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Protocol Details

Non-Invasive Assessment of Atherosclerosis in Patients with CGD and Other Disorders of the Immune System

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number

10-I-0029

Sponsoring Institute

National Institute of Allergy and Infectious Diseases (NIAID)

Recruitment Detail

Type: Participants currently recruited/enrolled
Gender: Male & Female
Min Age: 18
Max Age: 999

Referral Letter Required

No

Population Exclusion(s)

Children

Special Instructions

Currently Not Provided

Keywords

Chronic Granulomatous Disease (CGD);
Atherosclerosis;
Inflammatory Bowel Disease;
Immune Deficiencies

Recruitment Keyword(s)

Atherosclerosis;
Immune System Deficiences;
Chronic Granulomatous Disease;
CGD

Condition(s)

Chronic Granulomatous Disease (CGD);
Atherosclerosis;
Immune Deficiencies;
Inflammatory Bowel Disease

Investigational Drug(s)

None

Investigational Device(s)

None

Intervention(s)

None

Supporting Site

National Institute of Allergy and Infectious Diseases

Background:

- Atherosclerosis, the arterial plaques or blockages that cause heart disease, develops in many people by the time they are in their mid-20s. The rate of atherosclerosis in patients with immune system disorders has not been well studied, but it may be very different from the general population.

- Patients with chronic granulomatous disease (CGD) produce less of a group of molecules known as free radicals, which help to fight infection and may play a role in the development of atherosclerosis. Patients with CGD may develop atherosclerosis much more slowly than people without CGD. On the other hand, carrier mothers of children with genetically-linked CGD often have problems with autoimmune problems in addition to a problem with making free radicals. Patients with other immune system disorders also have very different responses to infection, and many of them also have autoimmune-like problems that may change the risk of developing atherosclerosis.

Objectives:

- To study the prevalence of atherosclerosis in patients with immune system disorders, compared with healthy individuals.

Eligibility:

- Individuals at least 18 years of age who either have been diagnosed with an immune system disorder or are healthy volunteers.

Design:

- The active part of the study involves one or two visits to the National Institutes of Health Clinical Center for a series of imaging tests and scans.

- Participants will have the following tests during the active part of the study:

- (1) CAT scan to obtain images of the chest arteries and measure the amount of calcium in the artery walls.

- (2) Magnetic resonance imaging scan to obtain images of the coronary and carotid arteries in the chest and neck.

- (3) Electrocardiogram to provide data on current heart function.

- (4) Blood samples to provide data on heart, kidney, and immune system function.

- Participants will be contacted every 2 years in the future for up to 30 years to determine whether they have developed heart disease. Researchers will ask participants to provide contact information for two other people who may likely know how to get in touch with the participant in the future.

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Eligibility

INCLUSION CRITERIA:

Patients will be identified for this protocol who are enrolled on existing protocols studying patients with disorders of the immune system who volunteer for participation and who do not have any of the listed exclusion criteria. Patients will remain enrolled on their existing protocol. Normal volunteers will be enrolled as controls on this protocol. They will be recruited through the normal volunteer office which will provide a list of volunteers including their age to allow for inclusion of controls that approximate the study population.

All patients enrolled on this protocol will be over the age of 18 and may be male or female and will be accrued without regard to religion, race or sexual orientation. They must be able to understand and sign informed consent documents and comply with study procedures that include undergoing a CT scan and an MRI scan. Patients who are unable or unwilling to complete one or more of the studies will not be excluded. The available data will be included in the appropriate analysis.

EXCLUSION CRITERIA:

For Participation in MRI-Based Studies Only:

1. Subjects with contraindication to MRI scanning. These contraindications include but are not limited to the following devices or conditions:

a. Implanted cardiac pacemaker or defibrillator

b. Cochlear Implants

c. Ocular foreign body (i.e., metal shavings)

d. Embedded shrapnel fragments

e. Central nervous system aneurysm clips

f. Implanted neural stimulator

g. Medical infusion pumps

h. Any implanted device that is incompatible with MRI

2. Patients whose medical condition is such that in the referring physicians estimation, they could not tolerate an MRI scan. Examples of medical conditions that would not be accepted would include unstable angina and dyspnea at rest.

3. Subjects with a condition precluding entry into the scanner (e.g. morbid obesity, claustrophobia, etc.) or who require sedation for anxiety associate with MRI studies.

4. Pregnant or lactating women are excluded from this study because excessive exposure of the developing human fetus and child to radiation and/or intravenous contrast agents can be detrimental.

5. Subjects with severe back-pain or motion disorders who will be unable to tolerate supine positioning within the MRI scanner and hold still for the duration of the examination.

For Gadolinium-Based MRI Studies Only:

6. History of severe allergic reaction to gadolinium contrast agents despite the use of premedication with an anti-histaminic and/or corticosteroid.

