NIH Clinical Research Studies Listed By Institute of the Principal Investigator

National Institute of Neurological Disorders and Stroke (NINDS)

118 Protocols (92 Active Accrual of new subjects, 26 Follow-up of previously enrolled subjects)

Active Accrual, Protocols Recruiting New Patients 
* 17-N-0168:
Influence of Brain Oscillation-Dependent TMS on Motor Function

* 17-N-0160:
Non-invasive Intermittent Theta Burst Stimulation of the Dorsolateral Prefrontal Cortex in Patients with Functional Movement Disorders

* 17-N-0159:
Study of the Photic Blink Reflex in patients with Blepharospasm and Increased Blinking

* 17-N-0151:
Interhemispheric Interaction of Parieto-Motor Cortico-Cortical Plasticity in Human Brain

* 17-N-0150:
Technical Development of Clinical Laboratory Studies

* 17-N-0145:
PD-1 Inhibition to Determine CNS Reservoir of HIV-Infection

* 17-N-0131:
Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

* 17-N-0128:
Measuring the Latency Connectome in the Central Nervous System Using Neuroimaging and Neurophysiological Techniques

* 17-N-0126:
Investigations of Pathophysiology of Dystonia and Complex Regional Pain Syndrome

* 17-N-0123:
Loss of Depotentiation in Focal Dystonia

* 17-N-0083:
Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS)

* 17-N-0076:
Does N-Acetylcysteine Decrease Spontaneous Oxidation of Central Neural Dopamine in Parkinson's Disease?

* 17-N-0055:
Functional Connectivity as a Biomarker of rTMS

* 17-N-0053:
Neurophysiologic Study of Patients with Essential Tremor and Dystonic Tremor

* 17-N-0035:
Clinical and Physiological Studies of Tremor Syndromes

* 17-N-0031:
Detailed Evaluation of the Neurophysiology of Surround Inhibition in the Human Motor Cortex

* 17-N-0025:
INCEPTUS: A Prospective, Non-Interventional Clinical Assessment Study in X-Linked Myotubular Myopathy (XLMTM) Subjects Aged 3 Years and Younger

* 16-N-0170:
Effects of Prism Adaption and rTMS on Brain Connectivity and Visual Representation

* 16-N-0158:
Disease Natural History and Biomarkers of SPG3A, SPG4A and SPG31

* 16-N-0114:
The Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques: An Investigator-Blinded Study

* 16-N-0072:
A Pilot Study of Adoptive Cellular Immunotherapy for Progressive Multifocal Leukoencephalopathy with Ex Vivo Generated Polyomavirus-Specific T-cells

* 16-N-0064:
Cholinergic Receptor Imaging in Dystonia

* 16-N-0058:
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

* 16-N-0055:
The Pathological Basis of MRI Signal Changes in Multiple Sclerosis: A Longitudinal In Vivo-to-Postmortem Study

* 16-N-0041:
Tumor Related Epilepsy

* 16-N-0031:
An All-Night Functional Magnetic Resonance Imaging Sleep Study With Auditory Stimuli

* 15-N-0183:
Anakinra, a Recombinant Human IL-1 Receptor Antagonist for Neuroinflammation in HIV-1 Infection

* 15-N-0167:
Propensity to Develop Plasticity in the Parieto- & Cerebello-Motor Networks in Dystonia from the Perspective of Abnormal High-Order Motor Processing

* 15-N-0158:
Thematic Studies of Multiple Sclerosis and Related Diseases

* 15-N-0156:
In Vivo Characterization of Inflammation with Ferumoxytol, an Ultrasmall Superparamagnetic Iron Oxide Nanoparticle, on 7 Tesla Magnetic Resonance Imaging

* 15-N-0126:
HERV-K Suppression using Antiretroviral Therapy in Volunteers with Amyotrophic Lateral Sclerosis (ALS)

* 15-N-0125:
Natural History Study of Inflammatory and Infectious Diseases of the Nervous System

* 15-N-0117:
Phase I Study of Oral Guanabenz for Multiple Sclerosis

* 15-N-0081:
An Investigator-Initiated, Prospective, Multi-Center, Controlled Feasibility Study of Direct Brain Recording and Stimulation for Memory Enhancement

