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444 Studies found from all possible combinations of your search terms. Select a protocol that you wish to review.
Protocol Number
Title
Protocol Status
Min-Max Age
Institute
Keywords
001109-C
Defining the Natural History of Squamous Cell Carcinoma in Fanconi Anemia
Participants currently recruited/enrolled
8-125 Years
NCI
Long Syndrome
001058-DK
A Phase 1b/2a Open-label Multiple-ascending Dose Exploratory Study of CRN04894 in ACTH-dependent Cushing's Syndrome (Cushing's Disease or Ectopic ACTH Syndrome)
Recruitment has not started
18-75 Years
NIDDK
Long Syndrome
000821-I
An Open-Label, Single-Arm, Phase 1/2 Dose-Escalation Trial of Long-Acting Recombinant Human IL-7 (NT-I7, Efineptakin Alfa) for Idiopathic CD4 Lymphopenia
Recruitment has not started
18-75 Years
NIAID
Long Syndrome
000387-H
The Natural History of Acquired and Inherited Bone Marrow Failure Syndromes.
Participants currently recruited/enrolled
2-125 Years
NHLBI
Long Syndrome
000344-DK
Natural History Study of Parathyroid Disorders
Participants currently recruited/enrolled
0-125 Years
NIDDK
Long Syndrome
000137-CH
Implications of Maternal 45,X Mosaicism As A Secondary Genomic Finding Following Cell-free DNA Sequencing During Pregnancy: A Deep Phenotype Study
Recruitment has not started
18-99 Years
NICHD
Long Syndrome
20-I-0117
Surveillance of Individuals Following SARS-CoV-2 infection
Completed Study; data analyses ongoing
18-125 Years
NIAID
Long Syndrome
19-CH-0051
Long-Term Follow-UP of Survivors of Pediatric Cushing Disease
Participants currently recruited/enrolled
2-90 Years
NICHD
Long Syndrome
17-CH-0078
Setmelanotide (RM-493; Rhythm Pharmaceuticals, Inc.) Phase 2 Open-Label Treatment Trials in Patients with Rare Genetic Disorders of Obesity
No longer recruiting/follow-up only
6-100 Years
NICHD
Long Syndrome
16-N-0058
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Completed Study; data analyses ongoing
18-60 Years
NINDS
Long Syndrome
16-I-0165
An open-label, non-randomized extension study to evaluate the long term safety, tolerability, efficacy and pharmacokinetics of CDZ173 (leniolisib) in patients with APDS/PASLI (Activated phosphoinositide 3-kinase delta syndrome/p110 delta-activating mutat
No longer recruiting/follow-up only
12-75 Years
NIAID
Long Syndrome
15-I-0162
Natural History and Genetics of Food Allergy and Related Conditions
Participants currently recruited/enrolled
0-99 Years
NIAID
Long Syndrome
15-I-0135
An open-label, non-randomized, within-patient dose-finding study followed by a randomized, subject, investigator and sponsor-blinded placebo controlled study to assess the efficacy and safety of CDZ173 (leniolisib) in patients with APDS/PASLI (Activated
Completed Study; data analyses ongoing
12-75 Years
NIAID
Long Syndrome
14-C-0161
Phase I Trial of the Combination of Bortezomib and Clofarabine in Adults with Refractory Solid Tumors, Lymphomas, or Myelodysplastic Syndromes
Participants currently recruited/enrolled
18-125 Years
NCI
Long Syndrome
11-I-0187
The Natural History and Pathogenesis of Human Fungal Infections
Participants currently recruited/enrolled
0-99 Years
NIAID
Long Syndrome
11-CC-0152
The Natural History of Liver Disease in a Cohort of Participants with Hepatitis B and/or Hepatitis C with or without HIV Infection
Completed Study; data analyses ongoing
18-99 Years
CC
Long Syndrome
09-I-0200
A Phase I Study of MozobilTM in the Treatment of Patients with WHIMS
Participants currently recruited/enrolled
18-75 Years
NIAID
Long Syndrome
09-I-0184
Studies in the Pathogenesis of Systemic Capillary Leak Syndrome
Participants currently recruited/enrolled
0-125 Years
NIAID
Long Syndrome
09-DK-0223
Rituximab Plus Cyclosporine in Idiopathic Membranous Nephropathy
Participants currently recruited/enrolled
18-125 Years
NIDDK
Long Syndrome
08-H-0046
Co-Infusion of Umbilical Cord Blood and Haploidentical CD34+ Cells Following Nonmyeloablative Conditioning as Treatment for Severe Aplastic Anemia and MDS Associated with Severe Neutropenia Refractory to Immunosuppressive Therapy
Completed Study; data analyses ongoing
4-75 Years
NHLBI
Long Syndrome
04-I-0286
A Longitudinal Study of Familial Hypereosinophilia (FE): Natural History and Markers of Disease Progression
Participants currently recruited/enrolled
1-100 Years
NIAID
Long Syndrome
03-CC-0060
Virtual Function Anatomy (VFA)
Participants currently recruited/enrolled
5-95 Years
CC
Long Syndrome
03-AR-0173
Studies of Natural History, Pathogenesis, and Outcomes in Autoimmune and Inflammatory Diseases Including Juvenile Dermatomyositis
Participants currently recruited/enrolled
2-125 Years
NIAMS
Long Syndrome
02-C-0212
Clinical, Genetic, Behavioral, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Breast/Ovarian Cancer
Completed Study; data analyses ongoing
18-100 Years
NCI
Long Syndrome
00-I-0159
Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES)
Participants currently recruited/enrolled
0-125 Years
NIAID
Long Syndrome
93-I-0086
Evaluation and Long-Term Follow-Up of Patients with Acute or Chronic Inflammatory Disorders
Enrolling by Invitation
2-125 Years
NIAID
Long Syndrome
93-I-0063
Study of the Immunopathogenesis, Natural History, and Genetics of Autoimmune Lymphoproliferative Syndrome (ALPS) Associated with an Expansion of CD4-8-/TCR alpha/beta+ T Cells
Participants currently recruited/enrolled
0-99 Years
NIAID
Long Syndrome
89-I-0158
Studies of Immune Regulation in Patients with Common Variable Immunodeficiency and Related Humoral Immunodeficiency Syndromes
Participants currently recruited/enrolled
2-125 Years
NIAID
Long Syndrome
001180-CC
A Phase I/II Trial Evaluating Long-Term Use of a Pediatric Robotic Exoskeleton (P.REX/Agilik) to Improve Gait in Children with Movement Disorders
Participants currently recruited/enrolled
3-17 Years
CC
Long
001099-C
A Phase 1/2, First-in-Human, Open-Label, Dose Escalation and Expansion Study of STAR0602, a Selective T Cell Receptor (TCR)-Targeting, Bifunctional Antibody-Fusion Molecule, in Subjects with Unresectable, Locally Advanced, or Metastatic Solid Tumors that
Participants currently recruited/enrolled
18-125 Years
NCI
Long
001084-CH
A Prospective Natural History Study of Lymphatic Anomalies
Participants currently recruited/enrolled
0-125 Years
NICHD
Long
001078-I
Phase 1 Trial to Model Primary, Secondary, and Tertiary Dengue Using a Monovalent Vaccine
Participants currently recruited/enrolled
18-59 Years
NIAID
Long
001061-H
Observational Study Investigating the Mechanistic Effects of Mitapivat in Subjects with Sickle Cell Disease
Enrolling by Invitation
16-125 Years
NHLBI
Syndrome
001056-C
Longitudinal Early Advance Care Planning Discussions and Documentation (LEADD) Program: An Exploratory Study in Adolescents and Young Adults (AYAs) Receiving Hematopoietic Stem Cell Transplant
Participants currently recruited/enrolled
18-125 Years
NCI
Long
001043-I
Evaluating the Genetics and Immunology of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome and Other Tonsil Disorders
Recruitment has not started
0-125 Years
NIAID
Syndrome
001037-I
A Randomized Placebo-controlled Study to Evaluate the Safety and Effects of Repeated Doses of 3BNC117-LS and 10-1074-LS on Persistent Viral Reservoirs in People Living with HIV and on Suppressive Antiretroviral Therapy
Participants currently recruited/enrolled
18-70 Years
NIAID
Long
001018-CH
Establishment of Genomic and Phenotypic Database for Niemann-Pick Disease, Type C
Participants currently recruited/enrolled
0-125 Years
NICHD
Long
001004-C
A Phase 1b/2 Basket Study of ACR-368 as Monotherapy and in Combination with Gemcitabine in Adult Subjects with Platinum-Resistant Ovarian Carcinoma, Endometrial Adenocarcinoma, and Urothelial Carcinoma Based on Acrivon Oncosignature (R) Status
Participants currently recruited/enrolled
18-120 Years
NCI
Long
000975-C
Collection of Blood, Bone Marrow, Skin, Saliva, and Stool Samples from Healthy Volunteers Used for Comparative Analysis of Myeloid Malignancies
Participants currently recruited/enrolled
18-125 Years
NCI
Syndrome
000954-C
A Phase 1/2 Single Arm Open-Label Clinical Trial of TC-510 In Patients with Advanced Mesothelin-Expressing Cancer
Participants currently recruited/enrolled
18-125 Years
NCI
Long
000942-M
A Cognitive Test Battery for Intellectual Disabilities
Participants currently recruited/enrolled
4-125 Years
NIMH
Syndrome
000908-DK
Peripheral Blood and Urine Immune Cell Phenotyping in Membranous Nephropathy using FACS and Single Cell RNA-seq
Participants currently recruited/enrolled
18-125 Years
NIDDK
Syndrome
000871-CC
Mediterranean-like Unprocessed (CLEAN-MED) Diet Intervention Study of the Gut Microbiome of Healthy Adults
Participants currently recruited/enrolled
18-60 Years
CC
Long
000862-CH
Pilot Study of the Use of Functional Near-Infrared Spectroscopy (fNIRS) Combined with Diffuse Correlation Spectroscopy (DCS) in Neurocognitive Disease as Compared to Healthy Neurotypical Controls
Participants currently recruited/enrolled
0-125 Years
NICHD
Syndrome
000809-I
A Pilot Study of Fecal Microbiota Transplantation for Chronic Granulomatous Disease-Associated Colitis
Participants currently recruited/enrolled
10-60 Years
NIAID
Long
000798-D
A Phase 2 Study of Burosumab for Fibroblast Growth Factor-23 Mediated Hypophosphatemia in Fibrous Dysplasia
Participants currently recruited/enrolled
1-125 Years
NIDCR
Syndrome
000784-N
Assessing and Improving Quantitative Magnetic Resonance Imaging Metrics in Human Subjects
Participants currently recruited/enrolled
18-125 Years
NINDS
Long
000783-C
Phase I/Ib Trial Evaluating the Safety and Efficacy of BET Inhibitor, ZEN003694 with PD-1 Inhibitor, Nivolumab with or without CTLA-4 Inhibitor, Ipilumumab in Solid Tumors
Participants currently recruited/enrolled
18-125 Years
NCI
Long
000780-D
A Phase 2 Study of Denosumab for Prevention of Skeletal Disease Progression in Children with Fibrous Dysplasia
Participants currently recruited/enrolled
4-14 Years
NIDCR
Syndrome
000760-H
Extension Study (extended access) of Syk-inhibition Using Fostamatinib to Treat Post-Transplant Immune-mediated Cytopenias
Enrolling by Invitation
18-75 Years
NHLBI
Long
000756-DK
Phase II Study of Growth Hormone Inhibition Using Pegvisomant In Severe Insulin Resistance
Participants currently recruited/enrolled
18-65 Years
NIDDK
Syndrome
000748-DK
Analysis of the Utility of Polygenic Scores for Prediction of Incident Type 2 Diabetes Across Multiple Ancestry Groups
No longer recruiting/follow-up only
0-125 Years
NIDDK
Long
000744-HG
Development of Virtual Reality-based Interventions to Strengthen Cognitive Skillsets Related to Attention Deficit Hyperactivity Disorder (ADHD): A Randomized Controlled Phase II Trial
Recruitment has not started
7-14 Years
NHGRI
Long
000740-CH
A Phase 3 Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Chronocort in the Treatment of Participants Aged 16 Years and Over with Congenital Adrenal Hyperplasia
Enrolling by Invitation
18-125 Years
NICHD
Long
000736-CC
Imaging Characterization of the Biomechanical Coupling of Brain and Skull: An Observational Study
Participants currently recruited/enrolled
21-65 Years
CC
Long
000732-C
A Long-Term Follow-Up Study of Patients Who Received VOR33
Recruitment has not started
18-125 Years
NCI
Long
000726-C
A Randomized Phase 2 Study of Atezolizumab with or without Selinexor in Alveolar Soft Part Sarcoma (AXIOM)
Participants currently recruited/enrolled
18-125 Years
