or without Selinexor in Alveolar Soft Part Sarcoma (AXIOM)Participants currently recruited/enrolled18-125 YearsNCI Type
000697-HU01 Cooperative Assessment of Late Effects for SCD Curative Therapies (COALESCE)Participants currently recruited/enrolled18-65 YearsNHLBILung
000696-CA Phase III, Multicenter, International Study with a Parallel, Randomized, Double-blind, Placebo-controlled, 2 Arm Design to Assess the Efficacy and Safety of Selumetinib in Adult Participants with NF1 who have Symptomatic, Inoperable Plexiform NeurofibrParticipants currently recruited/enrolled18-120 YearsNCI Type
000686-CHIntrathecal 2-Hydroxypropyl-Beta-Cyclodextrin for Neurological Decline in Patients with Niemann-Pick Disease Type C1Participants currently recruited/enrolled18-125 YearsNICHDType
000678-CRare Tumors and Cancer Predisposition in Individuals and FamiliesParticipants currently recruited/enrolled0-125 YearsNCI Type
000666-CA Phase I/II Study of Palbociclib and Sasanlimab for the Treatment of Advanced Clear Cell Renal Cell Carcinoma (ccRCC) or Papillary Renal Cell Carcinoma (pRCC)Recruitment has not started18-125 YearsNCI Carcinoma
000647-CAn Open-label, Multicenter Follow-up Study to Collect Long-term Data on Participants from Multiple Bintrafusp alfa (M7824) Clinical StudiesRecruitment has not started18-125 YearsNCI Type
000643-CPhase I/II Study of Pacritinib, A JAK2/IRAK1/CSF1R Inhibitor, in Refractory Chronic Graft-Versus-Host Disease (cGVHD) After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)Participants currently recruited/enrolled18-125 YearsNCI Lung
000612-CPhase 1 Study of NT-I7 (rhIL-7-hyFc) for the Treatment of Kaposi Sarcoma in Patients With or Without Infection with HIVParticipants currently recruited/enrolled18-125 YearsNCI Type
000611-CA Phase II Trial of Focal Ultrahypofractionated Stereotactic Radiation Therapy for the Treatment of Unifocal Prostate CancerRecruitment has not started18-125 YearsNCI Type
000596-CPhase II Study of Olaparib in Subjects with Advanced Pancreatic Acinar Cell CarcinomaParticipants currently recruited/enrolled18-125 YearsNCI Carcinoma
000580-CA Phase 1/2, Open Label Dose-Escalation and Expansion Trial of Nkt2152, an Orally Administered Hif2a Inhibitor, to Investigate Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity in Patients with Advanced Clear Cell Renal Cell CarcinomaParticipants currently recruited/enrolled18-125 YearsNCI Carcinoma
000577-HGGenomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African Americans Study (GENEFORECAST): Prospective COVID-19 Natural History StudyParticipants currently recruited/enrolled21-125 YearsNHGRICombined
000519-EIPhase II, Multicenter, Open-label Safety Study of Bilateral NT-501 in Participants with Macular Telangiectasia Type 2No longer recruiting/follow-up only18-125 YearsNEI Type
000488-INatural History of Systemic and Nasal Mucosal Immunity after Influenza Vaccination in a Pediatric PopulationNo longer recruiting/follow-up only2-17 YearsNIAIDType
000479-HObservational Study to Deeply Phenotype Major Organs in Sickle Cell Disease After Curative TherapiesParticipants currently recruited/enrolled18-125 YearsNHLBILung
000475-CPhase 2 Study of Rogaratinib (BAY 1163877) in the Treatment of Patients with Sarcoma Harboring Alterations in Fibroblast Growth Factor Receptor (FGFR) 1-4 and SDH-deficient Gastrointestinal Stromal Tumor (GIST)Participants currently recruited/enrolled18-125 YearsNCI Type
000444-HVaccine Responses in Patients with B Cell MalignanciesParticipants currently recruited/enrolled18-125 YearsNHLBIType
000428-NAn Observational Study to Assess Clinical, Molecular and Imaging Biomarkers in Spinal and Bulbar Muscular Atrophy (SBMA)Participants currently recruited/enrolled18-125 YearsNINDSLung
000423-CFeasibility and Preliminary Efficacy of Acceptance and Commitment Therapy (ACT) for Sleep Disturbances in Adults with Sickle Cell Disease (SCD): A Pilot Randomized Controlled TrialParticipants currently recruited/enrolled18-55 YearsNCI Type
000421-AAIndividual Variations of Taste and Smell Perception in Alcohol Use Disorder (AUD)Recruitment has not started18-65 YearsNIAAAType
000414-CHPilot Study of an Optic-to-Audio Device in a Pediatric Cohort with CLN3-related Conditions or Low VisionParticipants currently recruited/enrolled6-18 YearsNICHDType
000411-CCA Feasibility Pilot Study of a Virtual Education-Based Transition Intervention to Improve Transition Readiness in Adolescent and Young Adults with Congenital Adrenal Hyperplasia.Recruitment has not started16-22 YearsCC Type
000410-IVRC 325 (000410): A Phase I Open-Label Clinical Trial to Evaluate the Dose, Safety, Tolerability and Immunogenicity of Mosaic Quadrivalent Influenza Vaccine with and without Adjuplex Compared with a Licensed Inactivated Seasonal QIV, In Healthy AdultsParticipants currently recruited/enrolled18-50 YearsNIAIDLung
000406-AAAddictions Neuroclinical AssessmentEnrolling by Invitation18-125 YearsNIAAACombined
000404-CA Phase II Study of Allogeneic Hematopoietic Stem Cell Transplant for Subjects with VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) SyndromeParticipants currently recruited/enrolled18-75 YearsNCI Lung
000393-DKDiabetic Kidney Disease and Related Complications in American Indians with Type 2 DiabetesParticipants currently recruited/enrolled18-125 YearsNIDDKType
000387-HThe Natural History of Acquired and Inherited Bone Marrow Failure Syndromes.Participants currently recruited/enrolled2-125 YearsNHLBILung
000384-IAnalysis of the Immune Response to COVID-19 Vaccination and Outcomes in Individuals With and Without Immune Deficiencies and DysregulationsParticipants currently recruited/enrolled3-125 YearsNIAIDType
000359-CPhase I/II study to reduce post-transplantation cyclophosphamide dosing for older or unfit patients undergoing bone marrow transplantation for hematologic malignanciesParticipants currently recruited/enrolled12-85 YearsNCI Lung
000350-DUse of Clear Aligners for the Treatment of Dental Malocclusion In Individuals with Osteogenesis Imperfecta Types III and IVParticipants currently recruited/enrolled12-40 YearsNIDCRType
000344-DKNatural History Study of Parathyroid DisordersParticipants currently recruited/enrolled0-125 YearsNIDDKType
000328-CBicalutamide Implants (Biolen ) with Radiation Therapy in Patients with Localized Prostate CancerParticipants currently recruited/enrolled18-125 YearsNCI Type
000326-HA Phase 1, Dose Escalation, Safety and Tolerability Study of NX- 2127, a Bruton's Tyrosine Kinase (BTK) Degrader, in Adults with Relapsed/Refractory B-cell MalignanciesParticipants currently recruited/enrolled18-125 YearsNHLBIType
000317-CA Phase II, Open-Label Trial of PT-112 in Subjects with Thymoma and Thymic CarcinomaParticipants currently recruited/enrolled18-125 YearsNCI Carcinoma
000305-CExploratory Phase II Study of LAnreotide in Unresectable or Metastatic Pheochromocytoma / PARAgangliomaParticipants currently recruited/enrolled18-125 YearsNCI Type
000302-CA Multi-Center Natural History of Urothelial Cancer and Rare Genitourinary Tract MalignanciesParticipants currently recruited/enrolled18-125 YearsNCI Carcinoma
000299-HTechnical Development of Cardiovascular MRIParticipants currently recruited/enrolled18-125 YearsNHLBILung
000293-CManaging Cancer and Living Meaningfully (CALM) Therapy in Individuals Diagnosed with a Primary Central Nervous System TumorEnrolling by Invitation18-125 YearsNCI Type
000288-CA Phase II, Open-Label, Single-Arm Study of Berzosertib (M6620) in Combination with Topotecan in Participants with Relapsed Platinum-Resistant Small-Cell Lung CancerCompleted Study; data analyses ongoing18-125 YearsNCI Lung
000272-HDefining the Genetic Etiology of Suppurative Lung Disease in Children and AdultsParticipants currently recruited/enrolled5-45 YearsNHLBILung
000264-CA Pharmacodynamics-Driven Trial of Talazoparib, an Oral PARP Inhibitor, in Patients With Advanced Solid Tumors and Aberrations in Genes Involved in DNA Damage ResponseParticipants currently recruited/enrolled18-125 YearsNCI Type
000237-CPhase II Study of Intravenous and Intraperitoneal Paclitaxel and Oral Nilotinib for Peritoneal Carcinomatosis from Colorectal, Appendiceal, Small Bowel, Gastric, Ovarian, or Other Gynecologic Primary CancerParticipants currently recruited/enrolled18-125 YearsNCI Carcinoma
000236-IA Phase 1 Study of Empagliflozin as Treatment for Severe Congenital Neutropenia Due to G6PC3 DeficiencyParticipants currently recruited/enrolled18-125 YearsNIAIDLung
000220-DKPhase II Trial of the Combination of Alpha-lipoic Acid and Mirabegron in Women and in Men with ObesityRecruitment has not started18-65 YearsNIDDKCombined
000213-HGClinical and Laboratory Study of Rare Skeletal DisordersParticipants currently recruited/enrolled0-125 YearsNHGRIType
000212-IInduced Blood-Stage Plasmodium Vivax Infection with HMPBS02-Pv Challenge Agent in Healthy Malaria-Naive Adults to Produce a Plasmodium Vivax Parasite Cell Bank for Future StudiesNo longer recruiting/follow-up only18-50 YearsNIAIDType
000201-IPediatric SARS-CoV-2 and MIS-C Long-term Follow-upParticipants currently recruited/enrolled0-21 YearsNIAIDLung
000194-CA Phase I Trial of ProAgio, an anti- alpha-v-beta3 Integrin Cytotoxin, for Previously Treated Advanced Pancreatic Cancer and Other Solid Tumor MalignanciesParticipants currently recruited/enrolled18-125 YearsNCI Type
000193-CPhase 1 Study of Copanlisib with Dose-adjusted EPOCH-R in Relapsed and Refractory Burkitt Lymphoma and other High-Grade B-cell LymphomasClinical hold/Recruitment or enrollment suspended18-125 YearsNCI Type
000187-EIAdaptive Optics Imaging of Outer Retinal DiseasesParticipants currently recruited/enrolled21-125 YearsNEI Type
000186-IPart B- Phase I/II, Non-randomized, Multicenter, Open-label Study of G1XCGD (Lentiviral Vector Transduced CD34+ Cells) in Patients with X-Linked Chronic Granulomatous DiseaseClinical hold/Recruitment or enrollment suspended3-12 YearsNIAIDLung
