National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)s

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

97 Protocols (55 Active Accrual of new subjects, 42 Follow-up of previously enrolled subjects)

Active Accrual, Protocols Recruiting New Patients 
* 19-DK-0072:
Non-Alcoholic Fatty Liver Disease, the Hepatic Response to Oral Glucose, and the Effect of Semaglutide (NAFLD HEROES)

* 19-DK-0067:
Effect of Low Fat versus Low Carbohydrate Diets on Energy Metabolism

* 19-DK-0066:
The Evaluation and Management of Endocrine-Related Conditions and Physiology

* 19-DK-0050:
The Use of 124-I-PET/CT Whole Body and Lesional Dosimetry in Differentiated Thyroid Cancer

* 18-DK-0132:
Brain Dopamine Function in Human Obesity

* 18-DK-0123:
Treatment of Chronic Delta Hepatitis with Lonafarnib, Ritonavir and Lambda Interferon

* 18-DK-0116:
Use of Hepatitis B Immune Globulin (HBIg) to Restore Immune Control in Patients with Chronic Hepatitis B

* 18-DK-0091:
Long-Term Follow-Up Of Subjects With CHC Who Achieved A Sustained Virological Response Following Therapy With Direct Acting Antiviral Agents

* 18-DK-0047:
Effects of Sucralose on Drug Absorption and Metabolism (The SweetMeds Study)

* 18-DK-0044:
Effect of Ultra Processed versus Unprocessed Diets on Energy Intake

* 17-DK-0054:
The Physiological Responses and Adaptation of Brown Adipose Tissue to Chronic Treatment with Beta-3-Adrenergic Receptor Agonists

* 17-DK-0013:
Therapeutic Targets in African-American Youth with Type 2 Diabetes

* 16-DK-0173:
MEASuRE: Metreleptin Effectiveness and Safety Registry

* 16-DK-0143:
Idiosyncratic Liver Injury Associated with Drugs (ILIAD): A Retrospective Study

* 16-DK-0075:
Study Glomerulopathy

* 16-DK-0068:
The Molecular, Cellular, and Genetic Characterization of Human Adipose Tissue and its Role in Metabolism

* 15-DK-0174:
Dynamic Post-Prandial Metabolism in Patients with Non-Alcoholic Fatty Liver Disease

* 15-DK-0108:
Natural History of Noncirrhotic Portal Hypertension

* 15-DK-0003:
Compassionate Use of Metreleptin in Previously-Treated Patients with Generalized Lipodystrophy

* 15-DK-0002:
Compassionate Use of Metreleptin in Previously-Treated Patients with Partial Lipodystrophy

* 14-DK-0195:
Acute Effects of Canagliflozin, a Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitor on Bone Metabolism in Healthy Volunteers

* 14-DK-0060:
Famine from Feast: Linking Vitamin C, Red Blood Cell Fragility, and Diabetes

* 13-DK-0200:
The Mechanism of Human Non-Shivering Thermogenesis and Basal Metabolic Rate

* 13-DK-0196:
Evaluation of Sickle Cell Liver Disease

* 12-DK-0154:
Evaluation of Patients with Gastrointestinal Disease

* 12-DK-0097:
Energy Expenditure Responses to Different Temperatures

* 11-DK-0168:
Magnetic Resonance of Body, Arterial Wall and Angiography Imaging for Non-Invasive Assessment of Arterial Distensibility, Endothelial Dysfunction and Atherosclerotic Disease Using 1.5T High Field (3T) MRI: A Technical Development Study of Cardiac and Bod

* 11-DK-0023:
The Nephrotic Syndrome Study Network (NEPTUNE)

* 10-DK-0163:
Metabolic Effects of Non-Nutritive Sweeteners

* 10-DK-0102:
Clinical and Genetic Studies in Familial Non-Medullary Thyroid Cancer

* 09-DK-0223:
Rituximab Plus Cyclosporine in Idiopathic Membranous Nephropathy

* 09-DK-0140:
Natural History of Autoimmune Diabetes and Its Complications

* 09-DK-0097:
Vitamin E Pharmacokinetics and Biomarkers in Women

* 08-DK-0098:
Natural History of Familial Carcinoid Tumor

* 08-DK-0004:
High Sensitivity Screening of Compound Libraries to Discover a Drug for the Treatment of Sickle Cell Disease

