NIH Clinical Center: Search the Studies

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104 Studies found from all possible combinations of your search terms. Select a protocol that you wish to review.

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Protocol Number	Title	Protocol Status	Min-Max Age	Institute	Keywords
001124-I	Expanded Access IND Protocol: Use of Tecovirimat (TPOXX (R)) for Treatment of Human Non-Variola Orthopoxvirus Infections in Adults and Children	Enrolling by Invitation	0-125 Years	NIAID	7
001066-DA	Orexin's Role in The Neurobiology of Substance Use Disorder	Participants currently recruited/enrolled	18-60 Years	NIDA	7
001058-DK	A Phase 1b/2a Open-label Multiple-ascending Dose Exploratory Study of CRN04894 in ACTH-dependent Cushing's Syndrome (Cushing's Disease or Ectopic ACTH Syndrome)	Recruitment has not started	18-75 Years	NIDDK	7
001037-I	A Randomized Placebo-controlled Study to Evaluate the Safety and Effects of Repeated Doses of 3BNC117-LS and 10-1074-LS on Persistent Viral Reservoirs in People Living with HIV and on Suppressive Antiretroviral Therapy	Participants currently recruited/enrolled	18-70 Years	NIAID	7
000910-DA	Real-world Momentary Assessment of Kratom use Accompanied by Product Assays: A Natural-history Study for Interdisciplinary Characterization of Kratom use and Pharmacology	Completed Study; data analyses ongoing	18-125 Years	NIDA	7
000824-M	[11C]-(R)-Rolipram to Measure cAMP Signaling Before and After Ketamine	Enrolling by Invitation	18-70 Years	NIMH	7
000821-I	An Open-Label, Single-Arm, Phase 1/2 Dose-Escalation Trial of Long-Acting Recombinant Human IL-7 (NT-I7, Efineptakin Alfa) for Idiopathic CD4 Lymphopenia	Recruitment has not started	18-75 Years	NIAID	7
000780-D	A Phase 2 Study of Denosumab for Prevention of Skeletal Disease Progression in Children with Fibrous Dysplasia	Participants currently recruited/enrolled	4-14 Years	NIDCR	7
000758-H	A Phase II Study Using Fostamatinib to Treat Post-Hematopoietic Stem Cell Transplant Immune-Mediated Cytopenias	Participants currently recruited/enrolled	18-75 Years	NHLBI	7
000736-CC	Imaging Characterization of the Biomechanical Coupling of Brain and Skull: An Observational Study	Participants currently recruited/enrolled	21-65 Years	CC	7
000731-C	A First-In-Human, Open-Label, Multicenter Study of VOR33 in Patients with Acute Myeloid Leukemia who are at High-Risk for Leukemia Relapse following Hematopoietic Cell Transplantation	Participants currently recruited/enrolled	18-70 Years	NCI	7
000686-CH	Intrathecal 2-Hydroxypropyl-Beta-Cyclodextrin for Neurological Decline in Patients with Niemann-Pick Disease Type C1	Participants currently recruited/enrolled	18-125 Years	NICHD	7
000580-C	A Phase 1/2, Open Label Dose-Escalation and Expansion Trial of Nkt2152, an Orally Administered Hif2a Inhibitor, to Investigate Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity in Patients with Advanced Clear Cell Renal Cell Carcinoma	Participants currently recruited/enrolled	18-125 Years	NCI	7
000536-I	VRC 614: A Phase 1, Dose Escalation, Open-Label Clinical Trial with Experimental Controlled Human Malaria Infections (CHMI) to Evaluate Safety and Protective Efficacy of an Anti-Malaria Human Monoclonal Antibody, VRC-MALMAB0114-00-AB (L9LS), in Healthy M	Completed Study; data analyses ongoing	18-50 Years	NIAID	7
000487-CH	Natural History Investigation into Biochemical and Phenotypical Aspects of Smith-Lemli-Opitz Syndrome and Related Disorders of Cholesterol Metabolism	Participants currently recruited/enrolled	0-125 Years	NICHD	7
000486-C	A Phase 1 Trial of the ATR Inhibitor BAY 1895344 in Combination with Cisplatin and with Cisplatin Plus Gemcitabine in Advanced Solid Tumors with an Emphasis on Urothelial Carcinoma	Participants currently recruited/enrolled	18-125 Years	NCI	7
000315-MD	A Prospective Natural History Study of COVID-19 Using Digital Wearables	Participants currently recruited/enrolled	18-65 Years	NIMHD	7
