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362 Studies found from all possible combinations of your search terms. Select a protocol that you wish to review.
Protocol Number Title Protocol Status Min-Max Age Institute Keywords
15-DK-0108Natural History of Noncirrhotic Portal HypertensionParticipants currently recruited/enrolled12-125 YearsNIDDKLiver Disease Congenital
14-HG-0071Clinical and Basic Investigations into Known and Suspected Congenital Disorders of GlycosylationParticipants currently recruited/enrolled1-80 YearsNHGRILiver Disease Congenital
000740-CHA Phase 3 Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Chronocort in the Treatment of Participants Aged 16 Years and Over with Congenital Adrenal HyperplasiaEnrolling by Invitation18-125 YearsNICHDDisease Congenital
000665-DKA Randomized Double-Blind Placebo-Controlled Study of the LEPR Agonist Antibody REGN4461 for the Treatment of Metabolic Abnormalities in Patients with Familial Partial LipodystrophyParticipants currently recruited/enrolled18-125 YearsNIDDKLiver Disease
000494-DKNatural History of Fontan Associated Liver Disease and the Evaluation of Biomarkers for Disease Severity AssessmentParticipants currently recruited/enrolled18-125 YearsNIDDKLiver Congenital
000387-HThe Natural History of Acquired and Inherited Bone Marrow Failure Syndromes.Participants currently recruited/enrolled2-125 YearsNHLBILiver Disease
000236-IA Phase 1 Study of Empagliflozin as Treatment for Severe Congenital Neutropenia Due to G6PC3 DeficiencyParticipants currently recruited/enrolled18-125 YearsNIAIDLiver Congenital
20-DK-0067A Phase 3, Matrix Design, Partially Double-Blind, Randomized Study of the Efficacy and Safety of 50 mg Lonafarnib/100 mg Ritonavir BID with and without 180 mcg PEG IFN-alfa-2a for 48 Weeks Compared with PEG IFN-alfa-2a Monotherapy and Placebo Treatment iNo longer recruiting/follow-up only18-125 YearsNIDDKLiver Disease
20-C-0070A Phase II Study of Allogeneic Hematopoietic Stem Cell Transplant for Patients with Inborn Errors of ImmunityParticipants currently recruited/enrolled4-69 YearsNCI Disease Congenital
19-DK-0067Effect of Low Fat versus Low Carbohydrate Diets on Energy MetabolismCompleted Study; data analyses ongoing18-50 YearsNIDDKLiver Disease
19-CH-0020A Phase 1-2 Multi-Center Study to Assess the Efficacy and Safety of Abiraterone Acetate as Adjunctive Therapy in Pre-Pubescent Children with Classic 21-Hydroxylase DeficiencyRecruitment has not started2-9 YearsNICHDDisease Congenital
19-C-0085Phase II Trial of Allogeneic Hematopoietic Cell Transplantation for Peripheral T cell LymphomaClinical hold/Recruitment or enrollment suspended12-125 YearsNCI Disease Congenital
18-H-0004Low Dose Danazol for the Treatment of Telomere Related DiseasesParticipants currently recruited/enrolled3-125 YearsNHLBILiver Disease
18-DK-0091Long-Term Follow-Up Of Subjects With CHC Who Achieved A Sustained Virological Response Following Therapy With Direct Acting Antiviral AgentsParticipants currently recruited/enrolled18-125 YearsNIDDKLiver Disease
18-C-0135Phase II Trial of Allogeneic Hematopoietic Cell Transplantation for Disorders of T-cell Proliferation and/or DysregulationParticipants currently recruited/enrolled4-125 YearsNCI Disease Congenital
16-C-0003Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary ImmunodeficienciesParticipants currently recruited/enrolled4-75 YearsNCI Disease Congenital
14-HG-0055Study on Moebius Syndrome and Other Congenital Facial Weakness DisordersCompleted Study; data analyses ongoing2-80 YearsNHGRILiver Congenital
11-I-0109Viral Infections in Healthy and Immunocompromised HostsParticipants currently recruited/enrolled0-125 YearsNIAIDLiver Disease
10-HG-0065Whole Genome Medical Sequencing for Gene DiscoveryParticipants currently recruited/enrolled0-125 YearsNHGRIDisease Congenital
10-C-0201Apheresis and CD34+ Selection of Mobilized Peripheral Blood CD34+ Cells from Patients with DOCK8 Deficiency, LAD-1, and GATA2 DeficiencyParticipants currently recruited/enrolled18-40 YearsNCI Liver Disease
09-I-0102Etiology, Pathogenesis, and Natural History of Idiopathic CD4+ LymphocytopeniaParticipants currently recruited/enrolled18-125 YearsNIAIDLiver Disease
06-H-0217Genetic Disorders of Mucociliary ClearanceCompleted Study; data analyses ongoing2-65 YearsNHLBILiver Disease
06-CH-0011Natural History Study of Patients with Excess AndrogenParticipants currently recruited/enrolled0-99 YearsNICHDDisease Congenital
01-I-0238Host Response to Infection and Treatment in Leishmania Infection of HumansParticipants currently recruited/enrolled3-100 YearsNIAIDLiver Disease
93-I-0119Detection and Characterization of Host Defense DefectsParticipants currently recruited/enrolled0-125 YearsNIAIDLiver Disease
91-I-0140Studies of the Pathogenesis of HIV Infection in Human Peripheral Blood Cells and/or Body Fluids in HIV-Infected and HIV-Uninfected VolunteersParticipants currently recruited/enrolled18-125 YearsNIAIDLiver Disease
91-DK-0214Evaluation of Patients with Liver DiseaseParticipants currently recruited/enrolled2-125 YearsNIDDKLiver Disease
001146-IA Repository to Study Host-Microbiome Interactions in Health and DiseaseParticipants currently recruited/enrolled0-125 YearsNIAIDDisease
001125-DKOptimizing HBV Care Cascade among Foreign-Born in the United States (FOCUS-HBV Study)Participants currently recruited/enrolled18-100 YearsNIDDKLiver
001109-CDefining the Natural History of Squamous Cell Carcinoma in Fanconi AnemiaParticipants currently recruited/enrolled8-125 YearsNCI Liver
001084-CHA Prospective Natural History Study of Lymphatic AnomaliesParticipants currently recruited/enrolled0-125 YearsNICHDDisease
001048-IA Phase 1/2 Randomized, Double-Blinded, Placebo-Controlled Trial Evaluating the Immunogenicity and Safety of an Adjuvanted Epstein-Barr Virus (EBV) Glycoprotein 350 Vaccine in EBV-Seronegative PersonsRecruitment has not started18-22 YearsNIAIDDisease
001018-CHEstablishment of Genomic and Phenotypic Database for Niemann-Pick Disease, Type CParticipants currently recruited/enrolled0-125 YearsNICHDLiver
000958-CProspective Procurement of Tumor Tissue to Identify Novel Therapeutic Targets and Study the Tumor MicroenvironmentEnrolling by Invitation18-125 YearsNCI Liver
000957-HGA Phase 1/2, Open-Label, Single Dose Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of SEL-302 (MMA-101 following administration of SEL-110) in Pediatric Subjects with Mut Subtype Isolated Methylmalonic Acidemia (MMA)Participants currently recruited/enrolled3-17 YearsNHGRILiver
000894-ARNatural History of Inflammatory Muscle DiseasesRecruitment has not started12-125 YearsNIAMSDisease
000829-HControls and Healthy Vasculature InitiativeParticipants currently recruited/enrolled18-125 YearsNHLBIDisease
000826-CAn Open Label, Randomised, Phase 2 Study to Evaluate the Safety and Efficacy of MTL-CEBPA Administered in Combination with Sorafenib or Sorafenib Alone, in TKI Naive Participants with Previously Treated Advanced Hepatocellular Carcinoma (HCC) and HepatitRecruitment has not started18-125 YearsNCI Liver
000821-IAn Open-Label, Single-Arm, Phase 1/2 Dose-Escalation Trial of Long-Acting Recombinant Human IL-7 (NT-I7, Efineptakin Alfa) for Idiopathic CD4 LymphopeniaRecruitment has not started18-75 YearsNIAIDDisease
000809-IA Pilot Study of Fecal Microbiota Transplantation for Chronic Granulomatous Disease-Associated ColitisParticipants currently recruited/enrolled10-60 YearsNIAIDDisease
000784-NAssessing and Improving Quantitative Magnetic Resonance Imaging Metrics in Human SubjectsParticipants currently recruited/enrolled18-125 YearsNINDSLiver
000697-HU01 Cooperative Assessment of Late Effects for SCD Curative Therapies (COALESCE)Participants currently recruited/enrolled18-65 YearsNHLBIDisease
000688-ILongitudinal Observations of Vaccine Responses to SARS-CoV-2 and other Emerging Infectious DiseasesParticipants currently recruited/enrolled18-125 YearsNIAIDDisease
