NIH Clinical Center: Search the Studies

Search the Studies

76 Studies found from all possible combinations of your search terms. Select a protocol that you wish to review.

Protocol Number	Title	Protocol Status	Min-Max Age	Institute	Keywords
000821-I	An Open-Label, Single-Arm, Phase 1/2 Dose-Escalation Trial of Long-Acting Recombinant Human IL-7 (NT-I7, Efineptakin Alfa) for Idiopathic CD4 Lymphopenia	Recruitment has not started	18-75 Years	NIAID	Cytokine Deficiency
18-I-0022	Use of Ustekinumab (Anti-IL-12/23p40 Monoclonal Antibody) in Patients with Leukocyte Adhesion Deficiency Type 1 (LAD1) who have Inflammatory Pathology	Participants currently recruited/enrolled	12-65 Years	NIAID	Cytokine Deficiency
05-CH-0013	Adrenal Function in Critical Illness	Completed Study; data analyses ongoing	15-80 Years	NICHD	Cytokine Deficiency
03-AR-0173	Studies of Natural History, Pathogenesis, and Outcomes in Autoimmune and Inflammatory Diseases Including Juvenile Dermatomyositis	Participants currently recruited/enrolled	2-125 Years	NIAMS	Cytokine Deficiency
93-I-0119	Detection and Characterization of Host Defense Defects	Participants currently recruited/enrolled	0-125 Years	NIAID	Cytokine Deficiency
001074-CH	Characterization of Dysmorphology in Subjects with Creatine Transporter Deficiency	Participants currently recruited/enrolled	2-40 Years	NICHD	Deficiency
000977-I	Phase I/II Study using Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease with an Alemtuzumab, Busulfan and TBI-based Conditioning Regimen Combined with Cytokine (IL-6, +/- IFN-gamma) Antagonists	Participants currently recruited/enrolled	4-65 Years	NIAID	Cytokine
000862-CH	Pilot Study of the Use of Functional Near-Infrared Spectroscopy (fNIRS) Combined with Diffuse Correlation Spectroscopy (DCS) in Neurocognitive Disease as Compared to Healthy Neurotypical Controls	Participants currently recruited/enrolled	0-125 Years	NICHD	Deficiency
000686-CH	Intrathecal 2-Hydroxypropyl-Beta-Cyclodextrin for Neurological Decline in Patients with Niemann-Pick Disease Type C1	Participants currently recruited/enrolled	18-125 Years	NICHD	Deficiency
000612-C	Phase 1 Study of NT-I7 (rhIL-7-hyFc) for the Treatment of Kaposi Sarcoma in Patients With or Without Infection with HIV	Participants currently recruited/enrolled	18-125 Years	NCI	Cytokine
000487-CH	Natural History Investigation into Biochemical and Phenotypical Aspects of Smith-Lemli-Opitz Syndrome and Related Disorders of Cholesterol Metabolism	Participants currently recruited/enrolled	0-125 Years	NICHD	Deficiency
000476-E	The Investigation of Vitamin D and Menstrual Cycles Trial: A Phase II Clinical trial	Participants currently recruited/enrolled	19-40 Years	NIEHS	Deficiency
000392-I	Metabolic Profiling of Immune Responses in Immune-Mediated Diseases	Participants currently recruited/enrolled	18-75 Years	NIAID	Deficiency
000384-I	Analysis of the Immune Response to COVID-19 Vaccination and Outcomes in Individuals With and Without Immune Deficiencies and Dysregulations	Participants currently recruited/enrolled	3-125 Years	NIAID	Deficiency
000344-DK	Natural History Study of Parathyroid Disorders	Participants currently recruited/enrolled	0-125 Years	NIDDK	Deficiency
000272-H	Defining the Genetic Etiology of Suppurative Lung Disease in Children and Adults	Participants currently recruited/enrolled	5-45 Years	NHLBI	Deficiency
000236-I	A Phase 1 Study of Empagliflozin as Treatment for Severe Congenital Neutropenia Due to G6PC3 Deficiency	Participants currently recruited/enrolled	18-125 Years	NIAID	Deficiency
000110-H	A Phase II Study Evaluating Fostamatinib for Hospitalized Adults with COVID-19	Completed Study; data analyses ongoing	18-125 Years	NHLBI	Cytokine