000254-C	A Phase II Trial of the Superenhancer Inhibitor Minnelide in Advanced Refractory Adenosquamous Carcinoma of the Pancreas (ASCP)	Participants currently recruited/enrolled	18-125 Years	NCI	7
000251-C	The Effect of Diet and Exercise on ImmuNotherapy and the Microbiome (EDEN)	Participants currently recruited/enrolled	18-125 Years	NCI	7
000126-N	A Pilot Study of NT-I7, a Long-Acting Recombinant IL-7 Molecule, as an Immune Reconstitution Strategy for Lymphopenia in Patients with Progressive Multifocal Leukoencephalopathy	Participants currently recruited/enrolled	18-125 Years	NINDS	7
000124-C	A Phase 2 Study of the MEK inhibitor Trametinib (IND #119346, NSC# 763093) in Children with Relapsed or Refractory Juvenile Myelomonocytic Leukemia	Recruitment has not started	2-21 Years	NCI	7
000045-C	A Phase I Trial of T Cell Receptor Gene Therapy Targeting KK-LC-1 for Gastric, Breast, Cervical, Lung and other KK-LC-1 Positive Epithelial Cancers	Participants currently recruited/enrolled	18-120 Years	NCI	7
21-C-0012	Individualized Response Assessment to Heated Intraperitoneal Chemotherapy (HIPEC) for the Treatment of Peritoneal Carcinomatosis from Ovarian, Colorectal, Appendiceal, or Peritoneal Mesothelioma Histologies	Participants currently recruited/enrolled	18-125 Years	NCI	7
20-NR-0003	A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue	Participants currently recruited/enrolled	18-70 Years	NINR	7
20-M-0166	Electrophysiologic Sleep Phenotyping and Sleep-Dependent Neuro-maturation in Clinical and Healthy Pediatric Populations	Participants currently recruited/enrolled	0-8 Years	NIMH	7
20-M-0157	PET Imaging of Cyclooxygenase in Participants with Major Depressive Disorder (MDD)	Participants currently recruited/enrolled	18-70 Years	NIMH	7
20-HG-0156	A Multicenter, Multinational, Randomized, Double-Blind, Placebo-Controlled Study to Assess The Efficacy, Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of Venglustat in Late-Onset GM2 Gangliosidosis (Tay-Sachs Disease And Sandhoff Disease)	No longer recruiting/follow-up only	2-125 Years	NHGRI	7
20-H-0033	Early Initiation of Oral Therapy with Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA)	Participants currently recruited/enrolled	3-125 Years	NHLBI	7
19-N-0124	Anakinra for the Treatment of Chronically Inflamed White Matter Lesions in Multiple Sclerosis	Participants currently recruited/enrolled	18-120 Years	NINDS	7
19-N-0036	Exploring the Relationship Between Brain Asymmetry and Attention	Completed Study; data analyses ongoing	18-35 Years	NINDS	7
19-I-0126	Systems Analyses of the Immune Response to the Seasonal Influenza Vaccine	Completed Study; data analyses ongoing	18-125 Years	NIAID	7
19-I-0084	Skin Immunity Sample Collection Involving Blisters and Biopsies	Recruitment has not started	7-65 Years	NIAID	7
19-H-0118	Repeat Peripheral Blood Stem Cell Transplantation for Patients with Sickle Cell Disease or Beta-Thalassemia and Falling Donor Myeloid Chimerism Levels	Participants currently recruited/enrolled	2-80 Years	NHLBI	7
19-CC-0055	Cardiovascular Disease in HIV and Hepatitis C: Risk Outcomes after Hepatitis C Eradication	Participants currently recruited/enrolled	18-125 Years	CC	7
19-C-0127	A Phase II Study of LMB-100 Followed by Pembrolizumab in the Treatment of Adults with Mesothelin-Expressing Non-Squamous Non-Small Cell Lung Cancer (NSCLC)	No longer recruiting/follow-up only	18-125 Years	NCI	7
18-N-0020	The Natural History of Blood-Brain Barrier Disruption in Stroke Patients with White Matter Hyperintensities (A Cohort Study)	No longer recruiting/follow-up only	18-125 Years	NINDS	7
18-DA-N053	Imaging Biomarker for Addiction Treatment Outcome	Participants currently recruited/enrolled	21-125 Years	NIDA	7
18-CH-0031	Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks	Participants currently recruited/enrolled	7-70 Years	NICHD	7