000686-CHIntrathecal 2-Hydroxypropyl-Beta-Cyclodextrin for Neurological Decline in Patients with Niemann-Pick Disease Type C1Participants currently recruited/enrolled18-125 YearsNICHDLiver
000674-MAssessment of [18F]SF12051 for Imaging the 18-kDa Translocator Protein (TSPO) in Brain and Whole Body of Healthy SubjectsParticipants currently recruited/enrolled18-99 YearsNIMH Disease
000633-CPhase 1/2 Study of VIP152, Venetoclax, and Prednisone (VVIP) in Relapsed/Refractory Lymphoid MalignanciesParticipants currently recruited/enrolled18-125 YearsNCI Disease
000547-HGObservational Study of Advanced Data Analytics in Genetic ConditionsRecruitment has not started0-125 YearsNHGRIDisease
000545-DKPrevalence and Development of Liver Dysfunction in Hematopoietic Stem Cell Transplant: A Prospective Natural History StudyRecruitment has not started3-125 YearsNIDDKLiver
000520-CPhase I/II Evaluation of a Cancer Lysate Vaccine and Montanide(R) ISA-51 VG with or without the IL-15 Super-Agonist N-803 as Adjuvant Therapy for PD-L1 Negative Non-Small Cell Lung CancerRecruitment has not started18-125 YearsNCI Disease
000491-CTissue Procurement and Natural History Study of Neuroendocrine Neoplasms (NENs) Including Adrenocortical Carcinoma (ACC)Participants currently recruited/enrolled18-125 YearsNCI Liver
000487-CHNatural History Investigation into Biochemical and Phenotypical Aspects of Smith-Lemli-Opitz Syndrome and Related Disorders of Cholesterol MetabolismParticipants currently recruited/enrolled0-125 YearsNICHDDisease
000479-HObservational Study to Deeply Phenotype Major Organs in Sickle Cell Disease After Curative TherapiesParticipants currently recruited/enrolled18-125 YearsNHLBILiver
000473-CA Randomized Phase II Study of Systemic Chemotherapy with or without HAI FUDR-Dexamethasone in Patients with Unresectable Intrahepatic CholangiocarcinomaParticipants currently recruited/enrolled18-125 YearsNCI Liver
000464-HEvaluation of Clonal Hematopoiesis in Patients with Sickle Cell Disease Receiving Curative TherapiesEnrolling by Invitation4-125 YearsNHLBIDisease
000411-CCA Feasibility Pilot Study of a Virtual Education-Based Transition Intervention to Improve Transition Readiness in Adolescent and Young Adults with Congenital Adrenal Hyperplasia.Recruitment has not started16-22 YearsCC Congenital
000404-CA Phase II Study of Allogeneic Hematopoietic Stem Cell Transplant for Subjects with VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) SyndromeParticipants currently recruited/enrolled18-75 YearsNCI Disease
000392-IMetabolic Profiling of Immune Responses in Immune-Mediated DiseasesParticipants currently recruited/enrolled18-75 YearsNIAIDDisease
000356-CA Phase I/II Trial of BMS-986253 in Myelodysplastic SyndromesParticipants currently recruited/enrolled18-125 YearsNCI Disease
000344-DKNatural History Study of Parathyroid DisordersParticipants currently recruited/enrolled0-125 YearsNIDDKDisease
000343-HDetection of T cell Somatic Mutations in Bone Marrow Failure Using Whole Exome or Targeted SequencingEnrolling by Invitation18-125 YearsNHLBIDisease
000331-IInvestigating the Human Immune Response to Ixodes scapularis Tick BitesParticipants currently recruited/enrolled18-99 YearsNIAIDDisease
000310-CHA Phase 1/2, First-in-Human, Open-Label, Dose-Escalation Study of the Safety and Efficacy of Gene Therapy for Congenital Adrenal Hyperplasia through Administration of an Adeno-Associated Virus (AAV) Serotype 5-Based Recombinant Vector Encoding the Human Recruitment has not started18-125 YearsNICHDCongenital
000307-CPhase II Study Evaluating the Efficacy of M9241 in Combination with Hepatic Artery Infusion Pump (HAIP) and Systemic Therapy for Subjects with Metastatic Colorectal Cancer or Intrahepatic CholangiocarcinomaParticipants currently recruited/enrolled18-125 YearsNCI Liver
000297-CHA Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Crinecerfont (NBI-74788) in Adult Subjects with Classic Congenital Adrenal Hyperplasia, Followed by Open-Label TreatmentParticipants currently recruited/enrolled18-125 YearsNICHDCongenital
000291-IObservational Digital Biomarker Discovery in Respiratory Virus Challenge StudiesRecruitment has not started18-65 YearsNIAIDDisease
000272-HDefining the Genetic Etiology of Suppurative Lung Disease in Children and AdultsParticipants currently recruited/enrolled5-45 YearsNHLBIDisease
000247-DKEvaluation of Patients with Gastrointestinal DiseaseParticipants currently recruited/enrolled18-125 YearsNIDDKDisease
000226-IEfficacy of Belimumab and Rituximab Compared to Rituximab Alone for the Treatment of Primary Membranous NephropathyParticipants currently recruited/enrolled18-75 YearsNIAIDDisease
000207-ARThe Natural History of Coronavirus Disease (COVID-19) in Systemic Autoimmune Diseases; An Observational Prospective StudyParticipants currently recruited/enrolled15-125 YearsNIAMSDisease
000187-EIAdaptive Optics Imaging of Outer Retinal DiseasesParticipants currently recruited/enrolled21-125 YearsNEI Disease
000152-ENatural History of The Human Biological Response to Environmental Exposure and InjuryParticipants currently recruited/enrolled18-125 YearsNIEHSDisease
000137-CHImplications of Maternal 45,X Mosaicism As A Secondary Genomic Finding Following Cell-free DNA Sequencing During Pregnancy: A Deep Phenotype StudyRecruitment has not started18-99 YearsNICHDLiver
000130-DKUnraveling the Mechanisms Underlying Primary Sclerosing Cholangitis Through a Multidisciplinary, Integrative Research ApproachParticipants currently recruited/enrolled18-125 YearsNIDDKLiver
000124-CA Phase 2 Study of the MEK inhibitor Trametinib (IND #119346, NSC# 763093) in Children with Relapsed or Refractory Juvenile Myelomonocytic LeukemiaRecruitment has not started2-21 YearsNCI Disease
000118-DKProspective Cohort Study to Determine the Response to COVID-19 Vaccination and Prevalence of COVID-19 in Subjects with Chronic Liver DiseaseParticipants currently recruited/enrolled18-100 YearsNIDDKLiver
000080-C18F-DCFPyL PET/CT in Hepatocellular CarcinomaParticipants currently recruited/enrolled18-125 YearsNCI Liver
000079-DKThe Role of 68-Gallium-DOTATATE-PET/CT in the Imaging of Metastatic Thyroid CancerParticipants currently recruited/enrolled18-125 YearsNIDDKLiver
000037-CCDevelopment and Evaluation of Techniques for Computer Aided Detection and Diagnosis from Existing Radiologic ImagesNo longer recruiting/follow-up only0-125 YearsCC Disease
000036-AAA Phase I, Randomized, Double-Blind, Placebo-Controlled, Study of Safety, Tolerability, and Bioeffects of Alirocumab in Non-treatment Seeking Heavy DrinkersParticipants currently recruited/enrolled21-65 YearsNIAAALiver
22-DK-0002Effect of Ultra-processed versus Unprocessed Diets on Energy MetabolismParticipants currently recruited/enrolled18-60 YearsNIDDKDisease
21-I-0029Natural history, epidemiology and pathogenesis of severe HPV-related diseases (Neptune)Participants currently recruited/enrolled3-125 YearsNIAIDDisease
21-HG-0020Caregiving Networks Across Disease Context and the Life Course: A Comparative Longitudinal StudyParticipants currently recruited/enrolled18-125 YearsNHGRIDisease
21-CH-0028A Pilot Study to Evaluate a Noninvasive Multimodal Biosensing Device for Screening and Monitoring Response to Treatment of Infectious Respiratory Diseases.Participants currently recruited/enrolled18-125 YearsNICHDDisease
21-C-0030Phase I Study of GPC3 Targeted CAR-T Cell Therapy in Advanced GPC3 Expressing Hepatocellular Carcinoma (HCC)Participants currently recruited/enrolled18-125 YearsNCI Liver
20-M-0082Phase 1 Study: PET Imaging of Cyclooxygenases in Neurodegenerative Brain DiseaseParticipants currently recruited/enrolled18-99 YearsNIMH Disease
20-I-0132A Multicentre, Randomised, Double-blind, Parallel-group, Placebo-controlled, 24-week Phase 3 Study with an Open-label Extension to Evaluate the Efficacy and Safety of Benralizumab in Patients with Hypereosinophilic Syndrome (HES)Participants currently recruited/enrolled12-130 YearsNIAIDDisease