000183-IAn open-label single-arm Phase IIb study of F901318 as treatment of invasive fungal infections due to Lomentospora prolificans, Scedosporium spp., Aspergillus spp., and other resistant fungi in patients lacking suitable alternative treatment optionsParticipants currently recruited/enrolled16-125 YearsNIAIDLung
000176-CA Phase I/II Trial of Lurbinectedin with Berzosertib, an ATR Kinase Inhibitor in Small Cell Cancers and High Grade Neuroendocrine CancersParticipants currently recruited/enrolled18-125 YearsNCI Lung
000173-CSystematically Assessing Changes in Plexiform Neurofibroma Related Disfigurement from Photographs of Subjects with Neurofibromatosis Type 1 on a Phase 2 Clinical TrialCompleted Study; data analyses ongoing7-125 YearsNCI Type
000152-ENatural History of The Human Biological Response to Environmental Exposure and InjuryParticipants currently recruited/enrolled18-125 YearsNIEHSLung
000144-CA Phase I/II Study of Sacituzumab Govitecan plus Berzosertib in Small Cell Lung Cancer, Extra-Pulmonary Small Cell Neuroendocrine Cancer and Homologous Recombination-Deficient Cancers Resistant to PARP InhibitorsParticipants currently recruited/enrolled18-125 YearsNCI Lung
000137-CHImplications of Maternal 45,X Mosaicism As A Secondary Genomic Finding Following Cell-free DNA Sequencing During Pregnancy: A Deep Phenotype StudyRecruitment has not started18-99 YearsNICHDType
000134-IA Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Trial of Intravenous Zotatifin in Adults with Mild or Moderate Coronavirus Disease 2019 (COVID-19)Participants currently recruited/enrolled18-125 YearsNIAIDLung
000124-CA Phase 2 Study of the MEK inhibitor Trametinib (IND #119346, NSC# 763093) in Children with Relapsed or Refractory Juvenile Myelomonocytic LeukemiaRecruitment has not started2-21 YearsNCI Lung
000102-CCCOVID-19, Chronic Adaptation and Response to Exercise (COVID-CARE): A Randomized Controlled TrialParticipants currently recruited/enrolled18-80 YearsCC Lung
000096-CA Phase II study of Immunotherapy Combination: Irradiated PD-L1 CAR-NK cells plus Pembrolizumab plus N-803 for Subjects with Recurrent/Metastatic Gastric or Head and Neck CancerParticipants currently recruited/enrolled18-125 YearsNCI Combined
000081-CA Phase 2 Study of Anti-PD-L1 Antibody (Atezolizumab) in Chondrosarcoma and Clear Cell SarcomaCompleted Study; data analyses ongoing2-125 YearsNCI Type
000080-C18F-DCFPyL PET/CT in Hepatocellular CarcinomaParticipants currently recruited/enrolled18-125 YearsNCI Carcinoma
000077-DCCollection of Clinical Data and Specimens for Research on Head and Neck and Communication DisordersParticipants currently recruited/enrolled2-125 YearsNIDCDCarcinoma
000064-IA Phase 1/2 Open-label Study to Evaluate the Safety and Efficacy of Tofacitinib for Chronic Granulomatous Disease with Inflammatory ComplicationsEnrolling by Invitation18-125 YearsNIAIDLung
000062-CPhase I Evaluation of Immunotoxin LMB-100 Administered by Normothermic, Intrapleural Perfusion Following Cytoreductive Surgery in Participants with Pleural Mesotheliomas, or Pleural Effusions from Cancers Expressing MesothelinParticipants currently recruited/enrolled18-120 YearsNCI Lung
000051-NNIH Investigative Deep Phenotyping Study of Gulf War Veteran Health (Project NIH IN-DEPTH)Participants currently recruited/enrolled48-70 YearsNINDSLung
000049-HEvaluation of the Safety,Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects with Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of MitapivatNo longer recruiting/follow-up only18-70 YearsNHLBILung
000030-CPhase 2 Study of Bintrafusp alfa in Recurrent/Metastatic Olfactory Neuroblastoma (BARON).Participants currently recruited/enrolled18-125 YearsNCI Lung
22-C-0004A Phase II Study of Bevacizumab, Erlotinib and Atezolizumab in Subjects with Advanced Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) Associated or Sporadic Papillary Renal Cell CancerParticipants currently recruited/enrolled12-125 YearsNCI Carcinoma
21-N-0010A Phase 2 Clinical Trial of Tolebrutinib, a Brain-penetrant Bruton's Tyrosine Kinase Inhibitor, for the Modulation of Chronically Inflamed White Matter Lesions in Multiple SclerosisNo longer recruiting/follow-up only18-125 YearsNINDSType
21-M-0018Characterization of an Optically Pumped Magnetometer (OPM) Magnetoencephalography (MEG) ArrayParticipants currently recruited/enrolled18-65 YearsNIMH Type
21-I-0005Phase 1 Study of the Safety and Immunogenicity of an Epstein-Barr virus (EBV) gp350- Ferritin Nanoparticle Vaccine in Healthy Adults With or Without EBV InfectionParticipants currently recruited/enrolled18-29 YearsNIAIDType
21-DC-0002Phase III Interventional Study using Atorvastatin to Reduce Cisplatin-Induced Hearing Loss among Individuals with Head and Neck CancerRecruitment has not started18-125 YearsNIDCDCarcinoma
21-C-0024A Phase 2 Adaptive Study of Subcutaneous Daratumumab, Once Weekly Carfilzomib, and Dexamethasone (DKd) in Patients with High-Risk Smoldering Multiple MyelomaParticipants currently recruited/enrolled18-125 YearsNCI Lung
21-C-0023A Phase I Study of Pomalidomide and Nivolumab in Patients with Virus-Associated Malignancies With or Without HIVParticipants currently recruited/enrolled18-125 YearsNCI Carcinoma
21-C-0021SARC037: A Phase I/II Study to Evaluate the Safety of Trabectedin Administered as a 1-Hour Infusion in Ewing Sarcoma Patients in Combination with Low Dose Irinotecan and 3'-Deoxy-3'-18F Fluorothymidine (18F-FLT) ImagingParticipants currently recruited/enrolled6-125 YearsNCI Type
21-C-0015Phase II Trial Evaluating the Association of Peripheral Blood Immunologic Response to Therapeutic Response to Adjuvant Treatment with Immune Checkpoint Inhibition (ICI) in Patients with Newly Diagnosed Glioblastoma or GliosarcomaParticipants currently recruited/enrolled18-125 YearsNCI Type
21-C-0012Individualized Response Assessment to Heated Intraperitoneal Chemotherapy (HIPEC) for the Treatment of Peritoneal Carcinomatosis from Ovarian, Colorectal, Appendiceal, or Peritoneal Mesothelioma HistologiesParticipants currently recruited/enrolled18-125 YearsNCI Carcinoma
21-C-0011A Phase I/II Study of the Cyclin-Dependent Kinase(CDK)4/6 Inhibitor Abemaciclib for Neurofibromatosis Type 1 (NF1) Related Atypical NeurofibromasParticipants currently recruited/enrolled12-125 YearsNCI Type
21-C-0007A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon CancersParticipants currently recruited/enrolled18-125 YearsNCI Type
21-C-0006Phase I/II Study Evaluating Safety and Efficacy of Tivozanib (AV-951) in CholangiocarcinomaClinical hold/Recruitment or enrollment suspended18-125 YearsNCI Type
20-N-0064An observational study to assess clinical manifestations and biomarkers in amyotrophic lateral sclerosis type 4 and other inherited neurological disorders of RNA processing.Participants currently recruited/enrolled5-125 YearsNINDSType
20-N-0060Mechanisms Underlying the Beneficial Effects of Naps on Motor LearningParticipants currently recruited/enrolled18-80 YearsNINDSType
20-N-0019The Effect of Vorinostat on ACTH Producing Pituitary Adenomas in Cushing's DiseaseParticipants currently recruited/enrolled18-125 YearsNINDSType
20-I-0160Dose-Escalation Study of a Low Pathogenicity Avian H10N7 Influenza Virus in a Healthy Human Challenge ModelRecruitment has not started18-50 YearsNIAIDLung
20-I-0123A Longitudinal Study of COVID-19 Sequelae and ImmunityParticipants currently recruited/enrolled18-125 YearsNIAIDLung
20-I-0117Surveillance of Individuals Following SARS-CoV-2 infectionCompleted Study; data analyses ongoing18-125 YearsNIAIDType
20-I-0111COVID-19-associated Lymphopenia Pathogenesis Study in BloodParticipants currently recruited/enrolled18-125 YearsNIAIDType
20-I-0088An Open-label Efficacy and Safety Study of Pozelimab in Patients with CD55 deficient Protein-losing Enteropathy (CHAPLE Disease)Participants currently recruited/enrolled3-125 YearsNIAIDLung
20-HG-0034A Multi-Cohort Phase 2 Dose-Escalation Study of MK-7075 (Miransertib) in Proteus SyndromeParticipants currently recruited/enrolled3-125 YearsNHGRILung
20-H-0158Natural History Study: Gene First Approach to Connective Tissue DiseaseParticipants currently recruited/enrolled2-100 YearsNHLBILung
20-H-0099Data Collection of Standard Care and Evaluation of NHLBI Patients and DonorsEnrolling by Invitation2-120 YearsNHLBILung
20-H-0068Venous Thrombosis Biomarkers in Sickle Cell Disease and Sickle Cell TraitParticipants currently recruited/enrolled18-80 YearsNHLBILung
20-DK-0018Prebiotics and Metformin Influences Gut and Hormones in Type 2 Diabetes YouthCompleted Study; data analyses ongoing10-25 YearsNIDDKType
20-D-0122A Phase IIb, Open-label Dose-ranging Study Evaluating the Safety, Tolerability, Pharmacodynamics and Pharmacokinetics, and Efficacy of CLTX-305 (encaleret) in Autosomal Dominant Hypocalcemia Type 1 (ADH1)No longer recruiting/follow-up only16-125 YearsNIDCRType
20-D-0094Transmissibility and Viral Load of SARS-CoV-2 Through Oral SecretionsCompleted Study; data analyses ongoing18-125 YearsNIDCRType
20-CC-0113Cardiopulmonary Inflammation and Multi-System Imaging During the Clinical Course of COVID-19 Infection in Asymptomatic and Symptomatic Persons (COVID ARC 19)No longer recruiting/follow-up only18-80 YearsCC Lung
20-CC-0039A Feasibility Study to Evaluate the Combination of Electromagnetic Tracking and Optical Imaging with Indocyanine Green (ICG) for Hepatic BiopsiesEnrolling by Invitation18-125 YearsCC Carcinoma
20-C-0152Phase II Study of combination of Trametinib (MEK inhibitor) and Hydroxychloroquine (HCQ) (autophagy inhibitor) in Patients with KRAS Mutation Refractory Bile Tract Carcinoma (BTC).Participants currently recruited/enrolled18-125 YearsNCI Carcinoma
