Protocol Details

Ovarian Follicle Function in Patients with Premature Ovarian Failure

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number	91-CH-0127
Sponsoring Institute	National Institute of Child Health and Human Development (NICHD)
Recruitment Detail	Type: Participants currently recruited/enrolled Gender: Female Min Age: 18 Max Age: 42
Referral Letter Required	Yes
Population Exclusion(s)	Male; Children
Special Instructions	Currently Not Provided
Keywords	Menopause; Estrogen; Infertility; Ovulation; Amenorrhea; Hypergonadotropic Hypogonadism; Young Women; Gonadal Steroid Deficiency; Mineralocorticoid Deficiency
Recruitment Keyword(s)	Premature Ovarian Failure; POF
Condition(s)	Amenorrhea; Hypoaldosteronism; Hypogonadism; Infertility; Premature Ovarian Failure
Investigational Drug(s)	None
Investigational Device(s)	None
Intervention(s)	None
Supporting Site	National Institute of Child Health and Human Development

No proven therapy to restore ovarian function and fertility is available to patients with karyotypically normal spontaneous premature ovarian failure. We know that one-half of these patients have primordial follicles remaining in the ovary, and these follicles can function intermittently. This is a diagnostic omnibus protocol that permits baseline clinical evaluation of patients with prematurem ovarian failure. The findings will determine patients' suitability for specifically focused therapeutic research protocols.

--Back to Top--

Eligibility

INCLUSION CRITERIA:

Women 18 to 42 years of age with premature ovarian failure who meet the following requirements will be candidates for the study: 1) at least a four month history of amenorrhea not due to pregnancy, and 2) at least two documented serum FSH levels or two documented LH levels in the menopausal range for the corresponding assay (greater than or equal to 20 U/ml for FSH and greater than or equal to15 U/L for LH in the current Clinical Center assays).

EXCLUSION CRITERIA:

Women with evidence for karyotypic, metabolic, toxic, or iatrogenic cause of the ovarian failure will not be candidates.

--Back to Top--

Citations:

Development of luteinized Graafian follicles in patients with karyotypically normal spontaneous premature ovarian failure

The use of human recombinant gonadotropin receptors to search for IgG mediated premature ovarian failure

Routine endocrine screening for patients with karyotypically normal spontaneous premature ovarian failure

--Back to Top--

Contacts:

Principal Investigator	Referral Contact	For more information:
Lawrence M. Nelson, M.D. National Institute of Child Health and Human Development (NICHD) National Institutes of Health Building 10 Room 1E3140 10 Center Drive Bethesda, Maryland 20892 (301) 496-5800 nelsonl@cc1.nichd.nih.gov	Vien H. Vanderhoof, C.R.N.P. National Institute of Child Health and Human Development (NICHD) National Institutes of Health Building 10 Room 1-3140 10 Center Drive Bethesda, Maryland 20892 (301) 496-4686 vanderhv@mail.nih.gov	Patient Recruitment and Public Liaison Office Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 prpl@mail.cc.nih.gov

Clinical Trials Number:

NCT00001275

--Back to Top--

QUESTIONS?

Contact the Patient Recruitment and Public Liaison Office for:

• Details on how to participate in a study
• Details on how to refer a patient to a study

NIH Clinical Studies Information Request

---

Contact the Office of Communications for:

• General information about the NIH Clinical Center

www.cc.nih.gov/contact.shtml

---

Contact the Department Clinical Research Informatics, (DCRI) for:

• Technical questions about Adobe Acrobat and the PDF format
• Technical questions about this web server

webmaster@cc.nih.gov