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Protocol Details

Structural and Functional Brain Imaging Markers of Upper Motor Neuron Function

This study is NOT currently recruiting participants.

Summary | Eligibility | Citations | Contacts




Sponsoring Institute

National Institute of Neurological Disorders and Stroke (NINDS)

Recruitment Detail

Type: Completed Study; data analyses ongoing
Gender: Male & Female
Min Age: 35
Max Age: N/A

Referral Letter Required


Population Exclusion(s)


Special Instructions

Currently Not Provided


Cerebrospinal Fluid;
Magnetic Resonance Spectroscopy;
Transcranial Magnetic Stimulation (TMS);
Diffusion Tensor Imaging;
Functional Magnetic Resonance Imaging (fMRI)

Recruitment Keyword(s)

Healthy Volunteer;


Healthy Subjects;
Magnetic Resonance Imaging;
Central Nervous System;
Neurological Disorder

Investigational Drug(s)


Investigational Device(s)




Supporting Site

National Institute of Neurological Disorders and Stroke


- People with motor neuron disorders have changes in the parts of the brain that control movement. Some tests that are currently used to study these changes are magnetic resonance imaging (MRI) and transcranial magnetic stimulation (TMS). We don t know if MRI scans and TMS give the same results if done at different times in the same person. Researchers want to see if these tests produce different results if given to healthy adults on two separate occasions.


- To test the reliability of different tests of the brain used to study motor neuron disorders.


-<TAB>Healthy individuals at least 35 years of age who have no history of neurological disorders and take no medications.

-<TAB>Pregnant women may not participate.


- Participants will be screened with a medical history and physical exam.

- Participants will have two testing visits 1 to 6 months apart.

- The first visit will have three parts. The first part is a neurological exam to test strength, sensation, reflexes, and coordination of movement. The second part will be TMS tests. The third part will involve an MRI scan to study the parts of the brain that control movement.

- At the second visit, participants will have MRI scanning only.

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- Healthy adults aged 35 and older

- No history of a neurological disorder

- Able to give informed consent


- Treatment within the preceding week with medications that affect neuronal excitability, such as antidepressants, sedatives, and drugs for epilepsy or migraine.

- Change in blood pressure medications within the preceding week.

- Metal in the body such as pacemakers, implanted pumps or other implanted electronic devices, some types of dental implants, aneurysm clips (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and cochlear implants), permanent eyeliner or shrapnel fragments.

- Pregnancy. Women of childbearing potential will undergo urine pregnancy testing before MRI scanning.

- Fear of confined spaces.

- Serious medical illness.

- Employees or staff in the investigator's section.

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Ellis CM, Simmons A, Jones DK, Bland J, Dawson JM, Horsfield MA, Williams SC, Leigh PN. Diffusion tensor MRI assesses corticospinal tract damage in ALS. Neurology. 1999 Sep 22;53(5):1051-8.

Tartaglia MC, Laluz V, Rowe A, Findlater K, Lee DH, Kennedy K, Kramer JH, Strong MJ. Brain atrophy in primary lateral sclerosis. Neurology. 2009 Apr 7;72(14):1236-41.

Wong JC, Concha L, Beaulieu C, Johnston W, Allen PS, Kalra S. Spatial profiling of the corticospinal tract in amyotrophic lateral sclerosis using diffusion tensor imaging. J Neuroimaging. 2007 Jul;17(3):234-40.

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Principal Investigator

Referral Contact

For more information:

Mary Kay Floeter, M.D.
National Institute of Neurological Disorders and Stroke (NINDS)
BG 10-CRC RM 1D45
(301) 496-7428

Carol H. Hoffman
National Institute of Neurological Disorders and Stroke (NINDS)
National Institutes of Health
Building 10
Room 1D45
10 Center Drive
Bethesda, Maryland 20892
(301) 451-1229

Office of Patient Recruitment
National Institutes of Health Clinical Center (CC)
Building 61, 10 Cloister Court
Bethesda, Maryland 20892
Toll Free: 1-800-411-1222
Local Phone: 301-451-4383
TTY: 1-866-411-1010

Clinical Trials Number:


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