Protocol Details

Evaluation and Treatment of Bone and Mineral Disorders

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number	01-D-0184
Sponsoring Institute	National Institute of Dental And Craniofacial Research (NIDCR)
Recruitment Detail	Type: Participants currently recruited/enrolled Gender: Male & Female Min Age: N/A Max Age: N/A
Referral Letter Required	No
Population Exclusion(s)	None
Special Instructions	Currently Not Provided
Keywords	Bone; Dysplasia; Fragility; Osteomalacia
Recruitment Keyword(s)	Osteoporosis; Dysplasia; Osteomalacia; Bone Diseases; Skeletal Disease
Condition(s)	Bone Disease
Investigational Drug(s)	None
Investigational Device(s)	None
Intervention(s)	None
Supporting Site	National Institute of Dental and Craniofacial Research

This study has four objectives: 1) to provide investigators the opportunity to study bone specimens from patients with various skeletal diseases; 2) to treat patients with skeletal diseases at the NIH; 3) to expose NIH trainees to certain skeletal diseases; and 4) to gain more knowledge about skeletal diseases and stimulate further study of bone biology.

Anyone with a disease that affects the skeleton may be eligible for this study.

All evaluations, tests, procedures and treatments given study participants are used in the standard care of skeletal diseases. No experimental evaluations or treatments are offered. Patient evaluations include a medical history, review of medical records and routine physical examination. Based on the findings, other procedures may be recommended, including blood tests, urine tests, and imaging tests, such as X-rays, bone densitometry, bone scan, computed tomography (CT) and magnetic resonance imaging (MRI).

Bone specimens from participants will be collected for research use. Specimens will be obtained from bone removed during a patient's planned surgical procedure performed for medical care, or patients may be requested to have a bone biopsy-removal of a small piece of bone tissue-as part of the patient evaluation procedure.

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Eligibility

INCLUSION CRITERIA:

1. Specimens to be shipped will be either "surgical waste," or the harvesting of the specimen will be allowed for by an IRB-approved protocol at the sending institution. The specimen will be sent with a copy of the signed consent.

2. Patients of any age, gender, or ethnicity may enroll.

3. Patients with known or suspected bone disease, as demonstrated by any one of the following: a fracture, or abnormal bone findings on x-ray, CT scan, MRI, or bone densitometry.

4. Patients with a known or suspected disorder of mineral metabolism, as demonstrated by any one of the following: laboratory measurement above or below the normal NIH laboratory reference values for either blood or urine calcium, phosphorus, magnesium, parathyroid hormone or vitamin D.

EXCLUSION CRITERIA:

1. Patients not able to give informed consent.

2. Patients unwilling or unable to abide by procedures of protocol.

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Citations:

Not Provided

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Contacts:

Principal Investigator	Referral Contact	For more information:
Michael T. Collins, M.D. National Institute of Dental And Craniofacial Research (NIDCR) National Institutes of Health 30 Convent Drive, MSC 4320 Building 30, Room 228 Bethesda, Maryland 20892-4320 (301) 496-4563 mcollins@mail.nih.gov	Michael T. Collins, M.D. National Institute of Dental And Craniofacial Research (NIDCR) National Institutes of Health 30 Convent Drive, MSC 4320 Building 30, Room 228 Bethesda, Maryland 20892-4320 (301) 496-4563 mcollins@mail.nih.gov	Patient Recruitment and Public Liaison Office Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 prpl@mail.cc.nih.gov

Clinical Trials Number:

NCT00024804

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