* 15-N-0073:
A Phase I Study of Intrathecal Administration of scAAV9/JeT-GAN for the Treatment of Giant Axonal Neuropathy

* 15-N-0066:
Influence on Plasticity of Brain Temperature

* 15-N-0035:
Comparison of Electrophysiologic and Ultrasound Guidance for Onabotulinum Toxin A Injections in Focal Upper Extremity Dystonia and Spasticity

* 15-N-0018:
Congenital Muscular Dystrophy Ascending Multiple Dose Cohort Study analyzing Pharmacokinetics at three dose Levels In Children and Adolescents with Assessment of Safety and Tolerability of Omigapil

* 14-N-0132:
A Multicenter Observational Study to Assess the Variability of Molecular Biomarkers and Clinical Measures in Patients with Myotonic Dystrophy Type 1

* 14-N-0122:
Clinical Autonomic Disorders: A Training Protocol

* 14-N-0099:
Evaluation of Hepatic Function in Patients with Spinal and Bulbar Muscular Atrophy

* 14-N-0086:
Deep Brain Stimulation Therapy in Movement Disorders

* 14-N-0083:
Neural Basis of Decision Making Deficits in Traumatic Brain Injury

* 14-N-0069:
Real-time fMRI Neurofeedback for Motor Rehabilitation

* 14-N-0067:
Pilot Study of the Effect of Vorinostat on Nervous System Hemangioblastomas In Von Hippel-Lindau Disease

* 14-N-0061:
Noninvasive Pre-surgical Evaluation of Patients with Focal Epilepsy and Establishment of a Normative Imaging Database

* 14-N-0033:
Phase 2 Clinical Trial of SGS-742 Therapy in Succinic Semialdehyde Dehydrogenase Deficiency

* 14-N-0002:
Functional Brain Imaging in Healthy Volunteers to Study Cognitive Functions

* 13-N-0188:
Natural History and Biomarkers of C9ORF72 Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

* 13-N-0165:
Electrical Impedance Myography: Exploratory Studies in Normal Subjects and Patients with Neuromuscular Disorders

* 13-N-0149:
Screening and Recruitment for HIV-associated Neurocognitive Disorders (HAND) Studies and an Evaluation of HIV-associated Neurocognitive Disorders in Virologically Controlled Patients

* 13-N-0140:
Cerebrospinal Fluid Collection and Repository Storage

* 13-N-0135:
Pilot Study of Raltegravir, an Integrase Inhibitor, in Human T-Cell Lymphotrophic Virus-1(HTLV-1) Associated Myelopathy, Tropical Spastic Paraparesis (HAM/TSP)

* 13-N-0088:
Open Label Extension Trial of Idebenone for Primary Progressive Multiple Sclerosis

* 13-N-0085:
Clinical Manifestations and Biorepository for Focal Dystonia

* 13-N-0076:
Gamma Frequency Transcranial Magnetic Stimulation in Dystonia

* 13-N-0017:
Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)

* 12-N-0137:
A Phase 1 Open-Label Dose Escalation Safety Study of Convection Enhanced Delivery (CED) of Adeno-Associated Virus Encoding Glial Cell Line-Derived Neurotrophic Factor (AAV2-GDNF) in Subjects with Advanced Parkinson's Disease

* 12-N-0122:
Integrating Genetic and Environmental Risk Scores into an Algorithm to Predict Multiple Sclerosis Susceptibility

* 12-N-0095:
Clinical and Molecular Manifestations of Neuromuscular and Neurogenetic Disorders of Childhood

* 12-N-0083:
The Effectiveness of Botulinum Toxin on Persistent Pelvic Pain in Women with Endometriosis

* 12-N-0065:
Experienced Breacher Study: Evaluation of the Effects from Chronic Exposure to Low-Level Blast

* 12-N-0060:
Structural and Functional Brain Imaging Markers of Upper Motor Neuron Function