NCI
Long
000715-CH
Biorepository in Participants Who Undergo OTC for Gonadotoxic Therapy
Participants currently recruited/enrolled
4-35 Years
NICHD
Long
000711-N
Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2 (IN-PASC)
Enrolling by Invitation
18-125 Years
NINDS
Long
000697-H
U01 Cooperative Assessment of Late Effects for SCD Curative Therapies (COALESCE)
Participants currently recruited/enrolled
18-65 Years
NHLBI
Long
000688-I
Longitudinal Observations of Vaccine Responses to SARS-CoV-2 and other Emerging Infectious Diseases
Participants currently recruited/enrolled
18-125 Years
NIAID
Long
000661-C
Comprehensive Molecular and Clinical Evaluation of Pediatric and Adult Myelodysplastic Syndromes (MDS)
Participants currently recruited/enrolled
0-125 Years
NCI
Syndrome
000647-C
An Open-label, Multicenter Follow-up Study to Collect Long-term Data on Participants from Multiple Bintrafusp alfa (M7824) Clinical Studies
Recruitment has not started
18-125 Years
NCI
Long
000617-DK
A Natural History Study of Metabolic Sizing in Health and Disease
Participants currently recruited/enrolled
10-125 Years
NIDDK
Long
000580-C
A Phase 1/2, Open Label Dose-Escalation and Expansion Trial of Nkt2152, an Orally Administered Hif2a Inhibitor, to Investigate Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity in Patients with Advanced Clear Cell Renal Cell Carcinoma
Participants currently recruited/enrolled
18-125 Years
NCI
Long
000577-HG
Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African Americans Study (GENEFORECAST): Prospective COVID-19 Natural History Study
Participants currently recruited/enrolled
21-125 Years
NHGRI
Long
000567-C
Phase 1 Trial of Gemcitabine Combined with the BAY 1895344 ATR Inhibitor with Expansion Cohorts in Advanced Pancreatic and Ovarian Cancer
Participants currently recruited/enrolled
18-125 Years
NCI
Long
000516-C
Phase 1 Study of Venetoclax, Ibrutinib, Prednisone, Obinutuzumab, and Revlimid (VIPOR) for Diffuse Large B-cell Lymphoma involving the Central Nervous System
Participants currently recruited/enrolled
18-125 Years
NCI
Long
000509-C
An Open Label, Multi-Center Roll-Over Study to Assess Long-Term Safety in Patients Who are Ongoing or Have Completed a Prior Global Novartis or GSK Sponsored Tafinlar (Dabrafenib) and/or Mekinist (Trametinib) Study and are Judged by the Investigator to B
Enrolling by Invitation
18-125 Years
NCI
Long
000494-DK
Natural History of Fontan Associated Liver Disease and the Evaluation of Biomarkers for Disease Severity Assessment
Participants currently recruited/enrolled
18-125 Years
NIDDK
Long
000491-C
Tissue Procurement and Natural History Study of Neuroendocrine Neoplasms (NENs) Including Adrenocortical Carcinoma (ACC)
Participants currently recruited/enrolled
18-125 Years
NCI
Long
000489-C
Phase I/II Study Using Prophylactic Donor Lymphocyte Infusion Early Post-Transplant After Allogeneic Hematopoietic Cell Transplantation Using Post-Transplantation Cyclophosphamide for High-Risk Hematologic Malignancies
Clinical hold/Recruitment or enrollment suspended
12-125 Years
NCI
Syndrome
000487-CH
Natural History Investigation into Biochemical and Phenotypical Aspects of Smith-Lemli-Opitz Syndrome and Related Disorders of Cholesterol Metabolism
Participants currently recruited/enrolled
0-125 Years
NICHD
Syndrome
000481-C
Phase II Trial of 18F-DCFPyL Imaging as a Method to Assess Treatment Response to Stereotactic Body Radiation Therapy
Participants currently recruited/enrolled
18-125 Years
NCI
Long
000478-C
A Phase I/II Trial of Allogeneic Reduced-Intensity, HLA-Haploidentical Bone Marrow Transplantation Followed by GVHD Prophylaxis with Cyclophosphamide, Bortezomib and Maraviroc for Hematologic Malignancies in People Living with HIV (PLWH)
Participants currently recruited/enrolled
12-125 Years
NCI
Long
000473-C
A Randomized Phase II Study of Systemic Chemotherapy with or without HAI FUDR-Dexamethasone in Patients with Unresectable Intrahepatic Cholangiocarcinoma
Participants currently recruited/enrolled
18-125 Years
NCI
Long
000441-E
Women's Health Awareness Community Resiliency, Environmental Action and Collaborations for Health (REACH) Equity
Participants currently recruited/enrolled
18-125 Years
NIEHS
Long
000421-AA
Individual Variations of Taste and Smell Perception in Alcohol Use Disorder (AUD)
Recruitment has not started
18-65 Years
NIAAA
Long
000404-C
A Phase II Study of Allogeneic Hematopoietic Stem Cell Transplant for Subjects with VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Participants currently recruited/enrolled
18-75 Years
NCI
Syndrome
000356-C
A Phase I/II Trial of BMS-986253 in Myelodysplastic Syndromes
Participants currently recruited/enrolled
18-125 Years
NCI
Syndrome
000343-H
Detection of T cell Somatic Mutations in Bone Marrow Failure Using Whole Exome or Targeted Sequencing
Enrolling by Invitation
18-99 Years
NHLBI
Syndrome
000337-C
Natural History Study of KSHV-Associated Multicentric Castleman's Disease
Participants currently recruited/enrolled
18-125 Years
NCI
Long
000317-C
A Phase II, Open-Label Trial of PT-112 in Subjects with Thymoma and Thymic Carcinoma
Participants currently recruited/enrolled
18-125 Years
NCI
Long
000315-MD
A Prospective Natural History Study of COVID-19 Using Digital Wearables
Participants currently recruited/enrolled
18-65 Years
NIMHD
Long
000281-I
Pilot Assessment To Find Evidence of Gastric Motility Abnormalities in Eosinophilic Gastric Disorders (OAT-FEED)
Participants currently recruited/enrolled
18-59 Years
NIAID
Long
000264-C
A Pharmacodynamics-Driven Trial of Talazoparib, an Oral PARP Inhibitor, in Patients With Advanced Solid Tumors and Aberrations in Genes Involved in DNA Damage Response
Participants currently recruited/enrolled
18-125 Years
NCI
Long
000247-DK
Evaluation of Patients with Gastrointestinal Disease
Participants currently recruited/enrolled
18-125 Years
NIDDK
Long
000226-I
Efficacy of Belimumab and Rituximab Compared to Rituximab Alone for the Treatment of Primary Membranous Nephropathy
Participants currently recruited/enrolled
18-75 Years
NIAID
Syndrome
000224-CH
Development of a Wearable Point of Care Monitoring Device for Pediatric Obstructive Sleep Apnea
Participants currently recruited/enrolled
3-12 Years
NICHD
Long
000201-I
Pediatric SARS-CoV-2 and MIS-C Long-term Follow-up
Participants currently recruited/enrolled
0-21 Years
NIAID
Long
000186-I
Part B- Phase I/II, Non-randomized, Multicenter, Open-label Study of G1XCGD (Lentiviral Vector Transduced CD34+ Cells) in Patients with X-Linked Chronic Granulomatous Disease
Clinical hold/Recruitment or enrollment suspended
3-12 Years
NIAID
Long
000176-C
A Phase I/II Trial of Lurbinectedin with Berzosertib, an ATR Kinase Inhibitor in Small Cell Cancers and High Grade Neuroendocrine Cancers
Participants currently recruited/enrolled
18-125 Years
NCI
Long
000144-C
A Phase I/II Study of Sacituzumab Govitecan plus Berzosertib in Small Cell Lung Cancer, Extra-Pulmonary Small Cell Neuroendocrine Cancer and Homologous Recombination-Deficient Cancers Resistant to PARP Inhibitors
Participants currently recruited/enrolled
18-125 Years
NCI
Long
000141-DC
Deep Phenotyping of Hearing Instability Disorders: Cohort Establishment, Biomarker Identification, Development of Novel Phenotyping Measures, and Discovery of Therapeutic Targets
Participants currently recruited/enrolled
18-80 Years
NIDCD
Syndrome
000134-I
A Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Trial of Intravenous Zotatifin in Adults with Mild or Moderate Coronavirus Disease 2019 (COVID-19)
Participants currently recruited/enrolled
18-125 Years
NIAID
Syndrome
000126-N
A Pilot Study of NT-I7, a Long-Acting Recombinant IL-7 Molecule, as an Immune Reconstitution Strategy for Lymphopenia in Patients with Progressive Multifocal Leukoencephalopathy
Participants currently recruited/enrolled
18-125 Years
NINDS
Long
000106-CH
Gonadal Tissue Freezing for Fertility Preservation in Individuals at risk for Ovarian Dysfunction and Premature Ovarian Insufficiency
Participants currently recruited/enrolled
4-21 Years
NICHD
Syndrome
000094-N
An Observational Study of Neurologic Function After COVID -19 Infection
No longer recruiting/follow-up only
18-125 Years
NINDS
Long
000092-C
Phase 1/2 study of Vincristine and Temozolomide in Combination with PEN-866 for Adolescents and Young Adults with Relapsed or Refractory Solid Tumors
Recruitment has not started
12-39 Years
NCI
Long
000057-C
A Phase 1 Study of AZD8186 in Combination with Docetaxel in Patients with PTEN Mutated or PIK3CB Mutated Advanced Solid Tumors, Potentially Amenable to Docetaxel
Completed Study; data analyses ongoing
18-125 Years
NCI
Long
000049-H
Evaluation of the Safety,Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects with Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of Mitapivat
No longer recruiting/follow-up only
18-70 Years
NHLBI
Long
000048-C
A Multi-Center Natural History Study of Precision-Based Genomics in Prostate Cancer
Participants currently recruited/enrolled
18-125 Years
NCI
Long
000045-C
A Phase I Trial of T Cell Receptor Gene Therapy Targeting KK-LC-1 for Gastric, Breast, Cervical, Lung and other KK-LC-1 Positive Epithelial Cancers
Participants currently recruited/enrolled
18-120 Years
NCI
Long
000036-AA
A Phase I, Randomized, Double-Blind, Placebo-Controlled, Study of Safety, Tolerability, and Bioeffects of Alirocumab in Non-treatment Seeking Heavy Drinkers
Participants currently recruited/enrolled
21-65 Years
NIAAA
Long
22-C-0005
Phase I Dose Escalation and Expansion Study of Tazemetostat in Combination with Topotecan and Pembrolizumab in Recurrent Small Cell Lung Cancer
Participants currently recruited/enrolled
18-125 Years
NCI
Long
21-N-0010
A Phase 2 Clinical Trial of Tolebrutinib, a Brain-penetrant Bruton's Tyrosine Kinase Inhibitor, for the Modulation of Chronically Inflamed White Matter Lesions in Multiple Sclerosis
No longer recruiting/follow-up only
18-125 Years
NINDS
Long
21-HG-0020
Caregiving Networks Across Disease Context and the Life Course: A Comparative Longitudinal Study
Participants currently recruited/enrolled
18-125 Years
NHGRI
Long
21-DC-0002
Phase III Interventional Study using Atorvastatin to Reduce Cisplatin-Induced Hearing Loss among Individuals with Head and Neck Cancer
Recruitment has not started
18-125 Years
NIDCD
Long
21-C-0022
A Phase 2 Single Arm Open-Label Clinical Trial of ADP-A2M4 SPEAR(TM) T Cells in Subjects with Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma
Participants currently recruited/enrolled
10-75 Years
NCI
Long
21-C-0019
Phase I Study of Anti-CD22 Chimeric Receptor T Cells in Patients with Relapsed/Refractory Hairy Cell Leukemia and Variant
Participants currently recruited/enrolled
18-125 Years
NCI
Long
21-C-0017
Magnetic Resonance Image (MRI) Guided High Energy Ultrasound for Focal Prostate Cancer Ablation
Recruitment has not started
18-125 Years
NCI
Long
21-C-0011
A Phase I/II Study of the Cyclin-Dependent Kinase(CDK)4/6 Inhibitor Abemaciclib for Neurofibromatosis Type 1 (NF1) Related Atypical Neurofibromas
Participants currently recruited/enrolled
12-125 Years
NCI
Long
20-NR-0003
A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue
Participants currently recruited/enrolled
18-70 Years
NINR
Syndrome
20-N-0064
An observational study to assess clinical manifestations and biomarkers in amyotrophic lateral sclerosis type 4 and other inherited neurological disorders of RNA processing.
