NIH Clinical Center logo     America's Clinical Research Hospital File folder iconExplore the NIH
Clinical Center
Search the Studies - NIH Clinical Research Studies

Protocol Details

Brain Procurement for the Human Brain Collection Core

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number

90-M-0142

Sponsoring Institute

National Institute of Mental Health (NIMH)

Recruitment Detail

Type: Participants currently recruited/enrolled
Gender: Male & Female
Min Age: N/A
Max Age: N/A

Referral Letter Required

Yes

Population Exclusion(s)

None

Special Instructions

Currently Not Provided

Keywords

Schizophrenia;
Neuropathology;
Neurochemistry;
Substance Abuse;
Bipolar Disorder;
Aging;
Normal Development;
Depression;
Anxiety Disorders;
Suicide

Recruitment Keyword(s)

Dementia;
Depression;
Bipolar Disorder;
Neuropsychiatric Disorders;
Suicide;
Tourette's Syndrome;
Normal Controls;
Schizophrenia

Condition(s)

Bipolar Disorder;
Depression;
Anxiety Disorders;
Schizophrenia;
Tourette's Syndrome;
Brain Diseases

Investigational Drug(s)

None

Investigational Device(s)

None

Intervention(s)

None

Supporting Site

National Institute of Mental Health

The purpose of this study is to collect and study the brain tissue of deceased individuals to learn more about the nervous system and mental disorders. Information gained from donated tissue may lead to better treatments and potential cures for nervous system and mental disorders.

This study will ask relatives of deceased individuals to donate the brains of their deceased relatives to allow further study of neurological and psychiatric disorders. We do not accept prospective donations.

--Back to Top--

Eligibility

INCLUSION CRITERIA:

Brain tissue is needed from individuals suffering from a variety of neuropsychiatric disorders, especially schizophrenia, but also anxiety disorders, suicide, bipolar disorder, depression, Tourette's Syndrome, drug addictions (PCP, cocaine, alcohol, heroin or the like) and any form of dementia. In addition, brains from normal individuals without a history of neuropsychiatric disease will be needed for controls.

EXCLUSION CRITERIA:

No living subjects are enrolled in this protocol. Tissue is obtained after death, with the permission of next of kin, or from existing institutions with appropriate samples via an MTA or other applicable agreement.

Brain tissue is excluded from collection if there is a previously known history of strokes, lesions, or other major neuropathological abnormalities prior to the consenting process.


--Back to Top--

Citations:

Meyer-Lindenberg A, Straub RE, Lipska BK, Verchinski BA, Goldberg T, Callicott JH, Egan MF, Huffaker SS, Mattay VS, Kolachana B, Kleinman JE, Weinberger DR. Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition. J Clin Invest. 2007 Feb 8; [Epub ahead of print]

Law AJ, Lipska BK, Weickert CS, Hyde TM, Straub RE, Hashimoto R, Harrison PJ, Kleinman JE, Weinberger DR. Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6747-52. Epub 2006 Apr 17.

Egan MF, Straub RE, Goldberg TE, Yakub I, Callicott JH, Hariri AR, Mattay VS, Bertolino A, Hyde TM, Shannon-Weickert C, Akil M, Crook J, Vakkalanka RK, Balkissoon R, Gibbs RA, Kleinman JE, Weinberger DR. Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12604-9. Epub 2004 Aug 13.

--Back to Top--

Contacts:

Principal Investigator

Referral Contact

For more information:

Barbara Lipska, M.D.
National Institute of Mental Health (NIMH)
National Institutes of Health
Building 10
Room 4N306
10 Center Drive
Bethesda, Maryland 20892
(301) 496-9501
lipskab@intra.nimh.nih.gov

Barbara Lipska, M.D.
National Institute of Mental Health (NIMH)
National Institutes of Health
Building 10
Room 4N306
10 Center Drive
Bethesda, Maryland 20892
(301) 496-9501
lipskab@intra.nimh.nih.gov

Barbara Lipska, M.D.
National Institutes of Health
Building 10
Room 4N306
10 Center Drive
Bethesda, Maryland 20892
(301) 496-9501
lipskab@intra.nimh.nih.gov

Clinical Trials Number:

NCT00001260

--Back to Top--

QUESTIONS?

Contact the Patient Recruitment and Public Liaison Office for:

  • Details on how to participate in a study
  • Details on how to refer a patient to a study

NIH Clinical Studies Information Request


Contact the Office of Communications for:

  • General information about the NIH Clinical Center

www.cc.nih.gov/contact.shtml


Contact the Department Clinical Research Informatics, (DCRI) for:

  • Technical questions about Adobe Acrobat and the PDF format
  • Technical questions about this web server

webmaster@cc.nih.gov