NIH Clinical Research Studies Listed By Institute of the Principal Investigator

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

95 Protocols (58 Active Accrual of new subjects, 37 Follow-up of previously enrolled subjects)

Active Accrual, Protocols Recruiting New Patients 
* 17-DK-0107:
Effect of Isocaloric Ultra Processed Versus Unprocessed Diets on Insulin Sensitivity

* 17-DK-0054:
The Physiological Responses and Adaptation of Brown Adipose Tissue to Chronic Treatment with Beta-3-Adrenergic Receptor Agonists

* 17-DK-0013:
Therapeutic Targets in African-American Youth with Type 2 Diabetes

* 16-DK-0173:
MEASuRE: Metreleptin Effectiveness and Safety Registry

* 16-DK-0167:
A Phase II Randomized, Placebo-Controlled, Double-Blind, Parallel Arms With Switchover, Pilot Study To Evaluate The Efficacy And Safety Of Intravenous Abatacept In Treatment Resistant Nephrotic Syndrome (Focal Segmental Glomerulosclerosis/Minimal Change)

* 16-DK-0143:
Idiosyncratic Liver Injury Associated with Drugs (ILIAD): A Retrospective Study

* 16-DK-0075:
Study Glomerulopathy

* 16-DK-0068:
The Molecular, Cellular, and Genetic Characterization of Human Adipose Tissue and its Role in Metabolism

* 16-DK-0038:
A Randomized, Double Blind, Placebo-Controlled Study to Assess Efficacy, Safety and Tolerability of ISIS 304801 in Patients with Partial Lipodystrophy with an Open-Label Extension

* 16-DK-0036:
A Phase 1 Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ManNAc in Subjects with Primary Podocyte Diseases

* 15-DK-0174:
Dynamic Post-Prandial Metabolism in Patients with Non-Alcoholic Fatty Liver Disease

* 15-DK-0143:
Investigation of Viral Kinetics, Interferon Stimulated Genes (ISGs) and mirRNA Among Subjects Infected with Different Hepatitis C Virus Genotypes During Therapy with Sofosbuvir and GS-5816

* 15-DK-0119:
Thyroid Hormone to Induce Non-Insulin Mediated Glucose Disposal in Patients with Insulin Receptor Mutations

* 15-DK-0108:
Natural History of Noncirrhotic Portal Hypertension

* 15-DK-0082:
Mechanisms Associated with Favorable Response to Peginterferon-Alpha Add-on Therapy Following Long-term Nucleos(t)ide Analogue Treatment in Patients with Chronic Hepatitis B

* 15-DK-0080:
Palmitate Breath Test to Assess Fatty Acid Oxidation in Non Alcoholic Fatty Liver Disease

* 15-DK-0079:
Observational Study of Hepatitis B Virus (HBV) in Patients Coinfected with Human Immunodeficiency Virus (HIV)

* 15-DK-0003:
Compassionate Use of Metreleptin in Previously-Treated Patients with Generalized Lipodystrophy

* 15-DK-0002:
Compassionate Use of Metreleptin in Previously-Treated Patients with Partial Lipodystrophy

* 14-DK-0195:
Acute Effects of Canagliflozin, a Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitor on Bone Metabolism in Healthy Volunteers

* 14-DK-0060:
Famine from Feast: Linking Vitamin C, Red Blood Cell Fragility, and Diabetes

* 13-DK-0200:
The Mechanism of Human Non-Shivering Thermogenesis and Basal Metabolic Rate

* 13-DK-0196:
Evaluation of Sickle Cell Liver Disease

* 13-DK-0090:
Identifying Risk for Diabetes and Heart Disease in Women: A Study of African-American, African and White Federal Employees and Contractors

* 13-DK-0057:
Short Term Effects of Leptin Withdrawal or Initiation in Lipodystrophy Independent of Energy Intake

* 12-DK-0154:
Evaluation of Patients with Gastrointestinal Disease

* 12-DK-0097:
Energy Expenditure Responses to Different Temperatures

* 11-DK-0168:
Magnetic Resonance of Body, Arterial Wall and Angiography Imaging for Non-Invasive Assessment of Arterial Distensibility, Endothelial Dysfunction and Atherosclerotic Disease Using 1.5T High Field (3T) MRI: A Technical Development Study of Cardiac and Bod

