NIH Clinical Research Studies Listed By Institute of the Principal Investigator

National Institute of Mental Health (NIMH)

104 Protocols (84 Active Accrual of new subjects, 20 Follow-up of previously enrolled subjects)

Active Accrual, Protocols Recruiting New Patients 
* 13-M-0100:
Brain Inflammation In Major Depressive Disorder

* 13-M-0070:
Assessment of [11C]DPA-713 in Temporal Lobe Epilepsy

* 13-M-0028:
Diagnosis and Treatment of Childhood-onset Behavioral Disorders, Neuropsychiatric Disorders and Neurodevelopmental Disorders

* 13-M-0019:
Pilot Study to Extend the K-SADS-PL to Adolescents and Young Adults

* 13-M-0007:
Near Infra-Red Spectroscopy (NIRS) in Neurodevelopmental Disorders and Typically Developing Children

* 13-M-0004:
The Use of Daily, Intranasal Oxytocin for the Treatment of Childhood-Onset Schizophrenia (COS), a Randomized Double-Blind Trial

* 12-M-0128:
TMS Investigations of the Human Visual System

* 12-M-0063:
PET Imaging of Translocator Protein in Subjects with Traumatic Brain Injury

* 12-M-0059:
Inflammation and Function of P-gp in HIV Infection of Brain

* 11-M-0251:
A Longitudinal Investigation of the Endocrine and Neurobiologic Events Accompanying Puberty

* 11-M-0202:
PET Imaging of CB1 Receptors Using [11C]SD5024

* 11-M-0195:
The Serotonin-1A Receptor Radioligand (18F)FCWAY as a Potential Substrate for Efflux Transport at the Blood-Brain Barrier

* 11-M-0144:
Markers of Autism Spectrum Disorders in At-Risk Toddlers: A Pilot Study

* 11-M-0118:
Neuroimmune Activation in Austism: Imaging Translocator Protein Using Positron Emission Tomography (PET)

* 11-M-0104:
The Role of Oxytocin and Arginine Vasopressin in Human Placebo Analgesia

* 11-M-0058:
A Placebo-Controlled Trial of Intravenous Immunoglobulin (IVIG) for PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections)

* 11-M-0045:
Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites and Neurotransmitters in Human Brain

* 10-M-0204:
PET Brain and Whole Body Distribution Studies for Nociceptin/Orphanin FQ Peptide (NOP) Receptor Using [(11)C]NOP-1A

* 10-M-0112:
Defining the Brain Phenotype of Children with Williams Syndrome

* 10-M-0049:
Effects of a CRF1 Receptor Antagonist on Human Startle in Normal Female Volunteers

* 10-M-0047:
Top-Down Attentional Control of Visual-Processing

* 10-M-0027:
Cognitive Neuroscience of Autism Spectrum Disorders

* 09-M-0198:
Screening and Evaluation of Patients with Signs and Symptoms of Alzheimer's Disease

* 09-M-0194:
Characterizing Lone Parenting: A Multi-Institutional Pilot Study of the Perceptions of Support and Perceived Stress of Lone Parents of Children with Cancer

* 09-M-0176:
Functional Relevance of Dopamine Receptors in Healthy Controls and Patients with Schizophrenia: Characterization through [11C]NNC-112 and [18F]Fallypride Positron Emission Tomography

* 09-M-0123:
Regional Rates of Cerebral Protein Synthesis: Effects of Sleep and Memory Consolidation

* 09-M-0040:
Imaging Cannabinoid CB1 Receptors in Alcohol Dependence

* 09-M-0034:
A Controlled Trial of Citalopram Added to Methylphenidate in Youth with Severe Mood Dysregulation

* 09-M-0022:
The Use of a Distress Thermometer in a Pediatric Research Setting: An Exploratory, Pilot Study

* 08-M-0211:
Safety of Transcranial Direct Current Brain Stimulation (TDCS) for Improvement of Psychotic Symptoms and Cognitive Functioning in Childhood Onset Schizophrenia (COS)

* 08-M-0150:
An Investigation to Determine Whether Levels of P11 Protein in Peripheral Blood Cells Correlate with Treatment Response to Citalopram in Patients with Major Depressive Disorder

* 08-M-0066:
PET Evaluation of Brain Peripheral Benzodiazepine Receptors using [11C]PBR28 in Neurological Disorders

* 08-M-0062:
Brain and Whole Body Imaging of P-Glycoprotein Function Using [11C]dLop