22-I-0001	NADPH Oxidase Correction in mRNA transfected Granulocyte-enriched Cells in Chronic Granulomatous Disease (CGD)	Participants currently recruited/enrolled	18-75 Years	NIAID	Deficiency
21-I-0003	A Phase 1/2 Study to Evaluate the Safety, Tolerability and Efficacy, of JSP191 for Hematopoietic Cell Transplantation Conditioning to Achieve Engraftment and Immune Reconstitution in Subjects with SCID	Participants currently recruited/enrolled	3-125 Years	NIAID	Deficiency
20-I-0140	A Double-Blind, Randomized, Placebo-Controlled, Phase 1, Single-Dose, Dose-Escalating Trial of Long-Acting Recombinant Human IL-7 (NT-I7) for COVID-19	Participants currently recruited/enrolled	19-75 Years	NIAID	Cytokine
20-I-0111	COVID-19-associated Lymphopenia Pathogenesis Study in Blood	Participants currently recruited/enrolled	18-125 Years	NIAID	Cytokine
20-I-0037	Matched Related and Unrelated Donor Stem Cell Transplantation for Severe Combined Immune Deficiency (SCID): Busulfan-based Conditioning with h-ATG, Radiation, and Sirolimus	Enrolling by Invitation	3-40 Years	NIAID	Deficiency
20-H-0044	Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Immune Activation in Psoriasis	Completed Study; data analyses ongoing	18-80 Years	NHLBI	Cytokine
19-I-0027	A Phase 2 Randomized Double-Blinded Placebo-Controlled Study to Evaluate the Safety and Efficacy of Subcutaneous Sarilumab in Improving the Quality of Life in Subjects with Indolent Systemic Mastocytosis	Participants currently recruited/enrolled	18-75 Years	NIAID	Cytokine
19-I-0015	Phase 1/2 Randomized, Double-Blind, Placebo-Controlled Study of Safety and Efficacy of Abatacept for Treating Chronic Cytopenia in Cytotoxic T-lymphocyte Antigen 4 (CTLA4) Haploinsufficiency	Participants currently recruited/enrolled	8-65 Years	NIAID	Deficiency
19-CH-0020	A Phase 1-2 Multi-Center Study to Assess the Efficacy and Safety of Abiraterone Acetate as Adjunctive Therapy in Pre-Pubescent Children with Classic 21-Hydroxylase Deficiency	Recruitment has not started	2-9 Years	NICHD	Deficiency
18-N-0077	Cytokine Microdialysis For Real Time Immune Monitoring in Glioblastoma Patients Undergoing Checkpoint Blockade	Completed Study; data analyses ongoing	18-125 Years	NINDS	Cytokine
18-I-0041	Investigating the Mechanistic Biology of Primary Immunodeficiency Disorders	Participants currently recruited/enrolled	0-75 Years	NIAID	Deficiency
18-H-0146	Genotype -Phenotype Correlation of PKLR Variants with Pyruvate Kinase, 2,3-Diphosphglycerate and ATP Activities in Red Blood Cells of Patients with Sickle Cell Disease	Participants currently recruited/enrolled	18-80 Years	NHLBI	Deficiency
17-I-0016	Studies of the Natural History, Pathogenesis, and Outcome of Autoinflammatory Diseases (NOMID/CAPS, DIRA, CANDLE, SAVI, NLRC4-MAS, Still's-like Diseases, and Other Undifferentiated Autoinflammatory Diseases)	Participants currently recruited/enrolled	0-99 Years	NIAID	Cytokine
17-CH-0078	Setmelanotide (RM-493; Rhythm Pharmaceuticals, Inc.) Phase 2 Open-Label Treatment Trials in Patients with Rare Genetic Disorders of Obesity	No longer recruiting/follow-up only	6-100 Years	NICHD	Deficiency
17-CH-0020	Observational Study of Males with Creatine Transporter Deficiency (CTD)	No longer recruiting/follow-up only	2-40 Years	NICHD	Deficiency
17-C-0048	Anti-CD30 CAR T Cells with Fully-human Binding Domains for Treating CD30-expressing Lymphomas Including Anaplastic Large Cell Lymphomas	Completed Study; data analyses ongoing	18-73 Years	NCI	Cytokine
16-E-0157	CaREFREE Study (Calorie Restriction, Environment and Fitness: Reproductive Effects Evaluation Study)	Completed Study; data analyses ongoing	18-28 Years	NIEHS	Deficiency