Participants currently recruited/enrolled
5-125 Years
NINDS
Syndrome
20-N-0060
Mechanisms Underlying the Beneficial Effects of Naps on Motor Learning
Participants currently recruited/enrolled
18-80 Years
NINDS
Long
20-M-0166
Electrophysiologic Sleep Phenotyping and Sleep-Dependent Neuro-maturation in Clinical and Healthy Pediatric Populations
Participants currently recruited/enrolled
0-8 Years
NIMH
Syndrome
20-M-0159
Role of GABAergic Transmission in Auditory Processing in Autism Spectrum Disorder
Participants currently recruited/enrolled
14-25 Years
NIMH
Syndrome
20-M-0082
Phase 1 Study: PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease
Participants currently recruited/enrolled
18-99 Years
NIMH
Syndrome
20-I-0140
A Double-Blind, Randomized, Placebo-Controlled, Phase 1, Single-Dose, Dose-Escalating Trial of Long-Acting Recombinant Human IL-7 (NT-I7) for COVID-19
Participants currently recruited/enrolled
19-75 Years
NIAID
Long
20-I-0132
A Multicentre, Randomised, Double-blind, Parallel-group, Placebo-controlled, 24-week Phase 3 Study with an Open-label Extension to Evaluate the Efficacy and Safety of Benralizumab in Patients with Hypereosinophilic Syndrome (HES)
Participants currently recruited/enrolled
12-130 Years
NIAID
Syndrome
20-I-0123
A Longitudinal Study of COVID-19 Sequelae and Immunity
Participants currently recruited/enrolled
18-125 Years
NIAID
Long
20-I-0111
COVID-19-associated Lymphopenia Pathogenesis Study in Blood
Participants currently recruited/enrolled
18-125 Years
NIAID
Syndrome
20-I-0002
Pilot Study of Mepolizumab in Episodic Angioedema with Eosinophilia
Completed Study; data analyses ongoing
18-125 Years
NIAID
Syndrome
20-HG-0034
A Multi-Cohort Phase 2 Dose-Escalation Study of MK-7075 (Miransertib) in Proteus Syndrome
Participants currently recruited/enrolled
3-125 Years
NHGRI
Syndrome
20-HG-0025
A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study to Evaluate the Efficacy of ManNAc in Subjects with GNE Myopathy
Participants currently recruited/enrolled
18-125 Years
NHGRI
Long
20-H-0141
Long-term Follow-up of Subjects With Sickle Cell Disease Treated With Ex Vivo Gene Therapy Using Autologous Hematopoietic Stem Cells Transduced With a Lentiviral Vector
Enrolling by Invitation
18-125 Years
NHLBI
Long
20-H-0080
Red Cell Half Life Determination in Patients with and without Sickle Cell Disease
Completed Study; data analyses ongoing
18-100 Years
NHLBI
Long
20-H-0021
Treatment of Refractory Diamond-Blackfan Anemia with Eltrombopag
No longer recruiting/follow-up only
2-125 Years
NHLBI
Long
20-H-0016
Duvelisib for Ibrutinib-Resistant Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)
Completed Study; data analyses ongoing
18-125 Years
NHLBI
Long
20-E-0108
A Prospective Natural History Study of Smoking, Immune Cell Profiles, Epigenetics and COVID-19
Completed Study; data analyses ongoing
30-55 Years
NIEHS
Long
20-DK-0168
LYNC-LD Prospective Multicenter Natural History Study of Lipodystrophy Syndromes to Determine Prevalence, Incidence and Predictors of Diabetes and Severe Hypertriglyceridemia, and their Complications.
Participants currently recruited/enrolled
3-125 Years
NIDDK
Syndrome
20-D-0131
Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sj(SqrRoot)(Delta)gren's Syndrome; a Phase Ib-IIa Placebo-controlled Clinical Trial and Associated Mechanistic Studies
Participants currently recruited/enrolled
18-75 Years
NIDCR
Syndrome
20-CH-0165
Androgen Receptor, Implications for Health and Wellbeing: Natural History Study of Individuals with Androgen Insensitivity
Participants currently recruited/enrolled
0-99 Years
NICHD
Syndrome
20-CC-0113
Cardiopulmonary Inflammation and Multi-System Imaging During the Clinical Course of COVID-19 Infection in Asymptomatic and Symptomatic Persons (COVID ARC 19)
No longer recruiting/follow-up only
18-80 Years
CC
Long
20-CC-0031
A single cohort study collecting interval timed incisional epidermal and dermal tissue samples during surgical procedures to profile temporal response of tissue after noxious stimuli.
Completed Study; data analyses ongoing
18-125 Years
CC
Long
20-C-0167
Close Assessment and Testing for Chronic Graft-vs-Host Disease (CATCH Study)
Participants currently recruited/enrolled
18-125 Years
NCI
Long
20-C-0164
Multiparametric Magnetic Resonance Imaging of the Prostate to Assess Disease Progression and Genomics in Patients Undergoing Active Surveillance for Prostate Cancer
Participants currently recruited/enrolled
18-125 Years
NCI
Long
20-C-0154
Pilot Study of DS-8201a Pharmacodynamics in Patients with HER2-expressing Advanced Solid Tumors
Participants currently recruited/enrolled
18-125 Years
NCI
Long
20-C-0107
Clinical, Genetic, and Epidemiologic Study of Children and Adults with RASopathies
Participants currently recruited/enrolled
0-125 Years
NCI
Syndrome
20-C-0106
Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients with BAP1 Tumor Predisposition Syndrome
Participants currently recruited/enrolled
30-125 Years
NCI
Syndrome
20-C-0104
Phase I/II Trial of HPV Vaccine PRGN-2009 Alone or in Combination with Anti-PD-L1/TGF-Beta Trap (M7824) in Subjects with HPV Positive Cancers
Participants currently recruited/enrolled
18-125 Years
NCI
Long
20-C-0097
A Phase II, Open-Label Trial of Bintrafusp Alfa (M7824) in Subjects with Thymoma and Thymic Carcinoma
Participants currently recruited/enrolled
18-125 Years
NCI
Long
20-C-0076
Phase 2 Trial of Encorafenib plus Binimetinib for Patients with BRAF V600 Mutated Relapsed/Refractory HCL
Participants currently recruited/enrolled
18-125 Years
NCI
Long
20-C-0075
Phase 2 Trial for Binimetinib for Patients with Relapsed/Refractory BRAF Wild Type Hairy Cell Leukemia and Variant
Participants currently recruited/enrolled
18-125 Years
NCI
Long
20-C-0069
A First-In-Human Phase I Single-Agent Dose-Escalation, Food Effect and Dose Expansion Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms
Participants currently recruited/enrolled
18-125 Years
NCI
Long
20-C-0062
A phase 1b Study of Nivolumab in Patients with Autoimmune Disorders and Advanced Malignancies (AIM-NIVO)
Participants currently recruited/enrolled
18-125 Years
NCI
Syndrome
20-C-0051
Gene Therapy Follow up Protocol for Subjects Previously Enrolled in NCI Genitourinary Malignancies Branch Studies
Enrolling by Invitation
18-125 Years
NCI
Long
20-C-0011
Phase 1 Study of Recombinant Human IL-15 (rhIL-15) and Mogamulizumab for Patients with Refractory or Relapsed Adult T-Cell Leukemia and Mycosis Fungoides/Sezary Syndrome
Completed Study; data analyses ongoing
18-125 Years
NCI
Syndrome
20-C-0010
Phase II Trial of Radium-223 in Biochemically Recurrent Prostate Cancer
Participants currently recruited/enrolled
18-125 Years
NCI
Long
20-C-0009
Randomized Phase II Trial of Topotecan Plus M6620 (VX-970) vs. Topotecan Alone in Patients with Relapsed Small-Cell Lung Cancer
Participants currently recruited/enrolled
18-125 Years
NCI
Long
20-AG-0087
Ketone ester effects on biomarkers of brain metabolism and cognitive performance in cognitively intact adults (Bullet) 55 years old. A double-blinded randomized controlled clinical trial
Participants currently recruited/enrolled
55-125 Years
NIA
Syndrome
19-NR-0098
Patient-Centered Assessment of Symptoms and Outcomes
Participants currently recruited/enrolled
18-125 Years
NINR
Syndrome
19-N-0124
Anakinra for the Treatment of Chronically Inflamed White Matter Lesions in Multiple Sclerosis
Participants currently recruited/enrolled
18-120 Years
NINDS
Long
19-N-0036
Exploring the Relationship Between Brain Asymmetry and Attention
Completed Study; data analyses ongoing
18-35 Years
NINDS
Long
19-M-0107
The Mechanism of Action Underlying Ketamine's Antidepressant Effects: An Investigation of the AMPA Throughput Theory in Patients with Treatment-Resistant Major Depression
Participants currently recruited/enrolled
18-70 Years
NIMH
Long
19-M-0054
Mapping the Phenotype in Adults with Phelan-McDermid Syndrome
Completed Study; data analyses ongoing
0-125 Years
NIMH
Syndrome
19-I-0133
Paradoxical Tuberculosis Reactions in Patients without HIV Infection
Participants currently recruited/enrolled
18-125 Years
NIAID
Syndrome
19-I-0108
Elemental Diet for Treatment of Inflammatory Bowel Disease in Patients with Chronic Granulomatous Disease
Enrolling by Invitation
8-65 Years
NIAID
Long
19-I-0084
Skin Immunity Sample Collection Involving Blisters and Biopsies
Recruitment has not started
7-65 Years
NIAID
Syndrome
19-I-0015
Phase 1/2 Randomized, Double-Blind, Placebo-Controlled Study of Safety and Efficacy of Abatacept for Treating Chronic Cytopenia in Cytotoxic T-lymphocyte Antigen 4 (CTLA4) Haploinsufficiency
Participants currently recruited/enrolled
8-65 Years
NIAID
Long
19-HG-0059
Longitudinal Studies of Patients with FPDMM
Participants currently recruited/enrolled
0-125 Years
NHGRI
Long
19-H-0139
Investigation of the Natural Progression of Clonal Hematopoiesis of Indeterminate Potential and Clonal Cytopenia of Undetermined Significance.