20-HG-0156A Multicenter, Multinational, Randomized, Double-Blind, Placebo-Controlled Study to Assess The Efficacy, Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of Venglustat in Late-Onset GM2 Gangliosidosis (Tay-Sachs Disease And Sandhoff Disease) No longer recruiting/follow-up only2-125 YearsNHGRIDisease
20-H-0158Natural History Study: Gene First Approach to Connective Tissue DiseaseParticipants currently recruited/enrolled2-100 YearsNHLBIDisease
20-H-0141Long-term Follow-up of Subjects With Sickle Cell Disease Treated With Ex Vivo Gene Therapy Using Autologous Hematopoietic Stem Cells Transduced With a Lentiviral VectorEnrolling by Invitation18-125 YearsNHLBILiver
20-H-0099Data Collection of Standard Care and Evaluation of NHLBI Patients and DonorsEnrolling by Invitation2-120 YearsNHLBIDisease
20-H-0044Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Immune Activation in PsoriasisCompleted Study; data analyses ongoing18-80 YearsNHLBIDisease
20-H-0029An Intravenous, Open-Label, Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Fx-5A in Healthy VolunteersParticipants currently recruited/enrolled18-125 YearsNHLBIDisease
20-H-0021Treatment of Refractory Diamond-Blackfan Anemia with EltrombopagNo longer recruiting/follow-up only2-125 YearsNHLBILiver
20-DK-0168LYNC-LD Prospective Multicenter Natural History Study of Lipodystrophy Syndromes to Determine Prevalence, Incidence and Predictors of Diabetes and Severe Hypertriglyceridemia, and their Complications.Participants currently recruited/enrolled3-125 YearsNIDDKDisease
20-DK-0079A Randomized, Double-Blinded, Placebo-Controlled Study of REGN4661, A Leptin Receptor Agonist Antibody, In Patients with Generalized LipodystrophyNo longer recruiting/follow-up only12-125 YearsNIDDKLiver
20-CH-0165Androgen Receptor, Implications for Health and Wellbeing: Natural History Study of Individuals with Androgen InsensitivityParticipants currently recruited/enrolled0-99 YearsNICHDLiver
20-CH-0126Data Collection Study of Pediatric and Adolescent Gynecology ConditionsParticipants currently recruited/enrolled0-125 YearsNICHDCongenital
20-CC-0039A Feasibility Study to Evaluate the Combination of Electromagnetic Tracking and Optical Imaging with Indocyanine Green (ICG) for Hepatic BiopsiesEnrolling by Invitation18-125 YearsCC Liver
20-C-0167Close Assessment and Testing for Chronic Graft-vs-Host Disease (CATCH Study)Participants currently recruited/enrolled18-125 YearsNCI Disease
20-C-0162A Phase 1 Study of Venetoclax with Obinutuzumab and Magrolimab (VENOM) in Relapsed and Refractory Indolent B-cell MalignanciesParticipants currently recruited/enrolled18-125 YearsNCI Liver
20-C-0152Phase II Study of combination of Trametinib (MEK inhibitor) and Hydroxychloroquine (HCQ) (autophagy inhibitor) in Patients with KRAS Mutation Refractory Bile Tract Carcinoma (BTC).Participants currently recruited/enrolled18-125 YearsNCI Liver
20-C-0097A Phase II, Open-Label Trial of Bintrafusp Alfa (M7824) in Subjects with Thymoma and Thymic CarcinomaParticipants currently recruited/enrolled18-125 YearsNCI Disease
20-C-0062A phase 1b Study of Nivolumab in Patients with Autoimmune Disorders and Advanced Malignancies (AIM-NIVO)Participants currently recruited/enrolled18-125 YearsNCI Disease
20-C-0041Protocol for a Research Database for Hematopoietic Cell Transplantation, Other Cellular Therapies and Marrow Toxic InjuriesEnrolling by Invitation1-125 YearsNCI Disease
20-C-0028Phase 1/2 Study of Anti-CD33 Chimeric Antigen Receptor-Expressing T Cells (CD33CART) in Children and Young Adults with Relapsed/Refractory Acute Myeloid LeukemiaParticipants currently recruited/enrolled3-35 YearsNCI Liver
20-C-0022Phase II trial of VB-111 in Combination with Nivolumab in Patients with Metastatic Colorectal Cancer (mCRC)Completed Study; data analyses ongoing18-125 YearsNCI Liver
20-C-0006A National Translational Science Network of Precision-based Immunotherapy for Primary Liver Cancer (PLC)Participants currently recruited/enrolled18-125 YearsNCI Liver
20-AA-0057The Effect of Acute Alcohol Intoxication on Neural Processes During Decisions to Engage in HIV Risk BehaviorsParticipants currently recruited/enrolled21-65 YearsNIAAADisease
19-M-0095PET Imaging of Neuroinflammation in Neurodegenerative Diseases via a Novel TSPO RadioligandParticipants currently recruited/enrolled18-125 YearsNIMH Disease
19-M-0079Evaluation of Novel PET Radioligands as Inflammatory Biomarkers in Rheumatoid Arthritis and MyositisParticipants currently recruited/enrolled18-99 YearsNIMH Disease
19-I-0069Phase I Open-Label Study of Safety and Immunogenicity of AD4-HIV Envelope Vaccine Vectors in Healthy VolunteersParticipants currently recruited/enrolled18-65 YearsNIAIDDisease
19-HG-0101A Phase 1/2 Study of Intravenous Gene Transfer with an AAV9 Vector Expressing Human Beta-galactosidase in Type I and Type II GM1 GangliosidosisNo longer recruiting/follow-up only0-12 YearsNHGRIDisease
19-HG-0059Longitudinal Studies of Patients with FPDMMParticipants currently recruited/enrolled0-125 YearsNHGRIDisease
19-H-0139Investigation of the Natural Progression of Clonal Hematopoiesis of Indeterminate Potential and Clonal Cytopenia of Undetermined Significance.Participants currently recruited/enrolled18-125 YearsNHLBILiver
19-H-0057Multiple Patient Program for Lamprene (clofazimine) for the treatment of Non-Tuberculous Mycobacterial (NTM) Infections- CLAM320B2002MParticipants currently recruited/enrolled18-99 YearsNHLBILiver
19-EI-0056A Survey Study of Retinitis Pigmentosa (RP) Clinical Measures and Repeatability Testing of Potential Outcome Measures.Participants currently recruited/enrolled12-125 YearsNEI Disease
19-DK-0072Non-Alcoholic Fatty Liver Disease, the Hepatic Response to Oral Glucose, and the Effect of Semaglutide (NAFLD HEROES)Participants currently recruited/enrolled18-125 YearsNIDDKLiver
19-CH-0071An Open-Label Phase 3 Study of the Safety and Efficacy of Pegvisomant in Children with Growth Hormone ExcessParticipants currently recruited/enrolled2-18 YearsNICHDLiver
19-C-0094A Phase II Study of Combined Treatment of Durvalumab, Bevacizumab, Tremelimumab and Transarterial Chemoembolization (TACE) in Subjects with Hepatocellular Carcinoma (HCC) or Biliary Tract Carcinoma (BTC)Participants currently recruited/enrolled18-125 YearsNCI Liver
19-C-0039Perioperative MVT-5873, a Fully Human Monoclonal Antibody Against a CA 19-9 Epitope, for Operable CA 19-9 Producing Pancreatic Cancers, Cholangiocarcinomas, and Metastatic Colorectal CancersCompleted Study; data analyses ongoing18-125 YearsNCI Liver
19-C-0033Phase II Study of Nivolumab (anti-PD1), Tadalafil and Oral Vancomycin in Patients with Refractory Primary Hepatocellular Carcinoma or Liver Dominant Metastatic Cancer from Colorectal or Pancreatic CancersCompleted Study; data analyses ongoing18-125 YearsNCI Liver
18-I-0139Defining Skin Immunity of a Bite of Key Insect Vectors in HumansCompleted Study; data analyses ongoing18-64 YearsNIAIDDisease
18-I-0128Send-In Sample Collection to Achieve Genetic and Immunologic Characterization of Primary ImmunodeficienciesParticipants currently recruited/enrolled0-99 YearsNIAIDDisease
18-I-0092A Phase 2, Open-Label Study to Assess the Immunogenicity of the 9-Valent Human Papillomavirus Recombinant Vaccine in Patients with Idiopathic CD4 T cell LymphocytopeniaParticipants currently recruited/enrolled18-70 YearsNIAIDDisease
18-I-0041Investigating the Mechanistic Biology of Primary Immunodeficiency DisordersParticipants currently recruited/enrolled0-75 YearsNIAIDDisease
18-HG-0129Reverse Phenotyping Core (RPC)Enrolling by Invitation4-125 YearsNHGRIDisease
18-HG-0064A Natural History Study of Patients with Generalized Arterial Calcification of Infancy (GACI) or Autosomal Recessive Hypophosphatemic Rickets Type 2 (ARHR2)Completed Study; data analyses ongoing0-125 YearsNHGRIDisease
18-H-0118Technical and Translational Development of Cardiovascular MRI (CMR)Participants currently recruited/enrolled7-125 YearsNHLBIDisease
18-H-0108Vascular Disease Discovery ProtocolParticipants currently recruited/enrolled2-100 YearsNHLBIDisease
