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Protocol Details

Studies of the Pathogenesis and Natural History of arthritis and Related Conditions

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number

00-AR-0222

Sponsoring Institute

National Institute of arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Recruitment Detail

Type: Participants currently recruited/enrolled
Gender: Male & Female
Min Age: N/A
Max Age: N/A

Referral Letter Required

No

Population Exclusion(s)

None

Special Instructions

Currently Not Provided

Keywords

Rheumatoid arthritis;
Inflammation;
Synovitis;
Genetics;
Synovial Biopsy;
arthritis;
Juvenile Rheumatoid arthritis

Recruitment Keyword(s)

Rheumatoid arthritis;
Juvenile Rheumatoid arthritis;
JRA

Condition(s)

arthritis;
Synovitis

Investigational Drug(s)

None

Investigational Device(s)

None

Intervention(s)

None

Supporting Site

National Institute of arthritis and Musculoskeletal and Skin Diseases

This research protocol will recruit patients with arthritis and related conditions for the purpose of screening patients for treatment protocols, and evaluating the natural history of arthritis and related conditions. Patients will be evaluated clinically, radiographically and serologically, and standardized data will be uniformly collected on all patients. Additional imaging using sensitive MRI methods will be obtained in some patients. The collected blood and tissue will be utilized for laboratory studies to continue research on the pathogenic mechanisms of rheumatoid arthritis and related autoimmune joint diseases. Data from the history and physical examination as well as several disability questionnaires in the adult and pediatric population will be used to phenotypically characterize these patients and assess outcome and functional status. Any medical care recommended or provided to the patients will be consistent with routine standards of practice and provided in consultation with the patient's referring physician.

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Eligibility

INCLUSION CRITERIA:

No age limits.

History of inflammatory synovitis of at least one or more swollen joints.

Patient's ability and willingness to give informed consent or in the pediatric patients, the parent's willingness to give informed consent and the patient's willingness to assent to the protocol whenever possible.

EXCLUSION CRITERIA:

None if patients fulfill inclusion criteria.


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Citations:

Familial clustering of rheumatoid arthritis with other autoimmune diseases

Transin/stromelysin expression in rheumatoid synovium A transformation-associated metalloproteinase secreted by phenotypically invasive synoviocytes

Juvenile rheumatoid arthritis as a complex genetic trait

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Contacts:

Principal Investigator

Referral Contact

For more information:

Michael M. Ward, M.D.
National Institute of arthritis and Musculoskeletal and Skin Diseases (NIAMS)
BG 10-CRC RM 4-1339
10 CENTER DR
BETHESDA MD 20814
(301) 496-7263
wardm1@mail.nih.gov

Michael M. Ward, M.D.
National Institute of arthritis and Musculoskeletal and Skin Diseases (NIAMS)
BG 10-CRC RM 4-1339
10 CENTER DR
BETHESDA MD 20814
(301) 496-7263
wardm1@mail.nih.gov

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

prpl@mail.cc.nih.gov

Clinical Trials Number:

NCT00006333

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