Participants currently recruited/enrolled
18-125 Years
NHLBI
Syndrome
19-H-0118
Repeat Peripheral Blood Stem Cell Transplantation for Patients with Sickle Cell Disease or Beta-Thalassemia and Falling Donor Myeloid Chimerism Levels
Participants currently recruited/enrolled
2-80 Years
NHLBI
Long
19-H-0034
Exploratory Study of Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome
Completed Study; data analyses ongoing
18-70 Years
NHLBI
Syndrome
19-E-0110
Reproductive Axis Maturation in the Early Post-Menarchal Years: A Pilot Study
Participants currently recruited/enrolled
8-34 Years
NIEHS
Long
19-DA-N019
Outcome Inference in the Sensory Preconditioning Task in Opioid-use Disorder
Participants currently recruited/enrolled
21-60 Years
NIDA
Long
19-CH-0026
Randomized, Double-Blind, Placebo-Controlled Study Plus Open Label Extension with a Double-Blind, Placebo-Controlled, Randomized Withdrawal Period of Diazoxide Choline Extended-Release Tablets (DCCR, Soleno Therapeutics, Inc.) in Participants with Prader
No longer recruiting/follow-up only
4-125 Years
NICHD
Syndrome
19-CH-0020
A Phase 1-2 Multi-Center Study to Assess the Efficacy and Safety of Abiraterone Acetate as Adjunctive Therapy in Pre-Pubescent Children with Classic 21-Hydroxylase Deficiency
Recruitment has not started
2-9 Years
NICHD
Syndrome
19-CC-0063
Impact of Steady State Cobicistat and Darunavir/Cobicistat on the Pharmacokinetics and Pharmacodynamics of Oral Anticoagulants (Rivaroxaban, Apixaban) in Healthy Volunteers
Participants currently recruited/enrolled
18-65 Years
CC
Long
19-CC-0055
Cardiovascular Disease in HIV and Hepatitis C: Risk Outcomes after Hepatitis C Eradication
Participants currently recruited/enrolled
18-125 Years
CC
Long
19-CC-0005
Short or Long Infusion Duration for Platelets: The SOLID Platelet Study
Participants currently recruited/enrolled
18-100 Years
CC
Long
19-C-0135
Evaluation of the Natural History and Management of Von Hippel-Lindau (VHL) Associated Pancreatic Neuroendocrine Tumors
Participants currently recruited/enrolled
12-125 Years
NCI
Syndrome
19-C-0129
A Phase II Study of Intraperitoneal and Intravenous Paclitaxel Chemotherapy with Oral Capecitabine for Gastric Adenocarcinoma with Peritoneal Carcinomatosis
Participants currently recruited/enrolled
18-125 Years
NCI
Long
19-C-0096
Studying the Biology of IDH-mutant Gliomas via Longitudinal Observation of 2-Hydroxyglutarate (2-HG) Using MR Spectroscopy
Participants currently recruited/enrolled
18-125 Years
NCI
Long
19-C-0094
A Phase II Study of Combined Treatment of Durvalumab, Bevacizumab, Tremelimumab and Transarterial Chemoembolization (TACE) in Subjects with Hepatocellular Carcinoma (HCC) or Biliary Tract Carcinoma (BTC)
Participants currently recruited/enrolled
18-125 Years
NCI
Long
19-C-0076
A Phase 1 Study of Interleukin-15 in Combination with Avelumab (Bavencio) in Relapsed/Refractory Mature T-cell Malignancies
Completed Study; data analyses ongoing
18-125 Years
NCI
Syndrome
19-C-0049
Long Term Follow-up of Mesothelioma Patients and Their Family Members with Germline Mutations in BAP1 and Other Genes
Participants currently recruited/enrolled
2-125 Years
NCI
Long
19-C-0040
Natural History Study of Men at High Genetic Risk for Prostate Cancer
Participants currently recruited/enrolled
30-75 Years
NCI
Syndrome
19-C-0016
Natural History and Biospecimen Acquisition Study for Children and Adults with Rare Solid Tumors
Participants currently recruited/enrolled
0-125 Years
NCI
Syndrome
18-M-0015
Development of Non-Invasive Brain Stimulation Techniques
Participants currently recruited/enrolled
18-65 Years
NIMH
Long
18-I-0039
Challenge Infection of Healthy Adult Volunteers with RSV A2
Completed Study; data analyses ongoing
18-50 Years
NIAID
Long
18-H-0118
Technical and Translational Development of Cardiovascular MRI (CMR)
Participants currently recruited/enrolled
7-125 Years
NHLBI
Long
18-H-0090
Haplo-identical Transplantation for Severe Aplastic Anemia, Hypo-plastic MDS and PNH using Peripheral Blood Stem Cells and post-transplant Cyclophosphamide for GVHD prophylaxis
Participants currently recruited/enrolled
4-75 Years
NHLBI
Syndrome
18-DK-N071
Early Tracking of Childhood Health Determinants Study
Participants currently recruited/enrolled
0-125 Years
NIDDK
Long
18-DK-0091
Long-Term Follow-Up Of Subjects With CHC Who Achieved A Sustained Virological Response Following Therapy With Direct Acting Antiviral Agents
Participants currently recruited/enrolled
18-125 Years
NIDDK
Long
18-CH-0120
A Natural History of the Collagen-Related Disorder Osteogenesis Imperfecta and the Genotype-Phenotype Correlation
No longer recruiting/follow-up only
0-125 Years
NICHD
Long
18-CH-0002
Investigations of Juvenile Neuronal Ceroid Lipofuscinosis (CLN3)
Participants currently recruited/enrolled
0-125 Years
NICHD
Long
18-CC-0087
Impact of Weekly Administration of Rifapentine and Isoniazid on Steady State Pharmacokinetics of Tenofovir Alafenamide in Healthy Volunteers
Completed Study; data analyses ongoing
18-65 Years
CC
Long
18-C-0138
An Open-Label Phase 2 Study to Evaluate PT2977 for the Treatment of Von Hippel-Lindau Disease-Associated Renal Cell Carcinoma.
No longer recruiting/follow-up only
18-125 Years
NCI
Long
18-C-0122
Phase 1B Study of Copanlisib in Combination with Nivolumab or with Nivolumab and Ipilimumab
Completed Study; data analyses ongoing
18-125 Years
NCI
Long
18-C-0093
Pilot Study of Medication Adherence in Children, Adolescents, and Adults with Neurofibromatosis Type 1 (NF1) on Clinical Treatment Trials
No longer recruiting/follow-up only
3-125 Years
NCI
Long
18-C-0049
A Phase II Study Using the Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in Patients with Metastatic Cancer
Participants currently recruited/enrolled
18-72 Years
NCI
Long
18-C-0038
Long Term Follow-up (LTFU) of Participants Treated with GSK Adoptive Cell Therapies
No longer recruiting/follow-up only
4-125 Years
NCI
Long
18-C-0033
Phase I Study of Recombinant Interleukin 15 in Combination With Checkpoint Inhibitors Nivolumab and Ipilimumab in Subjects with Refractory Cancers
Participants currently recruited/enrolled
18-125 Years
NCI
Long
18-C-0014
Phase I Trial of 5-aza-4'-thio-2'-Deoxycytidine (Aza-TdC) in Patients with Advanced Solid Tumors
Participants currently recruited/enrolled
18-120 Years
NCI
Long
18-C-0005
Phase II Trial of Combination Immunotherapy in Biochemically Recurrent Prostate Cancer
Participants currently recruited/enrolled
18-125 Years
NCI
Long
18-AR-0081
Investigation of the Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease and Related Inflammatory Conditions
Participants currently recruited/enrolled
0-125 Years
NIAMS
Syndrome
17-N-0131
Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
Participants currently recruited/enrolled
18-125 Years
NINDS
Syndrome
17-N-0035
Clinical and Physiological Studies of Tremor Syndromes
Completed Study; data analyses ongoing
18-125 Years
NINDS
Syndrome
17-I-0016
Studies of the Natural History, Pathogenesis, and Outcome of Autoinflammatory Diseases (NOMID/CAPS, DIRA, CANDLE, SAVI, NLRC4-MAS, Still's-like Diseases, and Other Undifferentiated Autoinflammatory Diseases)
Participants currently recruited/enrolled
0-99 Years
NIAID
Long
17-H-0121
Eltrombopag for Patients with Fanconi Anemia
Participants currently recruited/enrolled
2-125 Years
NHLBI
Long
17-H-0118
A Phase II Study Of Ibrutinib, Fludarabine, and Pembrolizumab in High-Risk or Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)
No longer recruiting/follow-up only
18-125 Years
NHLBI
Long
17-H-0091
Unrelated Umbilical Cord Blood Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS using CordIn, Umbilical Cord Blood-Derived Ex Vivo Expanded Stem and Progenitor Cells, to Expedite Engraftment and Improve Transplant Outcome
Participants currently recruited/enrolled
4-75 Years
NHLBI
Syndrome
17-EI-0112
A Long-term Follow-up Study of Participants Enrolled in 11-EI-0147: Longitudinal Investigation of Dark Adaptation in Participants with Age-Related Macular Degeneration (DA_AMD)
Participants currently recruited/enrolled
50-125 Years
NEI
Long
17-DK-0054
The Physiological Responses and Adaptation of Brown Adipose Tissue to Chronic Treatment with Beta3-Adrenergic Receptor Agonists
Participants currently recruited/enrolled
18-40 Years
NIDDK
Syndrome
17-C-0164
A Phase 1b/2 Trial of Hu5F9-G4 in Combination with Rituximab or Rituximab + Chemotherapy in Patients with Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma
No longer recruiting/follow-up only
18-125 Years
NCI
Long
17-C-0156
Longitudinal Sample Collection and Tracking for the Developmental Therapeutics Clinic, National Cancer Institute
Participants currently recruited/enrolled
18-125 Years
NCI
Long
17-C-0137
Leukapheresis for CAR or Adoptive Cell Therapy Manufacturing
Enrolling by Invitation
3-65 Years
NCI
Long
17-C-0090
DART: Dual Anti-CTLA-4 And Anti-Pd-1 Blockade In Rare Tumors
Participants currently recruited/enrolled
18-125 Years
NCI
Long
17-C-0087
Lu-177-DOTATATE (Lutathera) in Therapy of Inoperable Pheochromocytoma/ Paraganglioma
Participants currently recruited/enrolled
18-125 Years
NCI
Syndrome
17-C-0074
A Phase 2 Study of Anti-PD-L1 Antibody Atezolizumab in Alveolar Soft Part Sarcoma
Participants currently recruited/enrolled
2-125 Years
NCI
Long
17-C-0061
Phase II Trial of Pembrolizumab in Recurrent or Metastatic Medullary Thyroid Cancer
Completed Study; data analyses ongoing