18-EI-0068An Investigation of Vitamin A Palmitate Supplementation in Patients with Reticular Pseudodrusen (RPD) and Delayed Dark AdaptationParticipants currently recruited/enrolled50-125 YearsNEI Liver
18-EI-0067An Investigation of Vitamin A Palmitate Supplementation in Patients with Age-Related Macular Degeneration (and without reticular pseudodrusen) and Delayed Dark AdaptationParticipants currently recruited/enrolled50-125 YearsNEI Liver
18-DK-N071Early Tracking of Childhood Health Determinants StudyParticipants currently recruited/enrolled0-125 YearsNIDDKLiver
18-DK-0123Treatment of Chronic Delta Hepatitis with Lonafarnib, Ritonavir and Lambda InterferonCompleted Study; data analyses ongoing18-125 YearsNIDDKLiver
18-D-0114An Open Label Pilot Study of Denosumab Treatment for Fibrous DysplasiaNo longer recruiting/follow-up only18-125 YearsNIDCRDisease
18-CH-0031Clinical and Molecular Characteristics of Primary Aldosteronism in BlacksParticipants currently recruited/enrolled7-70 YearsNICHDDisease
18-C-0138An Open-Label Phase 2 Study to Evaluate PT2977 for the Treatment of Von Hippel-Lindau Disease-Associated Renal Cell Carcinoma.No longer recruiting/follow-up only18-125 YearsNCI Disease
18-C-0076Bicalutamide With or Without Metformin for Biochemical Recurrence in Prostate Cancer Patients (BIMET-1)Completed Study; data analyses ongoing18-85 YearsNCI Disease
18-C-0024A Single-Arm Phase II Study of Hepatic Artery Infusion Pump Chemotherapy with Floxuridine and Dexamethasone in Combination with Systemic Chemotherapy for Patients with Colorectal Cancer Metastatic to the LiverParticipants currently recruited/enrolled18-125 YearsNCI Liver
17-N-0131Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal DementiaParticipants currently recruited/enrolled18-125 YearsNINDSDisease
17-M-0179Evaluation of a Novel PET Radioligand to Image Cyclooxygenase-1 (COX-1)Participants currently recruited/enrolled18-99 YearsNIMH Disease
17-I-0016Studies of the Natural History, Pathogenesis, and Outcome of Autoinflammatory Diseases (NOMID/CAPS, DIRA, CANDLE, SAVI, NLRC4-MAS, Still's-like Diseases, and Other Undifferentiated Autoinflammatory Diseases)Participants currently recruited/enrolled0-99 YearsNIAIDDisease
17-H-0146Prospective Multicenter Registry On Radiation Dose Estimates of Cardiac CT Angiography in Daily Practice in 2017 (PROTECTION VI)Completed Study; data analyses ongoing18-100 YearsNHLBIDisease
17-H-0095Heart Catheterization Using Magnetic Resonance Imaging (MRI) Fluoroscopy and Passive GuidewiresParticipants currently recruited/enrolled18-125 YearsNHLBICongenital
17-H-0091Unrelated Umbilical Cord Blood Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS using CordIn, Umbilical Cord Blood-Derived Ex Vivo Expanded Stem and Progenitor Cells, to Expedite Engraftment and Improve Transplant OutcomeParticipants currently recruited/enrolled4-75 YearsNHLBIDisease
17-DK-0054The Physiological Responses and Adaptation of Brown Adipose Tissue to Chronic Treatment with Beta3-Adrenergic Receptor AgonistsParticipants currently recruited/enrolled18-40 YearsNIDDKLiver
17-DK-0013Therapeutic Targets in African-American Youth with Type 2 DiabetesParticipants currently recruited/enrolled12-25 YearsNIDDKLiver
17-DA-0093Exploring Gut-Brain and Brain-Gut Interactions in Alcohol Use Disorder via Microbiota Investigations: A Pilot StudyCompleted Study; data analyses ongoing21-70 YearsNIDA Liver
17-C-0174Molecular Characterization of Viral-associated Tumors, Tumors Occurring in the Setting of HIV or Other Immune Disorders and Castleman DiseaseParticipants currently recruited/enrolled18-125 YearsNCI Disease
17-C-0105Prospective Study of Clonal Evolution in Follicular LymphomaParticipants currently recruited/enrolled18-125 YearsNCI Disease
17-C-0086An Open-label Phase 2 Study to Evaluate PT2385 for the Treatment of Von Hippel-Lindau Disease-Associated Clear Cell Renal Cell CarcinomaNo longer recruiting/follow-up only18-125 YearsNCI Disease
17-C-0048Anti-CD30 CAR T Cells with Fully-human Binding Domains for Treating CD30-expressing Lymphomas Including Anaplastic Large Cell LymphomasCompleted Study; data analyses ongoing18-73 YearsNCI Liver
16-I-0165An open-label, non-randomized extension study to evaluate the long term safety, tolerability, efficacy and pharmacokinetics of CDZ173 (leniolisib) in patients with APDS/PASLI (Activated phosphoinositide 3-kinase delta syndrome/p110 delta-activating mutatNo longer recruiting/follow-up only12-75 YearsNIAIDDisease
16-I-0065Screening for Alpha Globin DeletionsParticipants currently recruited/enrolled18-39 YearsNIAIDDisease
16-HG-0156The Natural History, Physiology, Microbiome and Biochemistry Studies of Propionic AcidemiaParticipants currently recruited/enrolled0-125 YearsNHGRIDisease
16-HG-0017Genomic Services Research ProgramParticipants currently recruited/enrolled0-125 YearsNHGRIDisease
16-H-0074Williams Syndrome (WS) and Supravalvular Aortic Stenosis (SVAS) DNA and Tissue BankParticipants currently recruited/enrolled0-85 YearsNHLBIDisease
16-H-0063Williams Syndrome Skin and Vascular Elasticity Study (WS-SAVE Study)Completed Study; data analyses ongoing1-70 YearsNHLBIDisease
16-EI-0169A Pilot Study to Investigate Ustekinumab (STELARA) for the Treatment of Active Sight-Threatening UveitisCompleted Study; data analyses ongoing18-125 YearsNEI Disease
16-EI-0134Studies of the Natural History, Pathogenesis and Outcome of Ocular DisordersParticipants currently recruited/enrolled0-125 YearsNEI Disease
16-EI-0104Clinical and Molecular Studies in Families with Inherited Eye DiseaseParticipants currently recruited/enrolled4-125 YearsNEI Disease
16-EI-0024Rod and Cone Mediated Function in Retinal DiseaseParticipants currently recruited/enrolled5-125 YearsNEI Disease
16-E-0096Cytochrome P450 Epoxygenase Pathway Regulation of Macrophage FunctionParticipants currently recruited/enrolled18-65 YearsNIEHSDisease
16-DK-0143Idiosyncratic Liver Injury Associated with Drugs (ILIAD): A Retrospective StudyParticipants currently recruited/enrolled18-125 YearsNIDDKLiver
16-DK-0125Evaluation of Adults with Endocrine-Related ConditionsParticipants currently recruited/enrolled18-100 YearsNIDDKDisease
16-DK-0068The Molecular, Cellular, and Genetic Characterization of Human Adipose Tissue and its Role in MetabolismParticipants currently recruited/enrolled18-125 YearsNIDDKDisease
16-DK-0038A Randomized, Double Blind, Placebo-Controlled Study to Assess Efficacy, Safety and Tolerability of ISIS 304801 in Patients with Partial Lipodystrophy with an Open-Label ExtensionCompleted Study; data analyses ongoing18-125 YearsNIDDKLiver
16-CH-0164A Phase III Extension Study of Efficacy, Safety and Tolerability of Chronocort (Registered) in the Treatment of Congenital Adrenal HyperplasiaCompleted Study; data analyses ongoing18-80 YearsNICHDCongenital
16-CH-0113Evaluation of Children with Endocrine and Metabolic-Related ConditionsParticipants currently recruited/enrolled0-100 YearsNICHDDisease
16-CC-0162Longitudinal Changes in the Oral and Gut Microbiome of Individuals with Alcohol DependenceCompleted Study; data analyses ongoing18-125 YearsCC Disease
16-CC-0049A Phase II Study Using LC Bead LUMI Radio-Opaque Embolic Beads to Detect and Characterize the Vascularity of Hepatic Tumors During Treatment with Transarterial Embolization (TAE) Alone or Combined with Thermal AblationEnrolling by Invitation18-125 YearsCC Liver
16-C-0154A Phase I/II Trial of T Cell Receptor Gene Therapy Targeting HPV-16 E7 for HPV-Associated CancersParticipants currently recruited/enrolled18-125 YearsNCI Disease
16-C-0135A Pilot Study of Combined Immune Checkpoint Inhibition in combination with Ablative Therapies in Subjects with Hepatocellular Carcinoma (HCC) or Biliary Tract Carcinomas (BTC)No longer recruiting/follow-up only18-125 YearsNCI Liver
16-C-0094A Phase 1/2 Study of Baricitinib, a JAK1/2 Inhibitor, in Chronic Graft-Versus-Host Disease (cGVHD) after Allogeneic Hematopoietic Stem Cell Transplantation (SCT)No longer recruiting/follow-up only18-125 YearsNCI Disease