* 12-N-0031:
Imaging Biomarkers in Parkinson Disease

* 12-N-0007:
Prospective Evaluation of the Effect of Corticotropin-Releasing Hormone Stimulation on 18F-Fludeoxyglucose High-Resolution Positron-Emission Tomography in Cushing's Disease

* 11-N-0211:
Deep Brain Stimulation Surgery for Movement Disorders

* 11-N-0116:
Manganese-Enhanced Magnetic Resonance Imaging in Healthy Volunteers and People with Multiple Sclerosis

* 11-N-0084:
Evaluation and Diagnosis of Potential Research Subjects with Traumatic Brain Injury (TBI)

* 11-N-0051:
Surgery as a Treatment for Medically Intractable Epilepsy

* 10-N-0185:
Neural Dynamics and Connectivity in Response Inhibition and Traumatic Brain Injury

* 10-N-0143:
A Prospective Natural History Study of Patients with Syringomyelia

* 10-N-0122:
Evaluation, Pathogenesis, and Outcome of Subjects with or Suspected Traumatic Brain Injury

* 10-N-0012:
Screening Protocol for Patients with Stroke

* 09-N-0118:
Investigation of Neurofeedback with Real-Time fMRI in Healthy Volunteers and Patients with Hyperkinetic Movement Disorders

* 09-N-0032:
Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the CNS

* 07-N-0190:
Neurobiological Studies of Psychogenic Movement Disorders and Non-Epileptic Seizures

* 07-N-0122:
Modulation of Motor Function by Stimulation of the Central and Peripheral Nervous System

* 06-N-0047:
Reference Values for Plasma Catechols

* 05-N-0223:
Clinical Neurophysiology: Training and Normative Values

* 03-N-0164:
Evaluation and Treatment of Neurosurgical Disorders

* 03-N-0004:
Clinical Laboratory Evaluation of Primary Chronic Autonomic Failure

* 02-N-0014:
Research Study of Specimens Obtained During Epilepsy Surgery

* 01-N-0206:
Phenotype/Genotype Correlations in Movement Disorders

* 01-N-0139:
Evaluation and Treatment of Patients with Epilepsy

* 01-N-0007:
Evaluation, Pathogenesis, and Treatment of Patients with or at Risk for Cerebrovascular Disease (A Natural History/Disease Pathogenesis Protocol)

* 00-N-0089:
Genetic Analysis of the Chiari I Malformation

* 00-N-0082:
Characterization of Brain Morphology and Activity Using Functional and Anatomical MRI Contrast

* 00-N-0043:
Clinical and Molecular Manifestations of Inherited Neurological Disorders

* 98-N-0047:
Immuno-Virological Evaluation of Human T Cell Leukemia Virus Type-1 Associated Myelopathy (HAM/TSP)

* 93-N-0202:
Diagnosis and Natural History Protocol for Patients with Different Neurological Conditions

* 89-N-0045:
Evaluation of Progression in Multiple Sclerosis by Magnetic Resonance Imaging (MRI)

* 85-N-0195:
A Training Protocol for the use of Botulinum Toxin in the Treatment of Neurological Disorders

Active Follow-up, Protocols NOT Recruiting New Patients 

* 16-N-0166:
Deep Brain Stimulation Surgery for Treatment of Focal Hand Dystonia

* 15-N-0181:
International Nested, Double Blind Placebo-Controlled Clinical Trial of Corticosteroids in HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP)

* 15-N-0177:
Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy

* 15-N-0175:
A Multicenter, Open-Label, Phase 1b Safety and Efficacy Trial of Periganglionic Resiniferatoxin for the Treatment of Intractable Pain Due to Cancer-Induced Bone Pain

* 15-N-0057:
Physiological and Psychosomatic Effects of Exposure to MRI Scanning Environment

* 14-N-0169:
Dopamine Receptor Imaging to Predict Response to Stimulant Therapy in Chronic TBI

* 14-N-0051:
A Two-Part Placebo-Controlled Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of BVS857 in Patients with Spinal and Bulbar Muscular Atrophy (SBMA)

* 13-N-0127:
Increasing Self-Efficacy and Outcome Expectations For Exercise in Adults with Epilepsy: An Educational Motivation Intervention - E-MOVE

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