NIH Clinical Center: Search the Studies

Search the Studies

59 Studies found from all possible combinations of your search terms. Select a protocol that you wish to review.

Protocol Number	Title	Protocol Status	Min-Max Age	Institute	Keywords
06-C-0219	An Exploratory Study of Biologic and Pathophysiologic Effects of Radiation Therapy in Pediatric Patients with Central Nervous System Tumors	Completed Study; data analyses ongoing	0-21 Years	NCI	Clear Ependymoma
001124-I	Expanded Access IND Protocol: Use of Tecovirimat (TPOXX (R)) for Treatment of Human Non-Variola Orthopoxvirus Infections in Adults and Children	Enrolling by Invitation	0-125 Years	NIAID	Clear
001084-CH	A Prospective Natural History Study of Lymphatic Anomalies	Participants currently recruited/enrolled	0-125 Years	NICHD	Clear
000686-CH	Intrathecal 2-Hydroxypropyl-Beta-Cyclodextrin for Neurological Decline in Patients with Niemann-Pick Disease Type C1	Participants currently recruited/enrolled	18-125 Years	NICHD	Clear
000666-C	A Phase I/II Study of Palbociclib and Sasanlimab for the Treatment of Advanced Clear Cell Renal Cell Carcinoma (ccRCC) or Papillary Renal Cell Carcinoma (pRCC)	Recruitment has not started	18-125 Years	NCI	Clear
000617-DK	A Natural History Study of Metabolic Sizing in Health and Disease	Participants currently recruited/enrolled	10-125 Years	NIDDK	Clear
000585-CH	An Open-label Safety, Pharmacokinetic, and Efficacy Study of Miglustat for the Treatment of CLN3 Disease in Patients 17 Years of Age and Older	Participants currently recruited/enrolled	17-125 Years	NICHD	Clear
000580-C	A Phase 1/2, Open Label Dose-Escalation and Expansion Trial of Nkt2152, an Orally Administered Hif2a Inhibitor, to Investigate Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity in Patients with Advanced Clear Cell Renal Cell Carcinoma	Participants currently recruited/enrolled	18-125 Years	NCI	Clear
000354-C	Phase II Trial of Combination Anti-PD-1 and Aldesleukin for Metastatic Melanoma and Renal Cell Carcinoma	Participants currently recruited/enrolled	18-125 Years	NCI	Clear
000350-D	Use of Clear Aligners for the Treatment of Dental Malocclusion In Individuals with Osteogenesis Imperfecta Types III and IV	Participants currently recruited/enrolled	12-40 Years	NIDCR	Clear
000288-C	A Phase II, Open-Label, Single-Arm Study of Berzosertib (M6620) in Combination with Topotecan in Participants with Relapsed Platinum-Resistant Small-Cell Lung Cancer	Completed Study; data analyses ongoing	18-125 Years	NCI	Clear
000272-H	Defining the Genetic Etiology of Suppurative Lung Disease in Children and Adults	Participants currently recruited/enrolled	5-45 Years	NHLBI	Clear
000220-DK	Phase II Trial of the Combination of Alpha-lipoic Acid and Mirabegron in Women and in Men with Obesity	Recruitment has not started	18-65 Years	NIDDK	Clear
000149-H	Pilot Study to Explore the Anti-Inflammatory Effects of Time-Restricted Feeding	Participants currently recruited/enrolled	18-80 Years	NHLBI	Clear
000081-C	A Phase 2 Study of Anti-PD-L1 Antibody (Atezolizumab) in Chondrosarcoma and Clear Cell Sarcoma	Completed Study; data analyses ongoing	2-125 Years	NCI	Clear
21-N-0010	A Phase 2 Clinical Trial of Tolebrutinib, a Brain-penetrant Bruton's Tyrosine Kinase Inhibitor, for the Modulation of Chronically Inflamed White Matter Lesions in Multiple Sclerosis	No longer recruiting/follow-up only	18-125 Years	NINDS	Clear
19-N-0124	Anakinra for the Treatment of Chronically Inflamed White Matter Lesions in Multiple Sclerosis	Participants currently recruited/enrolled	18-120 Years	NINDS	Clear
19-H-0120	Pilot Study for Geospatial Analysis of Neighborhood Environmental Stress in Relation to Biological Markers of Cardiovascular Health and Health Behaviors in Women	Participants currently recruited/enrolled	19-45 Years	NHLBI	Clear