15-N-0125Natural History Study of Inflammatory and Infectious Diseases of the Nervous SystemParticipants currently recruited/enrolled2-125 YearsNINDSDisease
15-I-0135An open-label, non-randomized, within-patient dose-finding study followed by a randomized, subject, investigator and sponsor-blinded placebo controlled study to assess the efficacy and safety of CDZ173 (leniolisib) in patients with APDS/PASLI (Activated Completed Study; data analyses ongoing12-75 YearsNIAIDDisease
15-I-0131Xenodiagnosis after Antibiotic Treatment for Lyme Disease - Phase II StudyCompleted Study; data analyses ongoing18-125 YearsNIAIDDisease
15-I-0056Collection of Plasma from Subjects that Recovered From or Were Vaccinated To Emerging Infectious DiseasesEnrolling by Invitation18-70 YearsNIAIDDisease
15-HG-0130Clinical and Genetic Evaluation of Patients with Undiagnosed Disorders Through the Undiagnosed Diseases NetworkParticipants currently recruited/enrolled0-100 YearsNHGRIDisease
15-H-0190Human Biospecimen Procurement and Analysis to Support Translational Research to Identify Genetic Etiology and Disease Mechanism(s) in Rare Genetic Vascular/Cardiovascular DiseasesParticipants currently recruited/enrolled0-125 YearsNHLBIDisease
15-EI-0128The Genetics of Inherited Eye DiseaseParticipants currently recruited/enrolled0-125 YearsNEI Disease
15-EI-0020Adaptive Optics Retinal ImagingParticipants currently recruited/enrolled12-125 YearsNEI Disease
15-DK-0174Dynamic Post-Prandial Metabolism in Patients with Non-Alcoholic Fatty Liver DiseaseCompleted Study; data analyses ongoing18-125 YearsNIDDKLiver
15-DK-0170Treatment of Chronic Delta Hepatitis with Lonafarnib and RitonavirCompleted Study; data analyses ongoing18-99 YearsNIDDKLiver
15-DK-0143Investigation of Viral Kinetics, Interferon Stimulated Genes (ISGs) and mirRNA Among Subjects Infected with Different Hepatitis C Virus Genotypes During Therapy with Sofosbuvir and GS-5816Completed Study; data analyses ongoing18-80 YearsNIDDKLiver
15-DK-0100A Multidisciplinary Approach to Deciphering the Mechanisms Involved In Microbial Translocation Across the Spectrum of HCV Associated Liver FibrosisCompleted Study; data analyses ongoing18-125 YearsNIDDKLiver
15-DK-0082Mechanisms Associated with Favorable Response to Peginterferon-Alpha Add-on Therapy Following Long-term Nucleos(t)ide Analogue Treatment in Patients with Chronic Hepatitis BCompleted Study; data analyses ongoing18-125 YearsNIDDKLiver
15-DK-0079Observational Study of Hepatitis B Virus (HBV) in Patients Coinfected with Human Immunodeficiency Virus (HIV)Completed Study; data analyses ongoing18-125 YearsNIDDKLiver
15-DK-0003Compassionate Use of Metreleptin in Previously-Treated Patients with Generalized LipodystrophyParticipants currently recruited/enrolled0-125 YearsNIDDKLiver
15-DK-0002Compassionate Use of Metreleptin in Previously-Treated Patients with Partial LipodystrophyNo longer recruiting/follow-up only0-125 YearsNIDDKLiver
15-D-0051Characterization of Diseases with Salivary Gland InvolvementParticipants currently recruited/enrolled4-125 YearsNIDCRDisease
15-C-0157Phase I/II Trial of Vandetanib in Combination with Metformin in Subjects with HLRCC or SDH-Associated Kidney Cancer or Sporadic Papillary Renal Cell CarcinomaCompleted Study; data analyses ongoing18-125 YearsNCI Disease
15-C-0138Phase I Study of Ipilimumab, Nivolumab, and the Combination in Patients with Newly Diagnosed GlioblastomaCompleted Study; data analyses ongoing18-125 YearsNCI Liver
15-C-0099A Phase 1, Open-Label, Dose-Escalation Study of SNX-5422 and Everolimus in Subjects with Neuroendocrine TumorsCompleted Study; data analyses ongoing18-100 YearsNCI Disease
15-C-0067A Phase I/II Open Label, Dose Escalation Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell TransplantationParticipants currently recruited/enrolled18-125 YearsNCI Disease
15-AR-0144Studies of Dermatologic Diseases-Biospecimen Acquisition ProtocolParticipants currently recruited/enrolled2-125 YearsNIAMSDisease
15-AG-0123Intermittent Calorie Restriction, Insulin Resistance, and Biomarkers of Brain FunctionCompleted Study; data analyses ongoing55-70 YearsNIA Disease
15-AG-0063The Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT)Participants currently recruited/enrolled20-125 YearsNIA Disease
14-I-0194Screening of Volunteers for Clinical Trials of Investigational or Licensed Vaccines or Antiviral ProductsParticipants currently recruited/enrolled18-65 YearsNIAIDDisease
14-I-0146The Pathogenesis and Genetics of Disseminated or Refractory CoccidioidomycosisParticipants currently recruited/enrolled2-100 YearsNIAIDDisease
14-I-0091Analysis of Patients Treated for Chronic Granulomatous Disease Since January 1, 1995Completed Study; data analyses ongoing3-125 YearsNIAIDDisease
14-I-0039Elite Controller and ART-Treated HIV+ Statin Versus ASA Treatment Intervention StudyCompleted Study; data analyses ongoing18-125 YearsNIAIDDisease
14-H-0155A Phase 1/2 Study Evaluating Gene Therapy by Transplantation of Autologous CD34+ Stem Cells Transduced Ex Vivo with the LentiGlobin BB305 Lentiviral Vector in Subjects with Severe Sickle Cell DiseaseNo longer recruiting/follow-up only18-50 YearsNHLBILiver
14-EI-0064Whole Exome and Whole Genome Sequencing for Genotyping of Inherited and Congenital Eye ConditionsParticipants currently recruited/enrolled1-125 YearsNEI Congenital
14-AR-0200Studies of the Natural History, Pathogenesis, and Outcome of Idiopathic Systemic VasculitisParticipants currently recruited/enrolled3-125 YearsNIAMSDisease
14-AA-0144Reliability Of The Human Brain ConnectomeParticipants currently recruited/enrolled18-125 YearsNIAAADisease
13-N-0188Natural History and Biomarkers of C9ORF72 Amyotrophic Lateral Sclerosis and Frontotemporal DementiaCompleted Study; data analyses ongoing18-125 YearsNINDSDisease
13-N-0165Electrical Impedance Myography: Natural History Studies in Neuromuscular Disorders and Healthy VolunteersParticipants currently recruited/enrolled2-125 YearsNINDSDisease
13-N-0140Cerebrospinal Fluid Collection and Repository StorageParticipants currently recruited/enrolled2-125 YearsNINDSDisease
13-I-0177Natural History Study of the Complications Associated with Allogeneic Hematopoietic Stem Cell TransplantationsCompleted Study; data analyses ongoing2-125 YearsNIAIDDisease
13-I-0082Rituximab (Anti-CD20) for the Treatment of Subjects With Anticytokine Autoantibody-Associated DiseasesCompleted Study; data analyses ongoing18-125 YearsNIAIDDisease
13-I-0062A Double Blind Randomized Placebo Controlled Study Examining the Effects of a Non-Absorbable (Rifaximin) Antibiotic on the Chronic Immune Activation Observed In HIV-infected SubjectsCompleted Study; data analyses ongoing18-65 YearsNIAIDLiver
13-HG-0199NIH Participation to USIDNET RegistryParticipants currently recruited/enrolled0-125 YearsNHGRIDisease
13-HG-0053The NIH Mini Study: Metabolism, INfection and Immunity in Inborn Errors of Mitochondrial MetabolismParticipants currently recruited/enrolled2-125 YearsNHGRIDisease
13-H-0194Inflammatory Characterization of Known or Possible Cardiovascular DiseasesNo longer recruiting/follow-up only18-125 YearsNHLBIDisease
13-H-0116A Multicenter Safety Study of Unlicensed, Investigational Cryopreserved Cord Blood Units (CBUs) Manufactured by the National Cord Blood Program (NCBP) and Provided for Unrelated Hematopoietic Stem Cell Transplantation of Pediatric and Adult PatientsParticipants currently recruited/enrolled4-125 YearsNHLBIDisease
13-H-0065Human Translational Studies of Inflammation and Cardiometabolic Diseases: The Psoriasis, Atherosclerosis and Cardiometabolic Disease (PACI) InitiativeNo longer recruiting/follow-up only18-125 YearsNHLBIDisease
13-H-0060Analysis of Samples Collected from a Subject who Received ACP- 501 (Human Recombinant Lecithin:Cholesterol Acyltransferase [rhLCAT])Completed Study; data analyses ongoing18-100 YearsNHLBILiver
13-EI-0072Microbiome and Ocular Inflammatory DiseaseCompleted Study; data analyses ongoing18-125 YearsNEI Disease