* 08-M-0052:
fMRI Investigation of Cortical Reorganization and Phantom Limb Pain Following Amputation

* 07-M-0208:
PET Imaging of Peripheral Benzodiazepine Receptors in Patients with Neurocysticercosis Using [C-11]PBR28

* 07-M-0082:
PET Imaging of Brain mGluR5 Receptors Using [18F]SP203 and [11C]SP203

* 07-M-0035:
PET Whole Body Imaging Using a Peripheral Benzodiazepine Receptor Ligand [C-11]PBR28

* 07-M-0021:
Development of Functional and Structural Magnetic Resonance Imaging Techniques for the Study of Mood and Anxiety Disorders

* 06-M-0215:
Antidepressant Effects on cAMP Specific Phosphodiesterase (PDE 4) in Depressed Patients

* 06-M-0214:
PET Measurement of Regional Rates of Cerebral Protein Synthesis in Subjects with Fragile X Syndrome

* 06-M-0102:
Clinical and Immunological Investigations of Subtypes of Autism

* 06-M-0065:
Screening Protocol for Studies of the Pediatrics and Developmental Neuroscience Branch

* 05-M-0144:
MRS (Magnetic Resonance Spectroscopy) Measurement of Glutamate and GABA Metabolism in Brain

* 05-M-0105:
Investigating the Neuro-Cognitive Underpinnings of the Emotional Dysfunction Linked to Childhood Behavioral Disturbance

* 05-M-0059:
5HT1A and SERT Imaging During Pharmacologically Induced Hypogonadotropic Hypogonadism With and Without Estrogen and Progesterone Replacement

* 05-M-0035:
The Effects of Mood and Tryptophan Depletion on the Neural Correlates of Affective Shifting in Mood Disorders

* 04-M-0222:
Investigation of the Rapid (Next Day) Antidepressant Effects of an NMDA Antagonist

* 04-M-0139:
The Effects of Dutasteride on Mood, HPA Axis, and Serum Allopregnanolone Levels in Women with Menstrual-Related Mood Disorders and Controls

* 03-M-0211:
Family Study of Affective and Anxiety Spectrum Disorders

* 03-M-0186:
The Psychobiology of Temperament: An fMRI Study

* 03-M-0185:
Generalized Anxiety Disorder and Social Anxiety Disorder: Their Impact on the Processing of Social Emotional Information and Instrumental Learning

* 03-M-0161:
The Efficacy of 17Beta-Estradiol in Postpartum-Related Depressive Illness

* 03-M-0143:
Randomized, Double-Blinded, Placebo Controlled Study of the Effects of Modafinil on Cognitive Function in Patients with Schizophrenia and Normal Controls Based on COMT Genotype

* 03-M-0138:
A Screening Protocol to Evaluate Women with Postpartum-Related Mood and Behavioral Disorders

* 03-M-0108:
Cholinergic Modulation of Cognition and Emotion in Mood Disorders: Functional Neuroimaging Studies

* 03-M-0093:
Predictability and Aversive Expectancies in Anxiety and Depressive Disorders

* 03-M-0092:
An Investigation of the Antidepressant Efficacy of an Antiglutamatergic Agent in Bipolar Depression

* 03-M-0035:
Screening, Evaluation, Diagnosis, Treatment Optimization and Follow-up for Childhood Onset Psychotic Disorders

* 02-M-0321:
fMRI Investigation of Explicit Cue and Contextual Fear

* 02-M-0263:
Psychopharmacology of Fear-Potentiated Startle in Humans

* 02-M-0239:
Randomized, Double-Blinded, Placebo Controlled Study of the Effects of Tolcapone and Entacapone on Cognitive Function in Patients with Schizophrenia and Normal Controls Based on COMT Genotype

* 02-M-0120:
The Efficacy of Phytoestrogens and Selective Estrogen Receptor Modulators in Perimenopause-Related Depression

* 02-M-0021:
Characterization and Pathophysiology of Severe Mood and Behavioral Dysregulation in Children and Youth

* 01-M-0254:
The Evaluation of Patients with Mood and Anxiety Disorders and Healthy Volunteers

* 01-M-0232:
Positron Emission Tomography (PET) Scanning in Dopamine Disorders: Parkinson's Disease and Schizophrenia

* 01-M-0192:
Fluoxetine's Effects on Attention and Emotional Memory in Anxious and Depressed Youth and Adults

