NIH Clinical Research Studies Listed By Institute of the Principal Investigator

National Institute of Neurological Disorders and Stroke (NINDS)

124 Protocols (97 Active Accrual of new subjects, 27 Follow-up of previously enrolled subjects)

Active Accrual, Protocols Recruiting New Patients 
* 10-N-0012:
Screening Protocol for Patients with Stroke

* 10-N-0009:
Physiological Investigations of Movement Disorders

* 10-N-0003:
Recording and Modulation of Neuronal Mechanisms During Operant Conditioning: A MEG Study

* 09-N-0221:
50 Hz Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Parkinson's Disease

* 09-N-0197:
Double Blind Placebo-Controlled Phase I/II Clinical Trial of Idebenone in Patients with Primary Progressive Multiple Sclerosis

* 09-N-0196:
High-Density Direct Current Brain Polarization

* 09-N-0193:
A Study of Acetyl Hexapeptide-8 (AH8) in Treatment of Blepharospasm

* 09-N-0182:
GABA/Glutamate Balance in Temporal Lobe Epilepsy with and without Major Depression

* 09-N-0160:
Convection Enhanced Delivery of Muscimol to Study the Pathophysiology Underlying the Clinical Features of Parkinson's Disease

* 09-N-0146:
Changes in the Posterior Parietal Cortex - Primary Motor Cortex Pathway Induced by Motor Training

* 09-N-0125:
Magnetoencephalography in Absence Seizures

* 09-N-0124:
Effects of Reward on Learning in the Motor Cortex

* 09-N-0118:
Investigation of Neurofeedback with Real-Time fMRI in Healthy Volunteers and Patients with Hyperkinetic Movement Disorders

* 09-N-0098:
Exploring a Motor Learning Technique Based on the Mirror Motor Neuron System

* 09-N-0084:
Double-Blind, Placebo Controlled Pilot-Study of Octanoic Acid in Essential Tremor

* 09-N-0032:
Comprehensive Multimodal Analysis of Patients with Neuroimmunological Diseases of the CNS

* 09-N-0021:
Enhancing the Beneficial Effects of Upper Extremity Visuomotor Training with tDCS

* 09-N-0010:
Biomarkers of Risk of Parkinson Disease

* 08-N-0215:
Understanding the Anatomy and Physiology of the Sensory Experience and its Role in Generating Tics in Tourette Syndrome

* 08-N-0198:
Warfighter Head Injury Study - a Comprehensive, Multidisciplinary Research Evaluation

* 08-N-0192:
Functional Neuro-Imaging of Strategy use During Human Behavior

* 08-N-0189:
The Relationship Between Temporal Discrimination and Cortical Excitability in Humans

* 08-N-0181:
Role of Neurotransmission and Functional CNS Networks in Spasmodic Dysphonia and Other Focal Dystonias

* 08-N-0161:
Noninvasive Language Mapping in Patients with Localization-Related Epilepsy

* 08-N-0153:
The Role of Autoimmunity in Neurologic Complications of Celiac Disease

* 08-N-0134:
Pilot Study of Tolerability of Lithium Therapy in Patients with Spinocerebellar Ataxia Type I (SCA1)

* 08-N-0095:
Assessment of Cerebral Circulation and Perfusion in Adults after Neonatal Carotid Occlusion

* 08-N-0044:
A Prospective Natural History Study of Patients with Neurofibromatosis Type 2 (NF2)

* 08-N-0027:
HHV6B in Epilepsy Imaging and CSF Studies

* 08-N-0012:
L-Dihydroxyphenylserine (L-DOPS) for Norepinephrine Deficiency: Interactions with Carbidopa and Entacapone

* 07-N-0190:
Neurobiological Studies of Psychogenic Movement Disorders and Non-Epileptic Seizures

* 07-N-0187:
Brain Connectivity and Sensorimotor Integration during Single/Dual Motor Tasks

* 07-N-0165:
Suppression and Facilitation of the Motor Cortex by Stimulation of the Cerebellum in Patients with Dystonia and Healthy Controls