16-DK-0038	A Randomized, Double Blind, Placebo-Controlled Study to Assess Efficacy, Safety and Tolerability of ISIS 304801 in Patients with Partial Lipodystrophy with an Open-Label Extension	Completed Study; data analyses ongoing	18-125 Years	NIDDK	Deficiency
16-C-0094	A Phase 1/2 Study of Baricitinib, a JAK1/2 Inhibitor, in Chronic Graft-Versus-Host Disease (cGVHD) after Allogeneic Hematopoietic Stem Cell Transplantation (SCT)	No longer recruiting/follow-up only	18-125 Years	NCI	Cytokine
15-DK-0108	Natural History of Noncirrhotic Portal Hypertension	Participants currently recruited/enrolled	12-125 Years	NIDDK	Deficiency
14-I-0091	Analysis of Patients Treated for Chronic Granulomatous Disease Since January 1, 1995	Completed Study; data analyses ongoing	3-125 Years	NIAID	Deficiency
14-I-0089	A Retrospective and Cross-Sectional Analysis of Patients Treated for Severe Combined Immunodeficiency (SCID) Since January 1, 1968	Enrolling by Invitation	2-125 Years	NIAID	Deficiency
14-I-0072	A Prospective Natural History Study of Diagnosis, Treatment and Outcomes of Children with SCID Disorders	Completed Study; data analyses ongoing	2-125 Years	NIAID	Deficiency
14-I-0009	Characterization and Management of Patients with HIV-1 Infection Who Experience Virologic Failure Despite Combination Antiretroviral Therapy	Completed Study; data analyses ongoing	18-100 Years	NIAID	Deficiency
14-C-0079	An Exploratory Study of Voicing My CHOiCES as a Tool for Advanced Care Planning in Young Adults with Cancer and Other Chronic Illnesses	Participants currently recruited/enrolled	18-125 Years	NCI	Deficiency
13-I-0157	The Natural History of GATA2 Deficiency and Related Disorders	Participants currently recruited/enrolled	2-100 Years	NIAID	Deficiency
13-HG-0199	NIH Participation to USIDNET Registry	Participants currently recruited/enrolled	0-125 Years	NHGRI	Deficiency
13-H-0060	Analysis of Samples Collected from a Subject who Received ACP- 501 (Human Recombinant Lecithin:Cholesterol Acyltransferase [rhLCAT])	Completed Study; data analyses ongoing	18-100 Years	NHLBI	Deficiency
13-CH-0112	Pilot Study to Assess Biomarkers of Changes in Barrier Function of Skeletal Muscle in Patients with a Fragile Sarcolemmal Muscular Dystrophy	No longer recruiting/follow-up only	18-125 Years	NICHD	Cytokine
13-C-0152	A Phase I Study of Autologous Activated Natural Killer (NK) Cells +/- rhIL15 in Children and Young Adults with Refractory Solid Tumors	Completed Study; data analyses ongoing	2-29 Years	NCI	Cytokine
13-C-0132	Allogeneic Hematopoietic Stem Cell Transplant for Patients with Mutations in GATA2 or the MonoMAC Syndrome	Participants currently recruited/enrolled	8-70 Years	NCI	Deficiency
12-H-0110	An Open-label, Non-Randomized, Single-Arm Pilot Study to Evaluate the Effectiveness of Etidronate Treatment for Arterial Calcifications due to Deficiency in CD73 (ACDC)	Completed Study; data analyses ongoing	18-80 Years	NHLBI	Deficiency
12-E-0050	The Role of Gonadotropin Pulsations in the Regulation of Puberty and Fertility	Participants currently recruited/enrolled	14-125 Years	NIEHS	Deficiency
11-NR-0014	Characterizing Fatigue Experienced by Cancer Patients Receiving Primary Treatment and Cancer Survivors	Participants currently recruited/enrolled	18-125 Years	NINR	Cytokine
11-H-0134	A Pilot Study of a Thrombopoietin-Receptor Agonist (TPO-R Agonist), Eltrombopag, in Moderate Aplastic Anemia Patients	No longer recruiting/follow-up only	2-125 Years	NHLBI	Cytokine
11-C-0220	Natural History Study of the KSHV Inflammatory Cytokine Syndrome (KICS) Incorporating Pilot Evaluation of KSHV Targeted Therapies	Participants currently recruited/enrolled	18-125 Years	NCI	Cytokine
