Protocol Number: 91-CH-0127

Title:

Ovarian Follicle Function in Patients with Premature Ovarian Failure

Number:

91-CH-0127

Summary:

No proven therapy to restore ovarian function and fertility is available to patients with karyotypically normal spontaneous premature ovarian failure. We know that one-half of these patients have primordial follicles remaining in the ovary, and these follicles can function intermittently. This is a diagnostic omnibus protocol that permits baseline clinical evaluation of patients with prematurem ovarian failure. The findings will determine patients' suitability for specifically focused therapeutic research protocols.

Sponsoring Institute:

National Institute of Child Health and Human Development (NICHD)

Recruitment Detail

Type: Participants currently recruited/enrolled

Gender: Female

Referral Letter Required: Yes

Population Exclusion(s): Male

Children

Eligibility Criteria:

INCLUSION CRITERIA:

Women 18 to 42 years of age with premature ovarian failure who meet the following requirements will be candidates for the study: 1) at least a four month history of amenorrhea not due to pregnancy, and 2) at least two documented serum FSH levels or two documented LH levels in the menopausal range for the corresponding assay (greater than or equal to 20 U/ml for FSH and greater than or equal to15 U/L for LH in the current Clinical Center assays).

EXCLUSION CRITERIA:

Women with evidence for karyotypic, metabolic, toxic, or iatrogenic cause of the ovarian failure will not be candidates.

Special Instructions:

Currently Not Provided

Keywords:

Menopause

Estrogen

Infertility

Ovulation

Amenorrhea

Hypergonadotropic Hypogonadism

Young Women

Gonadal Steroid Deficiency

Mineralocorticoid Deficiency

Recruitment Keyword(s):

Premature Ovarian Failure

POF

Condition(s):

Amenorrhea

Hypoaldosteronism

Hypogonadism

Infertility

Premature Ovarian Failure

Investigational Drug(s):

None

Investigational Device(s):

None

Intervention(s):

None

Supporting Site:

National Institute of Child Health and Human Development

Contact(s):

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citation(s):

Development of luteinized Graafian follicles in patients with karyotypically normal spontaneous premature ovarian failure

The use of human recombinant gonadotropin receptors to search for IgG mediated premature ovarian failure

Routine endocrine screening for patients with karyotypically normal spontaneous premature ovarian failure

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department of Clinical Research Informatics, CC.

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National Institutes of Health Clinical Center Bethesda, Maryland 20892. Last update: 11/25/2009