19-CH-0026	Randomized, Double-Blind, Placebo-Controlled Study Plus Open Label Extension with a Double-Blind, Placebo-Controlled, Randomized Withdrawal Period of Diazoxide Choline Extended-Release Tablets (DCCR, Soleno Therapeutics, Inc.) in Participants with Prader	No longer recruiting/follow-up only	4-125 Years	NICHD	Clear
19-C-0016	Natural History and Biospecimen Acquisition Study for Children and Adults with Rare Solid Tumors	Participants currently recruited/enrolled	0-125 Years	NCI	Clear
18-I-0039	Challenge Infection of Healthy Adult Volunteers with RSV A2	Completed Study; data analyses ongoing	18-50 Years	NIAID	Clear
18-H-0012	A Phase I Study of HERV-E TCR Transduced Autologous T Cells in Patients with Metastatic Clear Cell Renal Cell Carcinoma	Participants currently recruited/enrolled	18-75 Years	NHLBI	Clear
18-CH-0120	A Natural History of the Collagen-Related Disorder Osteogenesis Imperfecta and the Genotype-Phenotype Correlation	No longer recruiting/follow-up only	0-125 Years	NICHD	Clear
18-C-0138	An Open-Label Phase 2 Study to Evaluate PT2977 for the Treatment of Von Hippel-Lindau Disease-Associated Renal Cell Carcinoma.	No longer recruiting/follow-up only	18-125 Years	NCI	Clear
18-C-0034	A Phase 2 Study of ONC201 in Recurrent/Refractory Metastatic Breast Cancer and Advanced Endometrial Carcinoma	Completed Study; data analyses ongoing	18-125 Years	NCI	Clear
17-EI-0008	The Natural History of Geographic Atrophy Associated with Age-Related Macular Degeneration	Participants currently recruited/enrolled	55-125 Years	NEI	Clear
17-DK-0013	Therapeutic Targets in African-American Youth with Type 2 Diabetes	Participants currently recruited/enrolled	12-25 Years	NIDDK	Clear
17-C-0175	CC-4047-BRN-001: A Phase 2 Clinical Study of Pomalidomide (CC-4047) Monotherapy for Children and Young Adults with Recurrent or Progressive Primary Brain Tumors	Completed Study; data analyses ongoing	3-20 Years	NCI	Ependymoma
17-C-0117	A Phase 1/2a, Open-Label, Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Anti-Tumor Activity of PEN-866 in Advanced Solid Malignancies	Completed Study; data analyses ongoing	18-125 Years	NCI	Clear
17-C-0102	Phase II Trial of the Immune Checkpoint Inhibitor Nivolumab in Patients with Recurrent Select Rare CNS Cancers	Participants currently recruited/enrolled	18-99 Years	NCI	Ependymoma
17-C-0086	An Open-label Phase 2 Study to Evaluate PT2385 for the Treatment of Von Hippel-Lindau Disease-Associated Clear Cell Renal Cell Carcinoma	No longer recruiting/follow-up only	18-125 Years	NCI	Clear
16-HG-0156	The Natural History, Physiology, Microbiome and Biochemistry Studies of Propionic Acidemia	Participants currently recruited/enrolled	0-125 Years	NHGRI	Clear
16-C-0009	Phase II Trial of Carboplatin and Bevacizumab for the Treatment of Recurrent Low-Grade and Anaplastic Supratentorial, Infratentorial and Spinal Cord Ependymoma in Adults: A Multi-Center Trial	Completed Study; data analyses ongoing	18-125 Years	NCI	Ependymoma
15-EI-0202	Evaluation of Oral Minocycline in the Treatment of Geographic Atrophy Associated with Age-Related Macular Degeneration	No longer recruiting/follow-up only	55-125 Years	NEI	Clear
15-DK-0143	Investigation of Viral Kinetics, Interferon Stimulated Genes (ISGs) and mirRNA Among Subjects Infected with Different Hepatitis C Virus Genotypes During Therapy with Sofosbuvir and GS-5816	Completed Study; data analyses ongoing	18-80 Years	NIDDK	Clear
14-CC-0143	Sleep Disturbance and Relapse in Individuals with Alcohol Dependence: An Exploratory Mixed Methods Study	Completed Study; data analyses ongoing	18-125 Years	CC	Clear