18-C-0110	Safety Run-In and Phase II Trial of M7824 and Topotecan or Temozolomide in Relapsed Small Cell Cancers	Participants currently recruited/enrolled	18-125 Years	NCI	7
18-C-0026	A Phase 2 Study of Inotuzumab Ozogamicin (NSC# 772518, IND#133494) in Children and Young Adults with Relapsed or Refractory CD22+ B-Acute Lymphoblastic Leukemia (B-ALL)	Participants currently recruited/enrolled	1-21 Years	NCI	7
17-N-0055	Functional Connectivity as a Biomarker of rTMS	Completed Study; data analyses ongoing	18-125 Years	NINDS	7
17-I-0067	Sanaria PfSPZ Challenge with Pyrimethamine Chemoprophylaxis (PfSPZ-CVac Approach): Phase 1 Dose Escalation Trial to Determine Safety and Development of Protective Efficacy after Exposure to Only Pre-erythrocytic Stages of Plasmodium falciparum	Completed Study; data analyses ongoing	18-50 Years	NIAID	7
17-CH-0130	Break It Up: A Study Evaluating Breaking Up daily sedentary behavior in youth	Completed Study; data analyses ongoing	7-11 Years	NICHD	7
17-C-0070	Phase II Trial of Heated Intraperitoneal Chemotherapy and Gastrectomy for Gastric Cancer with Positive Peritoneal Cytology	Participants currently recruited/enrolled	18-125 Years	NCI	7
17-C-0048	Anti-CD30 CAR T Cells with Fully-human Binding Domains for Treating CD30-expressing Lymphomas Including Anaplastic Large Cell Lymphomas	Completed Study; data analyses ongoing	18-73 Years	NCI	7
16-N-0114	The Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques: An Investigator-Blinded Study	Participants currently recruited/enrolled	18-125 Years	NINDS	7
16-N-0058	Myalgic Encephalomyelitis/Chronic Fatigue Syndrome	Completed Study; data analyses ongoing	18-60 Years	NINDS	7
16-C-0135	A Pilot Study of Combined Immune Checkpoint Inhibition in combination with Ablative Therapies in Subjects with Hepatocellular Carcinoma (HCC) or Biliary Tract Carcinomas (BTC)	No longer recruiting/follow-up only	18-125 Years	NCI	7
15-N-0126	HERV-K Suppression using Antiretroviral Therapy in Volunteers with Amyotrophic Lateral Sclerosis (ALS)	No longer recruiting/follow-up only	18-125 Years	NINDS	7
15-H-0155	Hereditary Parkinson Disease Natural History Protocol	Completed Study; data analyses ongoing	18-80 Years	NHLBI	7
15-CC-0164	Effect of Exercise Training on Physical, Cognitive and Behavioral Function in Patients with Traumatic Brain Injury	Completed Study; data analyses ongoing	18-79 Years	CC	7
14-N-0061	Noninvasive Pre-surgical Evaluation of Patients with Focal Epilepsy and Establishment of a Normative Imaging Database	Participants currently recruited/enrolled	8-65 Years	NINDS	7
14-I-0009	Characterization and Management of Patients with HIV-1 Infection Who Experience Virologic Failure Despite Combination Antiretroviral Therapy	Completed Study; data analyses ongoing	18-100 Years	NIAID	7
14-DK-0060	Famine from Feast: Linking Vitamin C, Red Blood Cell Fragility, and Diabetes	Participants currently recruited/enrolled	18-65 Years	NIDDK	7
14-C-0059	A Phase I Trial of T Cells Expressing an Anti-GD2 Chimeric Antigen Receptor in Children and Young Adults with GD2+ Solid Tumors	Completed Study; data analyses ongoing	1-35 Years	NCI	7
14-C-0022	A Phase II Study for Metastatic Melanoma Using High-Dose Chemotherapy Preparative Regimen Followed by Cell Transfer Therapy Using Tumor-Infiltrating Lymphocytes Plus IL-2 with the Administration of Pembrolizumab in the Retreatment Arm	Completed Study; data analyses ongoing	18-70 Years	NCI	7
14-C-0001	Phase II Study of Axitinib (AG-013736) with Evaluation of the VEGF-pathway in Metastatic, Recurrent or Primary Unresectable Pheochromocytoma/Paraganglioma	Completed Study; data analyses ongoing	18-125 Years	NCI	7
13-DK-0057	Short Term Effects of Leptin Withdrawal or Initiation in Lipodystrophy Independent of Energy Intake	Completed Study; data analyses ongoing	14-70 Years	NIDDK	7