13-DK-0091Combination Therapy of Pegylated Interferon Alfa-2a and Tenofovir DF versus Tenofovir DF Monotherapy in HBeAg-Positive and HBeAg-Negative Chronic Hepatitis BCompleted Study; data analyses ongoing18-125 YearsNIDDKLiver
13-DK-0057Short Term Effects of Leptin Withdrawal or Initiation in Lipodystrophy Independent of Energy IntakeCompleted Study; data analyses ongoing14-70 YearsNIDDKLiver
13-D-0033Diagnosis and Treatment of Patients in Need of Third Molar Removal and Oral Specimen AcquisitionParticipants currently recruited/enrolled16-50 YearsNIDCRDisease
13-D-0014Bacterial Arrangement in Supragingival BiofilmsCompleted Study; data analyses ongoing18-999 YearsNIDCRDisease
13-CC-0012A Natural History Study of Novel Biomarkers in Pulmonary Arterial HypertensionParticipants currently recruited/enrolled18-125 YearsCC Disease
13-C-0153A Phase II Trial of Enzalutamide in Combination with PSA-TRICOM in Patients with Non-Metastatic Castration Sensitive Prostate CancerCompleted Study; data analyses ongoing18-125 YearsNCI Disease
13-C-0132Allogeneic Hematopoietic Stem Cell Transplant for Patients with Mutations in GATA2 or the MonoMAC SyndromeParticipants currently recruited/enrolled8-70 YearsNCI Disease
13-C-0131Inpatient Hospice with Procurement of Tissue on Expiration in Thoracic Malignancies, Bladder Cancer, Ovarian Cancer, Epithelial Cancer and Patients Treated with an Adoptive Cellular TherapyParticipants currently recruited/enrolled18-125 YearsNCI Disease
13-AR-0056Stopping Tumor Necrosis Factor-Alpha Inhibitors in Rheumatoid ArthritisCompleted Study; data analyses ongoing18-125 YearsNIAMSDisease
12-HG-0181The Clinical Study of Patients with Sex Chromosome VariantsCompleted Study; data analyses ongoing18-125 YearsNHGRIDisease
12-HG-0022Inherited Diseases, Caregiving, and Social NetworksCompleted Study; data analyses ongoing18-125 YearsNHGRIDisease
12-H-0092An Intravenous, Open-Label, Single-Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of rhLCAT in Patients with Stable Coronary Artery DiseaseCompleted Study; data analyses ongoing30-75 YearsNHLBILiver
12-H-0064A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients with Hematologic Malignancies and Other IndicationsParticipants currently recruited/enrolled4-75 YearsNHLBIDisease
12-EI-0203Natural History of ABCA4-Related RetinopathiesNo longer recruiting/follow-up only12-125 YearsNEI Disease
12-EI-0042NEI Intramural Biorepository for Retinal DiseasesParticipants currently recruited/enrolled2-125 YearsNEI Disease
12-E-0190The Role of Functionally Relevant Cyclooxygenase-2 (COX-2) Gene Single Nucleotide Polymorphisms - 765G>C and 8473T>C in Lymphocyte DifferentiationCompleted Study; data analyses ongoing18-150 YearsNIEHSDisease
12-E-0061The Role of the Functionally Relevant Single Nucleotide Polymorphisms CYP2J2 -50G>T (CYP2J2 7) and EPHX2 9846A>G (EPHX2 K55R) in Human Endothelial FunctionCompleted Study; data analyses ongoing18-65 YearsNIEHSDisease
12-DK-0071Combination Entecavir and Peginterferon Therapy in HBeAg-Positive Immune-Tolerant Adults with Chronic Hepatitis BCompleted Study; data analyses ongoing18-40 YearsNIDDKLiver
12-C-0175Prospective Procurement of Solid Tumor Tissue to Identify Novel Therapeutic TargetsCompleted Study; data analyses ongoing18-125 YearsNCI Liver
12-AR-0159Effects of Treatments on the Microbiome in Healthy Volunteers and Patients with Atopic DermatitisParticipants currently recruited/enrolled2-50 YearsNIAMSDisease
11-I-0183Screening for LID Clinical Studies Unit Healthy Volunteer ProtocolsParticipants currently recruited/enrolled18-65 YearsNIAIDDisease
11-I-0164VRC 500: Screening Volunteers for Clinical Trials of Investigational Products and Licensed Products Evaluated for Research PurposesParticipants currently recruited/enrolled18-125 YearsNIAIDDisease
11-HG-0218A Natural History Study of Patients with GNE Myopathy and GNE-Related DiseasesParticipants currently recruited/enrolled4-80 YearsNHGRIDisease
11-HG-0110Genetics of Obesity, Diabetes, and Heart Disease in African Diaspora PopulationsEnrolling by Invitation18-125 YearsNHGRIDisease
11-H-0209Male Hormones for Telomere Related DiseasesCompleted Study; data analyses ongoing2-125 YearsNHLBIDisease
11-H-0134A Pilot Study of a Thrombopoietin-Receptor Agonist (TPO-R Agonist), Eltrombopag, in Moderate Aplastic Anemia PatientsNo longer recruiting/follow-up only2-125 YearsNHLBIDisease
11-H-0046Cross-Sectional Characterization of Idiopathic BronchiectasisCompleted Study; data analyses ongoing18-125 YearsNHLBIDisease
11-EI-0245Generation of Induced Pluripotent Stem (iPS) Cell Lines from Somatic Cells of Participants with Eye Diseases and from Somatic Cells of Matched ControlsParticipants currently recruited/enrolled1-125 YearsNEI Disease
11-E-0072Environmental Risk Factors for the Anti-Synthetase SyndromeParticipants currently recruited/enrolled2-100 YearsNIEHSDisease
11-DK-0151Withdrawal of Therapy After Long-Term Oral Nucleos(t)ide Analogue Treatment in Patients with Chronic Hepatitis BCompleted Study; data analyses ongoing18-125 YearsNIDDKLiver
11-DK-0108Observational Study of Persons with Hepatitis B Virus Infection in North America (Cohort Study)Completed Study; data analyses ongoing18-100 YearsNIDDKLiver
11-CC-0152The Natural History of Liver Disease in a Cohort of Participants with Hepatitis B and/or Hepatitis C with or without HIV InfectionCompleted Study; data analyses ongoing18-99 YearsCC Liver
11-CC-0120Stereophotogrammetry of the Torso in Healthy Individuals and Patients with Scoliosis, Chest Wall Deformations, or ObesityCompleted Study; data analyses ongoing2-125 YearsCC Disease
11-C-0112Acquisition of Blood and Tumor Tissue Samples from Patients with Gastrointestinal CancerParticipants currently recruited/enrolled18-125 YearsNCI Liver
11-C-0061Phase I Trial of Z-Endoxifen in Adults with Refractory Hormone Receptor-Positive Breast Cancer, Desmoid Tumors, Gynecologic Tumors, or other Hormone Receptor-Positive Solid TumorsNo longer recruiting/follow-up only18-125 YearsNCI Liver
10-I-0197Admission and Management of Occupational or Other Exposures to Biodefense/Bioterrorism Agents or to Epidemic/Emerging Infectious DiseasesParticipants currently recruited/enrolled2-99 YearsNIAIDDisease
10-I-0148Natural History of Severe Allergic Inflammation and ReactionsParticipants currently recruited/enrolled2-80 YearsNIAIDDisease
10-I-0139Searching for Persistence of Infection in Lyme DiseaseCompleted Study; data analyses ongoing18-125 YearsNIAIDDisease
10-I-0109VRC 900: Evaluation of Tissue-Specific Immune Responses in Adults 18 Years of Age and OlderParticipants currently recruited/enrolled18-125 YearsNIAIDDisease
10-H-0154Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused with a Reduced Dose of Non-Mobilized Donor T-CellsParticipants currently recruited/enrolled4-80 YearsNHLBIDisease
10-H-0126Cardiovascular Disease Discovery ProtocolParticipants currently recruited/enrolled1-100 YearsNHLBIDisease
10-EI-0140Genotype - phenotype Study of Patients with Plaquenil-induced Retinal ToxicityParticipants currently recruited/enrolled18-125 YearsNEI Disease
10-E-0134Effect of SNPs in p53 and p53 Response Elements on the Inflammatory Response to DNA DamageCompleted Study; data analyses ongoing18-100 YearsNIEHSDisease
10-E-0129Study of the Effect of Innate Immunity on the Inflammatory Response to EndotoxinParticipants currently recruited/enrolled18-125 YearsNIEHSDisease
10-CC-0217A Comparison of Methods for Assisting Needle Angle Selection During Image-Guided Tissue BiopsyCompleted Study; data analyses ongoing18-125 YearsCC Liver
10-CC-0053Collection of Bone Marrow from Healthy Volunteers and Patients for the Production of Clinical Bone Marrow Stromal Cell (BMSC) ProductsCompleted Study; data analyses ongoing18-125 YearsCC Disease
10-C-0066A Study of Hairy Cell and other Leukemias with a Focus on Recombinant Immunotoxins for Cancer TreatmentParticipants currently recruited/enrolled18-125 YearsNCI Disease
10-C-0056A Phase I Study of Indenoisoquinolines LMP400 and LMP776 in Adults With Relapsed Solid Tumors and LymphomasCompleted Study; data analyses ongoing18-125 YearsNCI Disease