20-C-0142A Phase II Study of Bintrafusp alfa (M7824) in Checkpoint Inhibitor Naive and Refractory Subjects with Urothelial CarcinomaCompleted Study; data analyses ongoing18-125 YearsNCI Carcinoma
20-C-0130A Feasibility Study Investigating the Use of Machine Learning to Analyze Facial Imaging, Voice and Spoken Language for the Capture and Classification of Cancer/Tumor PainEnrolling by Invitation12-125 YearsNCI Type
20-C-0106Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients with BAP1 Tumor Predisposition SyndromeParticipants currently recruited/enrolled30-125 YearsNCI Lung
20-C-0104Phase I/II Trial of HPV Vaccine PRGN-2009 Alone or in Combination with Anti-PD-L1/TGF-Beta Trap (M7824) in Subjects with HPV Positive CancersParticipants currently recruited/enrolled18-125 YearsNCI Combined
20-C-0076Phase 2 Trial of Encorafenib plus Binimetinib for Patients with BRAF V600 Mutated Relapsed/Refractory HCLParticipants currently recruited/enrolled18-125 YearsNCI Lung
20-C-0075Phase 2 Trial for Binimetinib for Patients with Relapsed/Refractory BRAF Wild Type Hairy Cell Leukemia and VariantParticipants currently recruited/enrolled18-125 YearsNCI Type
20-C-0062A phase 1b Study of Nivolumab in Patients with Autoimmune Disorders and Advanced Malignancies (AIM-NIVO)Participants currently recruited/enrolled18-125 YearsNCI Lung
20-C-0061Phase I/II study of NHS-IL12 Monotherapy and in Combination with M7824 in Advanced Kaposi SarcomaParticipants currently recruited/enrolled18-125 YearsNCI Lung
20-C-0058A Study of Front Line Ibrutinib for Newly Diagnosed Chronic Graft-Versus-Host DiseaseParticipants currently recruited/enrolled18-125 YearsNCI Lung
20-C-0045Phase I/II Trial of Combination Immunotherapy in Subjects with Advanced HPV Associated MalignanciesNo longer recruiting/follow-up only18-125 YearsNCI Lung
20-C-0024A Sequential Window of Opportunity Trial of Anti-PD-L1/TGF-beta trap (M7824 ) Alone and in Combination with TriAd Vaccine, and N-803 for Resectable Head and Neck Squamous Cell Carcinoma not Associated with Human Papillomavirus Infection.No longer recruiting/follow-up only18-125 YearsNCI Carcinoma
20-C-0022Phase II trial of VB-111 in Combination with Nivolumab in Patients with Metastatic Colorectal Cancer (mCRC)Completed Study; data analyses ongoing18-125 YearsNCI Carcinoma
20-C-0006A National Translational Science Network of Precision-based Immunotherapy for Primary Liver Cancer (PLC)Participants currently recruited/enrolled18-125 YearsNCI Carcinoma
19-I-0140A Phase 1 Evaluation of the Safety of Belimumab in People with Idiopathic CD4 Lymphopenia and Autoantibodies (Phoebe)Participants currently recruited/enrolled18-70 YearsNIAIDType
19-I-0093Collection of Human Biospecimens for Basic and Clinical Research into Globin VariantsParticipants currently recruited/enrolled18-70 YearsNIAIDLung
19-I-0058Mucosal Correlates of Protection After Influenza Viral Challenge of Vaccinated and Unvaccinated Healthy VolunteersCompleted Study; data analyses ongoing18-55 YearsNIAIDLung
19-I-0053Prospective Study to Identify Food-Specific and Component IgE Threshold Levels that Predict Food Allergy in Patients with Elevated Total Serum IgE Levels and Atopic DermatitisParticipants currently recruited/enrolled3-21 YearsNIAIDLung
19-I-0022A Prospective, Multicenter Study to Compare and Validate Endoscopic, Histologic, Molecular, and Patient-Reported Outcomes in Pediatric and Adult Patients with Eosinophilic Esophagitis (EoE), Gastritis (EG) and Colitis (EC)Participants currently recruited/enrolled3-125 YearsNIAIDType
19-I-0015Phase 1/2 Randomized, Double-Blind, Placebo-Controlled Study of Safety and Efficacy of Abatacept for Treating Chronic Cytopenia in Cytotoxic T-lymphocyte Antigen 4 (CTLA4) HaploinsufficiencyParticipants currently recruited/enrolled8-65 YearsNIAIDLung
19-HG-0101A Phase 1/2 Study of Intravenous Gene Transfer with an AAV9 Vector Expressing Human Beta-galactosidase in Type I and Type II GM1 GangliosidosisNo longer recruiting/follow-up only0-12 YearsNHGRIType
19-HG-0092New Approaches for Empowering Studies of Asthma in Populations of African DescentCompleted Study; data analyses ongoing18-125 YearsNHGRILung
19-H-0057Multiple Patient Program for Lamprene (clofazimine) for the treatment of Non-Tuberculous Mycobacterial (NTM) Infections- CLAM320B2002MParticipants currently recruited/enrolled18-99 YearsNHLBILung
19-DA-N019Outcome Inference in the Sensory Preconditioning Task in Opioid-use DisorderParticipants currently recruited/enrolled21-60 YearsNIDA Type
19-CC-0070Translational Development of Photon-Counting CT ImagingCompleted Study; data analyses ongoing18-125 YearsCC Type
19-CC-0063Impact of Steady State Cobicistat and Darunavir/Cobicistat on the Pharmacokinetics and Pharmacodynamics of Oral Anticoagulants (Rivaroxaban, Apixaban) in Healthy VolunteersParticipants currently recruited/enrolled18-65 YearsCC Combined
19-C-0143A Phase II Study Using the Administration of Autologous T-Cells Engineered using the Sleeping Beauty Transposon/Transposase System to Express T-Cell Receptors Reactive Against Mutated Neoantigens in Patients with Metastatic CancerParticipants currently recruited/enrolled18-70 YearsNCI Lung
19-C-0138Phase I/II Study of Lu-177-DOTATATE (Lutathera) in Combination with Olaparib in Inoperable Gastroenteropancreatico Neuroendocrine Tumors (GEP-NET)Participants currently recruited/enrolled18-125 YearsNCI Type
19-C-0136A Phase 2, Randomized, Multicenter Study to Evaluate the Efficacy and Safety of KD025 in Subjects with Chronic Graft Versus Host Disease (CGVHD) After at Least 2 Prior Lines of Systemic TherapyCompleted Study; data analyses ongoing18-125 YearsNCI Lung
19-C-0135Evaluation of the Natural History and Management of Von Hippel-Lindau (VHL) Associated Pancreatic Neuroendocrine TumorsParticipants currently recruited/enrolled12-125 YearsNCI Type
19-C-0134A Phase 1/1b Study of Enhancement of Immune Reconstitution and Vaccine Responses with Administration of Recombinant Human IL-7-hyFc (NT-I7) in Older Subjects Following ChemotherapyParticipants currently recruited/enrolled60-125 YearsNCI Carcinoma
19-C-0129A Phase II Study of Intraperitoneal and Intravenous Paclitaxel Chemotherapy with Oral Capecitabine for Gastric Adenocarcinoma with Peritoneal CarcinomatosisParticipants currently recruited/enrolled18-125 YearsNCI Carcinoma
19-C-0128A Phase I Study of Mesothelin-Targeted Immunotoxin LMB-100 in Combination with Tofacitinib in Persons with Previously Treated Pancreatic Adenocarcinoma, Cholangiocarcinoma and other Mesothelin Expressing Solid TumorsCompleted Study; data analyses ongoing18-125 YearsNCI Combined
19-C-0127A Phase II Study of LMB-100 Followed by Pembrolizumab in the Treatment of Adults with Mesothelin-Expressing Non-Squamous Non-Small Cell Lung Cancer (NSCLC)No longer recruiting/follow-up only18-125 YearsNCI Lung
19-C-0117A Phase 1 / 2 Single Arm Open-label Clinical Trial of Gavocabtagene Autoleucel (gavo-cel) in Patients with Advanced Mesothelin Expressing CancerParticipants currently recruited/enrolled18-120 YearsNCI Lung
19-C-0116A Phase 2 Study of Acalabrutinib with DA-EPOCH-R or R-CHOP for Patients with Untreated Diffuse Large B-cell LymphomaParticipants currently recruited/enrolled18-125 YearsNCI Type
19-C-0096Studying the Biology of IDH-mutant Gliomas via Longitudinal Observation of 2-Hydroxyglutarate (2-HG) Using MR SpectroscopyParticipants currently recruited/enrolled18-125 YearsNCI Type
19-C-0085Phase II Trial of Allogeneic Hematopoietic Cell Transplantation for Peripheral T cell LymphomaClinical hold/Recruitment or enrollment suspended12-125 YearsNCI Type
19-C-0082Natural History Study of Children and Adults with ChordomaParticipants currently recruited/enrolled2-125 YearsNCI Type
19-C-0062A Phase II Study of Neoadjuvant Androgen Deprivation Therapy Combined with Enzalutamide and Abiraterone Using Multiparametric MRI and 18F-DCFPyL-PET/CT in Newly Diagnosed Prostate CancerParticipants currently recruited/enrolled18-125 YearsNCI Combined
19-C-0061A Phase 2 Trial of the MEK Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in Combination with the mTOR Inhibitor Sirolimus for Patients with Unresectable or Metastatic Malignant Peripheral Nerve Sheath TumorsParticipants currently recruited/enrolled12-125 YearsNCI Type
19-C-0041Birinapant and Intensity Modulated Re-Irradiation Therapy (IMRRT) for Locoregionally Recurrent Head and Neck Squamous Cell Carcinoma (HNSCC)Participants currently recruited/enrolled18-125 YearsNCI Carcinoma
19-C-0039Perioperative MVT-5873, a Fully Human Monoclonal Antibody Against a CA 19-9 Epitope, for Operable CA 19-9 Producing Pancreatic Cancers, Cholangiocarcinomas, and Metastatic Colorectal CancersCompleted Study; data analyses ongoing18-125 YearsNCI Carcinoma
19-C-0033Phase II Study of Nivolumab (anti-PD1), Tadalafil and Oral Vancomycin in Patients with Refractory Primary Hepatocellular Carcinoma or Liver Dominant Metastatic Cancer from Colorectal or Pancreatic CancersCompleted Study; data analyses ongoing18-125 YearsNCI Carcinoma
19-C-0023A Phase II Study of Olaparib (AZD2281) in Patients with Metastatic/Advanced Urothelial Carcinoma and other genitourinary tumors with DNA-Repair DefectsParticipants currently recruited/enrolled18-125 YearsNCI Carcinoma
19-C-0017A Phase I/II Study Administering Peripheral Blood Lymphocytes Transduced with a Murine T-Cell Receptor Recognizing the G12D Variant of Mutated RAS in HLA-A*11:01 PatientsParticipants currently recruited/enrolled18-70 YearsNCI Lung
19-C-0016Natural History and Biospecimen Acquisition Study for Children and Adults with Rare Solid TumorsParticipants currently recruited/enrolled0-125 YearsNCI Carcinoma
19-C-0010A Phase 1 Trial of MK-3475 Plus Ziv-Aflibercept in Patients with Advanced Solid TumorsCompleted Study; data analyses ongoing18-125 YearsNCI Type
