Protocol Details

Evaluation and Treatment of Patients with Epilepsy

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number	01-N-0139
Sponsoring Institute	National Institute of Neurological Disorders and Stroke (NINDS)
Recruitment Detail	Type: Participants currently recruited/enrolled Gender: Male & Female Min Age: 2 Max Age: N/A
Referral Letter Required	No
Population Exclusion(s)	None
Special Instructions	Currently Not Provided
Keywords	Seizures; Anti-Epileptic Drugs; Pharmacotherapy; Neuropsychology; Temporal Lobe Epilepsy; Frontal Lobe Epilepsy; Complex Partial Seizures; Grand Mal Seizures; Generalized Seizures
Recruitment Keyword(s)	Epilepsy; Seizures
Condition(s)	Epilepsy
Investigational Drug(s)	None
Investigational Device(s)	None
Intervention(s)	None
Supporting Site	National Institute of Neurological Disorders and Stroke

This protocol has three purposes: 1) to screen patients with seizures for participation in research studies of NINDS's Clinical Epilepsy Section (CES), 2) to follow the natural course of seizure disorders, and 3) to train CES fellows in evaluating and treating epilepsy. Only standard diagnostic tests and treatments will be used in this study.

Patients of any age with seizures who are referred to CES may participate in this study. At the end of the study, patients may be discharged to the care of their referring physician, offered participation in another NINDS research protocol, or followed for teaching purposes.

Participants will undergo standard diagnostic procedures used to determine the type of their seizures, what part of the brain they are coming from, what is causing them, and whether standard drug treatments can help them. These may include some or all of the following:

- Physical and neurological examination

- Neuropsychological tests - tests of learning and memory

- Electroencephalography (EEG) - brain wave recording

- Evoked potentials - tests of nerve reactions to lights and sounds

- Polysomnography - simultaneous recordings of brain waves, breathing and eye movements

- Video-EEG monitoring - simultaneous recording of seizures using a video camera and brain waves

- Video-EEG monitoring with extra electrodes to record muscle activity, breathing and eye movements for analyzing sleep patterns

- Imaging studies, such as magnetic resonance imaging (MRI) and positron emission tomography (PET) scans to examine the structure and function of the brain

- Frequent blood tests to measure blood levels of anti-seizure drugs

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Eligibility

INCLUSION CRITERIA:

All patients older than 2 years referred to the Clinical Epilepsy Section will be included for outpatient screening.

EXCLUSION CRITERIA:

None.

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Citations:

Current issues in the management of epilepsy: the impact of frequent seizures on cost of illness, quality of life, and mortality

The cost of epilepsy in the United States: an estimate from population-based clinical and survey data

Quality of life in children with epilepsy

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Contacts:

Principal Investigator	Referral Contact	For more information:
William H. Theodore, M.D. National Institute of Neurological Disorders and Stroke (NINDS) National Institutes of Health BG 10 RM 7D43 MSC 1408 10 CENTER DR BETHESDA MD 20892-1408 (301) 496-1505 theodorw@ninds.nih.gov	Patricia M. Reeves-Tyer, R. EEG T. National Institute of Neurological Disorders and Stroke (NINDS) National Institutes of Health Building 10 Room 5S217 10 Center Drive Bethesda, Maryland 20892 (301) 496-1923 tyerp@ninds.nih.gov	Patient Recruitment and Public Liaison Office Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 prpl@mail.cc.nih.gov

Clinical Trials Number:

NCT00013845

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