Protocol Details

Functional and Metabolic Imaging Using Magnetic Resonance at 3.0 Tesla

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number	99-CC-0163
Sponsoring Institute	National Institutes of Health Clinical Center (CC)
Recruitment Detail	Type: Participants currently recruited/enrolled Gender: Male & Female Min Age: 18 Max Age: N/A
Referral Letter Required	No
Population Exclusion(s)	Children
Special Instructions	Currently Not Provided
Keywords	MRI/MRS; Functional MRI; Metabolic Imaging; Brain
Recruitment Keyword(s)	Healthy Volunteer
Condition(s)	Healthy
Investigational Drug(s)	None
Investigational Device(s)	None
Intervention(s)	None
Supporting Site	NIH Clinical Center

This study will evaluate new magnetic resonance imaging (MRI ) methods using a MRI machine more powerful than those in most hospitals. MRI is a diagnostic tool that uses a large magnet and radio waves to produce images of the human body. It can also provide information about brain chemistry and physiology. This study will use the new MRI hardware and methods to measure blood flow and metabolism in regions of the brain during simple tasks, such as listening to tones or watching flashing checkerboards.

Healthy normal volunteers will undergo MRI scanning. For this procedure, the person lies on a stretcher that is moved into a MRI machine, which produces a strong magnetic field. A special lightweight coil is placed on the person's head to obtain better pictures. The scan time ranges from 20 minutes to 2 hours, with the average scan lasting between 45 and 90 minutes.

During the MRI, the person may be asked to perform simple tasks, such as listening to tones or watching a screen, tapping fingers or moving a hand. More complex tasks may require thinking about tones or pictures and responding to them by pressing buttons.

The images produced in this study will be compared with those produced using standard MRI. The results will be used to develop improved imaging methods for better patient care and research.

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Eligibility

INCLUSION CRITERIA:

a. age 18 and older

b. capable of providing own informed consent

c. capable of filling out MRI screening form

EXCLUSION CRITERIA:

a. contraindications for MRI including aneurysm clip; implanted neural stimulator; implanted cardiac pacemaker or auto-defibrillator; cochlear implant; ocular foreign body (e.g. metal shavings); or insulin pump, or other metal in the body.

b. pregnancy

c. Subjects will be excluded if it is deemed that they have a condition that would preclude their participation for technical development (e.g. claustrophobia)

d. Subjects will be excluded if they present unnecessary risk (e.g. Brain surgery of uncertain type, etc.).

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Citations:

Brain magnetic resonance imaging with contrast dependent on blood oxygenation

Functional mapping of the human visual cortex by magnetic resonance imaging

Functional magnetic resonance imaging of the human brain: data acquisition and analysis

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Contacts:

Principal Investigator	Referral Contact	For more information:
Joseph A. Frank, M.D. National Institutes of Health Clinical Center (CC) National Institutes of Health Building 10 Room B1N256 10 Center Drive Bethesda, Maryland 20892 (301) 402-3586 jafrank@helix.nih.gov	Bobbi K. Lewis National Institutes of Health Clinical Center (CC) National Institutes of Health Building 10 Room B1N256 10 Center Drive Bethesda, Maryland 20892 (301) 435-3866 blewis@cc.nih.gov	Patient Recruitment and Public Liaison Office Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 prpl@mail.cc.nih.gov

Clinical Trials Number:

NCT00001844

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