18-M-0144The effects of an ER beta agonist (Lilly Compound LY500307) on estradiol-withdrawal-induced mood symptoms in women with past perimenopausal depression.Participants currently recruited/enrolled45-65 YearsNIMH Type
18-I-0041Investigating the Mechanistic Biology of Primary Immunodeficiency DisordersParticipants currently recruited/enrolled0-75 YearsNIAIDCombined
18-I-0022Use of Ustekinumab (Anti-IL-12/23p40 Monoclonal Antibody) in Patients with Leukocyte Adhesion Deficiency Type 1 (LAD1) who have Inflammatory PathologyParticipants currently recruited/enrolled12-65 YearsNIAIDType
18-HG-0064A Natural History Study of Patients with Generalized Arterial Calcification of Infancy (GACI) or Autosomal Recessive Hypophosphatemic Rickets Type 2 (ARHR2)Completed Study; data analyses ongoing0-125 YearsNHGRIType
18-H-0108Vascular Disease Discovery ProtocolParticipants currently recruited/enrolled2-100 YearsNHLBILung
18-H-0090Haplo-identical Transplantation for Severe Aplastic Anemia, Hypo-plastic MDS and PNH using Peripheral Blood Stem Cells and post-transplant Cyclophosphamide for GVHD prophylaxisParticipants currently recruited/enrolled4-75 YearsNHLBILung
18-H-0011Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner SystemParticipants currently recruited/enrolled18-125 YearsNHLBILung
18-H-0004Low Dose Danazol for the Treatment of Telomere Related DiseasesParticipants currently recruited/enrolled3-125 YearsNHLBILung
18-H-0003Discovery of Sirolimus Sensitive Biomarkers in BloodParticipants currently recruited/enrolled18-90 YearsNHLBILung
18-EI-0055A Phase III Multicenter Randomized Sham Controlled Study to Determine the Safety and Efficacy of NT-501 in Macular Telangiectasia Type 2Completed Study; data analyses ongoing21-80 YearsNEI Type
18-DK-0091Long-Term Follow-Up Of Subjects With CHC Who Achieved A Sustained Virological Response Following Therapy With Direct Acting Antiviral AgentsParticipants currently recruited/enrolled18-125 YearsNIDDKCarcinoma
18-CH-0120A Natural History of the Collagen-Related Disorder Osteogenesis Imperfecta and the Genotype-Phenotype CorrelationNo longer recruiting/follow-up only0-125 YearsNICHDType
18-CC-0087Impact of Weekly Administration of Rifapentine and Isoniazid on Steady State Pharmacokinetics of Tenofovir Alafenamide in Healthy VolunteersCompleted Study; data analyses ongoing18-65 YearsCC Lung
18-C-0147Phase 1 with Expansion Cohorts in a Study of NEO-201 In Adults with Chemo-Resistant Solid TumorsParticipants currently recruited/enrolled18-125 YearsNCI Carcinoma
18-C-0135Phase II Trial of Allogeneic Hematopoietic Cell Transplantation for Disorders of T-cell Proliferation and/or DysregulationParticipants currently recruited/enrolled4-125 YearsNCI Lung
18-C-0102Pilot Study of the MEK1/2 Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) for Adults with Neurofibromatosis Type 1 (NF1) and Cutaneous Neurofibromas (cNF)Completed Study; data analyses ongoing18-125 YearsNCI Type
18-C-0093Pilot Study of Medication Adherence in Children, Adolescents, and Adults with Neurofibromatosis Type 1 (NF1) on Clinical Treatment TrialsNo longer recruiting/follow-up only3-125 YearsNCI Type
18-C-0059Phase 1 Dose Escalation Study of CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults with Recurrent or Refractory CD19/CD22-expressing B Cell MalignanciesParticipants currently recruited/enrolled3-39 YearsNCI Lung
18-C-0034A Phase 2 Study of ONC201 in Recurrent/Refractory Metastatic Breast Cancer and Advanced Endometrial CarcinomaCompleted Study; data analyses ongoing18-125 YearsNCI Carcinoma
18-C-0024A Single-Arm Phase II Study of Hepatic Artery Infusion Pump Chemotherapy with Floxuridine and Dexamethasone in Combination with Systemic Chemotherapy for Patients with Colorectal Cancer Metastatic to the LiverParticipants currently recruited/enrolled18-125 YearsNCI Carcinoma
18-C-0008Phase III Randomized Adjuvant study of Pembrolizumab in muScle invaSive and locAlly aDvanced urOthelial caRcinoma (AMBASSADOR) versus ObservationNo longer recruiting/follow-up only18-125 YearsNCI Carcinoma
17-N-0131Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal DementiaParticipants currently recruited/enrolled18-125 YearsNINDSLung
17-M-0147Concurrent fMRI-guided rTMS and Cognitive Therapy for the Treatment of Major Depressive EpisodesParticipants currently recruited/enrolled18-65 YearsNIMH Combined
17-I-0083Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS)Participants currently recruited/enrolled18-125 YearsNIAIDCombined
17-I-0072Herpesviruses Reactivation In Hiv-Infected Women Initiating ART (HERA)Completed Study; data analyses ongoing18-99 YearsNIAIDType
17-H-0091Unrelated Umbilical Cord Blood Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS using CordIn, Umbilical Cord Blood-Derived Ex Vivo Expanded Stem and Progenitor Cells, to Expedite Engraftment and Improve Transplant OutcomeParticipants currently recruited/enrolled4-75 YearsNHLBILung
17-H-0069Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell DiseaseParticipants currently recruited/enrolled2-125 YearsNHLBILung
17-H-0026Pembrolizumab and Decitabine for Refractory or Relapsed Acute Myeloid LeukemiaCompleted Study; data analyses ongoing18-99 YearsNHLBICombined
17-DK-0054The Physiological Responses and Adaptation of Brown Adipose Tissue to Chronic Treatment with Beta3-Adrenergic Receptor AgonistsParticipants currently recruited/enrolled18-40 YearsNIDDKType
17-DK-0013Therapeutic Targets in African-American Youth with Type 2 DiabetesParticipants currently recruited/enrolled12-25 YearsNIDDKType
17-DC-0138Observational Study of Hearing Loss and the Effects of Statin Drugs in Head and Neck Squamous Cell Carcinoma Patients Treated with Cisplatin ChemoradiationCompleted Study; data analyses ongoing18-125 YearsNIDCDCarcinoma
17-CC-0148Obtaining Samples from Human Subjects to Facilitate Basic, Translational and Clinical ResearchParticipants currently recruited/enrolled18-125 YearsCC Type
17-CC-0111Pilot Study Characterizing Aerobic Exercise in Women with Systemic Lupus Erythematosus (Exercise SLE Pilot).Completed Study; data analyses ongoing21-80 YearsCC Lung
17-C-0175CC-4047-BRN-001: A Phase 2 Clinical Study of Pomalidomide (CC-4047) Monotherapy for Children and Young Adults with Recurrent or Progressive Primary Brain TumorsCompleted Study; data analyses ongoing3-20 YearsNCI Type
17-C-0174Molecular Characterization of Viral-associated Tumors, Tumors Occurring in the Setting of HIV or Other Immune Disorders and Castleman DiseaseParticipants currently recruited/enrolled18-125 YearsNCI Type
17-C-0158A Feasibility Study of Mobile Sensor Technologies to Assess General Symptomology of Cancer PatientsEnrolling by Invitation18-125 YearsNCI Lung
17-C-0157A Phase I Single-Arm Study of the Combination of Durvalumab (MEDI4736) and Vicineum (oportuzumab monatox, VB4-845) in Subjects with High-Grade Non-Muscle-Invasive Bladder Cancer Previously Treated with Bacillus Calmette-Gu(SqrRoot)(Copyright)rin (BCG)Participants currently recruited/enrolled18-125 YearsNCI Carcinoma
17-C-0153Phase I Trial of Image Guided Focally Dose Escalated Prostate SBRT for Locally Recurrent Prostate Cancer after Prior RadiotherapyParticipants currently recruited/enrolled18-125 YearsNCI Type
17-C-0149Phase 2 Trial of Pembrolizumab in Relapsed and Refractory Gray-Zone Lymphoma (GZL), Primary Central Nervous System Lymphoma (PCNSL),and Other Extranodal Diffuse Large B-cell LymphomasNo longer recruiting/follow-up only18-125 YearsNCI Type
17-C-0125Phase 2 Trial of Nivolumab in Epstein-Barr Virus (EBV)-Positive Lymphoproliferative Disorders and EBV-Positive Non-Hodgkin LymphomasParticipants currently recruited/enrolled12-125 YearsNCI Type
17-C-0105Prospective Study of Clonal Evolution in Follicular LymphomaParticipants currently recruited/enrolled18-125 YearsNCI Type
17-C-0100Collection of Malignant Ascites, Pleural Fluid and Blood from Patients with Solid TumorsNo longer recruiting/follow-up only18-125 YearsNCI Lung
17-C-0090DART: Dual Anti-CTLA-4 And Anti-Pd-1 Blockade In Rare TumorsParticipants currently recruited/enrolled18-125 YearsNCI Combined
17-C-0089Evaluation of 18F-DCFPyL PSMA- versus 18F-NaF-PET imaging for Detection of Metastatic Prostate CancerEnrolling by Invitation18-125 YearsNCI Type
17-C-0086An Open-label Phase 2 Study to Evaluate PT2385 for the Treatment of Von Hippel-Lindau Disease-Associated Clear Cell Renal Cell CarcinomaNo longer recruiting/follow-up only18-125 YearsNCI Carcinoma
17-C-0066A Pilot Study to Investigate the Safety and Clinical Activity of Avelumab (MSB0010718C) in Thymoma and Thymic Carcinoma after Progression on Platinum-Based ChemotherapyParticipants currently recruited/enrolled18-125 YearsNCI Carcinoma
17-C-0061Phase II Trial of Pembrolizumab in Recurrent or Metastatic Medullary Thyroid CancerCompleted Study; data analyses ongoing18-125 YearsNCI Type
17-C-0052Phase II Evaluation of Nivolumab, an Immune Checkpoint Inhibitor, alone or in combination with Oral Decitabine/Tetrahydrouridine as Second Line Therapy for Non-Small Cell Lung CancerCompleted Study; data analyses ongoing18-125 YearsNCI Lung
17-C-0048Anti-CD30 CAR T Cells with Fully-human Binding Domains for Treating CD30-expressing Lymphomas Including Anaplastic Large Cell LymphomasCompleted Study; data analyses ongoing18-73 YearsNCI Type
17-AT-0075Sensory and Opioid Mechanisms of Affective TouchCompleted Study; data analyses ongoing18-50 YearsNCCIHType
16-N-0114The Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques: An Investigator-Blinded StudyParticipants currently recruited/enrolled18-125 YearsNINDSType
16-HG-0026New Technology and Child HealthParticipants currently recruited/enrolled18-125 YearsNHGRIType
16-EI-0090Natural History of Spinocerebellar Ataxia Type 7 (SCA7)Participants currently recruited/enrolled12-125 YearsNEI Type