* 01-M-0185:
Effects of Arousal and Stress on Classical Conditioning

* 00-M-0198:
The Phenomenology and Neurophysiology of Affective Dysregulation in Children and Adolescents with Bipolar Disorder

* 00-M-0103:
The Treatment of Menstrually-Related Mood Disorders with Continuous Gonadal Steroid Replacement

* 00-M-0085:
Structural and Functional Imaging of Neuropsychiatric Patients and Normal Volunteers with 3.0 Tesla MRI and Magnetoencephalography

* 99-M-0172:
Integrating EEG/MEG and fMRI: Activity Correlation between Frontal and Temporal Lobe Structures in Schizophrenic Patients, Their Siblings and Unrelated Normal Volunteers

* 95-M-0150:
A Neurobiological Investigation of Patients with Schizophrenia Spectrum Disorders and Their Siblings

* 95-M-0097:
An Endocrine Model for Postpartum Mood Disorders

* 93-M-0170:
Regional Cerebral Blood Flow Studies of Object Perception, Identification, Localization, and Memory

* 92-M-0174:
The Central Nervous System Effects of Pharmacologically Induced Hypogonadotropic Hypogonadism with and without Estrogen and Progesterone Replacement

* 90-M-0142:
Brain Procurement for the Neuropathology Section, CBDB

* 90-M-0088:
The Treatment of Menstrually-Related Mood Disorders with the Gonadotropin Releasing Hormone (GnRH) Agonist, Depot Leuprolide Acetate (Lupron)

* 90-M-0014:
Studies of Frontal Lobe Function During Cognitive Stimulation as Measured with Oxygen-15 Water Positron Emission Tomography in Normal Subjects and Patients with Neuropsychiatric Disorders

* 89-M-0160:
Inpatient Evaluation of Neuropsychiatric Patients

* 89-M-0006:
Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Controls

* 88-M-0131:
The Evaluation of Women with Perimenopause-Related Mood and Behavioral Disorders

* 84-M-0050:
Biochemical, Physiological, and Psychological Measures in Normal Controls and Relatives of Psychiatric Patients

* 81-M-0126:
The Evaluation of Women with Menstrually Regulated Mood and Behavioral Disorders

* 80-M-0083:
Bipolar Genetics: A Collaborative Study

Active Follow-up, Protocols NOT Recruiting New Patients 

* 09-M-0240:
An Investigation of the Antidepressant Effects of a Low-Trapping Mixed NR2A/2B Antagonist in Treatment-Resistant Major Depression

* 09-M-0177:
CO2 Inhalation and Risk for Panic Disorder

* 08-M-0196:
An Investigation of the Antidepressant Efficacy of a Selective, High Affinity Enkephalinergic Agonist in Anxious Major Depressive Disorder

* 08-M-0158:
PET Imaging of Peripheral Benzodiazepine Receptors Using [11C](R)-PK 11195 and [11C]PBR28

* 08-M-0124:
Measurement of P-Glycoprotein Function in Alzheimer Disease, Parkinson Disease, and Frontotemporal Dementia Using Positron Emission Tomography

* 07-M-0209:
PET Imaging of Peripheral Benzodiazepine Receptors in Patients with Neurocysticercosis Using [F-18]FBR

* 07-M-0129:
PET Evaluation of Brain Peripheral Benzodiazepine Receptors Using (11C)PBR28 in HIV-Seropositive Patients with (MCMD)

* 06-M-0002:
PET Whole Body Biodistribution and Test Retest Brain Imaging Studies Using a Phosphodiesterase 4 Inhibitor (R)-[11C]rolipram

* 05-M-0198:
Effect of D-Cycloserine on Treatment of Social Phobia

* 04-M-0183:
Association between Adenosine Receptor Gene Polymorphisms and Physiological Responses to Caffeine in Subjects with Panic Disorder and Healthy Controls

* 03-M-0175:
The Effects of Acute Withdrawal of Estradiol on Mood Symptoms in Women with Perimenopausal Depression

* 03-M-0014:
Neural Circuitry and Risk for Depression in Adolescents: A Study Using Functional Magnetic Resonance Imaging

* 02-M-0092:
Reward-Related Processes and Brain Function

* 02-M-0036:
A Behavioral and Functional Neuroimaging Study of Inhibitory Motor Control

* 01-M-0152:
Adolescence, Puberty, Hormones, and Emotion Regulation: An fMRI Study

* 97-M-0126:
Childhood Onset Psychotic Disorders: Characterization and Treatment with Atypical Neuroleptics

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