* 07-N-0154:
Influence of Lesion Location on Cortical Reorganization after Chronic Stroke

* 07-N-0147:
Effect of Direct Current Brain Polarization on Verbal Memory

* 07-N-0139:
Cross-Validating NIRS with fMRI

* 07-N-0137:
Expanding the Phenotype of the LRRK-2 Mutation in Individuals with History of Parkinson's Disease and their Relatives: a Prospective Study

* 07-N-0122:
Modulation of Motor Function by Stimulation of the Central and Peripheral Nervous System

* 07-N-0103:
Imaging Serotoninergic Neurotransmission in Epilepsy

* 07-N-0092:
PET Evaluation of Brain Peripheral Benzodiazepine Receptors Using [(11)C]PBR28 in Patients with Multiple Sclerosis (MS)

* 07-N-0072:
Neural Substrates of Lasting Motor Skill Learning by Spacing Effect

* 07-N-0063:
Detecting a Reward Signal in the Motor Cortex

* 06-N-0242:
The Effect of Surround Inhibition During Phasic Compared to Tonic Voluntary Finger Movement in Focal Hand Dystonia

* 06-N-0232:
Hypersensitivity in Tourette Syndrome: An Evaluation of Perceived Intensity Versus Threshold

* 06-N-0225:
Influencing Motor Performance in Patients with Stroke by Combined Theta Burst Stimulation and Carbidopa-Levodopa

* 06-N-0224:
Collection of Blood Samples for DNA Analysis in Motor Neuron Diseases

* 06-N-0174:
Cortical Function in Primary Lateral Sclerosis and Amyotrophic Lateral Sclerosis

* 06-N-0161:
Long-Term Motor Learning in Focal Hand Dystonia

* 06-N-0154:
An Exploratory Study on Detection of Cortical and White Matter Damage in Patients with Multiple Sclerosis Using Magnetic Resonance Imaging at 7 Tesla

* 06-N-0138:
Long-Term Improvement in Training Effects by Transcranial DC Stimulation

* 06-N-0128:
fMRI Studies of Task Specificity in Focal Hand Dystonia

* 06-N-0125:
Physiology of Weakness with Movement Disorders

* 06-N-0085:
Two-Compartment Model of Diffusion Tensor Magnetic Resonance Imaging (DT-MRI) for the Diagnosis of Glioma Tumor Recurrence versus Radiation Necrosis

* 06-N-0048:
Changes in Activation Patterns in the Ventro-Medial Prefrontal Cortex of Healthy Adolescents During the Imagination and Observation of Aggressive Behavior

* 06-N-0047:
Reference Values for Plasma Catechols

* 06-N-0031:
Evaluation of Density and Pattern of Distribution of GABA A Receptors in the Brain of Patients with Focal Hand Dystonia Studied with PET using [11C] Flumazenil

* 06-N-0012:
Moving a Paralyzed Hand through a Brain-Computer Interface Controlled by the Affected Hemisphere After Stroke or Traumatic Brain Injury

* 05-N-0228:
The Role of Cortical Coherence in Focal Hand Dystonia

* 05-N-0223:
Clinical Neurophysiology: Training and Normative Values

* 05-N-0189:
Neuropathological Basis of Spasmodic Dysphonia and Related Voice Disorders

* 05-N-0179:
MRI Measurement of Brain Metabolism Across the Sleep-Wake Cycle

* 05-N-0142:
Effects of Unilateral and Bilateral Training on Motor Function in Chronic Stroke

* 05-N-0122:
Placebo Controlled Study of the Therapeutic Effect of the Transcranial Electrical Polarization in Patients with Focal Hand Dystonia

* 05-N-0063:
NINDS Biomarkers in Multiple Sclerosis Study (BioMS)

* 04-N-0159:
Functional MRI (fMRI) and Diffusion Tensor Imaging (DTI) in Temporal Lobe Epilepsy

* 04-N-0113:
Examining Associative Relations in Structured Event Complexes Using Functional Neuroimaging

* 04-N-0071:
Phase I/II Study of HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) Using the Humanized MiK-beta-1 Monoclonal Antibody Directed Toward the IL-2/IL-15Rbeta Subunit (CD122) that Blocks IL-15 Action