16-E-0096Cytochrome P450 Epoxygenase Pathway Regulation of Macrophage FunctionParticipants currently recruited/enrolled18-65 YearsNIEHSLung
16-CC-0049A Phase II Study Using LC Bead LUMI Radio-Opaque Embolic Beads to Detect and Characterize the Vascularity of Hepatic Tumors During Treatment with Transarterial Embolization (TAE) Alone or Combined with Thermal AblationEnrolling by Invitation18-125 YearsCC Combined
16-C-0121A Pilot Clinical Trial of Genomic Based Assignment of Therapy in Advanced Urothelial CarcinomaCompleted Study; data analyses ongoing18-125 YearsNCI Carcinoma
16-C-0094A Phase 1/2 Study of Baricitinib, a JAK1/2 Inhibitor, in Chronic Graft-Versus-Host Disease (cGVHD) after Allogeneic Hematopoietic Stem Cell Transplantation (SCT)No longer recruiting/follow-up only18-125 YearsNCI Lung
16-C-0087Phase I Study of Veliparib (ABT-888), an Oral PARP Inhibitor, and VX-970, an ATR Inhibitor in Combination with Cisplatin in Patients with Refractory Solid TumorsCompleted Study; data analyses ongoing18-125 YearsNCI Combined
16-C-0066Phase I Study of MK-3475 (Pembrolizumab) in Patients with Human Immunodeficiency Virus (HIV) and Relapsed/Refractory or Disseminated Malignant NeoplasmParticipants currently recruited/enrolled18-125 YearsNCI Lung
16-C-0062A Phase I Study of Subcutaneous Recombinant Human IL-15 (S.C. Rhil-15) and Alemtuzumab for Patients with Refractory or Relapsed Chronic and Acute Adult T-Cell Leukemia (ATL)Completed Study; data analyses ongoing18-125 YearsNCI Combined
16-C-0061Biospecimen Procurement for Center for Immuno-Oncology Immunotherapy ProtocolsParticipants currently recruited/enrolled18-125 YearsNCI Lung
16-C-0060A Phase 1b/2 Study of alvelestat (MPH966), an Oral Neutrophil Elastase Inhibitor, in Bronchiolitis Obliterans Syndrome after Allogeneic Hematopoietic Stem Cell TransplantationParticipants currently recruited/enrolled18-125 YearsNCI Lung
16-C-0047A Phase 1 Trial of Pomalidomide in Combination with Liposomal Doxorubicin in Patients with Advanced or Refractory Kaposi SarcomaParticipants currently recruited/enrolled18-125 YearsNCI Lung
16-C-0043Phase II Trial of the MEK1/2 Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate in Adults with Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform NeurofibromasNo longer recruiting/follow-up only18-125 YearsNCI Type
16-C-0035Prostvac in Patients with Biochemically Recurrent Prostate CancerNo longer recruiting/follow-up only18-125 YearsNCI Type
16-C-0027A Prospective Randomized and Phase II Trial for Metastatic Melanoma Using Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes Plus IL-2 Either Alone or Following the Administration of PembrolizumabParticipants currently recruited/enrolled18-70 YearsNCI Lung
16-C-0003Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary ImmunodeficienciesParticipants currently recruited/enrolled4-75 YearsNCI Lung
15-N-0073A Phase I Study of Intrathecal Administration of scAAV9/JeT-GAN for the Treatment of Giant Axonal NeuropathyParticipants currently recruited/enrolled3-99 YearsNINDSLung
15-I-0148A Phase I Study of Respiratory Syncytial Virus Human Challenge in Healthy Adult VolunteersCompleted Study; data analyses ongoing18-50 YearsNIAIDLung
15-H-0172A Pilot Phase II Study Using Ibrutinib and Short-Course Fludarabine in Previously Untreated Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)No longer recruiting/follow-up only18-125 YearsNHLBICombined
15-H-0017Characterization of Apolipoprotein A-I Pathways in Idiopathic Pulmonary FibrosisCompleted Study; data analyses ongoing18-100 YearsNHLBILung
15-E-0058Natural History of Asthma with Longitudinal Environmental SamplingParticipants currently recruited/enrolled18-60 YearsNIEHSLung
15-DK-0108Natural History of Noncirrhotic Portal HypertensionParticipants currently recruited/enrolled12-125 YearsNIDDKType
15-CC-0091Pulmonary Effects of Bronchial Segmental Endotoxin Instillation in HumansClinical hold/Recruitment or enrollment suspended18-45 YearsCC Lung
15-C-0205Phase II Randomized, Placebo-Controlled Trial of PROSTVAC (PSA-TRICOM) in Patients with Clinically Localized Prostate Cancer Undergoing Active SurveillanceCompleted Study; data analyses ongoing18-99 YearsNCI Lung
15-C-0200Molecular Analysis for Therapy Choice (MATCH) (EAY131)Completed Study; data analyses ongoing18-125 YearsNCI Type
15-C-0160A Phase I Study of Cabozantinib Plus Nivolumab (CaboNivo) Alone or in Combination with Ipilimumab (CaboNivoIpi) in Patients with Advanced/Metastatic Urothelial Carcinoma and other Genitourinary TumorsNo longer recruiting/follow-up only18-125 YearsNCI Carcinoma
15-C-0157Phase I/II Trial of Vandetanib in Combination with Metformin in Subjects with HLRCC or SDH-Associated Kidney Cancer or Sporadic Papillary Renal Cell CarcinomaCompleted Study; data analyses ongoing18-125 YearsNCI Carcinoma
15-C-0145Phase I/II Study of the Anti-Programmed Death Ligand-1 Antibody Durvalumab (MEDI4736) in Combination with Olaparib and/or Cediranib for Advanced Solid Tumors and Advanced or Recurrent Ovarian, Triple Negative Breast, Lung, Prostate and Colorectal CancersParticipants currently recruited/enrolled18-125 YearsNCI Lung
15-C-0142Acceptance and Commitment Training for Adolescents and Adults with Neurofibromatosis Type 1, Plexiform Neurofibromas, and Chronic Pain: A Phase III Clinical TrialCompleted Study; data analyses ongoing16-59 YearsNCI Type
15-C-0138Phase I Study of Ipilimumab, Nivolumab, and the Combination in Patients with Newly Diagnosed GlioblastomaCompleted Study; data analyses ongoing18-125 YearsNCI Type
15-C-0093Phase I Trial of Turalio(R) (pexidartinib, PLX3397) in Children and Young Adults with Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN)Participants currently recruited/enrolled3-35 YearsNCI Type
15-C-0076A Pilot Study of Long Term TARP Vaccination Using A Multi-Epitope TARP Peptide Autologous Dendritic Cell Vaccination in Previously Vaccinated Men on NCI 09-C-0139Completed Study; data analyses ongoing18-125 YearsNCI Type
15-C-0067A Phase I/II Open Label, Dose Escalation Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell TransplantationParticipants currently recruited/enrolled18-125 YearsNCI Lung
15-C-0029Phase I Dose Escalation Study of Anti-CD22 Chimeric Receptor T Cells in Pediatric and Young Adults with Recurrent or Refractory CD22-expressing B Cell MalignanciesParticipants currently recruited/enrolled3-39 YearsNCI Type
15-C-0019The Impact of Ras/MAPK Signaling Pathway-Targeted Therapies on Neurocognitive Functioning in Individuals with NF1Completed Study; data analyses ongoing4-99 YearsNCI Type
15-AG-0123Intermittent Calorie Restriction, Insulin Resistance, and Biomarkers of Brain FunctionCompleted Study; data analyses ongoing55-70 YearsNIA Type
14-I-0206Novel Genetic Disorders of the Immune SystemParticipants currently recruited/enrolled0-99 YearsNIAIDType
14-I-0194Screening of Volunteers for Clinical Trials of Investigational or Licensed Vaccines or Antiviral ProductsParticipants currently recruited/enrolled18-65 YearsNIAIDLung
14-I-0091Analysis of Patients Treated for Chronic Granulomatous Disease Since January 1, 1995Completed Study; data analyses ongoing3-125 YearsNIAIDType
14-I-0089A Retrospective and Cross-Sectional Analysis of Patients Treated for Severe Combined Immunodeficiency (SCID) Since January 1, 1968Enrolling by Invitation2-125 YearsNIAIDCombined
14-I-0081A Phase 2a Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Subcutaneous Benralizumab (MEDI-563) in Reducing Eosinophilia in Subjects with Hypereosinophilic Syndrome (HES)No longer recruiting/follow-up only18-75 YearsNIAIDLung
14-I-0072A Prospective Natural History Study of Diagnosis, Treatment and Outcomes of Children with SCID DisordersCompleted Study; data analyses ongoing2-125 YearsNIAIDCombined
14-I-0063An Open-Label, Proof-of-Concept Study to Evaluate the Safety and Efficacy of Dexpramipexole (KNS-760704) in Subjects with Hypereosinophilic SyndromeNo longer recruiting/follow-up only18-125 YearsNIAIDLung
14-HG-0055Study on Moebius Syndrome and Other Congenital Facial Weakness DisordersCompleted Study; data analyses ongoing2-80 YearsNHGRICombined
14-DK-0060Famine from Feast: Linking Vitamin C, Red Blood Cell Fragility, and DiabetesParticipants currently recruited/enrolled18-65 YearsNIDDKType
14-CC-0027The NIH Exercise Therapy for Advanced Lung Disease Trials: Response and Adaptation to Aerobic Exercise in Patients with Interstitial Lung DiseaseParticipants currently recruited/enrolled21-80 YearsCC Lung
14-C-0163Transformation of Plexiform Neurofibromas to Malignant Peripheral Nerve Sheath Tumors in Neurofibromatosis Type 1: Clinical, Histopathologic, and Genomic AnalysisCompleted Study; data analyses ongoing10-125 YearsNCI Type
14-C-0105Tissue Procurement and Natural History Study of Patients with Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial TumorsParticipants currently recruited/enrolled18-125 YearsNCI Lung
14-C-0056Collection of Blood from Patients with Ovarian, Primary Peritoneal or Fallopian Tube CancerCompleted Study; data analyses ongoing18-125 YearsNCI Type
14-C-0052A Phase I/II Study of the Treatment of Metastatic Cancer that Expresses MAGE-A3 Using Lymphodepleting Conditioning Followed by Infusion of HLA-DP0401/0402 Restricted Anti-MAGE-A3 TCR-Gene Engineered Lymphocytes and AldesleukinCompleted Study; data analyses ongoing18-70 YearsNCI Type
14-C-0022A Phase II Study for Metastatic Melanoma Using High-Dose Chemotherapy Preparative Regimen Followed by Cell Transfer Therapy Using Tumor-Infiltrating Lymphocytes Plus IL-2 with the Administration of Pembrolizumab in the Retreatment ArmCompleted Study; data analyses ongoing18-70 YearsNCI Type
14-C-0015Pilot Trial of BMN 673, an Oral PARP Inhibitor, in Patients With Advanced Solid Tumors and Deleterious BRCA MutationsCompleted Study; data analyses ongoing18-125 YearsNCI Carcinoma