18-125 Years
NCI
Long
17-C-0049
A Phase I/II Trial of the Insulin-Like Growth Factor 1 Receptor (IGF-1R) Antibody AMG479 (Ganitumab) in Combination with the Src Family Kinase (SFK) Inhibitor Dasatinib in Patients with Embryonal and Alveolar Rhabdomyosarcoma
Completed Study; data analyses ongoing
2-125 Years
NCI
Long
17-C-0044
Prospective Evaluation and Molecular Profiling in Patients with Gastric Tumors
Participants currently recruited/enrolled
2-125 Years
NCI
Long
17-C-0043
Hereditary Gastric Cancer Syndromes: An Integrated Genomic and Clinicopathologic Study of the Predisposition to Gastric Cancer
Participants currently recruited/enrolled
2-125 Years
NCI
Syndrome
17-C-0027
Long-Term Follow up of Patients Undergoing Hematopoietic Stem Cell Transplantation
Participants currently recruited/enrolled
4-125 Years
NCI
Long
17-C-0012
A Phase I Study of a Combination of MM-398 and Veliparib in solid tumors
Completed Study; data analyses ongoing
18-125 Years
NCI
Long
17-C-0011
Phase 1 Study of Intraperitoneal Infusion of Autologous Monocytes with Sylatron (Peginterferon alfa-2b) and Actimmune (Interferon gamma-1b) in Women with Recurrent or Refractory Ovarian Cancer, Fallopian Tube Cancer or Primary Peritoneal Cancer
Completed Study; data analyses ongoing
18-125 Years
NCI
Long
17-C-0007
Phase I/II Study of PROSTVAC in Combination with Nivolumab in Men with Prostate Cancer
Participants currently recruited/enrolled
18-125 Years
NCI
Long
16-N-0055
The Pathological Basis of MRI Signal Changes in Multiple Sclerosis: A Longitudinal In Vivo-to-Postmortem Study
Participants currently recruited/enrolled
18-125 Years
NINDS
Long
16-I-0053
A Multicenter Study of the Immunogenicity of Recombinant Vesicular Stomatitis Vaccine for Ebola-Zaire (rVSVdeltaG-ZEBOV GP) for Pre-Exposure Prophylaxis in Individuals at Potential Occupational Risk for Ebola Virus Exposure (PREPARE)
No longer recruiting/follow-up only
18-125 Years
NIAID
Long
16-H-0144
Impact of Elastin Mediated Vascular Stiffness on End Organs
Participants currently recruited/enrolled
3-85 Years
NHLBI
Syndrome
16-H-0074
Williams Syndrome (WS) and Supravalvular Aortic Stenosis (SVAS) DNA and Tissue Bank
Participants currently recruited/enrolled
0-85 Years
NHLBI
Syndrome
16-H-0063
Williams Syndrome Skin and Vascular Elasticity Study (WS-SAVE Study)
Completed Study; data analyses ongoing
1-70 Years
NHLBI
Syndrome
16-DK-0173
MEASuRE: Metreleptin Effectiveness and Safety Registry
Participants currently recruited/enrolled
0-125 Years
NIDDK
Long
16-CH-0103
Evaluation of Patients with Genetic Disorders
Participants currently recruited/enrolled
0-125 Years
NICHD
Syndrome
16-CC-0162
Longitudinal Changes in the Oral and Gut Microbiome of Individuals with Alcohol Dependence
Completed Study; data analyses ongoing
18-125 Years
CC
Long
16-CC-0112
Impact of Once-Weekly Rifapentine and Isoniazid on the Steady State Pharmacokinetics of Dolutegravir and Darunavir Boosted with Cobicistat in Healthy Volunteers
Completed Study; data analyses ongoing
18-65 Years
CC
Long
16-C-0094
A Phase 1/2 Study of Baricitinib, a JAK1/2 Inhibitor, in Chronic Graft-Versus-Host Disease (cGVHD) after Allogeneic Hematopoietic Stem Cell Transplantation (SCT)
No longer recruiting/follow-up only
18-125 Years
NCI
Long
16-C-0092
A Pilot Study of Local Ablative Therapy for Treatment of Oligoprogressive, EGFR-mutated, Non-Small Cell Lung Cancer (NSCLC) After Treatment with Osimertinib (AZD9291, Tagrisso)
Completed Study; data analyses ongoing
18-125 Years
NCI
Long
16-C-0088
A Randomized Phase II/III Study of the Combination of Cediranib and Olaparib Compared to Cediranib or Olaparib Alone, or Standard of Care Chemotherapy in Women with Recurrent Platinum-Resistant or -Refractory Ovarian, Fallopian Tube, or Primary Peritonea
Completed Study; data analyses ongoing
18-125 Years
NCI
Long
16-C-0087
Phase I Study of Veliparib (ABT-888), an Oral PARP Inhibitor, and VX-970, an ATR Inhibitor in Combination with Cisplatin in Patients with Refractory Solid Tumors
Completed Study; data analyses ongoing
18-125 Years
NCI
Long
16-C-0081
A Phase I Dose Escalation Trial of Re-Irradiation in Good Prognosis Recurrent Glioblastoma
No longer recruiting/follow-up only
18-125 Years
NCI
Long
16-C-0073
A Phase 2 Study of Olaparib and Cediranib for the Treatment of Recurrent Ovarian Cancer
Completed Study; data analyses ongoing
18-125 Years
NCI
Long
16-C-0060
A Phase 1b/2 Study of alvelestat (MPH966), an Oral Neutrophil Elastase Inhibitor, in Bronchiolitis Obliterans Syndrome after Allogeneic Hematopoietic Stem Cell Transplantation
Participants currently recruited/enrolled
18-125 Years
NCI
Syndrome
16-C-0047
A Phase 1 Trial of Pomalidomide in Combination with Liposomal Doxorubicin in Patients with Advanced or Refractory Kaposi Sarcoma
Participants currently recruited/enrolled
18-125 Years
NCI
Long
16-C-0043
Phase II Trial of the MEK1/2 Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate in Adults with Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas
No longer recruiting/follow-up only
18-125 Years
NCI
Long
15-M-0139
Mapping the Genotype, Phenotype, and Natural History of Phelan McDermid Syndrome
Participants currently recruited/enrolled
1-125 Years
NIMH
Syndrome
15-I-0154
Long-Term Observation of Hemagglutinin and Neuraminidase Inhibition Antibody Titers After Influenza Challenge
Enrolling by Invitation
18-125 Years
NIAID
Long
15-I-0056
Collection of Plasma from Subjects that Recovered From or Were Vaccinated To Emerging Infectious Diseases
Enrolling by Invitation
18-70 Years
NIAID
Syndrome
15-H-0016
A Phase II Study Using ACP-196 in Patients with Relapsed/Refractory and Treatment Naive Deletion 17p CLL/SLL: Pharmacodynamic Assessment of BTK Inhibition and Anti-Tumor Response.
No longer recruiting/follow-up only
18-125 Years
NHLBI
Long
15-E-0058
Natural History of Asthma with Longitudinal Environmental Sampling
Participants currently recruited/enrolled
18-60 Years
NIEHS
Long
15-DK-0192
Quantifying Weight Regain and the Persistence of Metabolic Adaptation Following Extreme Weight Loss
Completed Study; data analyses ongoing
18-125 Years
NIDDK
Long
15-DK-0174
Dynamic Post-Prandial Metabolism in Patients with Non-Alcoholic Fatty Liver Disease
Completed Study; data analyses ongoing
18-125 Years
NIDDK
Syndrome
15-DK-0108
Natural History of Noncirrhotic Portal Hypertension
Participants currently recruited/enrolled
12-125 Years
NIDDK
Syndrome
15-DK-0082
Mechanisms Associated with Favorable Response to Peginterferon-Alpha Add-on Therapy Following Long-term Nucleos(t)ide Analogue Treatment in Patients with Chronic Hepatitis B
Completed Study; data analyses ongoing
18-125 Years
NIDDK
Long
15-DK-0079
Observational Study of Hepatitis B Virus (HBV) in Patients Coinfected with Human Immunodeficiency Virus (HIV)
Completed Study; data analyses ongoing
18-125 Years
NIDDK
Long
15-D-0051
Characterization of Diseases with Salivary Gland Involvement
Participants currently recruited/enrolled
4-125 Years
NIDCR
Syndrome
15-CC-0164
Effect of Exercise Training on Physical, Cognitive and Behavioral Function in Patients with Traumatic Brain Injury
Completed Study; data analyses ongoing
18-79 Years
CC
Long
15-C-0200
Molecular Analysis for Therapy Choice (MATCH) (EAY131)
Completed Study; data analyses ongoing
18-125 Years
NCI
Long
15-C-0157
Phase I/II Trial of Vandetanib in Combination with Metformin in Subjects with HLRCC or SDH-Associated Kidney Cancer or Sporadic Papillary Renal Cell Carcinoma
Completed Study; data analyses ongoing
18-125 Years
NCI
Syndrome
15-C-0141
Gene Therapy Follow up Protocol for Subjects Previously Enrolled in CAR T-Cell Studies
Enrolling by Invitation
18-125 Years
NCI
Long
15-C-0124
Neoadjuvant Androgen Deprivation and Enzalutamide: Using Multiparametric MRI to Evaluate Intraprostatic Tumor Responses and Androgen Resistance Patterns in Newly Diagnosed Prostate Cancer
No longer recruiting/follow-up only
18-125 Years
NCI
Long
15-C-0116
Phase I Trial of 4'-thio-2'-deoxycytidine (TdCyd) in Patients With Advanced Solid Tumors
Clinical hold/Recruitment or enrollment suspended
18-125 Years
NCI
Long
15-C-0078
Safety and Feasibility of Stem Cell Gene Transfer Following R-EPOCH for Non-Hodgkin Lymphoma in AIDS Patients Using Peripheral Blood Stem/Progenitor Cells Treated with a Lentivirus Vector-Encoding Multiple Anti-HIV RNAs
No longer recruiting/follow-up only
18-65 Years
NCI
Long
15-C-0076
A Pilot Study of Long Term TARP Vaccination Using A Multi-Epitope TARP Peptide Autologous Dendritic Cell Vaccination in Previously Vaccinated Men on NCI 09-C-0139
Completed Study; data analyses ongoing
18-125 Years
NCI
Long
15-C-0067
A Phase I/II Open Label, Dose Escalation Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation
Participants currently recruited/enrolled
18-125 Years
NCI
Syndrome
15-C-0028
Follow-Up Evaluation for Gene-Therapy Related Delayed Adverse Events After Participation in Pediatric Oncology Branch Clinical Trials
Enrolling by Invitation
1-99 Years
NCI
Long
15-AA-0203
Cross-Sectional and Longitudinal Study of Structural Imaging
Completed Study; data analyses ongoing
30-60 Years
NIAAA
Long
14-N-0086
Deep Brain Stimulation Therapy in Movement Disorders
Participants currently recruited/enrolled
18-125 Years
NINDS
Syndrome
14-I-0185
A Phase III Double-Blind Randomized Crossover Study of Plerixafor Versus G-CSF in the Treatment of Patients with WHIM Syndrome.
