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Genetic Analysis of hereditary Disorders of hearing and Balance
This study is currently recruiting participants.
Summary | Eligibility | Citations | Contacts
Summary
Number |
01-DC-0229 |
Sponsoring Institute |
National Institute on Deafness and Other Communication Disorders (NIDCD) |
Recruitment Detail |
Type: Participants currently recruited/enrolled |
Referral Letter Required |
No |
Population Exclusion(s) |
None |
Special Instructions |
Currently Not Provided |
Keywords |
Deafness; |
Recruitment Keyword(s) |
hereditary hearing Disorder; |
Condition(s) |
Sensorineural hearing loss; |
Investigational Drug(s) |
None |
Investigational Device(s) |
None |
Intervention(s) |
None |
Supporting Site |
|
People with a hearing or balance disorder that affects more than one family member may be eligible for this study. They and their immediate family members may undergo some or all of the following procedures:
- Medical and family history, including questions about hearing, balance and other ear-related issues, and review of medical records.
- Routine physical examination.
- Blood draw or buccal swab (brushing inside the cheek to collect cells) - Tissue is collected for DNA analysis to look for changes in genes that may be related to hearing loss.
- hearing tests - The subject listens for tones emitted through a small earphone.
- Balance tests to see if balance functions of the inner ear are associated with the hearing loss - In one test the subject wears goggles and watches moving lights while cold or warm air is blown into the ears. A second test involves sitting in a spinning chair in a quiet, dark room.
- Photograph - A photograph may be taken as a record of eye shape and color, distance between the eyes, and hair color.
- Computed tomography (CT) and magnetic resonance imaging (MRI) scans - These tests show the structure of the inner ear. For CT, the subject lies still for a short time while X-ray images are obtained. For MRI, the patient lies on a stretcher that is moved into a cylindrical machine with a strong magnetic field. The magnetic field and radio waves produce images of the inner ear. The radio waves cause loud thumping noises that can be muffled by the use of earplugs.
Eligibility
INCLUSION CRITERIA:
Persons with known SNHL and/or peripheral vestibular dysfunctions caused by genetic etiology
Family members of persons with known SNHL and/or peripheral vestibular dysfunction caused by genetic etiology
Adults must be able to provide informed consent
Minors must have a parent or guardian able to provide informed consent
Subjects must be 0-99 years of age
For Nigeria subjects with non-syndromic hearing loss, their hearing loss must be early-onset, before 10 years of age, to be eligible.
EXCLUSION CRITERIA:
Persons with SNHL and/or peripheral vestibular dysfunction caused by a nongenetic etiology such as trauma, infection, metabolic or immunologic disorders, or exposure to ototoxic agents such as noise or aminoglycoside antibiotics will not be included in this protocol.
Citations:
Contacts:
Principal Investigator |
Referral Contact |
For more information: |
| Andrew J. Griffith, M.D. National Institute on Deafness and Other Communication Disorders (NIDCD) National Institutes of Health BG 5RC RM 2B28 MSC 3320 5 RESEARCH CT ROCKVILLE MD 20892-3320 (301) 402-2829 griffita@mail.nih.gov |
Andrew J. Griffith, M.D. National Institute on Deafness and Other Communication Disorders (NIDCD) National Institutes of Health BG 5RC RM 2B28 MSC 3320 5 RESEARCH CT ROCKVILLE MD 20892-3320 (301) 402-2829 griffita@mail.nih.gov |
Patient Recruitment and Public Liaison Office Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 prpl@mail.cc.nih.gov |
Clinical Trials Number:
NCT00023049
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