13-N-0135Pilot Study of Raltegravir, an Integrase Inhibitor, in Human T-Cell Lymphotrophic Virus-1(HTLV-1) Associated Myelopathy, Tropical Spastic Paraparesis (HAM/TSP)Completed Study; data analyses ongoing18-125 YearsNINDSType
13-N-0085Clinical Manifestations and Biorepository for Focal DystoniaCompleted Study; data analyses ongoing18-125 YearsNINDSType
13-I-0177Natural History Study of the Complications Associated with Allogeneic Hematopoietic Stem Cell TransplantationsCompleted Study; data analyses ongoing2-125 YearsNIAIDType
13-I-0172Phase I Study of the Safety of a Replication-Defective Herpes Simplex Virus-2 Vaccine, HSV529, in Adults Aged 18 to 40 Years With or Without HSV InfectionCompleted Study; data analyses ongoing18-40 YearsNIAIDType
13-I-0157The Natural History of GATA2 Deficiency and Related DisordersParticipants currently recruited/enrolled2-100 YearsNIAIDType
13-I-0082Rituximab (Anti-CD20) for the Treatment of Subjects With Anticytokine Autoantibody-Associated DiseasesCompleted Study; data analyses ongoing18-125 YearsNIAIDType
13-H-0133Extended Dosing with Eltrombopag in Refractory Severe Aplastic AnemiaCompleted Study; data analyses ongoing2-125 YearsNHLBIType
13-H-0059Longitudinal Observational Study of Severe AsthmaParticipants currently recruited/enrolled18-125 YearsNHLBILung
13-DK-0200The Mechanism of Human Non-Shivering Thermogenesis and Basal Metabolic RateParticipants currently recruited/enrolled18-35 YearsNIDDKType
13-D-0014Bacterial Arrangement in Supragingival BiofilmsCompleted Study; data analyses ongoing18-999 YearsNIDCRType
13-CH-0001Intrathecal 2-Hydroxypropyl-B-Cyclodextrin in Patients with Niemann-Pick Disease, Type C1Completed Study; data analyses ongoing2-125 YearsNICHDType
13-CC-0210Evaluating an Extension Assist Knee Ankle Foot Orthosis to Improve Gait in Children with Movement DisordersParticipants currently recruited/enrolled5-125 YearsCC Type
13-CC-0012A Natural History Study of Novel Biomarkers in Pulmonary Arterial HypertensionParticipants currently recruited/enrolled18-125 YearsCC Lung
13-C-0202Tissue Procurement and Natural History Study of Patients with Malignant Mesothelioma and Other Mesothelin Expressing CancersParticipants currently recruited/enrolled2-125 YearsNCI Lung
13-C-0175A Phase II Protocol for Subjects with Stage T1 Bladder Cancer to Evaluate Selective Bladder Preserving Treatment by Radiation Therapy Concurrent with Radio-sensitizing Chemotherapy following a Thorough Transurethral Surgical Re-StagingCompleted Study; data analyses ongoing18-125 YearsNCI Type
13-C-0132Allogeneic Hematopoietic Stem Cell Transplant for Patients with Mutations in GATA2 or the MonoMAC SyndromeParticipants currently recruited/enrolled8-70 YearsNCI Type
13-C-0131Inpatient Hospice with Procurement of Tissue on Expiration in Thoracic Malignancies, Bladder Cancer, Ovarian Cancer, Epithelial Cancer and Patients Treated with an Adoptive Cellular TherapyParticipants currently recruited/enrolled18-125 YearsNCI Lung
13-C-0118A Phase I/II Trial of TRC102 (methoxyamine HCl) in Combination with Temozolomide in Patients with Relapsed Solid Tumors and LymphomasParticipants currently recruited/enrolled18-125 YearsNCI Carcinoma
13-C-0044A Phase 2 Study of Cabozantinib (XL184), a Dual Inhibitor of MET and VEGFR, in Patients With Metastatic Refractory Soft Tissue SarcomaNo longer recruiting/follow-up only18-120 YearsNCI Type
13-C-0006Phase I/II Trial Evaluating the Safety and Efficacy of Ruxolitinib in Patients with Smoldering and Chronic Adult T-cell Leukemia (ATL)Completed Study; data analyses ongoing18-125 YearsNCI Type
13-AR-0056Stopping Tumor Necrosis Factor-Alpha Inhibitors in Rheumatoid ArthritisCompleted Study; data analyses ongoing18-125 YearsNIAMSType
12-N-0095Clinical and Molecular Manifestations of Neuromuscular and Neurogenetic Disorders of ChildhoodParticipants currently recruited/enrolled0-125 YearsNINDSLung
12-I-0103Characterization of Innate Immune Responses to AS03 Adjuvanted H5N1 Vaccine Compared to Non-adjuvanted H5N1 VaccineCompleted Study; data analyses ongoing21-45 YearsNIAIDType
12-HG-0022Inherited Diseases, Caregiving, and Social NetworksCompleted Study; data analyses ongoing18-125 YearsNHGRIType
12-H-0035A Phase II study of Ibrutinib for Patients with Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) Who Need Therapy and are Older than 65 or have a 17p DeletionNo longer recruiting/follow-up only18-125 YearsNHLBIType
12-EI-0042NEI Intramural Biorepository for Retinal DiseasesParticipants currently recruited/enrolled2-125 YearsNEI Type
12-E-0190The Role of Functionally Relevant Cyclooxygenase-2 (COX-2) Gene Single Nucleotide Polymorphisms - 765G>C and 8473T>C in Lymphocyte DifferentiationCompleted Study; data analyses ongoing18-150 YearsNIEHSType
12-DC-0152Normative Values in Audiovestibular TestingParticipants currently recruited/enrolled5-80 YearsNIDCDType
12-CC-0211A Pilot Study of the Effect of Spironolactone Therapy on Exercise Capacity and Endothelial Dysfunction in Pulmonary Arterial HypertensionParticipants currently recruited/enrolled18-125 YearsCC Lung
12-C-0206Understanding the Perceived Influence of Childhood Cancer and NF1 on the Parents' Marital/Partner Relationship: A Descriptive StudyCompleted Study; data analyses ongoing18-125 YearsNCI Type
12-C-0205A Phase II Study of Cabozantinib (XL184) in Patients With Advanced/Metastatic Urothelial CarcinomaCompleted Study; data analyses ongoing18-125 YearsNCI Carcinoma
12-C-0197A Randomized Phase 2 Single-Center Study of Pomalidomide for Chronic GvHDCompleted Study; data analyses ongoing18-75 YearsNCI Lung
12-C-0193Lymphoid Malignancies and Precursors: Tissue Acquisition ProtocolParticipants currently recruited/enrolled18-125 YearsNCI Type
12-C-0178Longitudinal Assessment and Natural History Study of Children and Adults with MEN2A or MEN2B with or without Medullary Thyroid CarcinomaParticipants currently recruited/enrolled0-125 YearsNCI Carcinoma
12-C-0112Phase I Study of T Cells Expressing an Anti-CD19 Chimeric Receptor in Children and Young Adults with B Cell MalignanciesCompleted Study; data analyses ongoing1-30 YearsNCI Type
12-C-0081Phase I/II Study of Cediranib and Olaparib in Combination for Treatment of Recurrent Papillary-Serous Ovarian, Fallopian Tube, or Peritoneal Cancer or for Treatment of Recurrent Triple-Negative Breast CancerNo longer recruiting/follow-up only18-125 YearsNCI Combined
12-C-0079A Phase II Multicenter Study of AMG 386 and Abiraterone in Metastatic Castration Resistant Prostate CancerCompleted Study; data analyses ongoing18-125 YearsNCI Type
12-AR-0159Effects of Treatments on the Microbiome in Healthy Volunteers and Patients with Atopic DermatitisParticipants currently recruited/enrolled2-50 YearsNIAMSType
11-I-0187The Natural History and Pathogenesis of Human Fungal InfectionsParticipants currently recruited/enrolled0-99 YearsNIAIDType
11-I-0057Effect of Interferon Alpha 2b Intensification on HIV-1 Residual Viremia in Individuals Suppressed on Antiretroviral TherapyCompleted Study; data analyses ongoing18-65 YearsNIAIDType
11-HG-0110Genetics of Obesity, Diabetes, and Heart Disease in African Diaspora PopulationsEnrolling by Invitation18-125 YearsNHGRIType
11-H-0209Male Hormones for Telomere Related DiseasesCompleted Study; data analyses ongoing2-125 YearsNHLBILung
11-E-0006The Role of TGF-Beta in Asthmatic Epithelial Cell Susceptibility to RSV InfectionCompleted Study; data analyses ongoing18-60 YearsNIEHSLung
11-CC-0152The Natural History of Liver Disease in a Cohort of Participants with Hepatitis B and/or Hepatitis C with or without HIV InfectionCompleted Study; data analyses ongoing18-99 YearsCC Carcinoma
11-CC-0120Stereophotogrammetry of the Torso in Healthy Individuals and Patients with Scoliosis, Chest Wall Deformations, or ObesityCompleted Study; data analyses ongoing2-125 YearsCC Type
11-C-0255Clinical, Epidemiologic, and Genetic Studies of Li-Fraumeni SyndromeParticipants currently recruited/enrolled0-125 YearsNCI Type
11-C-0242Collection of Blood from Patients with Cancer, Other Tumors, or Tumor Predisposition Syndromes for Analysis of Genetic Differences in Drug DispositionParticipants currently recruited/enrolled3-125 YearsNCI Lung
11-C-0190Collection of Tissue Blocks or Slides from Patients with CancerParticipants currently recruited/enrolled18-125 YearsNCI Type
11-C-0161A Phase I/II Study of the Mitogen Activated Protein Kinase Kinase (MEK) 1 Inhibitor Selumetinib (AZD6244; Hydrogen Sulfate in Children with Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas (PN)No longer recruiting/follow-up only2-18 YearsNCI Type
11-C-0132Understanding the Psychosocial Needs of Parents Who Have Lost a Child to CancerCompleted Study; data analyses ongoing18-99 YearsNCI Type
11-C-0061Phase I Trial of Z-Endoxifen in Adults with Refractory Hormone Receptor-Positive Breast Cancer, Desmoid Tumors, Gynecologic Tumors, or other Hormone Receptor-Positive Solid TumorsNo longer recruiting/follow-up only18-125 YearsNCI Type
10-N-0122Evaluation, Pathogenesis, and Outcome of Subjects with or Suspected Traumatic Brain InjuryCompleted Study; data analyses ongoing18-125 YearsNINDSType
10-M-0047Top-Down Attentional Control of Visual-ProcessingParticipants currently recruited/enrolled18-125 YearsNIMH Type
10-I-0216Studies of Disorders with Increased Susceptibility to Fungal InfectionsParticipants currently recruited/enrolled0-125 YearsNIAIDType
10-I-0148Natural History of Severe Allergic Inflammation and ReactionsParticipants currently recruited/enrolled2-80 YearsNIAIDLung
10-I-0109VRC 900: Evaluation of Tissue-Specific Immune Responses in Adults 18 Years of Age and OlderParticipants currently recruited/enrolled18-125 YearsNIAIDLung
10-H-0141A Phase II Study of Ofatumumab-Based Induction Chemoimmunotherapy Followed by Consolidation Ofatumumab Immunotherapy in Previously Untreated Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma.No longer recruiting/follow-up only18-99 YearsNHLBIType
