National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)s

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

106 Protocols (56 Active Accrual of new subjects, 50 Follow-up of previously enrolled subjects)

 001690-DK:

Effect of Nicotinamide Riboside on Ketosis, Fat Oxidation & Metabolic Rate

 001651-DK:

A Pilot Study to Assess Feasibility of Adipose Tissue Triglyceride (TG) Labelling in Familial Partial Lipodystrophy (FPLD)

 001125-DK:

Optimizing HBV Care Cascade among Foreign-Born in the United States (FOCUS-HBV Study)

 001058-DK:

A Phase 1b/2a Open-label Multiple-ascending Dose Exploratory Study of CRN04894 in ACTH-dependent Cushing's Syndrome (Cushing's Disease or Ectopic ACTH Syndrome)

 000911-DK:

Dinner Time for Obesity and Prediabetes (DTOP)

 000908-DK:

Peripheral Blood and Urine Immune Cell Phenotyping in Membranous Nephropathy using FACS and Single Cell RNA-seq

 000869-DK:

The Effects of Increasing Caloric Intake on Diet-Induced Thermogenesis and 24h Energy Expenditure

 000757-DK:

Natural History of Pregnancy and Pregnancy Outcomes in Metreleptin-Treated vs Untreated Subjects with Lipodystrophy

 000756-DK:

Phase II Study of Growth Hormone Inhibition Using Pegvisomant In Severe Insulin Resistance

 000617-DK:

A Natural History Study of Metabolic Sizing in Health and Disease

 000494-DK:

Natural History of Fontan Associated Liver Disease and the Evaluation of Biomarkers for Disease Severity Assessment

 000344-DK:

Natural History Study of Parathyroid Disorders

 000247-DK:

Evaluation of Patients with Gastrointestinal Disease

 000130-DK:

Unraveling the Mechanisms Underlying Primary Sclerosing Cholangitis Through a Multidisciplinary, Integrative Research Approach

 000079-DK:

The Role of 68-Gallium-DOTATATE-PET/CT in the Imaging of Metastatic Thyroid Cancer

 000043-DK:

Developing Biomarkers of Dietary Intake: Dose Dependent Measurement of Sugar Intake

 22-DK-0002:

Effect of Ultra-processed versus Unprocessed Diets on Energy Metabolism

 20-DK-0168:

LYNC-LD Prospective Multicenter Natural History Study of Lipodystrophy Syndromes to Determine Prevalence, Incidence and Predictors of Diabetes and Severe Hypertriglyceridemia, and their Complications.

 19-DK-0072:

Non-Alcoholic Fatty Liver Disease, the Hepatic Response to Oral Glucose, and the Effect of Semaglutide (NAFLD HEROES)

 19-DK-0066:

The Evaluation and Management of Endocrine-Related Conditions and Physiology

 19-DK-0050:

The Use of 124-I-PET/CT Whole Body and Lesional Dosimetry in Differentiated Thyroid Cancer

 18-DK-N071:

Early Tracking of Childhood Health Determinants Study

 18-DK-0091:

Long-Term Follow-Up Of Subjects With CHC Who Achieved A Sustained Virological Response Following Therapy With Direct Acting Antiviral Agents

 17-DK-N004:

Energy Intake Response to Short-Term Alterations of Energy Expenditure in Humans

 17-DK-0054:

The Physiological Responses and Adaptation of Brown Adipose Tissue to Chronic Treatment with Beta3-Adrenergic Receptor Agonists

 16-DK-0173:

MEASuRE: Metreleptin Effectiveness and Safety Registry

 16-DK-0143:

Idiosyncratic Liver Injury Associated with Drugs (ILIAD): A Retrospective Study

 16-DK-0125:

Evaluation of Adults with Endocrine-Related Conditions

 16-DK-0068:

The Molecular, Cellular, and Genetic Characterization of Human Adipose Tissue and its Role in Metabolism

 15-DK-0108:

Natural History of Noncirrhotic Portal Hypertension

 15-DK-0003:

Compassionate Use of Metreleptin in Previously-Treated Patients with Generalized Lipodystrophy

 14-DK-0060:

Famine from Feast: Linking Vitamin C, Red Blood Cell Fragility, and Diabetes

 14-CH-0028:

Prospective Evaluation of 68Ga-DOTATATE PET/CT, Octreotide and F-DOPA PET Imaging in Ectopic Cushing Syndrome

 13-DK-0200:

The Mechanism of Human Non-Shivering Thermogenesis and Basal Metabolic Rate

 12-DK-0097:

Energy Expenditure Responses to Different Temperatures

 11-DK-0168:

Magnetic Resonance of Body, Arterial Wall, and Angiography Imaging for Non- Invasive Assessment of Arterial Distensibility, Endothelial Dysfunction and Atherosclerotic Disease Using 1.5T and High Field (3T) MRI: A Technical Development Study of Cardiac a

 10-DK-N091:

Molecular and Clinical Profile of Diabetes Mellitus and its Complications

 10-DK-0102:

Clinical and Genetic Studies in Familial Non-Medullary Thyroid Cancer

 09-DK-0223:

Rituximab Plus Cyclosporine in Idiopathic Membranous Nephropathy

 08-DK-N191:

The Effects of Transcranial Direct Current Stimulation (TDCS) on Food Intake and Weight Loss

 08-DK-0098:

Natural History of Familial Carcinoid Tumor

 08-DK-0004:

High Sensitivity Screening of Compound Libraries to Discover a Drug for the Treatment of Sickle Cell Disease

 07-DK-0077:

Study of the Phenotype of Overweight and Obese Adults

 04-DK-0021:

Urinary Vitamin C Loss in Subjects with and without Diabetes

 02-DK-N304:

Diabetes Prevention Program Outcomes Study (DPPOS)

 01-DK-N117:

Family Investigation of Nephropathy and Diabetes (F.I.N.D.)

 00-DK-0107:

Search for Novel Methods to Detect Acute Renal Failure

 OH99-DK-N019:

The Food Intake Phenotype: Assessing Eating Behavior and Food Preferences as Risk Factors for Obesity

 99-DK-0002:

Diabetes and Heart Disease Risk in Blacks

 92-DK-0156:

Studies of Immunologically-Mediated Kidney Diseases

 91-DK-0214:

Evaluation of Patients with Liver Disease

 91-DK-0066:

Fasting Hypoglycemia: Diagnosis and Treatment

 87-DK-0029:

Diagnosis and Treatment of Patients with Cystic Fibrosis

 77-DK-0096:

Studies on Thyroid Nodules and Thyroid Cancer

 77-DK-0002:

Natural History of Thyroid Function Disorders

 76-DK-0006:

Natural History of Disorders of Insulin Resistance

 001746-DK:

Pilot Study of Isocaloric Time Restricted Eating on Ketone Metabolism and Immunoregulation

 001707-DK:

Variability In Mixed Meal Tests: Fixed Versus Adjusted to Energy Needs Caloric Dose

 001680-DK:

Diet Order Effects of Low Fat vs. Low Carb Diets on Body Fat Change

 001606-DK:

A Pilot Study of the Combination of VIR-2218 and Peginterferon Alfa-2a for Chronic Hepatitis B

 001515-DK:

Open Label Phase 2 Clinical Study of Peginterferon Lambda and Lonafarnib Boosted with Ritonavir 48-Week Combination Therapy for Delta Hepatitis

 000748-DK:

Analysis of the Utility of Polygenic Scores for Prediction of Incident Type 2 Diabetes Across Multiple Ancestry Groups

 000665-DK:

A Randomized Double-Blind Placebo-Controlled Study of the LEPR Agonist Antibody REGN4461 for the Treatment of Metabolic Abnormalities in Patients with Familial Partial Lipodystrophy

 000545-DK:

Prevalence and Development of Liver Dysfunction in Hematopoietic Stem Cell Transplant: A Prospective Natural History Study

 000393-DK:

Diabetic Kidney Disease and Related Complications in American Indians with Type 2 Diabetes

 000220-DK:

Phase II Trial of the Combination of Alpha-lipoic Acid and Mirabegron in Women and in Men with Obesity

 000172-DK:

The Impact of the Food Environment and Psychosocial Stress from the COVID-19 Pandemic on Eating Behavior and Weight Change

 000118-DK:

Prospective Cohort Study to Determine the Response to COVID-19 Vaccination and Prevalence of COVID-19 in Subjects with Chronic Liver Disease

 20-DK-0079:

A Randomized, Double-Blinded, Placebo-Controlled Study of REGN4661, A Leptin Receptor Agonist Antibody, In Patients with Generalized Lipodystrophy

 20-DK-0018:

Prebiotics and Metformin Influences Gut and Hormones in Type 2 Diabetes Youth

 19-DK-0067:

Effect of Low Fat versus Low Carbohydrate Diets on Energy Metabolism

 18-DK-0132:

Brain Dopamine Function in Human Obesity

 18-DK-0123:

Treatment of Chronic Delta Hepatitis with Lonafarnib, Ritonavir and Lambda Interferon

 18-DK-0044:

Effect of Ultra Processed versus Unprocessed Diets on Energy Intake

 18-CH-0031:

Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks

 17-DK-0013:

Therapeutic Targets in African-American Youth with Type 2 Diabetes

 15-DK-0192:

Quantifying Weight Regain and the Persistence of Metabolic Adaptation Following Extreme Weight Loss

 15-DK-0174:

Dynamic Post-Prandial Metabolism in Patients with Non-Alcoholic Fatty Liver Disease

 15-DK-0170:

Treatment of Chronic Delta Hepatitis with Lonafarnib and Ritonavir

 15-DK-0143:

Investigation of Viral Kinetics, Interferon Stimulated Genes (ISGs) and mirRNA Among Subjects Infected with Different Hepatitis C Virus Genotypes During Therapy with Sofosbuvir and GS-5816

 15-DK-0100:

A Multidisciplinary Approach to Deciphering the Mechanisms Involved In Microbial Translocation Across the Spectrum of HCV Associated Liver Fibrosis

 15-DK-0082:

Mechanisms Associated with Favorable Response to Peginterferon-Alpha Add-on Therapy Following Long-term Nucleos(t)ide Analogue Treatment in Patients with Chronic Hepatitis B

 15-DK-0079:

Observational Study of Hepatitis B Virus (HBV) in Patients Coinfected with Human Immunodeficiency Virus (HIV)

 15-DK-0002:

Compassionate Use of Metreleptin in Previously-Treated Patients with Partial Lipodystrophy

 14-DK-0195:

Acute Effects of Canagliflozin, a Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitor on Bone Metabolism in Healthy Volunteers

 13-DK-0212:

Effect of a Eucaloric Ketogenic Diet on Energy Expenditure: A Pilot Study

 13-DK-0091:

Combination Therapy of Pegylated Interferon Alfa-2a and Tenofovir DF versus Tenofovir DF Monotherapy in HBeAg-Positive and HBeAg-Negative Chronic Hepatitis B

 13-DK-0090:

Identifying Risk for Diabetes and Heart Disease in Women: A Study of African-American, African and White Federal Employees and Contractors

 12-DK-0071:

Combination Entecavir and Peginterferon Therapy in HBeAg-Positive Immune-Tolerant Adults with Chronic Hepatitis B

 11-DK-0151:

Withdrawal of Therapy After Long-Term Oral Nucleos(t)ide Analogue Treatment in Patients with Chronic Hepatitis B

 11-DK-0108:

Observational Study of Persons with Hepatitis B Virus Infection in North America (Cohort Study)

 09-DK-0097:

Vitamin E Pharmacokinetics and Biomarkers in Normal and Obese Women

 09-DK-0081:

Selective Reduction of Dietary Carbohydrate Versus Fat: Effects on Metabolism, Endocrine Physiology, Brain Activity and Reward Circuitry

 08-DK-N140:

Predicting Adaptive Thermogenesis

 08-DK-0173:

A Trial of Segmental Stiffening Wires to Improve the Efficiency and Patient Tolerability of Colonoscopy

 08-DK-0149:

High Dose Ribavirin in Combination with Peginterferon for Patients with Chronic Hepatitis C Genotype 1 Infection Who Have Failed to Respond or Relapsed after Standard Therapy

 08-DK-0138:

A New Method for Determining Gastric Acid Output Using a Wireless Capsule

 07-DK-N215:

Study of Short-Term Metabolic Adaptation: Prediction of Weight Change and Effects of Macronutrient Manipulations

 07-DK-0115:

Natural History of Type 2 Diabetes Mellitus in Children and Young Adults

 03-DK-0257:

Phase II Trial of Effect of Metreleptin Therapy in Severe Insulin Resistance

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