09-NR-0088Molecular-Genetic Correlates of Fatigue in Cancer Patients Receiving Localized External Beam Radiation TherapyCompleted Study; data analyses ongoing18-125 YearsNINR Disease
09-N-0010Biomarkers of Risk of Parkinson DiseaseCompleted Study; data analyses ongoing18-70 YearsNINDSDisease
09-I-0133Establishing Fibroblast-derived Cell Lines from Skin/Tissue Biopsies of Patients with Immunodeficiency or Immunodysregulation DisordersEnrolling by Invitation2-85 YearsNIAIDDisease
09-I-0086Screening Protocol for Genetic Diseases of Allergic InflammationParticipants currently recruited/enrolled0-99 YearsNIAIDDisease
09-I-0032Comprehensive Multimodal Analysis of Patients with Neuroimmunological Diseases of the CNSParticipants currently recruited/enrolled0-99 YearsNIAIDDisease
09-I-0013Biomarkers of Inflammation, Coagulation, and Endothelial Function in HIV-Infected AdultsEnrolling by Invitation18-100 YearsNIAIDLiver
09-H-0225Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Severe Congenital Anemias Including Sickle Cell Disease and Beta-ThalassemiaNo longer recruiting/follow-up only2-125 YearsNHLBICongenital
09-H-0172Natural History of BronchiectasisParticipants currently recruited/enrolled5-125 YearsNHLBIDisease
09-DK-0223Rituximab Plus Cyclosporine in Idiopathic Membranous NephropathyParticipants currently recruited/enrolled18-125 YearsNIDDKDisease
09-DK-0097Vitamin E Pharmacokinetics and Biomarkers in Normal and Obese WomenCompleted Study; data analyses ongoing18-55 YearsNIDDKLiver
09-C-0024A Phase I Study of Quadrivalent Human Papilloma Virus (HPV) (Types 6, 11, 16, 18) Recombinant Vaccine in HIV-Infected and HIV-Negative Pre-Adolescents, Adolescents and Young AdultsCompleted Study; data analyses ongoing12-26 YearsNCI Disease
09-C-0005Randomized Trial of Cladribine (CdA) with Simultaneous or Delayed Rituximab to Eliminate Hairy Cell Leukemia Minimal Residual DiseaseParticipants currently recruited/enrolled18-125 YearsNCI Disease
08-EI-0102Screening Protocol for the Evaluation and Diagnosis of Potential Research ParticipantsParticipants currently recruited/enrolled2-125 YearsNEI Disease
08-EI-0031Visual Motor CoordinationParticipants currently recruited/enrolled18-125 YearsNEI Disease
08-DK-0149High Dose Ribavirin in Combination with Peginterferon for Patients with Chronic Hepatitis C Genotype 1 Infection Who Have Failed to Respond or Relapsed after Standard TherapyCompleted Study; data analyses ongoing18-65 YearsNIDDKLiver
08-DK-0098Natural History of Familial Carcinoid TumorParticipants currently recruited/enrolled18-125 YearsNIDDKLiver
08-C-0130A Phase II Trial of Peginterferon alfa-2b (PEG-Intron) for Neurofibromatosis Type 1 Related Unresectable, Symptomatic or Life-Threatening Plexiform NeurofibromasCompleted Study; data analyses ongoing0-21 YearsNCI Congenital
07-H-0142Research Respiratory Tract ProceduresParticipants currently recruited/enrolled10-125 YearsNHLBIDisease
07-H-0113Procurement and Analysis of Blood, Bone Marrow, and Buccal Mucosa Samples from Healthy Volunteers to Support Clinical and Translational Research Projects in the NHLBIParticipants currently recruited/enrolled8-125 YearsNHLBIDisease
07-E-0023Innate Immunity Signal Transduction in Human LeukocytesParticipants currently recruited/enrolled18-65 YearsNIEHSDisease
07-CH-0008Prospective, Open-Label, Multicenter, International Study of Mifepristone for Symptomatic Treatment of Cushing's Syndrome Caused by Ectopic Adrenal Corticotrophin Hormone (ACTH) SecretionCompleted Study; data analyses ongoing18-85 YearsNICHDDisease
06-M-0214PET Measurement of Regional Rates of Cerebral Protein Synthesis in Subjects with Fragile X SyndromeCompleted Study; data analyses ongoing18-24 YearsNIMH Disease
06-I-0153A Pilot Study of Hepatic Fibrosis in HIV/AIDS Patients with Chronically Elevated Transaminases on Antiretroviral TherapyNo longer recruiting/follow-up only18-100 YearsNIAIDLiver
06-I-0015Screening Protocol for Genetic Diseases of Lymphocyte Homeostasis and Programmed Cell DeathParticipants currently recruited/enrolled0-125 YearsNIAIDDisease
06-EI-0236National Ophthalmic Genotyping and Phenotyping Network Stage 1 - Creation of DNA Repository for Inherited Ophthalmic DiseasesNo longer recruiting/follow-up only2-125 YearsNEI Disease
06-C-0014Prospective Evaluation of Genetic and Epigenetic Alterations in Patients with Thoracic MalignanciesParticipants currently recruited/enrolled2-125 YearsNCI Disease
06-AR-0198A Pilot Pediatric/Adult Study of Gene Expression Profiling and Clinical Characterization of PhototoxicityCompleted Study; data analyses ongoing8-100 YearsNIAMSLiver
05-H-0130Long-Term Evaluation and Follow Up Care of Patients Treated with Allogeneic Stem Cell TransplantsParticipants currently recruited/enrolled7-80 YearsNHLBILiver
05-CC-0216Prospective Assessment of Functional Status, Psychosocial Adjustment, Health Related Quality of Life and the Symptom Experience in Patients Treated with Allogeneic Hematopoietic Stem Cell TransplantationCompleted Study; data analyses ongoing18-125 YearsCC Disease
05-CC-0091Electromagnetic Tracking of Devices During Interventional ProceduresEnrolling by Invitation18-125 YearsCC Liver
04-HG-0127Clinical and Basic Investigations of Methylmalonic Acidemia (MMA) and Related DisordersParticipants currently recruited/enrolled0-125 YearsNHGRILiver
04-H-0012Collection of Blood, Bone Marrow, Urine, and/or Tissue Samples from Patients with Solid Tumors, Hematological Malignancies or Non-Malignant Hematologic Disorders or HLA Compatible Family MembersParticipants currently recruited/enrolled2-125 YearsNHLBIDisease
04-E-0053Personalized Environment and Genes StudyParticipants currently recruited/enrolled18-130 YearsNIEHSDisease
04-CH-0077Investigations of Bone-Related Connective Tissue DisordersCompleted Study; data analyses ongoing0-70 YearsNICHDDisease
04-C-0274Follow-Up Study of Subjects Previously Enrolled in Immunotherapy Studies Utilizing Gene Transfer or Other Immunotherapeutic AgentsParticipants currently recruited/enrolled18-125 YearsNCI Liver
03-I-0263VRC 200: A Multicenter Specimen Collection Protocol to Obtain Human Biological Samples for Research StudiesParticipants currently recruited/enrolled18-125 YearsNIAIDDisease
03-H-0282Characterization of Cardiac Function in Subjects with Hereditary Hemochromatosis Who Are New York Heart Association Functional Class ICompleted Study; data analyses ongoing21-100 YearsNHLBILiver
03-H-0280Disease Pathogenesis and Natural History of Lipid DisordersParticipants currently recruited/enrolled2-100 YearsNHLBIDisease
03-H-0170Nonmyeloablative Allogeneic Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation For Severe Congenital Anemias Including Sickle Cell Disease (SCD) and Beta-ThalassemiaParticipants currently recruited/enrolled2-125 YearsNHLBICongenital
03-E-0099Pathogenic Studies In Families With Twins Or Siblings Discordant For Systemic Rheumatic DisordersCompleted Study; data analyses ongoing2-125 YearsNIEHSDisease
03-C-0066Hereditary Leiomyomatosis Renal Cell Cancer (HLRCC): Identification of the Disease Gene, and Characterization of the Predisposition to Renal CancerParticipants currently recruited/enrolled2-125 YearsNCI Liver
03-AR-0173Studies of Natural History, Pathogenesis, and Outcomes in Autoimmune and Inflammatory Diseases Including Juvenile DermatomyositisParticipants currently recruited/enrolled2-125 YearsNIAMSDisease
02-N-0014Research Study of Specimens Obtained During Epilepsy SurgeryCompleted Study; data analyses ongoing4-125 YearsNINDSDisease
02-I-0147Genetic Studies of Chronic Active Epstein-Barr Virus InfectionParticipants currently recruited/enrolled1-125 YearsNIAIDDisease
02-I-0086Evaluation of Viral Factors and Immune Parameters to Study HIV-Specific ImmunityParticipants currently recruited/enrolled18-125 YearsNIAIDLiver
02-HG-0107Natural History of Glycosphingolipid Storage Disorders and Glycoprotein DisordersParticipants currently recruited/enrolled0-125 YearsNHGRIDisease
