NIH Clinical Center logo     America's Clinical Research Hospital File folder iconExplore the NIH
Clinical Center
Search the Studies - NIH Clinical Research Studies

Protocol Details

Structural and Functional Brain Imaging Markers of Upper motor neuron Function

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number

12-N-0060

Sponsoring Institute

National Institute of Neurological Disorders and Stroke (NINDS)

Recruitment Detail

Type: Participants currently recruited/enrolled
Gender: Male & Female
Min Age: 35
Max Age: 130

Referral Letter Required

No

Population Exclusion(s)

Children

Special Instructions

Currently Not Provided

Keywords

motor Function;
Magnetic Resonance Spectroscopy;
Transcranial Magnetic Stimulation (TMS);
Diffusion Tensor Imaging;
Functional Magnetic Resonance Imaging (fMRI)

Recruitment Keyword(s)

Healthy Volunteer;
HV

Condition(s)

Magnetic Resonance Imaging;
Central Nervous System;
Volunteer;
Neurological Disorder

Investigational Drug(s)

None

Investigational Device(s)

None

Intervention(s)

None

Supporting Site

National Institute of Neurological Disorders and Stroke

Background:

- People with motor neuron disorders have changes in the parts of the brain that control movement. Some tests that are currently used to study these changes are magnetic resonance imaging (MRI) and transcranial magnetic stimulation (TMS). We don t know if MRI scans and TMS give the same results if done at different times in the same person. Researchers want to see if these tests produce different results if given to healthy adults on two separate occasions.

Objectives:

- To test the reliability of different tests of the brain used to study motor neuron disorders.

Eligibility:

-< TAB> Healthy individuals at least 35 years of age who have no history of neurological disorders and take no medications.

-< TAB> Pregnant women may not participate.

Design:

- Participants will be screened with a medical history and physical exam.

- Participants will have two testing visits 1 to 6 months apart.

- The first visit will have three parts. The first part is a neurological exam to test strength, sensation, reflexes, and coordination of movement. The second part will be TMS tests. The third part will involve an MRI scan to study the parts of the brain that control movement.

- At the second visit, participants will have MRI scanning only.

--Back to Top--

Eligibility

INCLUSION CRITERIA:

- Healthy adults aged 35 and older

- No history of a neurological disorder

- Able to give informed consent

EXCLUSION CRITERIA:

- Treatment within the preceding week with medications that affect neuronal excitability, such as antidepressants, sedatives, and drugs for epilepsy or migraine.

- Change in blood pressure medications within the preceding week.

- Metal in the body such as pacemakers, implanted pumps or other implanted electronic devices, some types of dental implants, aneurysm clips (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and cochlear implants), permanent eyeliner or shrapnel fragments.

- Pregnancy. Women of childbearing potential will undergo urine pregnancy testing before MRI scanning.

- Fear of confined spaces.

- Serious medical illness.


--Back to Top--

Citations:

Ellis CM, Simmons A, Jones DK, Bland J, Dawson JM, Horsfield MA, Williams SC, Leigh PN. Diffusion tensor MRI assesses corticospinal tract damage in ALS. Neurology. 1999 Sep 22;53(5):1051-8.

Tartaglia MC, Laluz V, Rowe A, Findlater K, Lee DH, Kennedy K, Kramer JH, Strong MJ. Brain atrophy in primary lateral sclerosis. Neurology. 2009 Apr 7;72(14):1236-41.

Wong JC, Concha L, Beaulieu C, Johnston W, Allen PS, Kalra S. Spatial profiling of the corticospinal tract in amyotrophic lateral sclerosis using diffusion tensor imaging. J Neuroimaging. 2007 Jul;17(3):234-40.

--Back to Top--

Contacts:

Principal Investigator

Referral Contact

For more information:

Mary Kay Floeter, M.D.
National Institute of Neurological Disorders and Stroke (NINDS)
BG 10-CRC RM 6-5724
10 CENTER DR
BETHESDA MD 20814
(301) 496-7428
floeterm@ninds.nih.gov

Carol H. Hoffman
National Institute of Neurological Disorders and Stroke (NINDS)
National Institutes of Health
Building 10
Room 7-5680
10 Center Drive
Bethesda, Maryland 20892
(301) 496-7428
carol.hoffman@nih.gov

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

prpl@mail.cc.nih.gov

Clinical Trials Number:

NCT01517087

--Back to Top--

QUESTIONS?

Contact the Patient Recruitment and Public Liaison Office for:

  • Details on how to participate in a study
  • Details on how to refer a patient to a study

NIH Clinical Studies Information Request


Contact the Office of Communications for:

  • General information about the NIH Clinical Center

www.cc.nih.gov/contact.shtml


Contact the Department Clinical Research Informatics, (DCRI) for:

  • Technical questions about Adobe Acrobat and the PDF format
  • Technical questions about this web server

webmaster@cc.nih.gov