Protocol Details

Relationship of Diastolic Function and Functional Capacity in Hypertrophic Cardiomyopathy: A Post-Hoc Analysis of Protocols 01-H-0066 and 96-H-0144

This study is NOT currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number	05-H-0163
Sponsoring Institute	National Heart, Lung and Blood Institute (NHLBI)
Recruitment Detail	Type: Completed Study; data analyses ongoing Gender: Male & Female Min Age: 20 Max Age: 75
Referral Letter Required	Yes
Population Exclusion(s)	Children
Special Instructions	Currently Not Provided
Keywords	HCM; Echocardiography; Diastolic Dysfunction; Enalapril
Recruitment Keyword(s)	None
Condition(s)	Angina, Unstable; Myocardial Infarction; Ischemic Heart Disease
Investigational Drug(s)	None
Investigational Device(s)	None
Intervention(s)	None
Supporting Site	National Heart, Lung, and Blood Institute

This study will examine the relationship between certain measures of heart function and exercise capacity in patients with hypertrophic cardiomyopathy (HCM).

Patients who participated in NHLBI studies 01-H-0006 ("Double Blind Placebo-Controlled Study of Pirfenidone - A Novel Anti-Fibrotic Drug - in Symptomatic Patients with Hypertrophic Cardiomyopathy Associated with Left Ventricular Diastolic Dysfunction") and 96-H-0144 ("Double Blind Placebo-Controlled Study of Long-Term Effects of Angiotensin-Converting Enzyme Inhibition (Enalapril) and Angiotensin II Receptor Blockade (Losartan) on Genetically-Induced Left Ventricular Diastolic Dysfunction") are eligible for this study. Data from echocardiograms and measures of left ventricular pressure obtained from patients in those studies will be analyzed in the current study to assess their influence on exercise capacity. No additional tests, treatments or other procedures are required.

Information from this study may help in the development of improved drug treatments for HCM.

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Eligibility

This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.

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Citations:

Not Provided

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Contacts:

Principal Investigator	Referral Contact	For more information http://clinicalstudies.info.nih.gov.
Dorothea R. McAreavey, M.D. National Heart, Lung and Blood Institute (NHLBI) National Institutes of Health Building 10 Room 3-5288 10 Center Drive Bethesda, Maryland 20892 (301) 451-7128 battiwam@mail.nih.gov	Jonathan F. Plehn, M.D. National Heart, Lung and Blood Institute (NHLBI) National Institutes of Health Building 10 Room 3NE-2473 10 Center Drive Bethesda, Maryland 20892 (301) 594-4709 ekozanas@nih.gov	Patient Recruitment and Public Liaison Office Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 prpl@mail.cc.nih.gov

Clinical Trials Number:

NCT00354328

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