* 11-DK-0108:
Observational Study of Persons with Hepatitis B Virus Infection in North America (Cohort Study)

* 11-DK-0023:
The Nephrotic Syndrome Study Network (NEPTUNE)

* 10-DK-0163:
Metabolic Effects of Non-Nutritive Sweeteners

* 09-DK-0223:
Rituximab Plus Cyclosporine in Idiopathic Membranous Nephropathy

* 09-DK-0140:
Natural History of Autoimmune Diabetes and Its Complications

* 09-DK-0097:
Vitamin E Pharmacokinetics and Biomarkers in Women

* 08-DK-0098:
Natural History of Familial Carcinoid Tumor

* 08-DK-0004:
High Sensitivity Screening of Compound Libraries to Discover a Drug for the Treatment of Sickle Cell Disease

* 07-DK-0115:
Natural History of Type 2 Diabetes Mellitus in Children and Young Adults

* 07-DK-0077:
Study of the Phenotype of Overweight and Obese Adults

* 04-DK-0021:
Urinary Vitamin C Loss in Subjects with and without Diabetes

* 03-DK-0257:
Effect of Leptin Therapy in the Treatment of Severe Insulin Resistance

* 03-DK-0256:
Inhibition of Intestinal Glucose Absorption by the Bioflavonoid Quercetin in the Obese and in Obese Type 2 Diabetics

* 00-DK-0107:
Search for Novel Methods to Detect Acute Renal Failure

* 99-DK-0002:
Diabetes and Heart Disease Risk in Blacks

* 94-DK-0133:
Genetic Markers for Focal Segmental Glomerulosclerosis

* 94-DK-0127:
Pathogenesis of Glomerulosclerosis

* 93-DK-0127:
Family Studies in Metabolic Diseases and Mineral Metabolism

* 92-DK-0156:
Studies of Immunologically-Mediated Kidney Diseases

* 92-DK-0033:
Pharmacokinetics and Biodistribution of Ascorbic Acid in Healthy Human Subjects

* 91-DK-0214:
Evaluation of Patients with Liver Disease

* 91-DK-0085:
Studies of Hyperparathyroidism and Related Disorders

* 91-DK-0066:
Fasting Hypoglycemia: Diagnosis and Treatment

* 89-DK-0173:
Studies of States with Resistance to Vitamin D and Parathyroid Hormone

* 89-DK-0152:
Determination of Glomerular Filtration Rate, Effective Renal Plasma Flow and Glomerular Capillary Wall Permselectivity

* 87-DK-0029:
Diagnosis and Treatment of Patients with Cystic Fibrosis and Other Disorders of the Respiratory System and Pancreas

* 85-DK-0082:
Acromegaly Treatment and Natural History

* 77-DK-0096:
Studies on Thyroid Nodules and Thyroid Cancer

* 77-DK-0002:
Evaluation of Patients with Thyroid Function Disorders

* 76-DK-0006:
Natural History of Disorders of Insulin Resistance

Active Follow-up, Protocols NOT Recruiting New Patients 

* 15-DK-0192:
Quantifying Weight Regain and the Persistence of Metabolic Adaptation Following Extreme Weight Loss

* 15-DK-0170:
Treatment of Chronic Delta Hepatitis with Lonafarnib and Ritonavir

* 15-DK-0100:
A Multidisciplinary Approach to Deciphering the Mechanisms Involved In Microbial Translocation Across the Spectrum of HCV Associated Liver Fibrosis

* 14-DK-0084:
Evaluation of Safety, Tolerability, and Antiviral Activity of Chlorcyclizine HCl Alone or in Combination with Ribavirin in Patients with Chronic Hepatitis C

* 13-DK-0212:
Effect of a Eucaloric Ketogenic Diet on Energy Expenditure: A Pilot Study

* 13-DK-0150:
Unraveling the Mechanisms of Non-Response in Patients With and Without Cirrhosis Due to Chronic Hepatitis C

* 13-DK-0142:
The Physiology of Fatigue in Patients with Chronic Liver Disease

* 13-DK-0091:
Combination Therapy of Pegylated Interferon Alfa-2a and Tenofovir DF versus Tenofovir DF Monotherapy in HBeAg-Positive and HBeAg-Negative Chronic Hepatitis B