13-C-0132	Allogeneic Hematopoietic Stem Cell Transplant for Patients with Mutations in GATA2 or the MonoMAC Syndrome	Participants currently recruited/enrolled	8-70 Years	NCI	7
12-H-0092	An Intravenous, Open-Label, Single-Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of rhLCAT in Patients with Stable Coronary Artery Disease	Completed Study; data analyses ongoing	30-75 Years	NHLBI	7
12-H-0035	A Phase II study of Ibrutinib for Patients with Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) Who Need Therapy and are Older than 65 or have a 17p Deletion	No longer recruiting/follow-up only	18-125 Years	NHLBI	7
12-E-0190	The Role of Functionally Relevant Cyclooxygenase-2 (COX-2) Gene Single Nucleotide Polymorphisms - 765G>C and 8473T>C in Lymphocyte Differentiation	Completed Study; data analyses ongoing	18-150 Years	NIEHS	7
12-DK-0097	Energy Expenditure Responses to Different Temperatures	Participants currently recruited/enrolled	18-75 Years	NIDDK	7
12-DC-0152	Normative Values in Audiovestibular Testing	Participants currently recruited/enrolled	5-80 Years	NIDCD	7
12-CC-0096	Collection of Granulocytes by Apheresis of Healthy Donors Stimulated with Filgrastim (G-CSF) and Dexamethasone	Participants currently recruited/enrolled	18-125 Years	CC	7
11-C-0132	Understanding the Psychosocial Needs of Parents Who Have Lost a Child to Cancer	Completed Study; data analyses ongoing	18-99 Years	NCI	7
10-M-0112	Defining the Brain Phenotype of Children with Williams Syndrome	Participants currently recruited/enrolled	5-125 Years	NIMH	7
10-CC-0149	Comparing Expectorated and Induced Sputum and Pharyngeal Swabs for Cultures, AFB Smears, and Cytokines in Pulmonary Nontuberculous Mycobacterial Infection	Completed Study; data analyses ongoing	18-80 Years	CC	7
10-C-0056	A Phase I Study of Indenoisoquinolines LMP400 and LMP776 in Adults With Relapsed Solid Tumors and Lymphomas	Completed Study; data analyses ongoing	18-125 Years	NCI	7
10-C-0054	Administration of Anti-CD19-Chimeric-Antigen-Receptor-Transduced T Cells from the Original Transplant Donor to Patients with Recurrent or Persistent B-Cell Malignancies After Allogeneic Stem Cell Transplantation	No longer recruiting/follow-up only	18-75 Years	NCI	7
09-N-0010	Biomarkers of Risk of Parkinson Disease	Completed Study; data analyses ongoing	18-70 Years	NINDS	7
09-I-0200	A Phase I Study of MozobilTM in the Treatment of Patients with WHIMS	Participants currently recruited/enrolled	18-75 Years	NIAID	7
09-C-0025	Phase II Trial of LMB-2, Fludarabine and Cyclophosphamide for Adult T-Cell Leukemia	No longer recruiting/follow-up only	18-125 Years	NCI	7
08-I-0184	Studies in the Pathogenesis of Anaphylaxis	Participants currently recruited/enrolled	13-75 Years	NIAID	7
08-H-0186	Safety and the Anti- Tumor Effects of Escalating Doses of Adoptively Infused Ex Vivo Expanded Autologous Natural Killer (NK) Cells Against Metastatic Cancers or Hematological Malignancies Sensitized to NK-TRAIL Cytotoxicity with Bortezomib	Completed Study; data analyses ongoing	18-70 Years	NHLBI	7
08-CC-0133	Response and Adaptation to Aerobic Exercise in Patients with Pulmonary Hypertension: Initial Studies for Establishing Guidelines	Completed Study; data analyses ongoing	21-82 Years	CC	7
08-AA-0178	Computer-Assisted Self-Administration of Ethanol (CASE) in Humans	Participants currently recruited/enrolled	21-60 Years	NIAAA	7
07-H-0142	Research Respiratory Tract Procedures	Participants currently recruited/enrolled	10-125 Years	NHLBI	7
07-H-0005	Pilot Study of Topical Dexamethasone 0.01% Solution for Prevention of Oral Chronic Graft Versus Host Disease	Completed Study; data analyses ongoing	12-110 Years	NHLBI	7
07-DK-0077	Study of the Phenotype of Overweight and Obese Adults	Participants currently recruited/enrolled	18-100 Years	NIDDK	7