10-H-0126Cardiovascular Disease Discovery ProtocolParticipants currently recruited/enrolled1-100 YearsNHLBILung
10-H-0083A Phase I Trial of Safety and Immunogenicity of Gardasil Vaccination Post Stem Cell Transplantation in Patients with and without ImmunosuppressionCompleted Study; data analyses ongoing18-50 YearsNHLBIType
10-E-0129Study of the Effect of Innate Immunity on the Inflammatory Response to EndotoxinParticipants currently recruited/enrolled18-125 YearsNIEHSType
10-DK-N091Molecular and Clinical Profile of Diabetes Mellitus and its ComplicationsParticipants currently recruited/enrolled18-125 YearsNIDDKType
10-DK-0102Clinical and Genetic Studies in Familial Non-Medullary Thyroid CancerParticipants currently recruited/enrolled7-125 YearsNIDDKType
10-CC-0217A Comparison of Methods for Assisting Needle Angle Selection During Image-Guided Tissue BiopsyCompleted Study; data analyses ongoing18-125 YearsCC Lung
10-CC-0149Comparing Expectorated and Induced Sputum and Pharyngeal Swabs for Cultures, AFB Smears, and Cytokines in Pulmonary Nontuberculous Mycobacterial InfectionCompleted Study; data analyses ongoing18-80 YearsCC Lung
10-CC-0118Long Term Clinical Correlates of TBI: Imaging, Biomarkers, and Clinical Phenotyping ParametersParticipants currently recruited/enrolled18-125 YearsCC Type
10-C-0174Related and Unrelated Donor Hematopoietic Stem Cell Transplant for DOCK8 DeficiencyParticipants currently recruited/enrolled4-125 YearsNCI Type
10-C-0086Comprehensive Omics Analysis of Pediatric Solid Tumors and Establishment of a Repository for Related Biological StudiesParticipants currently recruited/enrolled0-125 YearsNCI Type
10-C-0066A Study of Hairy Cell and other Leukemias with a Focus on Recombinant Immunotoxins for Cancer TreatmentParticipants currently recruited/enrolled18-125 YearsNCI Type
10-C-0056A Phase I Study of Indenoisoquinolines LMP400 and LMP776 in Adults With Relapsed Solid Tumors and LymphomasCompleted Study; data analyses ongoing18-125 YearsNCI Type
10-C-0025Randomized Phase II Trial of Rituximab with Either Pentostatin or Bendamustine for Multiply Relapsed or Refractory Hairy Cell LeukemiaParticipants currently recruited/enrolled18-125 YearsNCI Combined
09-N-0010Biomarkers of Risk of Parkinson DiseaseCompleted Study; data analyses ongoing18-70 YearsNINDSType
09-M-0176Functional Relevance of Dopamine Receptors in Healthy Controls and Patients with Schizophrenia: Characterization through [11C]NNC-112 and [18F]Fallypride Positron Emission TomographyParticipants currently recruited/enrolled18-90 YearsNIMH Type
09-I-0232FLU 003 Plus: An International Observational Study to Characterize Adults Who Are Hospitalized with Influenza or Other Targeted Respiratory VirusesParticipants currently recruited/enrolled18-125 YearsNIAIDType
09-I-0200A Phase I Study of MozobilTM in the Treatment of Patients with WHIMSParticipants currently recruited/enrolled18-75 YearsNIAIDLung
09-I-0133Establishing Fibroblast-derived Cell Lines from Skin/Tissue Biopsies of Patients with Immunodeficiency or Immunodysregulation DisordersEnrolling by Invitation2-85 YearsNIAIDCombined
09-I-0102Etiology, Pathogenesis, and Natural History of Idiopathic CD4+ LymphocytopeniaParticipants currently recruited/enrolled18-125 YearsNIAIDType
09-I-0013Biomarkers of Inflammation, Coagulation, and Endothelial Function in HIV-Infected AdultsEnrolling by Invitation18-100 YearsNIAIDCombined
09-H-0172Natural History of BronchiectasisParticipants currently recruited/enrolled5-125 YearsNHLBILung
09-DK-0097Vitamin E Pharmacokinetics and Biomarkers in Normal and Obese WomenCompleted Study; data analyses ongoing18-55 YearsNIDDKType
09-C-0192Phase II Study of Cediranib (AZD2171) in Patients With Alveolar Soft Part SarcomaNo longer recruiting/follow-up only0-125 YearsNCI Type
09-C-0161Follow-Up Protocol for Subjects Previously Enrolled on NCI Surgery Branch StudiesEnrolling by Invitation18-125 YearsNCI Carcinoma
09-C-0100A Pilot Study of High Dose Rate Brachytherapy in The Radiation Oncology BranchParticipants currently recruited/enrolled18-125 YearsNCI Type
09-C-0025Phase II Trial of LMB-2, Fludarabine and Cyclophosphamide for Adult T-Cell LeukemiaNo longer recruiting/follow-up only18-125 YearsNCI Type
09-C-0024A Phase I Study of Quadrivalent Human Papilloma Virus (HPV) (Types 6, 11, 16, 18) Recombinant Vaccine in HIV-Infected and HIV-Negative Pre-Adolescents, Adolescents and Young AdultsCompleted Study; data analyses ongoing12-26 YearsNCI Type
09-C-0019A Phase I Study of Dasatinib in Combination with Bevacizumab in Advanced Solid TumorsCompleted Study; data analyses ongoing18-125 YearsNCI Type
08-N-0044A Prospective Natural History Study of Patients with Neurofibromatosis Type 2 (NF2).Participants currently recruited/enrolled8-75 YearsNINDSType
08-H-0046Co-Infusion of Umbilical Cord Blood and Haploidentical CD34+ Cells Following Nonmyeloablative Conditioning as Treatment for Severe Aplastic Anemia and MDS Associated with Severe Neutropenia Refractory to Immunosuppressive TherapyCompleted Study; data analyses ongoing4-75 YearsNHLBIType
08-CC-0133Response and Adaptation to Aerobic Exercise in Patients with Pulmonary Hypertension: Initial Studies for Establishing GuidelinesCompleted Study; data analyses ongoing21-82 YearsCC Lung
08-C-0130A Phase II Trial of Peginterferon alfa-2b (PEG-Intron) for Neurofibromatosis Type 1 Related Unresectable, Symptomatic or Life-Threatening Plexiform NeurofibromasCompleted Study; data analyses ongoing0-21 YearsNCI Type
07-N-0122Modulation of Motor Function by Stimulation of the Central and Peripheral Nervous SystemCompleted Study; data analyses ongoing18-125 YearsNINDSType
07-H-0142Research Respiratory Tract ProceduresParticipants currently recruited/enrolled10-125 YearsNHLBILung
07-H-0113Procurement and Analysis of Blood, Bone Marrow, and Buccal Mucosa Samples from Healthy Volunteers to Support Clinical and Translational Research Projects in the NHLBIParticipants currently recruited/enrolled8-125 YearsNHLBILung
07-DK-0115Natural History of Type 2 Diabetes Mellitus in Children and Young AdultsCompleted Study; data analyses ongoing8-25 YearsNIDDKType
07-DK-0077Study of the Phenotype of Overweight and Obese AdultsParticipants currently recruited/enrolled18-100 YearsNIDDKType
07-C-0110Analysis of Stored Data Collected from Individuals Administered Neurobehavioral Assessments on IRB-Approved ProtocolsEnrolling by Invitation0-125 YearsNCI Type
06-I-0015Screening Protocol for Genetic Diseases of Lymphocyte Homeostasis and Programmed Cell DeathParticipants currently recruited/enrolled0-125 YearsNIAIDType
06-H-0217Genetic Disorders of Mucociliary ClearanceCompleted Study; data analyses ongoing2-65 YearsNHLBILung
06-H-0072Atorvastatin as a Disease Modifying Agent in Stage II and III Pulmonary Sarcoidosis: A Randomized, Double-Blind, Placebo-Controlled TrialCompleted Study; data analyses ongoing18-70 YearsNHLBILung
06-CH-0186Evaluation of Biochemical Markers and Clinical Investigation of Niemann-Pick Disease, Type CParticipants currently recruited/enrolled0-125 YearsNICHDType
06-CH-0011Natural History Study of Patients with Excess AndrogenParticipants currently recruited/enrolled0-99 YearsNICHDType
06-C-0134Natural History and Biology of Dermal Neurofibromas in Neurofibromatosis Type 1Completed Study; data analyses ongoing20-99 YearsNCI Type
06-C-0014Prospective Evaluation of Genetic and Epigenetic Alterations in Patients with Thoracic MalignanciesParticipants currently recruited/enrolled2-125 YearsNCI Lung
06-AR-0198A Pilot Pediatric/Adult Study of Gene Expression Profiling and Clinical Characterization of PhototoxicityCompleted Study; data analyses ongoing8-100 YearsNIAMSType
05-H-0130Long-Term Evaluation and Follow Up Care of Patients Treated with Allogeneic Stem Cell TransplantsParticipants currently recruited/enrolled7-80 YearsNHLBILung
05-CC-0216Prospective Assessment of Functional Status, Psychosocial Adjustment, Health Related Quality of Life and the Symptom Experience in Patients Treated with Allogeneic Hematopoietic Stem Cell TransplantationCompleted Study; data analyses ongoing18-125 YearsCC Type
05-CC-0091Electromagnetic Tracking of Devices During Interventional ProceduresEnrolling by Invitation18-125 YearsCC Carcinoma
05-CC-0041Endothelial Cell Dysfunction in Pulmonary Arterial Hypertension: Biomarkers, Mechanisms of Disease and Novel Therapeutic TargetsCompleted Study; data analyses ongoing18-125 YearsCC Lung
05-C-0152Variation in Gene Expression in Neurofibromatosis Type 1Completed Study; data analyses ongoing2-100 YearsNCI Type
04-I-0286A Longitudinal Study of Familial Hypereosinophilia (FE): Natural History and Markers of Disease ProgressionParticipants currently recruited/enrolled1-100 YearsNIAIDType
04-HG-0211Analysis of Specimens from Individuals with Pulmonary FibrosisParticipants currently recruited/enrolled18-125 YearsNHGRILung
04-DK-0021Urinary Vitamin C Loss in Subjects with and without DiabetesParticipants currently recruited/enrolled18-65 YearsNIDDKType
04-C-0275Targeted Oncolytic Virotherapy and Natural History Study of KSHV-Associated Multicentric Castleman's Disease with Laboratory and Clinical Correlates of Disease ActivityNo longer recruiting/follow-up only18-125 YearsNCI Combined
04-C-0232A Multi-Institutional Study of Proteomic Evaluation of Epithelial Ovarian Cancer, Primary Peritoneal Cancer, and Fallopian Tube Cancer Patients in First Clinical Remission: Development of a Protein Fingerprint Profile of RelapseCompleted Study; data analyses ongoing18-125 YearsNCI Type
04-C-0200Urinary and Serum VEGF and MMP Levels in Patients Receiving Radiation Therapy for Glioblastoma Multiforme: Prospective Determination of a Predictive Value for RecurrenceParticipants currently recruited/enrolled18-125 YearsNCI Type
