Protocol Details

Brain Procurement for the Neuropathology Section, CBDB

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number	90-M-0142
Sponsoring Institute	National Institute of Mental Health (NIMH)
Recruitment Detail	Type: Participants currently recruited/enrolled Gender: Male & Female Min Age: N/A Max Age: N/A
Referral Letter Required	Yes
Population Exclusion(s)	None
Special Instructions	Currently Not Provided
Keywords	Schizophrenia; Neuropathology; Neurochemistry; Substance Abuse; Bipolar Disorder; Aging; Normal Development; Depression; Anxiety Disorders; Suicide
Recruitment Keyword(s)	Dementia; Depression; Bipolar Disorder; Neuropsychiatric Disorders; Suicide; Tourette's Syndrome; Normal Controls; Schizophrenia
Condition(s)	Bipolar Disorder; Depression; Anxiety Disorders; Schizophrenia; Tourette's Syndrome; Brain Diseases
Investigational Drug(s)	None
Investigational Device(s)	None
Intervention(s)	None
Supporting Site	National Institute of Mental Health

The purpose of this study is to collect and study the brain tissue of deceased individuals to learn more about the nervous system and mental disorders. Information gained from donated tissue may lead to better treatments and potential cures for nervous system and mental disorders.

This study will ask relatives of deceased individuals to donate the brains of their deceased relatives to allow further study of neurological and psychiatric disorders.

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Eligibility

INCLUSION CRITERIA:

Brain tissue is needed from individuals suffering from a variety of neuropsychiatric disorders, especially schizophrenia, but also anxiety disorders, suicide, bipolar disorder, depression, Tourette's Syndrome, drug addictions (PCP, cocaine, alcohol, heroin or the like) and any form of dementia. In addition, brains from normal individuals without a history of neuropsychiatric disease will be needed for controls.

EXCLUSION CRITERIA:

No living subjects are enrolled in this protocol. Tissue is obtained after death, with the permission of next of kin, or from existing institutions with appropriate samples via an MTA or other applicable agreement.

Brain tissue is excluded from collection if there is a previously known history of strokes, lesions, or other major neuropathological abnormalities prior to the consenting process.

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Citations:

Meyer-Lindenberg A, Straub RE, Lipska BK, Verchinski BA, Goldberg T, Callicott JH, Egan MF, Huffaker SS, Mattay VS, Kolachana B, Kleinman JE, Weinberger DR. Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition. J Clin Invest. 2007 Feb 8; [Epub ahead of print]

Law AJ, Lipska BK, Weickert CS, Hyde TM, Straub RE, Hashimoto R, Harrison PJ, Kleinman JE, Weinberger DR. Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6747-52. Epub 2006 Apr 17.

Egan MF, Straub RE, Goldberg TE, Yakub I, Callicott JH, Hariri AR, Mattay VS, Bertolino A, Hyde TM, Shannon-Weickert C, Akil M, Crook J, Vakkalanka RK, Balkissoon R, Gibbs RA, Kleinman JE, Weinberger DR. Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12604-9. Epub 2004 Aug 13.

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Contacts:

Principal Investigator	Referral Contact	For more information:
Joel E. Kleinman, M.D. National Institute of Mental Health (NIMH) National Institutes of Health Building 10 Room 3C103 10 Center Drive Bethesda, Maryland 20892 (301) 402-7908 kleinmaj@intra.nimh.nih.gov	Joel E. Kleinman, M.D. National Institute of Mental Health (NIMH) National Institutes of Health Building 10 Room 3C103 10 Center Drive Bethesda, Maryland 20892 (301) 402-7908 kleinmaj@intra.nimh.nih.gov	Joel E. Kleinman, M.D. National Institutes of Health Building 10 Room 3C103 10 Center Drive Bethesda, Maryland 20892 (301) 402-7909 kleinmaj@intra.nimh.nih.gov

Clinical Trials Number:

NCT00001260

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