Completed Study; data analyses ongoing
10-75 Years
NIAID
Syndrome
14-I-0124
PET Imaging and Lymph Node Assessment of IRIS in Persons With AIDS
Participants currently recruited/enrolled
18-125 Years
NIAID
Syndrome
14-I-0091
Analysis of Patients Treated for Chronic Granulomatous Disease Since January 1, 1995
Completed Study; data analyses ongoing
3-125 Years
NIAID
Long
14-I-0081
A Phase 2a Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Subcutaneous Benralizumab (MEDI-563) in Reducing Eosinophilia in Subjects with Hypereosinophilic Syndrome (HES)
No longer recruiting/follow-up only
18-75 Years
NIAID
Syndrome
14-I-0063
An Open-Label, Proof-of-Concept Study to Evaluate the Safety and Efficacy of Dexpramipexole (KNS-760704) in Subjects with Hypereosinophilic Syndrome
No longer recruiting/follow-up only
18-125 Years
NIAID
Syndrome
14-I-0020
Hematopoietic Stem Cell Mobilization in Idiopathic CD4 Lymphocytopenia Patients and Healthy Controls for the Study of T Cell Maturation and Trafficking in Murine Models
Participants currently recruited/enrolled
18-65 Years
NIAID
Syndrome
14-I-0009
Characterization and Management of Patients with HIV-1 Infection Who Experience Virologic Failure Despite Combination Antiretroviral Therapy
Completed Study; data analyses ongoing
18-100 Years
NIAID
Syndrome
14-HG-0055
Study on Moebius Syndrome and Other Congenital Facial Weakness Disorders
Completed Study; data analyses ongoing
2-80 Years
NHGRI
Syndrome
14-HG-0048
Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST)
Participants currently recruited/enrolled
21-125 Years
NHGRI
Long
14-H-0155
A Phase 1/2 Study Evaluating Gene Therapy by Transplantation of Autologous CD34+ Stem Cells Transduced Ex Vivo with the LentiGlobin BB305 Lentiviral Vector in Subjects with Severe Sickle Cell Disease
No longer recruiting/follow-up only
18-50 Years
NHLBI
Long
14-CH-0028
Evaluation of 68Ga-DOTATATE PET/CT, Octreotide and F-DOPA PET Imaging in Patients with Ectopic Cushing Syndrome
Participants currently recruited/enrolled
18-80 Years
NICHD
Syndrome
14-C-0156
A Phase II Single Arm Pilot Study of the Chk1/2 Inhibitor (LY2606368) In BRCA1/2 Mutation Associated Breast or Ovarian Cancer, Triple Negative Breast Cancer, and High Grade Serous Ovarian Cancer
Completed Study; data analyses ongoing
18-125 Years
NCI
Syndrome
14-C-0104
A Phase II Study Using Autologous Young Tumor-Infiltrating Lymphocytes Derived from Patients with Non-Small Cell Lung Cancer Following Non-Myeloablative Lymphocyte Depleting Preparative Regimen
Participants currently recruited/enrolled
18-70 Years
NCI
Long
14-C-0052
A Phase I/II Study of the Treatment of Metastatic Cancer that Expresses MAGE-A3 Using Lymphodepleting Conditioning Followed by Infusion of HLA-DP0401/0402 Restricted Anti-MAGE-A3 TCR-Gene Engineered Lymphocytes and Aldesleukin
Completed Study; data analyses ongoing
18-70 Years
NCI
Long
14-C-0037
A Phase 2 Study of the MET Kinase Inhibitor INC280 in Papillary Renal Cell Cancer
Completed Study; data analyses ongoing
18-125 Years
NCI
Long
14-C-0022
A Phase II Study for Metastatic Melanoma Using High-Dose Chemotherapy Preparative Regimen Followed by Cell Transfer Therapy Using Tumor-Infiltrating Lymphocytes Plus IL-2 with the Administration of Pembrolizumab in the Retreatment Arm
Completed Study; data analyses ongoing
18-70 Years
NCI
Long
14-C-0004
A Multicenter Phase 2 Study of the Bruton's Tyrosine Kinase Inhibitor PCI-32765 (Ibrutinib) for Treatment of Relapsed Hairy Cell Leukemia
No longer recruiting/follow-up only
18-125 Years
NCI
Long
13-N-0149
An Evaluation of HIV-associated Neurocognitive Disorders (HAND) in Virologically Controlled Patients
Participants currently recruited/enrolled
18-125 Years
NINDS
Long
13-N-0017
Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)
Participants currently recruited/enrolled
2-125 Years
NINDS
Syndrome
13-I-0177
Natural History Study of the Complications Associated with Allogeneic Hematopoietic Stem Cell Transplantations
Completed Study; data analyses ongoing
2-125 Years
NIAID
Long
13-I-0157
The Natural History of GATA2 Deficiency and Related Disorders
Participants currently recruited/enrolled
2-100 Years
NIAID
Syndrome
13-HG-0199
NIH Participation to USIDNET Registry
Participants currently recruited/enrolled
0-125 Years
NHGRI
Syndrome
13-HG-0053
The NIH Mini Study: Metabolism, INfection and Immunity in Inborn Errors of Mitochondrial Metabolism
Participants currently recruited/enrolled
2-125 Years
NHGRI
Long
13-H-0133
Extended Dosing with Eltrombopag in Refractory Severe Aplastic Anemia
Completed Study; data analyses ongoing
2-125 Years
NHLBI
Long
13-H-0116
A Multicenter Safety Study of Unlicensed, Investigational Cryopreserved Cord Blood Units (CBUs) Manufactured by the National Cord Blood Program (NCBP) and Provided for Unrelated Hematopoietic Stem Cell Transplantation of Pediatric and Adult Patients
Participants currently recruited/enrolled
4-125 Years
NHLBI
Syndrome
13-H-0059
Longitudinal Observational Study of Severe Asthma
Participants currently recruited/enrolled
18-125 Years
NHLBI
Long
13-H-0051
Bronchodilator Effects of Nebulized versus Inhaled Albuterol in Subjects with Lymphangioleiomyomatosis
Participants currently recruited/enrolled
18-125 Years
NHLBI
Long
13-DK-0090
Identifying Risk for Diabetes and Heart Disease in Women: A Study of African-American, African and White Federal Employees and Contractors
Completed Study; data analyses ongoing
25-65 Years
NIDDK
Long
13-CC-0180
Microbiome in Clinical Center Patients
Enrolling by Invitation
2-125 Years
CC
Long
13-CC-0099
Vasti Control of Patellofemoral Kinematics in Patients with Chronic Patellofemoral Pain.
Participants currently recruited/enrolled
18-55 Years
CC
Syndrome
13-CC-0012
A Natural History Study of Novel Biomarkers in Pulmonary Arterial Hypertension
Participants currently recruited/enrolled
18-125 Years
CC
Long
13-C-0146
A Randomized Phase II Trial Combining Vaccine Therapy with PROSTVAC /TRICOM and Enzalutamide vs. Enzalutamide Alone in Men with Metastatic Castration Resistant Prostate Cancer
Completed Study; data analyses ongoing
18-125 Years
NCI
Long
13-C-0132
Allogeneic Hematopoietic Stem Cell Transplant for Patients with Mutations in GATA2 or the MonoMAC Syndrome
Participants currently recruited/enrolled
8-70 Years
NCI
Syndrome
13-C-0118
A Phase I/II Trial of TRC102 (methoxyamine HCl) in Combination with Temozolomide in Patients with Relapsed Solid Tumors and Lymphomas
Participants currently recruited/enrolled
18-125 Years
NCI
Long
13-C-0044
A Phase 2 Study of Cabozantinib (XL184), a Dual Inhibitor of MET and VEGFR, in Patients With Metastatic Refractory Soft Tissue Sarcoma
No longer recruiting/follow-up only
18-120 Years
NCI
Long
13-C-0006
Phase I/II Trial Evaluating the Safety and Efficacy of Ruxolitinib in Patients with Smoldering and Chronic Adult T-cell Leukemia (ATL)
Completed Study; data analyses ongoing
18-125 Years
NCI
Long
13-AR-0056
Stopping Tumor Necrosis Factor-Alpha Inhibitors in Rheumatoid Arthritis
Completed Study; data analyses ongoing
18-125 Years
NIAMS
Long
12-N-0137
A Phase 1 Open-Label Dose Escalation Safety Study of Convection Enhanced Delivery (CED) of Adeno-Associated Virus Encoding Glial Cell Line-Derived Neurotrophic Factor (AAV2-GDNF) in Subjects with Advanced Parkinson's Disease.
Completed Study; data analyses ongoing
18-125 Years
NINDS
Long
12-HG-0202
The Neurobehavioral, Environmental and Genetic Factors Impacting the Clinical Course of Attention Deficit Hyperactivity Disorder
Participants currently recruited/enrolled
3-125 Years
NHGRI
Long
12-HG-0181
The Clinical Study of Patients with Sex Chromosome Variants
Completed Study; data analyses ongoing
18-125 Years
NHGRI
Syndrome
12-H-0110
An Open-label, Non-Randomized, Single-Arm Pilot Study to Evaluate the Effectiveness of Etidronate Treatment for Arterial Calcifications due to Deficiency in CD73 (ACDC)
Completed Study; data analyses ongoing
18-80 Years
NHLBI
Long
12-H-0064
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients with Hematologic Malignancies and Other Indications
Participants currently recruited/enrolled
4-75 Years
NHLBI
Syndrome
12-H-0035
A Phase II study of Ibrutinib for Patients with Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) Who Need Therapy and are Older than 65 or have a 17p Deletion
No longer recruiting/follow-up only
18-125 Years
NHLBI
Long
12-EI-0042
NEI Intramural Biorepository for Retinal Diseases
Participants currently recruited/enrolled
2-125 Years
NEI
Syndrome
12-E-0050
The Role of Gonadotropin Pulsations in the Regulation of Puberty and Fertility
Participants currently recruited/enrolled
14-125 Years
NIEHS
Syndrome
12-E-0049
The Molecular Basis of Inherited Reproductive Disorders
Participants currently recruited/enrolled
0-125 Years
NIEHS
Syndrome
12-DA-N472
Health Outcomes by Neighborhood - HON Study Baltimore
Completed Study; data analyses ongoing
18-100 Years
NIDA
Long
12-C-0205
A Phase II Study of Cabozantinib (XL184) in Patients With Advanced/Metastatic Urothelial Carcinoma
Completed Study; data analyses ongoing
18-125 Years
NCI
Long
12-C-0178
Longitudinal Assessment and Natural History Study of Children and Adults with MEN2A or MEN2B with or without Medullary Thyroid Carcinoma
Participants currently recruited/enrolled
0-125 Years
NCI
Long
12-C-0118
A Phase II Study of Sunitinib in Patients with Advanced Relapsed or Refractory Thymoma or Thymic Carcinoma with at Least One Prior Line of Platinum-Based Systemic Chemotherapy
No longer recruiting/follow-up only
18-100 Years
NCI
Long
12-C-0081
Phase I/II Study of Cediranib and Olaparib in Combination for Treatment of Recurrent Papillary-Serous Ovarian, Fallopian Tube, or Peritoneal Cancer or for Treatment of Recurrent Triple-Negative Breast Cancer
No longer recruiting/follow-up only
18-125 Years
NCI
Long
12-C-0079
A Phase II Multicenter Study of AMG 386 and Abiraterone in Metastatic Castration Resistant Prostate Cancer
Completed Study; data analyses ongoing
18-125 Years
NCI
Long
12-C-0066
Phase I Trial of Oral 5-Fluoro-2'-Deoxycytidine with Oral Tetrahydrouridine in Patients with Advanced Solid Tumors
Completed Study; data analyses ongoing
18-125 Years
NCI
Long
12-AR-8001
Compassionate Use Treatment Protocol I4V-MC-JAGA; Treatment of Autoinflammatory Syndromes Expected to Benefit from JAK Inhibition
Completed Study; data analyses ongoing
1-125 Years
NIAMS
Syndrome
11-N-0084
Evaluation and Diagnosis of Potential Research Subjects with Traumatic Brain Injury (TBI)
Completed Study; data analyses ongoing
18-125 Years
NINDS
Syndrome
11-M-0251
A Longitudinal Investigation of the Endocrine and Neurobiologic Events Accompanying Puberty
Participants currently recruited/enrolled
7-35 Years
NIMH
Long
11-I-0057
Effect of Interferon Alpha 2b Intensification on HIV-1 Residual Viremia in Individuals Suppressed on Antiretroviral Therapy
Completed Study; data analyses ongoing
18-65 Years
NIAID
Long
11-I-0007
Lentiviral Gene Transfer for Treatment of Children Older Than 2 Years of Age with X-Linked Severe Combined Immunodeficiency
Clinical hold/Recruitment or enrollment suspended
2-40 Years
NIAID
Long
11-EI-0147
Longitudinal Investigation of Dark Adaptation in Participants with Age-Related Macular Degeneration
Participants currently recruited/enrolled
50-125 Years
NEI
Long
11-E-0072
Environmental Risk Factors for the Anti-Synthetase Syndrome
Participants currently recruited/enrolled
2-100 Years
NIEHS
Syndrome
11-DK-0151
Withdrawal of Therapy After Long-Term Oral Nucleos(t)ide Analogue Treatment in Patients with Chronic Hepatitis B
Completed Study; data analyses ongoing
18-125 Years
NIDDK
Long
11-DK-0108
Observational Study of Persons with Hepatitis B Virus Infection in North America (Cohort Study)
Completed Study; data analyses ongoing
18-100 Years
NIDDK
Long
11-D-0172
The Pathogenesis and Natural History of Sjogren's Syndrome
Participants currently recruited/enrolled
16-125 Years
NIDCR
Syndrome
11-C-0255
Clinical, Epidemiologic, and Genetic Studies of Li-Fraumeni Syndrome
Participants currently recruited/enrolled
0-125 Years
NCI
Syndrome
11-C-0242
Collection of Blood from Patients with Cancer, Other Tumors, or Tumor Predisposition Syndromes for Analysis of Genetic Differences in Drug Disposition
Participants currently recruited/enrolled
3-125 Years
NCI
Syndrome
11-C-0220
Natural History Study of the KSHV Inflammatory Cytokine Syndrome (KICS) Incorporating Pilot Evaluation of KSHV Targeted Therapies
Participants currently recruited/enrolled
18-125 Years
NCI
Syndrome
11-C-0190
Collection of Tissue Blocks or Slides from Patients with Cancer
Participants currently recruited/enrolled
18-125 Years
NCI
Long
11-C-0161
A Phase I/II Study of the Mitogen Activated Protein Kinase Kinase (MEK) 1 Inhibitor Selumetinib (AZD6244; Hydrogen Sulfate in Children with Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas (PN)
No longer recruiting/follow-up only
2-18 Years
NCI
Long
11-C-0136
Multi-Institutional Prospective Pilot Study of Lupron to Enhance Lymphocyte Immune Reconstitution Following Allogeneic Bone Marrow Transplantation in Post-Pubertal Children and Adults with Molecular Imaging Evaluation
Completed Study; data analyses ongoing
2-55 Years
NCI
Syndrome
11-C-0096
Pilot Trial of Molecular Profiling and Targeted Therapy for Advanced Non-Small Cell Lung Cancer, Small Cell Lung Cancer, and Thymic Malignancies
No longer recruiting/follow-up only
18-125 Years
NCI
Long
11-C-0061
Phase I Trial of Z-Endoxifen in Adults with Refractory Hormone Receptor-Positive Breast Cancer, Desmoid Tumors, Gynecologic Tumors, or other Hormone Receptor-Positive Solid Tumors
No longer recruiting/follow-up only
18-125 Years
NCI
Long
11-C-0034
DICER1-Related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study
Participants currently recruited/enrolled
0-125 Years
NCI
Syndrome
11-C-0033
Extended Follow-up of High Ovarian Cancer Risk Cohort from 02C0268 (GOG-199)
Completed Study; data analyses ongoing
18-100 Years
NCI
Long
10-N-0012
Screening Protocol for Patients with Stroke
Participants currently recruited/enrolled
18-90 Years
NINDS
Long
10-N-0009
Physiological Investigations of Movement Disorders
Completed Study; data analyses ongoing
18-125 Years
NINDS
Syndrome
10-M-0112
Defining the Brain Phenotype of Children with Williams Syndrome
Participants currently recruited/enrolled
5-125 Years
NIMH
Syndrome
10-I-0197
Admission and Management of Occupational or Other Exposures to Biodefense/Bioterrorism Agents or to Epidemic/Emerging Infectious Diseases
Participants currently recruited/enrolled
2-99 Years
NIAID
Syndrome
10-H-0154
Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused with a Reduced Dose of Non-Mobilized Donor T-Cells
Participants currently recruited/enrolled
4-80 Years
NHLBI
Syndrome
10-H-0141
A Phase II Study of Ofatumumab-Based Induction Chemoimmunotherapy Followed by Consolidation Ofatumumab Immunotherapy in Previously Untreated Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma.
