Protocol Details

Salivary Evaluation in Healthy Volunteers

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number	94-D-0018
Sponsoring Institute	National Institute of Dental And Craniofacial Research (NIDCR)
Recruitment Detail	Type: Participants currently recruited/enrolled Gender: Male & Female Min Age: 18 Max Age: 70
Referral Letter Required	No
Population Exclusion(s)	Children
Special Instructions	Currently Not Provided
Keywords	Saliva; Parotid; Lip Biopsy; Health; Exocrine
Recruitment Keyword(s)	Normal Volunteer
Condition(s)	Healthy; Salivary Gland Disease
Investigational Drug(s)	None
Investigational Device(s)	None
Intervention(s)	None
Supporting Site	National Institute of Dental and Craniofacial Research

Saliva is critical in maintaining oral health and comfort. Our laboratory has investigated several disorders of salivary glands. The purpose of this protocol is to obtain data from healthy volunteers for comparison with data from patients with salivary dysfunction. We plan to utilize the NIH Clinical Center Clinical Research Volunteer Program to solicit paid participation from healthy adults. Study procedures are accomplished in 2-3 outpatient visits that include an interview, saliva collection, lip biopsy, clinical laboratory studies, dry eye examination, and lip biopsy follow up, as needed. These are routine diagnostic procedures and their possible hazards are minor. Biopsy specimens may be used in clinical and laboratory studies, such as in vitro biochemical analysis or in vivo transplantation.

Some of the Healthy Volunteers may be asked to participate in an MRI study of the salivary glands.

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Eligibility

INCLUSION CRITERIA:

-Healthy male or female volunteers from 18 to 70 years old

-Ability to understand and sign an informed consent document.

EXCLUSION CRITERIA:

- Known pregnancy

- Chronic systemic medical illness, other than well-controlled hypertension or hyperlipidemia

- HIV, hepatitis B or C infection

- Sicca symptoms

- Chronic use of medications, with the exception of oral contraceptives, hormone replacement therapy, antihypertensives and antilipemics

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Citations:

Not Provided

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Contacts:

Principal Investigator	Referral Contact	For more information:
Gabor G. Illei, M.D. National Institute of Dental And Craniofacial Research (NIDCR) National Institutes of Health Building 10 Room 1N110 10 Center Drive Bethesda, Maryland 20892 (301) 496-1363 illeig@exchange.nih.gov	Lolita Bebris, R.N. National Institute of Dental And Craniofacial Research (NIDCR) National Institutes of Health Building 10 Room 1N103 10 Center Drive Bethesda, Maryland 20892 (301) 594-1644 bebrisl@mail.nih.gov	Patient Recruitment and Public Liaison Office Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 prpl@mail.cc.nih.gov

Clinical Trials Number:

NCT00001390

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