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Protocol Details

Regional Cerebral Blood Flow Studies of Object Perception, Identification, Localization, and Memory

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number

93-M-0170

Sponsoring Institute

National Institute of Mental Health (NIMH)

Recruitment Detail

Type: Participants currently recruited/enrolled
Gender: Male & Female
Min Age: 18
Max Age: 65

Referral Letter Required

Yes

Population Exclusion(s)

Children;
Adults who are or may become unable to consent

Special Instructions

Currently Not Provided

Keywords

Cognition;
Vision;
Cortex;
Visual Processing;
Magnetic Resonance Imaging

Recruitment Keyword(s)

None

Condition(s)

Healthy Volunteer

Investigational Drug(s)

None

Investigational Device(s)

None

Intervention(s)

None

Supporting Site

National Institute of Mental Health

The purpose of this study is to use brain imaging technology to measure changes in blood flow to areas in the brain as individuals perform intellectual tasks.

This study will use functional magnetic resonance imaging (fMRI) to examine blood flow to areas of the brain as participants engage in tasks associated with visual perception, visual recognition, and memory.

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Eligibility

INCLUSION CRITERIA:

Healthy adults, with at least a high school education, aged 18 to 65 years, will be recruited to participate in the study.

EXCLUSION CRITERIA:

Subjects will be excluded if they:

-are an NIMH employee or a relative

-have evidence of, or a history of:

-major medical, neurological or psychiatric illness

-serious head injury

-learning disability-drug or alcohol abuse or dependence in the past 3 months, except nicotine

-are taking prescription drugs or supplements that may affect brain function-

-have serious vision or hearing problems

In addition to the above, additional exclusion criteria apply for all MRI studies:

-Female subjects who are pregnant or have a positive pregnancy test 24 hours prior to an experiment will be excluded from neuroimaging studies.

-All subjects will be questioned prior to MRI scanning for possible occupational exposure to metal slivers or shavings, which may have become accidentally lodged in the tissues of the head or neck. Subjects with surgical clips or shrapnel in or near the brain or blood vessels, subjects with cochlear implants, subjects with any metallic body in the eye or CNS, and subjects with any form of implant wire or metal device which may concentrate radiofrequency fields will be excluded from MRI scanning experiments because of possible risks during MRI scanning. Those whose history is suggestive of such a problem will also be excluded from the MRI portion of the experiments. They may still participate in the behavioral and MEG experiments.

-Subjects unable to lie flat on their back for up to 2 hours may not be eligible to participate in MRI scans.


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Citations:

Corticocortical connections of anatomically and physiologically defined subdivisions within the inferior parietal lobule

Organization of visual inputs to the inferior temporal and posterior parietal cortex in macaques

Organization of afferent input to subdivisions of area 8 in rhesus monkey

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Contacts:

Principal Investigator

Referral Contact

For more information:

Leslie G. Ungerleider, Ph.D.
National Institute of Mental Health (NIMH)
National Institutes of Health
Building 10
Room 4C104
10 Center Drive
Bethesda, Maryland 20892
(301) 435-4932
ungerlel@intra.nimh.nih.gov

NIMH LBC Volunteer
National Institute of Mental Health (NIMH)
NIMH Lab of Brain and Cognition
(301) 827-5157
nimhlbcvolunteer@mail.nih.gov

Office of Patient Recruitment
National Institutes of Health Clinical Center (CC)
Building 61, 10 Cloister Court
Bethesda, Maryland 20892
Toll Free: 1-800-411-1222
Local Phone: 301-451-4383
TTY: 1-866-411-1010
PRPL@cc.nih.gov

Clinical Trials Number:

NCT00001360

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