Protocol Details

Studies of the Pathogenesis and Natural History of arthritis and Related Conditions

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number	00-AR-0222
Sponsoring Institute	National Institute of arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruitment Detail	Type: Participants currently recruited/enrolled Gender: Male & Female Min Age: N/A Max Age: N/A
Referral Letter Required	No
Population Exclusion(s)	None
Special Instructions	Currently Not Provided
Keywords	Rheumatoid arthritis; Inflammation; Synovitis; Genetics; Synovial Biopsy; arthritis; Juvenile Rheumatoid arthritis
Recruitment Keyword(s)	Rheumatoid arthritis; Juvenile Rheumatoid arthritis; JRA
Condition(s)	arthritis; Synovitis
Investigational Drug(s)	None
Investigational Device(s)	None
Intervention(s)	None
Supporting Site	National Institute of arthritis and Musculoskeletal and Skin Diseases

This research protocol will recruit patients with arthritis and related conditions for the purpose of screening patients for treatment protocols, and evaluating the natural history of arthritis and related conditions. Patients will be evaluated clinically, radiographically and serologically, and standardized data will be uniformly collected on all patients. Additional imaging using sensitive MRI methods will be obtained in some patients. The collected blood and tissue will be utilized for laboratory studies to continue research on the pathogenic mechanisms of rheumatoid arthritis and related autoimmune joint diseases. Data from the history and physical examination as well as several disability questionnaires in the adult and pediatric population will be used to phenotypically characterize these patients and assess outcome and functional status. Any medical care recommended or provided to the patients will be consistent with routine standards of practice and provided in consultation with the patient's referring physician.

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Eligibility

INCLUSION CRITERIA:

No age limits.

History of inflammatory synovitis of at least one or more swollen joints.

Patient's ability and willingness to give informed consent or in the pediatric patients, the parent's willingness to give informed consent and the patient's willingness to assent to the protocol whenever possible.

EXCLUSION CRITERIA:

None if patients fulfill inclusion criteria.

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Citations:

Familial clustering of rheumatoid arthritis with other autoimmune diseases

Transin/stromelysin expression in rheumatoid synovium A transformation-associated metalloproteinase secreted by phenotypically invasive synoviocytes

Juvenile rheumatoid arthritis as a complex genetic trait

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Contacts:

Principal Investigator	Referral Contact	For more information:
Mark F. Gourley, M.D. National Institute of arthritis and Musculoskeletal and Skin Diseases (NIAMS) National Institutes of Health BG 10 RM 6N216F 10 CENTER DR BETHESDA MD 20814 (301) 451-6807 gourleym@mail.nih.gov	Raphaela T. Goldbach-Mansky, M.D. National Institute of arthritis and Musculoskeletal and Skin Diseases (NIAMS) National Institutes of Health 10 CENTER DRIVE BLDG 10 RM 6D49 MSC 16508 BETHESDA MD 20892-1828 (301) 435-6243 goldbacr@mail.nih.gov	Patient Recruitment and Public Liaison Office Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 prpl@mail.cc.nih.gov

Clinical Trials Number:

NCT00006333

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