* 07-DK-0115:
Natural History of Type 2 Diabetes Mellitus in Children and Young Adults

* 07-DK-0077:
Study of the Phenotype of Overweight and Obese Adults

* 04-DK-0021:
Urinary Vitamin C Loss in Subjects with and without Diabetes

* 03-DK-0257:
Effect of Leptin Therapy in the Treatment of Severe Insulin Resistance

* 03-DK-0256:
Inhibition of Intestinal Glucose Absorption by the Bioflavonoid Quercetin in the Obese and in Obese Type 2 Diabetics

* 00-DK-0107:
Search for Novel Methods to Detect Acute Renal Failure

* 99-DK-0002:
Diabetes and Heart Disease Risk in Blacks

* 94-DK-0133:
Genetic Markers for Focal Segmental Glomerulosclerosis

* 94-DK-0127:
Pathogenesis of Glomerulosclerosis

* 93-DK-0127:
Family Studies in Metabolic Diseases and Mineral Metabolism

* 92-DK-0156:
Studies of Immunologically-Mediated Kidney Diseases

* 91-DK-0214:
Evaluation of Patients with Liver Disease

* 91-DK-0085:
Studies of Hyperparathyroidism and Related Disorders

* 91-DK-0066:
Fasting Hypoglycemia: Diagnosis and Treatment

* 89-DK-0173:
Studies of States with Resistance to Vitamin D and Parathyroid Hormone

* 89-DK-0152:
Determination of Glomerular Filtration Rate, Effective Renal Plasma Flow and Glomerular Capillary Wall Permselectivity

* 87-DK-0029:
Diagnosis and Treatment of Patients with Cystic Fibrosis and Other Disorders of the Respiratory System and Pancreas

* 77-DK-0096:
Studies on Thyroid Nodules and Thyroid Cancer

* 77-DK-0002:
Evaluation of Patients with Thyroid Function Disorders

* 76-DK-0006:
Natural History of Disorders of Insulin Resistance

Active Follow-up, Protocols NOT Recruiting New Patients 

* 16-DK-0167:
A Phase II Randomized, Placebo-Controlled, Double-Blind, Parallel Arms, Pilot Study To Evaluate The Efficacy And Safety Of Intravenous Abatacept In Treatment Resistant Nephrotic Syndrome (Focal Segmental Glomerulosclerosis/Minimal Change)

* 16-DK-0038:
A Randomized, Double Blind, Placebo-Controlled Study to Assess Efficacy, Safety and Tolerability of ISIS 304801 in Patients with Partial Lipodystrophy with an Open-Label Extension

* 16-DK-0036:
A Phase 1 Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ManNAc in Subjects with Primary Podocyte Diseases

* 15-DK-0192:
Quantifying Weight Regain and the Persistence of Metabolic Adaptation Following Extreme Weight Loss

* 15-DK-0170:
Treatment of Chronic Delta Hepatitis with Lonafarnib and Ritonavir

* 15-DK-0143:
Investigation of Viral Kinetics, Interferon Stimulated Genes (ISGs) and mirRNA Among Subjects Infected with Different Hepatitis C Virus Genotypes During Therapy with Sofosbuvir and GS-5816

* 15-DK-0119:
Thyroid Hormone to Induce Non-Insulin Mediated Glucose Disposal in Patients with Insulin Receptor Mutations

* 15-DK-0100:
A Multidisciplinary Approach to Deciphering the Mechanisms Involved In Microbial Translocation Across the Spectrum of HCV Associated Liver Fibrosis

* 15-DK-0082:
Mechanisms Associated with Favorable Response to Peginterferon-Alpha Add-on Therapy Following Long-term Nucleos(t)ide Analogue Treatment in Patients with Chronic Hepatitis B

* 15-DK-0080:
Palmitate Breath Test to Assess Fatty Acid Oxidation in Non Alcoholic Fatty Liver Disease

* 15-DK-0079:
Observational Study of Hepatitis B Virus (HBV) in Patients Coinfected with Human Immunodeficiency Virus (HIV)

* 14-DK-0084:
Evaluation of Safety, Tolerability, and Antiviral Activity of Chlorcyclizine HCl Alone or in Combination with Ribavirin in Patients with Chronic Hepatitis C

* 13-DK-0212:
Effect of a Eucaloric Ketogenic Diet on Energy Expenditure: A Pilot Study