02-DK-0022Long-Term Efficacy of Leptin Replacement in Treatment of LipodystrophyCompleted Study; data analyses ongoing1-125 YearsNIDDKLiver
02-C-0210Clinical, Laboratory, and Epidemiologic Characterization of Individuals and Families at High Risk of Blood and Lymph Node MalignancyParticipants currently recruited/enrolled0-125 YearsNCI Disease
02-C-0179Biospecimen Acquisition from Human SubjectsParticipants currently recruited/enrolled18-125 YearsNCI Liver
02-C-0052Etiologic Investigation of Cancer Susceptibility in Inherited Bone Marrow Failure Syndromes: A Natural History StudyParticipants currently recruited/enrolled0-125 YearsNCI Congenital
01-N-0206Phenotype/Genotype Correlations in Movement DisordersParticipants currently recruited/enrolled2-125 YearsNINDSDisease
01-N-0007Evaluation, Pathogenesis, and Treatment of Patients with or at Risk for Cerebrovascular Disease (A Natural History/Disease Pathogenesis Protocol)Participants currently recruited/enrolled18-125 YearsNINDSDisease
01-I-0202Natural History, Genetics, Phenotype, and Treatment of Mycobacterial InfectionsParticipants currently recruited/enrolled0-100 YearsNIAIDDisease
01-H-0122Collection and Storage of Umbilical Cord Hematopoietic Stem Cells for Sickle Cell Disease TherapyParticipants currently recruited/enrolled18-45 YearsNHLBIDisease
01-DK-N117Family Investigation of Nephropathy and Diabetes (F.I.N.D.)Clinical hold/Recruitment or enrollment suspended18-125 YearsNIDDKDisease
01-D-0184A Natural History Study of Bone and Mineral DisordersParticipants currently recruited/enrolled0-125 YearsNIDCRDisease
01-CC-0045Studies of Phlebotomy Therapy in Hereditary HemochromatosisParticipants currently recruited/enrolled18-125 YearsCC Liver
01-C-0009Breast Imaging Screening Studies in Women at High Genetic Risk of Breast Cancer: Annual Follow-up StudyCompleted Study; data analyses ongoing18-100 YearsNCI Disease
01-AR-0227Studies of the Natural History of Rheumatic Disease in Minority CommunitiesParticipants currently recruited/enrolled18-100 YearsNIAMSDisease
00-N-0043Clinical and Molecular Manifestations of Inherited Neurological DisordersParticipants currently recruited/enrolled2-125 YearsNINDSDisease
00-I-0159Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES)Participants currently recruited/enrolled0-125 YearsNIAIDDisease
00-HG-0209Molecular and Clinical Studies of Primary Immunodeficiency DiseasesNo longer recruiting/follow-up only3-125 YearsNHGRIDisease
00-CH-0093Diagnosis, Pathophysiology, and Molecular Biology of Pheochromocytoma and ParagangliomaParticipants currently recruited/enrolled3-125 YearsNICHDDisease
99-H-0050Non-Myeloablative Allogeneic Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Hematologic Malignancies in High Risk Patients and in Patients with Debilitating Hematologic DiseasesCompleted Study; data analyses ongoing2-80 YearsNHLBIDisease
99-DK-0002Diabetes and Heart Disease Risk in BlacksParticipants currently recruited/enrolled18-70 YearsNIDDKDisease
99-C-0099Examination of Clinical and Laboratory Abnormalities in Patients with Defective DNA Repair: Xeroderma Pigmentosum, Cockayne Syndrome, or TrichothiodystrophyParticipants currently recruited/enrolled0-125 YearsNCI Disease
98-CC-0019Volunteer Scanning on MRParticipants currently recruited/enrolled18-125 YearsCC Disease
97-HG-0192Genetic Studies in the Amish and MennonitesCompleted Study; data analyses ongoing18-125 YearsNHGRIDisease
97-C-0147Collection of Serum and Tissue Samples from Patients with Biopsy-Proved or Suspected Malignant DiseasesParticipants currently recruited/enrolled2-125 YearsNCI Disease
96-H-0100Role of Genetic Factors in the Pathogenesis of Lung DiseaseParticipants currently recruited/enrolled2-90 YearsNHLBIDisease
96-CH-0033An Open, Randomized, Long-Term Clinical Trial of Flutamide, Testolactone, and Reduced Hydrocortisone Dose vs. Conventional Treatment of Children with Congenital Adrenal HyperplasiaNo longer recruiting/follow-up only2-18 YearsNICHDCongenital
96-AR-0102Evaluation and Treatment of Subjects with Dermatologic DiseasesParticipants currently recruited/enrolled0-125 YearsNIAMSDisease
96-AR-0097The Acquisition of Blood and Skin Samples from Patient Volunteers to Support Research Activities on Dermatologic and Other DiseasesNo longer recruiting/follow-up only18-125 YearsNIAMSDisease
95-I-0066Genetic Analysis of Immune DisordersParticipants currently recruited/enrolled0-125 YearsNIAIDDisease
95-CH-0059Definition of the Genotype and Clinical Phenotype of Primary Pigmented Nodular Adrenocortical Disease (PPNAD), Carney Complex, Peutz-Jeghers Syndrome and Related ConditionsCompleted Study; data analyses ongoing3-70 YearsNICHDDisease
94-I-0079Eosinophil Activation and Function in Parasitic Infections and Other Conditions with Increased Tissue or Peripheral Blood Eosinophilia in HumansParticipants currently recruited/enrolled1-100 YearsNIAIDDisease
94-HG-0132The Phenotype and Etiology of Proteus SyndromeParticipants currently recruited/enrolled0-125 YearsNHGRICongenital
94-HG-0105An Exploratory Study of the Genetics, Pathophysiology, and Natural History of Autoinflammatory DiseasesParticipants currently recruited/enrolled0-125 YearsNHGRIDisease
94-DK-0133Genetic Markers for Focal Segmental GlomerulosclerosisCompleted Study; data analyses ongoing1-125 YearsNIDDKDisease
94-DK-0127Pathogenesis of GlomerulosclerosisCompleted Study; data analyses ongoing2-125 YearsNIDDKDisease
93-I-0086Evaluation and Long-Term Follow-Up of Patients with Acute or Chronic Inflammatory DisordersEnrolling by Invitation2-125 YearsNIAIDDisease
93-I-0063Study of the Immunopathogenesis, Natural History, and Genetics of Autoimmune Lymphoproliferative Syndrome (ALPS) Associated with an Expansion of CD4-8-/TCR alpha/beta+ T CellsParticipants currently recruited/enrolled0-99 YearsNIAIDLiver
92-DK-0156Studies of Immunologically-Mediated Kidney DiseasesParticipants currently recruited/enrolled10-125 YearsNIDDKDisease
91-CC-0117Epidemiology, Infectivity and Natural History of Hepatitis C Virus Infection in a Blood Donor PopulationNo longer recruiting/follow-up only18-125 YearsCC Liver
91-AR-0196Studies on the Natural History and Pathogenesis of Polymyositis, Dermatomyositis, and Related DiseasesParticipants currently recruited/enrolled16-125 YearsNIAMSDisease
90-CC-0168A Rigid Body Database on Human MovementParticipants currently recruited/enrolled0-125 YearsCC Disease
89-N-0045Evaluation of Progression in Multiple Sclerosis by Magnetic Resonance Imaging (MRI)Participants currently recruited/enrolled18-125 YearsNINDSDisease
89-M-0006Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy VolunteersParticipants currently recruited/enrolled3-125 YearsNIMH Congenital
88-I-0083Host Response to Infection and Treatment in the Filarial Diseases of HumansParticipants currently recruited/enrolled3-100 YearsNIAIDDisease
87-DK-0029Diagnosis and Treatment of Patients with Cystic FibrosisParticipants currently recruited/enrolled4-125 YearsNIDDKLiver
85-H-0105Cardiovascular Evaluation of Homozygous Familial HypercholesterolemiaCompleted Study; data analyses ongoing2-70 YearsNHLBILiver
82-I-0183A Natural History Study of the Immune Regulation of Idiopathic Inflammatory Bowel Diseases: Crohn's Disease, Ulcerative Colitis, and Other Inflammatory Conditions of the GutParticipants currently recruited/enrolled0-75 YearsNIAIDDisease
81-I-0164Procedures to Obtain Plasma, Lymphocytes, or Other Specimens for Research StudiesParticipants currently recruited/enrolled18-125 YearsNIAIDLiver
79-H-0100Teaching Protocol for the Evaluation of Plasma LipoproteinsNo longer recruiting/follow-up only2-99 YearsNHLBIDisease
78-I-0023Diagnosis and Management of Inflammatory and Infectious DiseasesParticipants currently recruited/enrolled3-125 YearsNIAIDDisease
76-HG-0238Diagnosis and Treatment of Patients with Inborn Errors of Metabolism or Other Genetic DisordersParticipants currently recruited/enrolled0-125 YearsNHGRIDisease
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