No longer recruiting/follow-up only
18-99 Years
NHLBI
Long
10-H-0126
Cardiovascular Disease Discovery Protocol
Participants currently recruited/enrolled
1-100 Years
NHLBI
Syndrome
10-E-0129
Study of the Effect of Innate Immunity on the Inflammatory Response to Endotoxin
Participants currently recruited/enrolled
18-125 Years
NIEHS
Syndrome
10-CH-0198
Testing and Calibration of Non-Invasive Optical Imaging Technology for Functional Brain Imaging
Participants currently recruited/enrolled
18-125 Years
NICHD
Long
10-CC-0118
Long Term Clinical Correlates of TBI: Imaging, Biomarkers, and Clinical Phenotyping Parameters
Participants currently recruited/enrolled
18-125 Years
CC
Long
10-C-0166
A Phase II Study Using Short-Term Cultured, Autologous Tumor-Infiltrating Lymphocytes Following a Lymphodepleting Regimen in Metastatic Cancers Plus the Administration of Pembrolizumab
Participants currently recruited/enrolled
18-72 Years
NCI
Long
10-C-0066
A Study of Hairy Cell and other Leukemias with a Focus on Recombinant Immunotoxins for Cancer Treatment
Participants currently recruited/enrolled
18-125 Years
NCI
Syndrome
10-C-0056
A Phase I Study of Indenoisoquinolines LMP400 and LMP776 in Adults With Relapsed Solid Tumors and Lymphomas
Completed Study; data analyses ongoing
18-125 Years
NCI
Long
09-I-0232
FLU 003 Plus: An International Observational Study to Characterize Adults Who Are Hospitalized with Influenza or Other Targeted Respiratory Viruses
Participants currently recruited/enrolled
18-125 Years
NIAID
Long
09-I-0126
Pathogenesis and Genetic Basis of Physical Induced Urticarial Syndromes
Participants currently recruited/enrolled
2-90 Years
NIAID
Syndrome
09-I-0102
Etiology, Pathogenesis, and Natural History of Idiopathic CD4+ Lymphocytopenia
Participants currently recruited/enrolled
18-125 Years
NIAID
Syndrome
09-H-0199
A Pilot Study of a Thrombopoietin-Receptor Agonist (TPO-R agonist), Eltrombopag, in Patients with Low to Int-2 Risk Myelodysplastic Syndrome (MDS)
Completed Study; data analyses ongoing
18-125 Years
NHLBI
Syndrome
09-CC-0217
Vasti Control of Patellofemoral Kinematics in Asymptomatic Volunteers
Completed Study; data analyses ongoing
18-55 Years
CC
Syndrome
09-C-0139
A Pilot Study of Vaccination with Epitope-Enhanced TARP Peptide and TARP Peptide-Pulsed Dendritic Cells in the Treatment of Stage D0 Prostate Cancer
Completed Study; data analyses ongoing
18-125 Years
NCI
Long
08-I-0184
Studies in the Pathogenesis of Anaphylaxis
Participants currently recruited/enrolled
13-75 Years
NIAID
Long
08-HG-0059
Studies of Skin Microflora in Healthy Individuals and Atopic Dermatitis Patients
Participants currently recruited/enrolled
2-125 Years
NHGRI
Syndrome
08-DK-0138
A New Method for Determining Gastric Acid Output Using a Wireless Capsule
Completed Study; data analyses ongoing
18-125 Years
NIDDK
Syndrome
08-CC-0133
Response and Adaptation to Aerobic Exercise in Patients with Pulmonary Hypertension: Initial Studies for Establishing Guidelines
Completed Study; data analyses ongoing
21-82 Years
CC
Long
08-C-0079
Natural History Study and Longitudinal Assessment of Children, Adolescents, and Adults with Neurofibromatosis Type 1
No longer recruiting/follow-up only
0-125 Years
NCI
Long
08-AA-0178
Computer-Assisted Self-Administration of Ethanol (CASE) in Humans
Participants currently recruited/enrolled
21-60 Years
NIAAA
Long
07-N-0122
Modulation of Motor Function by Stimulation of the Central and Peripheral Nervous System
Completed Study; data analyses ongoing
18-125 Years
NINDS
Long
07-D-0016
Effects of PTH Replacement on Bone in Hypoparathyroidism
Completed Study; data analyses ongoing
18-70 Years
NIDCR
Syndrome
07-CH-0008
Prospective, Open-Label, Multicenter, International Study of Mifepristone for Symptomatic Treatment of Cushing's Syndrome Caused by Ectopic Adrenal Corticotrophin Hormone (ACTH) Secretion
Completed Study; data analyses ongoing
18-85 Years
NICHD
Syndrome
07-C-0195
Phase II Trial of Targeted Immune-Depleting Chemotherapy and Reduced-Intensity Allogeneic Hematopoietic Stem Cell Transplantation Using 8/8 and 7/8 HLA-matched Unrelated Donors and Utilizing Two Graft-versus-Host Disease Prophylaxis Regimens for the Trea
Completed Study; data analyses ongoing
18-74 Years
NCI
Syndrome
07-C-0121
Phase 2 Study of the C-Met RTK Inhibitor Foretinib (Formerly GSK 1363089) in Subjects with Papillary Renal Cell Carcinoma (PRC)
Completed Study; data analyses ongoing
18-125 Years
NCI
Long
07-C-0100
Collection of Blood from Patients with Prostate Cancer
Participants currently recruited/enrolled
18-125 Years
NCI
Long
06-M-0214
PET Measurement of Regional Rates of Cerebral Protein Synthesis in Subjects with Fragile X Syndrome
Completed Study; data analyses ongoing
18-24 Years
NIMH
Syndrome
06-I-0015
Screening Protocol for Genetic Diseases of Lymphocyte Homeostasis and Programmed Cell Death
Participants currently recruited/enrolled
0-125 Years
NIAID
Syndrome
06-H-0072
Atorvastatin as a Disease Modifying Agent in Stage II and III Pulmonary Sarcoidosis: A Randomized, Double-Blind, Placebo-Controlled Trial
Completed Study; data analyses ongoing
18-70 Years
NHLBI
Long
06-DA-N415
Screening Protocol for the Evaluation of Potential Research Subjects
Participants currently recruited/enrolled
18-125 Years
NIDA
Long
06-CH-0186
Evaluation of Biochemical Markers and Clinical Investigation of Niemann-Pick Disease, Type C
Participants currently recruited/enrolled
0-125 Years
NICHD
Long
06-C-0213
Tissue Procurement Protocol for the Developmental Therapeutics Clinic, National Cancer Institute (NCI)
Participants currently recruited/enrolled
0-125 Years
NCI
Syndrome
05-H-0130
Long-Term Evaluation and Follow Up Care of Patients Treated with Allogeneic Stem Cell Transplants
Participants currently recruited/enrolled
7-80 Years
NHLBI
Long
05-CC-0216
Prospective Assessment of Functional Status, Psychosocial Adjustment, Health Related Quality of Life and the Symptom Experience in Patients Treated with Allogeneic Hematopoietic Stem Cell Transplantation
Completed Study; data analyses ongoing
18-125 Years
CC
Long
05-CC-0041
Endothelial Cell Dysfunction in Pulmonary Arterial Hypertension: Biomarkers, Mechanisms of Disease and Novel Therapeutic Targets
Completed Study; data analyses ongoing
18-125 Years
CC
Long
05-C-0152
Variation in Gene Expression in Neurofibromatosis Type 1
Completed Study; data analyses ongoing
2-100 Years
NCI
Syndrome
04-HG-0211
Analysis of Specimens from Individuals with Pulmonary Fibrosis
Participants currently recruited/enrolled
18-125 Years
NHGRI
Syndrome
04-H-0161
Studies of the Natural History of Sickle Cell Disease
Participants currently recruited/enrolled
2-125 Years
NHLBI
Syndrome
04-C-0281
Natural History Study of Clinical and Biological Factors Determining Outcomes in Chronic Graft-Versus-Host Disease
Participants currently recruited/enrolled
1-125 Years
NCI
Long
04-C-0275
Targeted Oncolytic Virotherapy and Natural History Study of KSHV-Associated Multicentric Castleman's Disease with Laboratory and Clinical Correlates of Disease Activity
No longer recruiting/follow-up only
18-125 Years
NCI
Long
04-C-0274
Follow-Up Study of Subjects Previously Enrolled in Immunotherapy Studies Utilizing Gene Transfer or Other Immunotherapeutic Agents
Participants currently recruited/enrolled
18-125 Years
NCI
Long
04-C-0238
A Phase 2 Study of 17-Allylamino-17-Demethoxygeldanamycin in Patients with Von Hippel Lindau Disease and Renal Tumors
Completed Study; data analyses ongoing
18-125 Years
NCI
Syndrome
04-C-0102
Hematologic Malignancy Biology Study
Enrolling by Invitation
1-75 Years
NCI
Syndrome
03-M-0211
Family Study of Affective and Anxiety Spectrum Disorders
Participants currently recruited/enrolled
7-120 Years
NIMH
Syndrome
03-E-0099
Pathogenic Studies In Families With Twins Or Siblings Discordant For Systemic Rheumatic Disorders
Completed Study; data analyses ongoing
2-125 Years
NIEHS
Long
03-C-0278
A Comparative Study of Pediatric CNS Tumor Activity as Assessed by 18F-FDG PET Imaging and Proton Magnetic Resonance Spectroscopic Imaging (1H-MRSI)
Completed Study; data analyses ongoing
1-21 Years
NCI
Long
03-AR-0131
Genetic Determinants of Ankylosing Spondylitis Severity - Longitudinal Study
Completed Study; data analyses ongoing
18-125 Years
NIAMS
Long
03-AG-0325
The Baltimore Longitudinal Study of Aging(BLSA)
Participants currently recruited/enrolled
20-125 Years
NIA
Long
02-I-0286
Efficacy of Tyrosine Kinase Inhibition in Reducing Eosinophilia in Patients with Myeloid and/or Steroid-Refractory Hypereosinophilic Syndrome
Participants currently recruited/enrolled
2-125 Years
NIAID
Syndrome
02-I-0202
Leukapheresis Procedures to Obtain Plasma and Lymphocytes for Research Studies on Antiretroviral-Naive HIV-Infected Patients
Participants currently recruited/enrolled
18-120 Years
NIAID
Long
02-I-0110
Natural History of Anthrax: A Study of Primary Infected, Recovered, and Exposed (SPoRE) Individuals and Evaluation of AVA Vaccinated Recipients
Participants currently recruited/enrolled
3-125 Years
NIAID
Long
02-I-0086
Evaluation of Viral Factors and Immune Parameters to Study HIV-Specific Immunity
Participants currently recruited/enrolled
18-125 Years
NIAID
Long
02-I-0080