* 13-DK-0150:
Unraveling the Mechanisms of Non-Response in Patients With and Without Cirrhosis Due to Chronic Hepatitis C

* 13-DK-0091:
Combination Therapy of Pegylated Interferon Alfa-2a and Tenofovir DF versus Tenofovir DF Monotherapy in HBeAg-Positive and HBeAg-Negative Chronic Hepatitis B

* 13-DK-0090:
Identifying Risk for Diabetes and Heart Disease in Women: A Study of African-American, African and White Federal Employees and Contractors

* 13-DK-0057:
Short Term Effects of Leptin Withdrawal or Initiation in Lipodystrophy Independent of Energy Intake

* 13-DK-0002:
Treatment for Non-Alcoholic Fatty Liver with Different Doses of Vitamin E

* 12-DK-0071:
Combination Entecavir and Peginterferon Therapy in HBeAG-Postive Immune-Tolerant Adults with Chronic Hepatitis B

* 12-DK-0046:
Treatment of Chronic Delta Hepatitis with Lonafarnib

* 11-DK-0256:
Pharmacokinetic and Pharmacodynamic Studies of Liothyronine. A Study on the Metabolic Effects of Thyroid Hormone

* 11-DK-0151:
Withdrawal of Therapy After Long-Term Oral Nucleos(t)ide Analogue Treatment in Patients with Chronic Hepatitis B

* 11-DK-0108:
Observational Study of Persons with Hepatitis B Virus Infection in North America (Cohort Study)

* 10-DK-0187:
Duration of Long-Term Immunity After Hepatitis B Virus Immunization

* 10-DK-0135:
Role of Donor Genetics and Recipient Genetics in Kidney Transplant Outcomes

* 10-DK-0064:
Effects of Caloric Restriction Alone versus Postoperative Caloric Restriction Following Bariatric Surgery on Glucose Metabolism in Patients with Diabetes Mellitus

* 09-DK-0081:
Selective Reduction of Dietary Carbohydrate Versus Fat: Effects on Metabolism, Endocrine Physiology, Brain Activity and Reward Circuitry

* 09-DK-0055:
Assessment of the Effects of a DPP-4 Inhibitor (Sitagliptin) Januvia on Immune Function in Healthy Individuals

* 08-DK-0173:
A Trial of Segmental Stiffening Wires to Improve the Efficiency and Patient Tolerability of Colonoscopy

* 08-DK-0149:
High Dose Ribavirin in Combination with Peginterferon for Patients with Chronic Hepatitis C Genotype 1 Infection Who Have Failed to Respond or Relapsed after Standard Therapy

* 08-DK-0138:
A New Method for Determining Gastric Acid Output Using a Wireless Capsule

* 05-DK-0119:
Peripheral Thyroid Hormone Conversion and Glucose and Energy Metabolism

* 03-DK-0245:
Effect of AC 2993 (Synthetic Exendin-4) - Administered Alone or in Combination with Daclizumab - on Islet Function in Patients with Type I Diabetes

* 02-DK-0022:
Long-Term Efficacy of Leptin Replacement in Treatment of Lipodystrophy

* 01-DK-0249:
Ingested Interferon-Alpha: Prolongation or Permanence of the "Honeymoon" Phase in Newly Diagnosed Diabetes Mellitus

* 01-DK-0246:
Combination of Lamivudine and Adefovir Dipivoxil for Treatment of Chronic Hepatitis B

* 01-DK-0062:
Genetic Analysis of Familial Keloids

* 01-DK-0036:
Solitary Islet Transplantation for Type 1 Diabetes Mellitus Using Steroid Sparing Immunosuppression

* 00-DK-0186:
The Hep C Antiviral Long-Term Tx Against Cirrhosis (HALT-C) Trial: A Randomized Controlled Trial to Evaluate the Safety & Efficacy of Long-Term Peginterferon Alpha2A for Tx of Chronic Hep C in Patients Who Failed to Respond to Previous Interferon Therap

* 92-DK-0033:
Pharmacokinetics and Biodistribution of Ascorbic Acid in Healthy Human Subjects

* 90-DK-0137:
Evaluation of the Gastrinoma in Patients with Zollinger-Ellison Syndrome

* 85-DK-0082:
Acromegaly Treatment and Natural History