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Protocol Details

Clinical, Laboratory, and Epidemiologic Characterization of Individuals and Families at High Risk of Blood and Lymph Node Malignancy

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number

02-C-0210

Sponsoring Institute

National cancer Institute (NCI)

Recruitment Detail

Type: Participants currently recruited/enrolled
Gender: Male & Female
Min Age: 1
Max Age: 100

Referral Letter Required

No

Population Exclusion(s)

None

Special Instructions

Currently Not Provided

Keywords

Genetics;
Risk Factors;
Natural History;
Lymphoma;
Leukemia

Recruitment Keyword(s)

Lymph Node cancer;
Lymphoma;
Leukemia

Condition(s)

Waldenstrom Macroglobulinemia;
Chronic Lymphocytic Leukemia;
Hodgkin Disease;
NonHodgkin Lymphoma;
Mixed Lymphoproliferative Disease

Investigational Drug(s)

None

Investigational Device(s)

None

Intervention(s)

None

Supporting Site

National cancer Institute

Background:

-Individuals may be prone to develop blood or lymph node cancers (leukemia or lymphoma) for a variety of reasons, including genetic predisposition to these cancers, environmental exposures or other medical conditions.

-Studies of people and families at high risk of cancer often lead to clues about their cause that may also be important regarding the sporadic occurrence of these cancers in the general population.

-Identifying genetic or environmental factors that play a role in the development of these diseases may be important in developing prevention trials, screening programs and treatments.

Objectives:

-Describe the cancers and other conditions in families with blood or lymph node cancer.

-Find and describe genes that may cause blood and lymph node cancer, and understand how they work in families.

-Use laboratory methods to try to determine if it is possible to identify who is at highest risk of blood or lymph node cancer.

-Test how genes act with other factors to alter the risk of disease, its severity or its manifestations in families.

Eligibility:

-Individuals of any age with a personal or family history of a blood or lymph node cancer.

-Individuals with a personal or family history of medical conditions or environmental exposures that may predispose to blood or lymph node cancer.

Design:

-Participants complete questionnaires about their personal and family medical history and provide consent for researchers to review their medical records and pathology materials related to their care and those of deceased relatives with blood or lymph node cancer, tumors, or other related illnesses for whom they are the legally authorized representative.

-Participants donate a sample of blood or cheek cells, or a lock of hair for genetic studies.

-Patients may also be evaluated at the NIH Clinical Center by one or more of the following specialists: cancer doctor or blood specialist, medical geneticist, research nurses or clinical social worker. They may have blood and urine tests and a cheek swab or mouth wash to collect cheek cells. Some patients may also be asked to have x-rays and routine imaging, such as CT scans or ultrasound tests, cell surface markers, skin biopsy, and, with special consents, bone marrow biopsy, MRI or PET scans, apheresis or fluorescein angiography and photography.

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Eligibility

INCLUSION CRITERIA:

On referral, persons of any age will be considered for inclusion in the study because of either:

-A family or personal medical history of hematologic/ lymphoproliferative malignancy of any unusual type, pattern, or number; or,

-Known or suspected factor(s) predisposing to hematologic malignancy, either genetic and/or congenital factors (birth defects, metabolic phenotype, chromosomal anomalies or Mendelian traits associated with tumors), environmental exposure (medications, occupation, radiation, diet, infectious agents, etc.), or unusual demographic features (very young age of onset multiple tumors, etc.).

Personal and family medical history must be verified through questionnaires, interviews, and review of pathology slides and medical records. For familial neoplasms, two or more living affected cases among family members are generally required, although in selected instances exceptions may be made, e.g., for WM, one cases plus a living 1st degree relative with an autoimmune condition will qualify a family for further investigations.

familial aggregation of any hematologic cancer(s) is eligible for study, our current active accrual efforts fall into 5 categories

1. Chronic lymphocytic leukemia (CLL)

2. Waldenstrom s macroglobulinemia (WM)

3. Non-Hodgkin s Lymphoma (NHL)

4. Hodgkin disease (HD)

5. Mixed hematologic and lymphoproliferative diseases

EXCLUSION CRITERIA:

-Referred individuals for whom reported diagnosis cannot be verified.

-Referred individuals who decline informed consent.


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Citations:

Goldin LR, et al., A genome scan of 18 families with chronic lymphocytic leukaemia. Br J Haematol. 2003 Jun;121(6):866-873.

Slager SL, Caporaso NE, de Sanjose S, Goldin LR. Genetic susceptibility to chronic lymphocytic leukemia. Semin Hematol. 2013 Oct;50(4):296-302. doi: 10.1053/j.seminhematol.2013.09.007.

Liang XS, Caporaso N, McMaster ML, Ng D, Landgren O, Yeager M, Chanock S, Goldin LR. Common genetic variants in candidate genes and risk of familial lymphoid malignancies. Br J Haematol. 2009 Aug;146(4):418-23. doi: 10.1111/j.1365-2141.2009.07790.x. Epub 2009 Jul 1.

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Contacts:

Principal Investigator

Referral Contact

For more information:

Neil E. Caporaso, M.D.
National cancer Institute (NCI)
BG 9609 RM 6E410
9609 MEDICAL CENTER DR
ROCKVILLE MD 20850
(240) 276-7228
caporasn@epndce.nci.nih.gov

Neil E. Caporaso, M.D.
National cancer Institute (NCI)
BG 9609 RM 6E410
9609 MEDICAL CENTER DR
ROCKVILLE MD 20850
(240) 276-7228
caporasn@epndce.nci.nih.gov

NCI Referral Office
National Institute of Health Clinical Center (CC), 9000 Rockville Pike, Bethesda, Maryland 20892, United States: NCI Clinical Trials Referral Office
1-888-NCI-1937

Clinical Trials Number:

NCT00039676

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