14-C-0059	A Phase I Trial of T Cells Expressing an Anti-GD2 Chimeric Antigen Receptor in Children and Young Adults with GD2+ Solid Tumors	Completed Study; data analyses ongoing	1-35 Years	NCI	Clear
14-C-0004	A Multicenter Phase 2 Study of the Bruton's Tyrosine Kinase Inhibitor PCI-32765 (Ibrutinib) for Treatment of Relapsed Hairy Cell Leukemia	No longer recruiting/follow-up only	18-125 Years	NCI	Clear
13-N-0149	An Evaluation of HIV-associated Neurocognitive Disorders (HAND) in Virologically Controlled Patients	Participants currently recruited/enrolled	18-125 Years	NINDS	Clear
13-D-0014	Bacterial Arrangement in Supragingival Biofilms	Completed Study; data analyses ongoing	18-999 Years	NIDCR	Clear
13-AR-0056	Stopping Tumor Necrosis Factor-Alpha Inhibitors in Rheumatoid Arthritis	Completed Study; data analyses ongoing	18-125 Years	NIAMS	Clear
11-NR-0014	Characterizing Fatigue Experienced by Cancer Patients Receiving Primary Treatment and Cancer Survivors	Participants currently recruited/enrolled	18-125 Years	NINR	Clear
11-M-0251	A Longitudinal Investigation of the Endocrine and Neurobiologic Events Accompanying Puberty	Participants currently recruited/enrolled	7-35 Years	NIMH	Clear
11-C-0033	Extended Follow-up of High Ovarian Cancer Risk Cohort from 02C0268 (GOG-199)	Completed Study; data analyses ongoing	18-100 Years	NCI	Clear
10-I-0014	The Natural History of Severe Viral Infections and Characterization of Immune Defects	Participants currently recruited/enrolled	2-125 Years	NIAID	Clear
09-N-0039	A Phase I Study of the Intrathecal Administration of Resiniferatoxin for Treating Severe Refractory Pain Associated with Advanced Cancer	Participants currently recruited/enrolled	18-125 Years	NINDS	Clear
08-N-0044	A Prospective Natural History Study of Patients with Neurofibromatosis Type 2 (NF2).	Participants currently recruited/enrolled	8-75 Years	NINDS	Ependymoma
08-I-0184	Studies in the Pathogenesis of Anaphylaxis	Participants currently recruited/enrolled	13-75 Years	NIAID	Clear
08-C-0020	A Phase II Study of ZD6474 (Vandetanib) in Patients with Von Hippel Lindau Disease and Renal Tumors	Completed Study; data analyses ongoing	18-125 Years	NCI	Clear
06-M-0214	PET Measurement of Regional Rates of Cerebral Protein Synthesis in Subjects with Fragile X Syndrome	Completed Study; data analyses ongoing	18-24 Years	NIMH	Clear
06-H-0217	Genetic Disorders of Mucociliary Clearance	Completed Study; data analyses ongoing	2-65 Years	NHLBI	Clear
04-DK-0021	Urinary Vitamin C Loss in Subjects with and without Diabetes	Participants currently recruited/enrolled	18-65 Years	NIDDK	Clear
03-C-0278	A Comparative Study of Pediatric CNS Tumor Activity as Assessed by 18F-FDG PET Imaging and Proton Magnetic Resonance Spectroscopic Imaging (1H-MRSI)	Completed Study; data analyses ongoing	1-21 Years	NCI	Clear
02-DK-N304	Diabetes Prevention Program Outcomes Study (DPPOS)	No longer recruiting/follow-up only	25-125 Years	NIDDK	Clear
01-C-0129	Eligibility Screening for the NIH Intramural Research Program Clinical Protocols	Enrolling by Invitation	0-125 Years	NCI	Clear
00-C-0074	Evaluation of Late Effects and Natural History of Disease in Patients Treated with Radiotherapy	Participants currently recruited/enrolled	18-125 Years	NCI	Clear
98-D-0145	Screening and Natural History of Patients with Polyostotic Fibrous Dysplasia and the McCune-Albright Syndrome	Participants currently recruited/enrolled	0-100 Years	NIDCR	Clear
89-C-0086	Von Hippel-Lindau (VHL): Clinical Manifestations, Diagnosis, Management and Molecular Bases of Inherited Renal and Other Urologic Malignant Disorders	Participants currently recruited/enrolled	2-125 Years	NCI	Clear
85-I-0127	Natural History of Treated Neurocysticercosis and Long-Term Outcomes	Participants currently recruited/enrolled	3-99 Years	NIAID	Clear