* 13-DK-0013:
Impact of Chronic Cold Exposure on Energy Metabolism in Humans

* 13-DK-0002:
Treatment for Non-Alcoholic Fatty Liver with Different Doses of Vitamin E

* 12-DK-0071:
Combination Entecavir and Peginterferon Therapy in HBeAG-Postive Immune-Tolerant Adults with Chronic Hepatitis B

* 12-DK-0046:
Treatment of Chronic Delta Hepatitis with Lonafarnib

* 11-DK-0256:
Pharmacokinetic and Pharmacodynamic Studies of Liothyronine. A Study on the Metabolic Effects of Thyroid Hormone

* 11-DK-0151:
Withdrawal of Therapy After Long-Term Oral Nucleos(t)ide Analogue Treatment in Patients with Chronic Hepatitis B

* 10-DK-0187:
Duration of Long-Term Immunity After Hepatitis B Virus Immunization

* 10-DK-0135:
Role of Donor Genetics and Recipient Genetics in Kidney Transplant Outcomes

* 10-DK-0064:
Effects of Caloric Restriction Alone versus Postoperative Caloric Restriction Following Bariatric Surgery on Glucose Metabolism in Patients with Diabetes Mellitus

* 09-DK-0081:
Selective Reduction of Dietary Carbohydrate Versus Fat: Effects on Metabolism, Endocrine Physiology, Brain Activity and Reward Circuitry

* 09-DK-0055:
Assessment of the Effects of a DPP-4 Inhibitor (Sitagliptin) Januvia on Immune Function in Healthy Individuals

* 08-DK-0173:
A Trial of Segmental Stiffening Wires to Improve the Efficiency and Patient Tolerability of Colonoscopy

* 08-DK-0165:
Thyroid Hormones Homeostasis and Energy Metabolism Changes During Stimulation of Endogenously Secreted Bile Acids (BAs)

* 08-DK-0149:
High Dose Ribavirin in Combination with Peginterferon for Patients with Chronic Hepatitis C Genotype 1 Infection Who Have Failed to Respond or Relapsed after Standard Therapy

* 08-DK-0138:
A New Method for Determining Gastric Acid Output Using a Wireless Capsule

* 07-DK-0219:
A Nutrigenomics Intervention for the Study of the Role of Dietary Sitosterol on Lipid, Glucose and Energy Metabolism

* 07-DK-0202:
Thyroid Hormones Homeostasis and Energy Metabolism Changes During Exposure to Cold Temperature in Humans

* 06-DK-0183:
Gene Expression and Release of Inflammatory Mediators in Overweight Subjects Before and After Weight Loss

* 06-DK-0025:
The Effects of Lithium Carbonate on Low Dose Radioiodine Ablation in Early Thyroid Cancer Treatment

* 05-DK-0119:
Peripheral Thyroid Hormone Conversion and Glucose and Energy Metabolism

* 03-DK-0245:
Effect of AC 2993 (Synthetic Exendin-4) - Administered Alone or in Combination with Daclizumab - on Islet Function in Patients with Type I Diabetes

* 03-DK-0098:
Study of Thyrotropin Releasing Hormone in Patients with Thyroid or Pituitary Abnormalities

* 02-DK-0022:
Long-Term Efficacy of Leptin Replacement in Treatment of Lipodystrophy

* 01-DK-0249:
Ingested Interferon-Alpha: Prolongation or Permanence of the "Honeymoon" Phase in Newly Diagnosed Diabetes Mellitus

* 01-DK-0246:
Combination of Lamivudine and Adefovir Dipivoxil for Treatment of Chronic Hepatitis B

* 01-DK-0062:
Genetic Analysis of Familial Keloids

* 01-DK-0036:
Solitary Islet Transplantation for Type 1 Diabetes Mellitus Using Steroid Sparing Immunosuppression

* 00-DK-0186:
The Hep C Antiviral Long-Term Tx Against Cirrhosis (HALT-C) Trial: A Randomized Controlled Trial to Evaluate the Safety & Efficacy of Long-Term Peginterferon Alpha2A for Tx of Chronic Hep C in Patients Who Failed to Respond to Previous Interferon Therap

* 90-DK-0137:
Evaluation of the Gastrinoma in Patients with Zollinger-Ellison Syndrome

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