07-C-0195	Phase II Trial of Targeted Immune-Depleting Chemotherapy and Reduced-Intensity Allogeneic Hematopoietic Stem Cell Transplantation Using 8/8 and 7/8 HLA-matched Unrelated Donors and Utilizing Two Graft-versus-Host Disease Prophylaxis Regimens for the Trea	Completed Study; data analyses ongoing	18-74 Years	NCI	7
06-H-0072	Atorvastatin as a Disease Modifying Agent in Stage II and III Pulmonary Sarcoidosis: A Randomized, Double-Blind, Placebo-Controlled Trial	Completed Study; data analyses ongoing	18-70 Years	NHLBI	7
05-CH-0013	Adrenal Function in Critical Illness	Completed Study; data analyses ongoing	15-80 Years	NICHD	7
04-C-0102	Hematologic Malignancy Biology Study	Enrolling by Invitation	1-75 Years	NCI	7
03-H-0280	Disease Pathogenesis and Natural History of Lipid Disorders	Participants currently recruited/enrolled	2-100 Years	NHLBI	7
02-M-0021	Characterization and Pathophysiology of Severe Mood and Behavioral Dysregulation in Children and Youth	Participants currently recruited/enrolled	7-60 Years	NIMH	7
02-H-0250	A Phase I/II Study of HLA-matched Mobilized Peripheral Blood Hematopoietic Stem Cell Transplantation for Advanced Mycosis Fungoides/Sezary Syndrome Using Nonmyeloablative Conditioning with Campath-1H	Completed Study; data analyses ongoing	18-125 Years	NHLBI	7
02-C-0212	Clinical, Genetic, Behavioral, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Breast/Ovarian Cancer	Completed Study; data analyses ongoing	18-100 Years	NCI	7
01-C-0009	Breast Imaging Screening Studies in Women at High Genetic Risk of Breast Cancer: Annual Follow-up Study	Completed Study; data analyses ongoing	18-100 Years	NCI	7
00-N-0140	A Prospective Natural History Study of VHL Patients with CNS Hemangioblastomas	No longer recruiting/follow-up only	8-75 Years	NINDS	7
00-CH-0160	Clinical and Molecular Analysis of ACTH-Independent Steroid Hormone Production in Adrenocortical Tissue	Completed Study; data analyses ongoing	3-70 Years	NICHD	7
94-I-0079	Eosinophil Activation and Function in Parasitic Infections and Other Conditions with Increased Tissue or Peripheral Blood Eosinophilia in Humans	Participants currently recruited/enrolled	1-100 Years	NIAID	7
83-C-0022	Psychological Benefits of a Normalized Camping Experience for Children with Cancer	Participants currently recruited/enrolled	7-25 Years	NCI	7
82-I-0183	A Natural History Study of the Immune Regulation of Idiopathic Inflammatory Bowel Diseases: Crohn's Disease, Ulcerative Colitis, and Other Inflammatory Conditions of the Gut	Participants currently recruited/enrolled	0-75 Years	NIAID	7
79-H-0100	Teaching Protocol for the Evaluation of Plasma Lipoproteins	No longer recruiting/follow-up only	2-99 Years	NHLBI	7
79-C-0111	The Treatment of Stage I and II Carcinoma of the Breast with Mastectomy and Axillary Dissection vs. Excisional Biopsy Axillary Dissection, and Definitive Irradiation	Completed Study; data analyses ongoing	18-125 Years	NCI	7
78-I-0023	Diagnosis and Management of Inflammatory and Infectious Diseases	Participants currently recruited/enrolled	3-125 Years	NIAID	7
78-HG-0093	Use of Cysteamine in the Treatment of Cystinosis	Participants currently recruited/enrolled	0-125 Years	NHGRI	7
78-C-0039	Clinical, Laboratory, and Epidemiologic Characterization of Individuals and Families at High Risk of Cancer	No longer recruiting/follow-up only	0-125 Years	NCI	7
77-DK-0096	Studies on Thyroid Nodules and Thyroid Cancer	Participants currently recruited/enrolled	0-125 Years	NIDDK	7
77-DK-0002	Evaluation of Patients with Thyroid Function Disorders	Participants currently recruited/enrolled	0-125 Years	NIDDK	7
76-HG-0238	Diagnosis and Treatment of Patients with Inborn Errors of Metabolism or Other Genetic Disorders	Participants currently recruited/enrolled	0-125 Years	NHGRI	7
76-H-0051	Lipoprotein Metabolism in Normal Volunteers and Hyperlipoproteinemic Patients	Completed Study; data analyses ongoing	18-80 Years	NHLBI	7
76-DK-0006	Natural History of Disorders of Insulin Resistance	Participants currently recruited/enrolled	0-125 Years	NIDDK	7