National Institute of Environmental Health Sciences (NIEHS)s

National Institute of Environmental Health Sciences (NIEHS)

23 Protocols (18 Active Accrual of new subjects, 5 Follow-up of previously enrolled subjects)

Active Accrual, Protocols Recruiting New Patients 
* 17-E-0161:
An Open-label Study of Sodium Thiosulfate for Treatment of Calcinosis Associated with Juvenile and Adult Dermatomyositis

* 16-E-0157:
CaREFREE Study (Calorie Restriction, Environment and Fitness: Reproductive Effects Evaluation Study)

* 16-E-0096:
Cytochrome P450 Epoxygenase Pathway Regulation of Macrophage Function

* 16-E-0006:
Investigating the Impact of Obesity on Pubertal Development in Girls

* 15-E-0134:
NIEHS EPA Pilot Study of Exposure to Chemicals in Consumer Products

* 15-E-0058:
Natural History of Asthma with Longitudinal Environmental Sampling

* 13-E-0015:
Environmental Risk Factors for the Development of Myositis in Military Personnel

* 12-E-0089:
Bisphenol A (BPA) Pharmacokinetic (PK): Controlled Exposure Study

* 11-E-0072:
Environmental Risk Factors for the Anti-Synthetase Syndrome

* 11-E-0006:
The Role of TGF-Beta in Asthmatic Epithelial Cell Susceptibility to RSV Infection

* 10-E-0134:
Effect of SNPs in p53 and p53 Response Elements on the Inflammatory Response to DNA Damage

* 10-E-0130:
The Role of Glucocorticoid Receptor SNPs in Receptor Function and Metabolic Disease

* 10-E-0129:
Study of the Effect of Innate Immunity on the Inflammatory Response to Endotoxin

* 10-E-0063:
Sample Collection Registry for Quality Control of Biological and Environmental Specimens and Assay Development and Testing

* 07-E-0023:
Innate Immunity Signal Transduction in Human Leukocytes

* 04-E-0053:
Environmental Polymorphism Registry (EPR)

* 03-E-0099:
Pathogenic Studies In Families With Twins Or Siblings Discordant For Systemic Rheumatic Disorders

* 94-E-0165:
Studies in the Natural History and Pathogenesis of Childhood-Onset and Adult-Onset Idiopathic Inflammatory Myopathies

Active Follow-up, Protocols NOT Recruiting New Patients 

* 17-E-0003:
Collection of Biological and Environmental Samples and Clinical Data from Anonymous Adult Men and Women for Quality Control and Methods Development and Evaluation (ASCA)

* 14-E-0204:
A Pharmacokinetic Study to Assess and Compare the Drug Interaction Risk of the Grapefruit Juice and Dietary Supplements Known to Inhibit CYP3A Enzyme Activity

* 12-E-0190:
The Role of Functionally Relevant Cyclooxygenase-2 (COX-2) Gene Single Nucleotide Polymorphisms -765G>C and 8473T>C in Lymphocyte Differentiation

* 12-E-0061:
The Role of the Functionally Relevant Single Nucleotide Polymorphisms CYP2J2 -50G>T (CYP2J2 7) and EPHX2 9846A>G (EPHX2 K55R) in Human Endothelial Function

* 07-E-0012:
Rituximab in the Treatment of Refractory Adult and Juvenile Dermatomyositis (DM) and Adult Polymyositis (PM)