The Gemini Study: Study of the Long-Term Safety and Persistence of Cells Following Cell Transfers or Gene Therapy in Identical Twins Discordant for HIV Infection
No longer recruiting/follow-up only
18-125 Years
NIAID
Long
02-HG-0107
Natural History of Glycosphingolipid Storage Disorders and Glycoprotein Disorders
Participants currently recruited/enrolled
0-125 Years
NHGRI
Long
02-H-0250
A Phase I/II Study of HLA-matched Mobilized Peripheral Blood Hematopoietic Stem Cell Transplantation for Advanced Mycosis Fungoides/Sezary Syndrome Using Nonmyeloablative Conditioning with Campath-1H
Completed Study; data analyses ongoing
18-125 Years
NHLBI
Syndrome
02-DK-N304
Diabetes Prevention Program Outcomes Study (DPPOS)
No longer recruiting/follow-up only
25-125 Years
NIDDK
Long
02-DK-0022
Long-Term Efficacy of Leptin Replacement in Treatment of Lipodystrophy
Completed Study; data analyses ongoing
1-125 Years
NIDDK
Long
02-CH-0311
Investigations into Inborn Errors of Cholesterol Synthesis and Related Disorders
Participants currently recruited/enrolled
0-125 Years
NICHD
Syndrome
02-C-0268
Prospective Study of Prophylactic Salpingo-Oophorectomy and Longitudinal CA-125 Screening Among Women at Increased Genetic Risk of Ovarian Cancer
Completed Study; data analyses ongoing
19-100 Years
NCI
Long
02-C-0211
Clinical, Laboratory, and Epidemiologic Characterization of Individuals and Families at High Risk of Melanoma
Participants currently recruited/enrolled
2-125 Years
NCI
Syndrome
02-C-0159
Birt-Hogg-Dub(SqrRoot)(Copyright) Syndrome: Characterization of the FLCN Disease Gene and Predisposition to Renal Cancer, Cutaneous Fibrofolliculoma and Pulmonary Cysts
Participants currently recruited/enrolled
2-125 Years
NCI
Syndrome
02-C-0052
Etiologic Investigation of Cancer Susceptibility in Inherited Bone Marrow Failure Syndromes: A Natural History Study
Participants currently recruited/enrolled
0-125 Years
NCI
Syndrome
01-I-0202
Natural History, Genetics, Phenotype, and Treatment of Mycobacterial Infections
Participants currently recruited/enrolled
0-100 Years
NIAID
Syndrome
01-HG-0109
Natural History Study of the Clinical and Molecular Manifestations of Smith-Magenis Syndrome (SMS)
No longer recruiting/follow-up only
0-125 Years
NHGRI
Syndrome
01-DK-N117
Family Investigation of Nephropathy and Diabetes (F.I.N.D.)
Clinical hold/Recruitment or enrollment suspended
18-125 Years
NIDDK
Long
01-DC-0228
Clinical and Molecular Analysis of Enlarged Vestibular Aqueducts
Completed Study; data analyses ongoing
0-99 Years
NIDCD
Syndrome
00-HG-0209
Molecular and Clinical Studies of Primary Immunodeficiency Diseases
No longer recruiting/follow-up only
3-125 Years
NHGRI
Syndrome
00-HG-0153
Investigations into Chediak-Higashi Syndrome and Related Disorders
Participants currently recruited/enrolled
0-70 Years
NHGRI
Syndrome
00-H-0051
Cutaneous Tumorigenesis in Patients with Tuberous Sclerosis
Participants currently recruited/enrolled
18-90 Years
NHLBI
Syndrome
00-CH-0160
Clinical and Molecular Analysis of ACTH-Independent Steroid Hormone Production in Adrenocortical Tissue
Completed Study; data analyses ongoing
3-70 Years
NICHD
Syndrome
00-C-0078
Collection of Blood, Fluid, Bone Marrow, Tumor, or Tissue Samples from Patients with Cancer or Normal Volunteers
Participants currently recruited/enrolled
18-125 Years
NCI
Long
00-C-0074
Evaluation of Late Effects and Natural History of Disease in Patients Treated with Radiotherapy
Participants currently recruited/enrolled
18-125 Years
NCI
Long
99-H-0050
Non-Myeloablative Allogeneic Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Hematologic Malignancies in High Risk Patients and in Patients with Debilitating Hematologic Diseases
Completed Study; data analyses ongoing
2-80 Years
NHLBI
Syndrome
99-C-0099
Examination of Clinical and Laboratory Abnormalities in Patients with Defective DNA Repair: Xeroderma Pigmentosum, Cockayne Syndrome, or Trichothiodystrophy
Participants currently recruited/enrolled
0-125 Years
NCI
Syndrome
98-N-0047
Immuno-Virological Evaluation of Human T Cell Leukemia Virus Type-1 Associated Myelopathy (HAM/TSP)
Participants currently recruited/enrolled
18-125 Years
NINDS
Long
98-D-0145
Screening and Natural History of Patients with Polyostotic Fibrous Dysplasia and the McCune-Albright Syndrome
Participants currently recruited/enrolled
0-100 Years
NIDCR
Syndrome
98-CH-0081
Clinical and Basic Investigations into Smith-Lemli-Opitz Syndrome
Completed Study; data analyses ongoing
0-125 Years
NICHD
Syndrome
97-HG-0192
Genetic Studies in the Amish and Mennonites
Completed Study; data analyses ongoing
18-125 Years
NHGRI
Syndrome
97-DC-0057
Genetic Studies of Stuttering
Completed Study; data analyses ongoing
6-125 Years
NIDCD
Long
97-CH-0064
Evaluation and Intervention for Ambulation, Growth, and Basilar Invagination in Osteogenesis Imperfecta
Completed Study; data analyses ongoing
0-10 Years
NICHD
Long
97-C-0147
Collection of Serum and Tissue Samples from Patients with Biopsy-Proved or Suspected Malignant Diseases
Participants currently recruited/enrolled
2-125 Years
NCI
Syndrome
96-I-0052
A Comprehensive Clinical, Microbiological and Immunological Assessment of Patients with Suspected Post Treatment Lyme Disease Syndrome and Selected Control Populations
Participants currently recruited/enrolled
13-125 Years
NIAID
Syndrome
96-CH-0033
An Open, Randomized, Long-Term Clinical Trial of Flutamide, Testolactone, and Reduced Hydrocortisone Dose vs. Conventional Treatment of Children with Congenital Adrenal Hyperplasia
No longer recruiting/follow-up only
2-18 Years
NICHD
Long
96-C-0071
Follow-up for Patients Previously Enrolled on the Center for Cancer Research Protocols
No longer recruiting/follow-up only
0-125 Years
NCI
Long
95-HG-0193
Clinical and Basic Investigations into Hermansky-Pudlak Syndrome
Participants currently recruited/enrolled
0-125 Years
NHGRI
Syndrome
95-CH-0059
Definition of the Genotype and Clinical Phenotype of Primary Pigmented Nodular Adrenocortical Disease (PPNAD), Carney Complex, Peutz-Jeghers Syndrome and Related Conditions
Completed Study; data analyses ongoing
3-70 Years
NICHD
Syndrome
94-HG-0132
The Phenotype and Etiology of Proteus Syndrome
Participants currently recruited/enrolled
0-125 Years
NHGRI
Syndrome
94-HG-0105
An Exploratory Study of the Genetics, Pathophysiology, and Natural History of Autoinflammatory Diseases
Participants currently recruited/enrolled
0-125 Years
NHGRI
Syndrome
94-DK-0133
Genetic Markers for Focal Segmental Glomerulosclerosis
Completed Study; data analyses ongoing
1-125 Years
NIDDK
Long
94-DK-0127
Pathogenesis of Glomerulosclerosis
Completed Study; data analyses ongoing
2-125 Years
NIDDK
Long
94-C-0074
Treatment and Natural History Study of Lymphomatoid Granulomatosis
Participants currently recruited/enrolled
12-125 Years
NCI
Long
94-AR-0066
Studies of the Pathogenesis and Natural History of Systemic Lupus Erythematosus (SLE)
Participants currently recruited/enrolled
9-125 Years
NIAMS
Long
93-I-0119
Detection and Characterization of Host Defense Defects
Participants currently recruited/enrolled
0-125 Years
NIAID
Long
92-DK-0156
Studies of Immunologically-Mediated Kidney Diseases
Participants currently recruited/enrolled
10-125 Years
NIDDK
Syndrome
92-CH-0034
Studies of Growth Deficiency and Growth Hormone Treatment in Children with Osteogenesis Imperfecta Types III and IV
Completed Study; data analyses ongoing
3-16 Years
NICHD
Long
91-AR-0196
Studies on the Natural History and Pathogenesis of Polymyositis, Dermatomyositis, and Related Diseases
Participants currently recruited/enrolled
16-125 Years
NIAMS
Long
90-M-0088
The Treatment of Menstrually-Related Mood Disorders with the Gonadotropin Releasing Hormone (GnRH) Agonist, Depot Leuprolide Acetate (Lupron)
Completed Study; data analyses ongoing
18-45 Years
NIMH
Syndrome
90-DK-0137
Evaluation of the Gastrinoma in Patients with Zollinger-Ellison Syndrome
Completed Study; data analyses ongoing
18-100 Years
NIDDK
Syndrome
89-N-0045
Evaluation of Progression in Multiple Sclerosis by Magnetic Resonance Imaging (MRI)
Participants currently recruited/enrolled
18-125 Years
NINDS
Long
89-M-0006
Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Volunteers
Participants currently recruited/enrolled
3-125 Years
NIMH
Syndrome
88-I-0172
A Phase III Study with Long-Term Follow-Up of Zidovudine Versus Zidovudine and Alpha-Interferon Versus Alpha-Interferon in Patients with Early HIV Infection
No longer recruiting/follow-up only
18-125 Years
NIAID
Long
85-I-0127
Natural History of Treated Neurocysticercosis and Long-Term Outcomes
Participants currently recruited/enrolled
3-99 Years
NIAID
Long
85-H-0105
Cardiovascular Evaluation of Homozygous Familial Hypercholesterolemia
Completed Study; data analyses ongoing
2-70 Years
NHLBI
Long
83-C-0022
Psychological Benefits of a Normalized Camping Experience for Children with Cancer
Participants currently recruited/enrolled
7-25 Years
NCI
Long
81-M-0126
The Evaluation of Women with Menstrually Regulated Mood and Behavioral Disorders
Participants currently recruited/enrolled
18-50 Years
NIMH
Syndrome
78-HG-0093
Use of Cysteamine in the Treatment of Cystinosis
Participants currently recruited/enrolled
0-125 Years
NHGRI
Long