Protocol Number: 96-M-0124

Title:

Genetics of Obsessive-Compulsive Disorder: A Collaborative Study

Number:

96-M-0124

Summary:

The purpose of this study is to identify genes that affect susceptibility to obsessive-compulsive disorder (OCD). By identifying genes that increase or decrease the risk of OCD, researchers can better understand how the condition develops and ultimately improve treatment for people with OCD.

OCD is a severe, familial condition that affects approximately 2% of the population. The way OCD is inherited is not clearly understood, but researchers believe it is complex and involves multiple genes. This study will detect and localize genes that increase or decrease susceptibility to OCD. The data collected from this study will be combined with data from other research studies to determine gene linkage and association.

Sponsoring Institute:

National Institute of Mental Health (NIMH)

Recruitment Detail

Type: Participants currently recruited/enrolled

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): Children

Eligibility Criteria:

INCLUSION CRITERIA

Must have a diagnosis of obsessive-compulsive disorder, or be a family member (usually a parent or sibling) of someone with obsessive-compulsive disorder.

Certain disorders are considered part of OCD "spectrum" disorders and often include family members with OCD. These include Tourette's Syndrome, other individuals with tics, and Trichotillomania (severe hair pulling), and other forms of repetitive behaviors.

Persons with primary behavioral difficulties who do no fit with the current definitions of "OCD and OCD spectrum disorders" may not be eligible. These include compulsive shopping, gambling, or compulsive sexual behaviors.

Special Instructions:

You may call toll free at 866-644-4363 or collect at 31-496-8977.

Keywords:

Genetic

Psychiatric Disorder

Affected Sib Pairs

Obsessions

Compulsions

Family Study

OCD Spectrum Disorders

Trichotillomania

Tourette's Syndrome

Recruitment Keyword(s):

None

Condition(s):

Obsessive Compulsive Disorder

Investigational Drug(s):

None

Investigational Device(s):

None

Intervention(s):

None

Supporting Site:

National Institute of Mental Health

Contact(s):

Diane M. Kazuba
National Institutes of Health
Building 10
Room 3D41
10 Center Drive
Bethesda, Maryland 20892
Phone: (301) 496-8977
Fax: (301) 402-0188
Electronic Address: kazubad@intra.nimh.nih.gov

Citation(s):

A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder. Wendland JR, Moya PR, Timpano KR, Anavitarte AP, Kruse MR, Wheaton MG, Ren-Patterson RF, Murphy DL. Arch Gen Psychiatry. 2009 Apr;66(4):408-16.

Multiple rare SAPAP3 missense variants in trichotillomania and OCD. ZŸchner S, Wendland JR, Ashley-Koch AE, Collins AL, Tran-Viet KN, Quinn K, Timpano KC, Cuccaro ML, Pericak-Vance MA, Steffens DC, Krishnan KR, Feng G, Murphy DL. Mol Psychiatry. 2009 Jan;14(1):6-9.

A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder. Wendland JR, Moya PR, Kruse MR, Ren-Patterson RF, Jensen CL, Timpano KR, Murphy DL. Hum Mol Genet. 2008 Mar 1;17(5):717-23. Epub 2007 Nov 30.

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