* 03-N-0196:
Social Knowledge Representation in the Human Prefrontal Cortex

* 03-N-0171:
Combination Anti-platelet and Anti-coagulation Treatment After Lysis of Ischemic Stroke Trial (CATALIST)

* 03-N-0164:
Evaluation and Treatment of Neurosurgical Disorders

* 03-N-0142:
Development of 7 Tesla MRI Methodology for Anatomical Functional and Spectroscopic Imaging of the Brain

* 03-N-0004:
Clinical Laboratory Evaluation of Primary Chronic Autonomic Failure

* 02-N-0132:
In Vivo Mapping Of Structural and Biochemical Abnormalities In Patients With Primary Focal Dystonia

* 02-N-0128:
Evaluation of Tourette's Syndrome with Multimetabolite H-Magnetic Resonance Spectroscopy at 3T

* 02-N-0109:
Real-time Analysis of Scalp Electroencephalography and Magnetoencephalography during Production of Human Voluntary Movement

* 02-N-0104:
Interhemispheric Interactions Associated with Performance of Voluntary Movements in Patients with Stroke Motor Disability

* 02-N-0014:
Research Study of Specimens Obtained During Epilepsy Surgery

* 02-N-0010:
EEG Study of Movement-Related Center-Surround Organization in Hand Dystonia

* 02-N-0001:
Testing A Model of the Representational Knowledge Stored in the Human Prefrontal Cortex

* 01-N-0206:
Phenotype/Genotype Correlations in Movement Disorders

* 01-N-0148:
Spasticity: Physiologic Studies

* 01-N-0145:
Screening: Neurologic Disorders with Muscle Stiffness

* 01-N-0139:
Evaluation and Treatment of Patients with Epilepsy

* 01-N-0085:
Establishing the Pathophysiology of Primary Spinal Syringomyelia

* 01-N-0007:
Evaluation, Pathogenesis, and Treatment of Patients with or at Risk For Cerebrovascular Disease (A Natural History/Disease Pathogenesis Protocol)

* 00-N-0158:
Trial of Intracerebral Infusion in Patients with Medically Intractable Epilepsy

* 00-N-0089:
Genetic Analysis of the Chiari I Malformation

* 00-N-0082:
Characterization of Brain Activation at 1.5 and 3.0 Tesla Using Perfusion Images and Blood Oxygen Level Dependent Images

* 00-N-0043:
Clinical and Molecular Manifestations of Inherited Neurological Disorders

* 98-N-0047:
Immuno-Virological Evaluation of Human T Cell Leukemia Virus Type-1 Associated Myelopathy (HAM/TSP)

* 97-N-0070:
Training Protocol for Various Sleep Disorders in Patients with Neurological Disorders

* 93-N-0202:
Diagnosis and Natural History Protocol for Patients with Different Neurological Conditions

* 92-N-0226:
Establishing the Physiology of Syringomyelia

* 89-N-0045:
Evaluation of Progression in Multiple Sclerosis by Magnetic Resonance Imaging (MRI)

* 85-N-0195:
A Training Protocol for the use of Botulinum Toxin in the Treatment of Neurological Disorders

* 81-N-0010:
Regional Cerebral Utilization of Glucose in Patients with a Diagnosis of Frontal Lobe Dementia, Atypical Parkinsonian Disorder, and Other Basal Ganglia Disorders

* 76-N-0021:
Combined Clinical, Immunological and Virological Assessment of Patients with Multiple Sclerosis (MS)

Active Follow-up, Protocols NOT Recruiting New Patients 

* 09-N-0117:
An Open Label Dose Escalation Safety Study of Convection-Enhanced Delivery of IL13-PE38QQR in Patients with Progressive Pediatric Diffuse Infiltrating Brainstem Glioma and Supratentorial High-Grade Glioma

* 08-N-0045:
Investigation of the Dopamine System in Frontotemporal Dementia

* 08-N-0023:
Motor Cortex Reward Signaling in Parkinson Disease

Next 24 Protocols

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