NIH Clinical Research Studies Listed By Institute of the Principal Investigator

National Institute of Mental Health (NIMH)

67 Protocols (53 Active Accrual of new subjects, 14 Follow-up of previously enrolled subjects)

Active Accrual, Protocols Recruiting New Patients 
* 17-M-0181:
Recruitment and Characterization of Healthy Research Volunteers for NIMH Intramural Studies

* 17-M-0179:
Evaluation of a Novel PET Radioligand to Image Cyclooxygenase-1 (COX-1)

* 17-M-0147:
Concurrent fMRI-guided rTMS and Cognitive Therapy for the Treatment of Major Depressive Episodes

* 17-M-0060:
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder

* 17-M-0046:
Effects of SRX246, a Vasopressin Receptor (V1a) Antagonist, on an Experimental Model of Fear and Anxiety in Humans

* 17-M-0042:
The Effect of Transcranial Magnetic Stimulation to the Dorsolateral Prefrontal Cortex on Anxiety Potentiated Startle

* 17-M-0041:
Evaluation of a Novel Positron Emission Tomography (PET) Radiotracer to Image Phosphodiesterase-4B (PDE4B)

* 16-M-0105:
Evaluation of a Novel PET Radioligand to Image OGA

* 15-M-0188:
The Neurobiology of Suicide

* 15-M-0182:
Psychological Treatments for Youth with Severe Irritability.

* 15-M-0151:
An Investigation of the Antidepressant Effects of the Glycine Receptor Antagonist AV 101 (4-chlorokynurenine) in Major Depressive Disorder

* 15-M-0139:
Mapping the Genotype, Phenotype, and Natural History of Phelan McDermid Syndrome

* 15-M-0114:
fMRI Spatial Context and Fear Conditioning

* 15-M-0109:
Checking out Checking In: The Development and Validation of an Electronic Screening Tool for Pediatric Psychosocial Distress

* 14-M-0109:
Ask Suicide-Screening Questions to Everyone in Medical Settings (asQ'em): Development of a Suicide Risk Screening Instrument for Adult Medical Inpatients

* 14-M-0085:
The Neurophysiological Effects of Intravenous Alcohol as Potential Biomarkers of Ketamine's Rapid Antidepressant Effects in Major Depressive Disorder

* 13-M-0190:
Imaging and Genetic Investigation of Learning and Decision Making

* 13-M-0028:
Diagnosis and Treatment of Childhood-onset Behavioral Disorders, Neuropsychiatric Disorders and Neurodevelopmental Disorders

* 12-M-0128:
TMS Investigations of the Human Visual System

* 11-M-0251:
A Longitudinal Investigation of the Endocrine and Neurobiologic Events Accompanying Puberty

* 11-M-0045:
Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle

* 10-M-0112:
Defining the Brain Phenotype of Children with Williams Syndrome

* 10-M-0047:
Top-Down Attentional Control of Visual-Processing

* 10-M-0027:
Cognitive Neuroscience of Autism Spectrum Disorders

* 09-M-0176:
Functional Relevance of Dopamine Receptors in Healthy Controls and Patients with Schizophrenia: Characterization through [11C]NNC-112 and [18F]Fallypride Positron Emission Tomography

* 09-M-0034:
A Controlled Trial of Citalopram Added to Methylphenidate in Youth with Severe Mood Dysregulation

* 07-M-0021:
Development of Functional and Structural Magnetic Resonance Imaging Techniques for the Study of Mood and Anxiety Disorders

* 06-M-0214:
PET Measurement of Regional Rates of Cerebral Protein Synthesis in Subjects with Fragile X Syndrome

* 06-M-0065:
Screening Protocol for Studies of the Pediatrics and Developmental Neuroscience Branch

* 05-M-0144:
MRS (Magnetic Resonance Spectroscopy) Measurement of Glutamate and GABA Metabolism in Brain

* 03-M-0211:
Family Study of Affective and Anxiety Spectrum Disorders

* 03-M-0186:
The Psychobiology of Temperament: An fMRI Study

* 03-M-0138:
A Screening Protocol to Evaluate Women with Postpartum-Related Mood and Behavioral Disorders

* 03-M-0093:
Predictability and Aversive Expectancies in Anxiety and Depressive Disorders