04-C-0102Hematologic Malignancy Biology StudyEnrolling by Invitation1-75 YearsNCI Type
03-I-0263VRC 200: A Multicenter Specimen Collection Protocol to Obtain Human Biological Samples for Research StudiesParticipants currently recruited/enrolled18-125 YearsNIAIDType
03-H-0280Disease Pathogenesis and Natural History of Lipid DisordersParticipants currently recruited/enrolled2-100 YearsNHLBIType
03-H-0105The Determination of Genetic Basis Of ImmunodeficiencyParticipants currently recruited/enrolled0-125 YearsNHLBICombined
03-E-0099Pathogenic Studies In Families With Twins Or Siblings Discordant For Systemic Rheumatic DisordersCompleted Study; data analyses ongoing2-125 YearsNIEHSType
03-DK-0257Phase II Trial of Effect of Metreleptin Therapy in Severe Insulin ResistanceNo longer recruiting/follow-up only5-125 YearsNIDDKType
03-DK-0256Inhibition of Intestinal Glucose Absorption by the Bioflavonoid Quercetin in the Obese and in Obese Type 2 DiabeticsCompleted Study; data analyses ongoing18-65 YearsNIDDKType
03-C-0278A Comparative Study of Pediatric CNS Tumor Activity as Assessed by 18F-FDG PET Imaging and Proton Magnetic Resonance Spectroscopic Imaging (1H-MRSI)Completed Study; data analyses ongoing1-21 YearsNCI Type
03-C-0277Cell Harvest and Preparation for Surgery Branch Adoptive Cell Therapy ProtocolsEnrolling by Invitation18-125 YearsNCI Lung
03-C-0066Hereditary Leiomyomatosis Renal Cell Cancer (HLRCC): Identification of the Disease Gene, and Characterization of the Predisposition to Renal CancerParticipants currently recruited/enrolled2-125 YearsNCI Type
03-AG-0325The Baltimore Longitudinal Study of Aging(BLSA)Participants currently recruited/enrolled20-125 YearsNIA Lung
02-I-0110Natural History of Anthrax: A Study of Primary Infected, Recovered, and Exposed (SPoRE) Individuals and Evaluation of AVA Vaccinated RecipientsParticipants currently recruited/enrolled3-125 YearsNIAIDLung
02-I-0086Evaluation of Viral Factors and Immune Parameters to Study HIV-Specific ImmunityParticipants currently recruited/enrolled18-125 YearsNIAIDType
02-H-0250A Phase I/II Study of HLA-matched Mobilized Peripheral Blood Hematopoietic Stem Cell Transplantation for Advanced Mycosis Fungoides/Sezary Syndrome Using Nonmyeloablative Conditioning with Campath-1HCompleted Study; data analyses ongoing18-125 YearsNHLBILung
02-DK-N304Diabetes Prevention Program Outcomes Study (DPPOS)No longer recruiting/follow-up only25-125 YearsNIDDKType
02-C-0313Cancer Risk in Xeroderma Pigmentosum HeterozygotesParticipants currently recruited/enrolled0-99 YearsNCI Carcinoma
02-C-0211Clinical, Laboratory, and Epidemiologic Characterization of Individuals and Families at High Risk of MelanomaParticipants currently recruited/enrolled2-125 YearsNCI Type
02-C-0179Biospecimen Acquisition from Human SubjectsParticipants currently recruited/enrolled18-125 YearsNCI Lung
02-C-0064Collection of Peripheral Blood and/or Urine From Patients Undergoing Radiation TherapyEnrolling by Invitation18-125 YearsNCI Carcinoma
02-C-0052Etiologic Investigation of Cancer Susceptibility in Inherited Bone Marrow Failure Syndromes: A Natural History StudyParticipants currently recruited/enrolled0-125 YearsNCI Type
01-M-0185Effects of Arousal and Stress on Classical ConditioningCompleted Study; data analyses ongoing18-50 YearsNIMH Type
01-I-0238Host Response to Infection and Treatment in Leishmania Infection of HumansParticipants currently recruited/enrolled3-100 YearsNIAIDType
01-I-0202Natural History, Genetics, Phenotype, and Treatment of Mycobacterial InfectionsParticipants currently recruited/enrolled0-100 YearsNIAIDLung
01-HG-0109Natural History Study of the Clinical and Molecular Manifestations of Smith-Magenis Syndrome (SMS)No longer recruiting/follow-up only0-125 YearsNHGRIType
01-H-0122Collection and Storage of Umbilical Cord Hematopoietic Stem Cells for Sickle Cell Disease TherapyParticipants currently recruited/enrolled18-45 YearsNHLBIType
01-H-0088Determining the Prevalence and Prognosis of Secondary Pulmonary Hypertension in Adult Patients with Sickle Cell AnemiaCompleted Study; data analyses ongoing18-125 YearsNHLBILung
01-DK-N117Family Investigation of Nephropathy and Diabetes (F.I.N.D.)Clinical hold/Recruitment or enrollment suspended18-125 YearsNIDDKType
01-C-0129Eligibility Screening for the NIH Intramural Research Program Clinical ProtocolsEnrolling by Invitation0-125 YearsNCI Lung
01-AR-0227Studies of the Natural History of Rheumatic Disease in Minority CommunitiesParticipants currently recruited/enrolled18-100 YearsNIAMSLung
00-N-0089Genetic Analysis of the Chiari I MalformationCompleted Study; data analyses ongoing1-125 YearsNINDSType
00-HG-0209Molecular and Clinical Studies of Primary Immunodeficiency DiseasesNo longer recruiting/follow-up only3-125 YearsNHGRILung
00-H-0051Cutaneous Tumorigenesis in Patients with Tuberous SclerosisParticipants currently recruited/enrolled18-90 YearsNHLBILung
00-CH-0160Clinical and Molecular Analysis of ACTH-Independent Steroid Hormone Production in Adrenocortical TissueCompleted Study; data analyses ongoing3-70 YearsNICHDType
00-C-0074Evaluation of Late Effects and Natural History of Disease in Patients Treated with RadiotherapyParticipants currently recruited/enrolled18-125 YearsNCI Combined
99-I-0084Studies of Human Pneumocystis InfectionParticipants currently recruited/enrolled3-99 YearsNIAIDLung
99-H-0076Asthma Sample Collection ProtocolParticipants currently recruited/enrolled18-125 YearsNHLBILung
99-C-0128Evaluation for NCI Surgery Branch Clinical Research ProtocolsParticipants currently recruited/enrolled18-125 YearsNCI Lung
98-N-0047Immuno-Virological Evaluation of Human T Cell Leukemia Virus Type-1 Associated Myelopathy (HAM/TSP)Participants currently recruited/enrolled18-125 YearsNINDSType
98-CH-0081Clinical and Basic Investigations into Smith-Lemli-Opitz SyndromeCompleted Study; data analyses ongoing0-125 YearsNICHDLung
97-H-0041Screening Protocol for Subjects Being Evaluated for National Heart, Lung and Blood Institute (NHLBI) ProtocolsEnrolling by Invitation2-125 YearsNHLBILung
97-CH-0064Evaluation and Intervention for Ambulation, Growth, and Basilar Invagination in Osteogenesis ImperfectaCompleted Study; data analyses ongoing0-10 YearsNICHDType
96-H-0100Role of Genetic Factors in the Pathogenesis of Lung DiseaseParticipants currently recruited/enrolled2-90 YearsNHLBILung
95-I-0066Genetic Analysis of Immune DisordersParticipants currently recruited/enrolled0-125 YearsNIAIDType
95-I-0027Virologic and Immunologic Evaluation of Lymph Node, Tonsillar and Intestinal Biopsies, and Bronchoalveolar Lavage FluidParticipants currently recruited/enrolled18-125 YearsNIAIDLung
95-HG-0193Clinical and Basic Investigations into Hermansky-Pudlak SyndromeParticipants currently recruited/enrolled0-125 YearsNHGRILung
95-H-0186Characterization of the Pathogenesis of Lymphangioleiomyomatosis (LAM)Participants currently recruited/enrolled16-125 YearsNHLBILung
94-E-0165Studies in the Natural History and Pathogenesis of Childhood-Onset and Adult-Onset Idiopathic Inflammatory MyopathiesParticipants currently recruited/enrolled2-100 YearsNIEHSLung
94-C-0074Treatment and Natural History Study of Lymphomatoid GranulomatosisParticipants currently recruited/enrolled12-125 YearsNCI Lung
93-I-0119Detection and Characterization of Host Defense DefectsParticipants currently recruited/enrolled0-125 YearsNIAIDLung
92-CH-0034Studies of Growth Deficiency and Growth Hormone Treatment in Children with Osteogenesis Imperfecta Types III and IVCompleted Study; data analyses ongoing3-16 YearsNICHDType
91-I-0140Studies of the Pathogenesis of HIV Infection in Human Peripheral Blood Cells and/or Body Fluids in HIV-Infected and HIV-Uninfected VolunteersParticipants currently recruited/enrolled18-125 YearsNIAIDType
91-AR-0196Studies on the Natural History and Pathogenesis of Polymyositis, Dermatomyositis, and Related DiseasesParticipants currently recruited/enrolled16-125 YearsNIAMSLung
89-N-0045Evaluation of Progression in Multiple Sclerosis by Magnetic Resonance Imaging (MRI)Participants currently recruited/enrolled18-125 YearsNINDSCombined
89-I-0158Studies of Immune Regulation in Patients with Common Variable Immunodeficiency and Related Humoral Immunodeficiency SyndromesParticipants currently recruited/enrolled2-125 YearsNIAIDLung
89-C-0086Von Hippel-Lindau (VHL): Clinical Manifestations, Diagnosis, Management and Molecular Bases of Inherited Renal and Other Urologic Malignant DisordersParticipants currently recruited/enrolled2-125 YearsNCI Carcinoma
88-CH-0032Specificity of Mother-Infant Interaction: The Influence of Maternal Age, Employment Status, and Parenthood StatusCompleted Study; data analyses ongoing0-23 YearsNICHDType
82-I-0183A Natural History Study of the Immune Regulation of Idiopathic Inflammatory Bowel Diseases: Crohn's Disease, Ulcerative Colitis, and Other Inflammatory Conditions of the GutParticipants currently recruited/enrolled0-75 YearsNIAIDType
81-I-0164Procedures to Obtain Plasma, Lymphocytes, or Other Specimens for Research StudiesParticipants currently recruited/enrolled18-125 YearsNIAIDType
79-H-0100Teaching Protocol for the Evaluation of Plasma LipoproteinsNo longer recruiting/follow-up only2-99 YearsNHLBIType
79-C-0111The Treatment of Stage I and II Carcinoma of the Breast with Mastectomy and Axillary Dissection vs. Excisional Biopsy Axillary Dissection, and Definitive IrradiationCompleted Study; data analyses ongoing18-125 YearsNCI Carcinoma
78-C-0039Clinical, Laboratory, and Epidemiologic Characterization of Individuals and Families at High Risk of CancerNo longer recruiting/follow-up only0-125 YearsNCI Type
76-DK-0006Natural History of Disorders of Insulin ResistanceParticipants currently recruited/enrolled0-125 YearsNIDDKType
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