7. eGFR less than 60mL/min

8. Serum creatinine greater than 3.0 mg/dl

For Iodine-Based Contrast CT Studies Only:

9. Contraindication to the use of iodine based CT contrast agents:

a. Serum creatinine greater than 1.4 mg/dl

b. History of multiple myeloma

c. Use of metformin-containing products less than 24 hours prior to contrast administration

d. History of significant allergic reaction to CT contrast agents despite the use of premedication with an anti-histaminic and cortisone.

For Coronary CT Angiography Only:

10. Contraindication to the use of CT contrast agents:

a. Creatinine value greater than1.4 mg/dl

b. History of multiple myeloma

c. Use of metformin-containing products less than 24 hours prior to contrast administration

d. History of significant allergic reaction to CT contrast agents despite the use of premedication with an anti-histaminic and cortisone.

11. Subjects with contraindication precluding the use of beta blockers necessary to perform the coronary CT angiography. These include:

a. Severe, uncontrolled asthma

b. Active bronchospasm

c. Moderate or severe COPD

d. 2nd or 3rd degree AV block

e. Decompensated cardiac failure

f. Allergy to beta blockers

g. Systolic blood pressure less than100 mm Hg

h. Pregnancy or nursing

Participation of Minors: Atherosclerosis is a disease that does not generally affect young children. This protocol involves exposure to a low dose of radiation. As radiation exposure may increase the risk of malignancy, it is prudent to avoid this in children. Therefore, patients under the age of 18 will not be considered for enrollment under this protocol.

Participation of Women: Excessive radiation exposure of the developing human fetus can be detrimental. For this reason, women of childbearing-age will have a pregnancy test prior to undergoing study procedures. Should a woman become pregnant or suspect that she is pregnant while participating in this study, she should immediately inform study staff and her primary care physician.

Pregnancy: Pregnant women are excluded from this study because excessive exposure of the developing human fetus to radiation can be detrimental.

Co-enrollment Guidelines: Co-enrollment in other trials is not restricted.

Medical Exclusions: Patients with current atrial fibrillation will not be considered for enrollment under this protocol. Patients who are medically unstable (e.g. severe sepsis, acute myocardial infarction) and/or would require active, acute medical management in order to be medically stable enough to participate in this protocol will not be enrolled.

X-linked CGD Cohort: Patients in this cohort must have X-linked CGD as demonstrated by DHR or genetic screening. Patients who have undergone bone marrow transplant may not be enrolled in this cohort for analysis.

AutosomalRecessive CGD Cohort: Patients in this cohort must have autosomal recessive CGD (p47phox, p67phox, or p22phox deficiency) as demonstrated by DHR or genetic screening. Patients who have undergone bone marrow transplant may not be enrolled in this cohort for analysis.

Inflammatory Bowel Disease Cohort: Patients enrolled into this cohort may not have been diagnosed with CGD.

Normal Volunteer Cohort: Patients in this cohort may not have been diagnosed with CGD, Inflammatory Bowel Disease, or another primary disease of the immune system.


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Citations:

Winkelstein JA, Marino MC, Johnston RB Jr, Boyle J, Curnutte J, Gallin JI, Malech HL, Holland SM, Ochs H, Quie P, Buckley RH, Foster CB, Chanock SJ, Dickler H. Chronic granulomatous disease. Report on a national registry of 368 patients. Medicine (Baltimore). 2000 May; 79(3):155-69.

Lass(SqrRoot)(Registered Trademark)gue B, Sorescu D, Sz(SqrRoot)(Delta)cs K, Yin Q, Akers M, Zhang Y, Grant SL, Lambeth JD, Griendling KK. Novel gp91(phox) homologues in vascular smooth muscle cells : nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways. Circ Res. 2001 May 11;88(9):888-94.

Sorescu D, Weiss D, Lass(SqrRoot)(Registered Trademark)gue B, Clempus RE, Sz(SqrRoot)(Delta)cs K, Sorescu GP, Valppu L, Quinn MT, Lambeth JD, Vega JD, Taylor WR, Griendling KK. Superoxide production and expression of nox family proteins in human atherosclerosis. Circulation. 2002 Mar 26;105(12):1429-35.

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Contacts:

Principal Investigator

Referral Contact

For more information:

John I. Gallin, M.D.
National Institute of Allergy and Infectious Diseases (NIAID)
BG 10-CRC RM 6-2551
10 CENTER DR
BETHESDA MD 20814
(301) 496-4114
jgallin@cc.nih.gov

Sandra M. Maxwell, R.N.
National Institute of Allergy and Infectious Diseases (NIAID)
National Institutes of Health
Building 10 CRC
Room 3-2473
@@StreetAddress
@@Bethesda, Maryland 20892
(301) 402-3595
maxwells@mail.nih.gov

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

prpl@mail.cc.nih.gov

Clinical Trials Number:

NCT01063309

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