10-I-0148	Natural History of Severe Allergic Inflammation and Reactions	Participants currently recruited/enrolled	2-80 Years	NIAID	Deficiency
10-CC-0149	Comparing Expectorated and Induced Sputum and Pharyngeal Swabs for Cultures, AFB Smears, and Cytokines in Pulmonary Nontuberculous Mycobacterial Infection	Completed Study; data analyses ongoing	18-80 Years	CC	Cytokine
10-C-0201	Apheresis and CD34+ Selection of Mobilized Peripheral Blood CD34+ Cells from Patients with DOCK8 Deficiency, LAD-1, and GATA2 Deficiency	Participants currently recruited/enrolled	18-40 Years	NCI	Deficiency
10-C-0174	Related and Unrelated Donor Hematopoietic Stem Cell Transplant for DOCK8 Deficiency	Participants currently recruited/enrolled	4-125 Years	NCI	Deficiency
09-I-0102	Etiology, Pathogenesis, and Natural History of Idiopathic CD4+ Lymphocytopenia	Participants currently recruited/enrolled	18-125 Years	NIAID	Cytokine
09-I-0086	Screening Protocol for Genetic Diseases of Allergic Inflammation	Participants currently recruited/enrolled	0-99 Years	NIAID	Deficiency
08-C-0130	A Phase II Trial of Peginterferon alfa-2b (PEG-Intron) for Neurofibromatosis Type 1 Related Unresectable, Symptomatic or Life-Threatening Plexiform Neurofibromas	Completed Study; data analyses ongoing	0-21 Years	NCI	Cytokine
07-I-0033	Screening Protocol for Detection and Characterization of Infections and Infection Susceptibility	Participants currently recruited/enrolled	0-125 Years	NIAID	Deficiency
06-I-0015	Screening Protocol for Genetic Diseases of Lymphocyte Homeostasis and Programmed Cell Death	Participants currently recruited/enrolled	0-125 Years	NIAID	Deficiency
06-CH-0011	Natural History Study of Patients with Excess Androgen	Participants currently recruited/enrolled	0-99 Years	NICHD	Deficiency
05-I-0213	Screening and Baseline Assessment of Patients with Abnormalities of Immune Function	Participants currently recruited/enrolled	0-125 Years	NIAID	Deficiency
03-H-0105	The Determination of Genetic Basis Of Immunodeficiency	Participants currently recruited/enrolled	0-125 Years	NHLBI	Cytokine
02-DK-0022	Long-Term Efficacy of Leptin Replacement in Treatment of Lipodystrophy	Completed Study; data analyses ongoing	1-125 Years	NIDDK	Deficiency
00-I-0159	Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES)	Participants currently recruited/enrolled	0-125 Years	NIAID	Deficiency
00-HG-0209	Molecular and Clinical Studies of Primary Immunodeficiency Diseases	No longer recruiting/follow-up only	3-125 Years	NHGRI	Deficiency
00-H-0051	Cutaneous Tumorigenesis in Patients with Tuberous Sclerosis	Participants currently recruited/enrolled	18-90 Years	NHLBI	Cytokine
00-CH-0136	A Trial of Pamidronate in Children with Osteogenesis Imperfecta	Completed Study; data analyses ongoing	2-17 Years	NICHD	Deficiency
95-HG-0193	Clinical and Basic Investigations into Hermansky-Pudlak Syndrome	Participants currently recruited/enrolled	0-125 Years	NHGRI	Deficiency
92-CH-0034	Studies of Growth Deficiency and Growth Hormone Treatment in Children with Osteogenesis Imperfecta Types III and IV	Completed Study; data analyses ongoing	3-16 Years	NICHD	Deficiency
91-I-0140	Studies of the Pathogenesis of HIV Infection in Human Peripheral Blood Cells and/or Body Fluids in HIV-Infected and HIV-Uninfected Volunteers	Participants currently recruited/enrolled	18-125 Years	NIAID	Cytokine
89-I-0158	Studies of Immune Regulation in Patients with Common Variable Immunodeficiency and Related Humoral Immunodeficiency Syndromes	Participants currently recruited/enrolled	2-125 Years	NIAID	Deficiency
76-HG-0238	Diagnosis and Treatment of Patients with Inborn Errors of Metabolism or Other Genetic Disorders	Participants currently recruited/enrolled	0-125 Years	NHGRI	Deficiency