* 02-M-0321:
fMRI Investigation of Explicit Cue and Contextual Fear

* 02-M-0021:
Characterization and Pathophysiology of Severe Mood and Behavioral Dysregulation in Children and Youth

* 01-M-0254:
The Evaluation of Patients with Mood and Anxiety Disorders and Healthy Volunteers

* 01-M-0232:
Positron Emission Tomography (PET) Scanning in Dopamine Disorders: Parkinson's Disease and Schizophrenia

* 01-M-0192:
Fluoxetine's Effects on Attention and Emotional Memory in Anxious and Depressed Youth and Adults

* 01-M-0185:
Effects of Arousal and Stress on Classical Conditioning

* 00-M-0198:
The Phenomenology and Neurophysiology of Affective Dysregulation in Children and Adolescents with Bipolar Disorder

* 00-M-0085:
Structural and Functional Imaging of Neuropsychiatric Patients and Normal Volunteers with 3.0 Tesla MRI and Magnetoencephalography

* 99-M-0172:
Integrating EEG/MEG and fMRI: Activity Correlation between Frontal and Temporal Lobe Structures in Schizophrenic Patients, Their Siblings and Unrelated Normal Volunteers

* 95-M-0150:
A Neurobiological Investigation of Patients with Schizophrenia Spectrum Disorders and Their Siblings

* 95-M-0097:
An Endocrine Model for Postpartum Mood Disorders

* 93-M-0170:
Regional Cerebral Blood Flow Studies of Object Perception, Identification, Localization, and Memory

* 92-M-0174:
The Central Nervous System Effects of Pharmacologically Induced Hypogonadotropic Hypogonadism with and without Estrogen and Progesterone Replacement

* 90-M-0088:
The Treatment of Menstrually-Related Mood Disorders with the Gonadotropin Releasing Hormone (GnRH) Agonist, Depot Leuprolide Acetate (Lupron)

* 89-M-0160:
Inpatient Evaluation of Neuropsychiatric Patients

* 89-M-0006:
Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Volunteers

* 88-M-0131:
The Evaluation of Women with Perimenopause-Related Mood and Behavioral Disorders

* 81-M-0126:
The Evaluation of Women with Menstrually Regulated Mood and Behavioral Disorders

* 80-M-0083:
Bipolar Genetics: A Collaborative Study

Active Follow-up, Protocols NOT Recruiting New Patients 

* 16-M-0093:
PET Imaging of Phosphodiesterase-4 (PDE4) in Brain and Peripheral Organs of Mccune-Albright Syndrome

* 14-M-0114:
Cognitive vs. Emotional Psycho-Pharmacological Manipulations of Fear vs. Anxiety

* 13-M-0100:
Brain Inflammation In Major Depressive Disorder

* 13-M-0019:
Pilot Study to Extend the K-SADS-PL to Adolescents and Young Adults

* 09-M-0194:
Characterizing Lone Parenting: A Multi-Institutional Pilot Study of the Perceptions of Support and Perceived Stress of Lone Parents of Children with Cancer

* 09-M-0177:
CO2 Inhalation and Risk for Panic Disorder

* 09-M-0022:
The Use of a Distress Thermometer in a Pediatric Research Setting: An Exploratory, Pilot Study

* 08-M-0052:
fMRI Investigation of Cortical Reorganization and Phantom Limb Pain Following Amputation

* 04-M-0183:
Association between Adenosine Receptor Gene Polymorphisms and Physiological Responses to Caffeine in Subjects with Panic Disorder and Healthy Controls

* 02-M-0036:
A Behavioral and Functional Neuroimaging Study of Inhibitory Motor Control

* 97-M-0126:
Childhood Onset Psychotic Disorders: Characterization and Treatment with Atypical Neuroleptics

* 91-M-0230:
Mechanisms of Individual Variation of Dextroamphetamine Effects in Normal Human Subjects

* 91-M-0124:
Structural and Functional Imaging of Neuropsychiatric Patients and Normal Volunteers with 1.5 Tesla MRI

* 90-M-0014:
Studies of Frontal Lobe Function During Cognitive Stimulation as Measured with Oxygen-15 Water Positron Emission Tomography in Normal Subjects and Patients with Neuropsychiatric Disorders

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