NIH Clinical Research Studies Listed By Institute of the Principal Investigator

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

92 Protocols (62 Active Accrual of new subjects, 30 Follow-up of previously enrolled subjects)


Active Accrual, Protocols Recruiting New Patients 
* 14-DK-0084:
Evaluation of Safety, Tolerability, and Antiviral Activity of Chlorcyclizine HCl Alone or in Combination with Ribavirin in Patients with Chronic Hepatitis C

* 14-DK-0060:
Famine from Feast: Linking Vitamin C, Red Blood Cell Fragility, and Diabetes

* 13-DK-0212:
Effect of a Eucaloric Ketogenic Diet on Energy Expenditure: A Pilot Study

* 13-DK-0200:
The Mechanism of Human Non-Shivering Thermogenesis and Basal Metabolic Rate

* 13-DK-0196:
Evaluation of Sickle Cell Liver Disease

* 13-DK-0150:
Unraveling the Mechanisms of Non-Response in Patients With and Without Cirrhosis Due to Chronic Hepatitis C

* 13-DK-0142:
The Physiology of Fatigue in Patients with Chronic Liver Disease

* 13-DK-0138:
A Phase 2, Multicenter, Double-Blind, Parallel Dosing, Randomized Study of Fresolimumab or Placebo in Patients with Steroid-Resistant Primary Focal Segmental Glomerulosclerosis

* 13-DK-0091:
Combination Therapy of Pegylated Interferon Alfa-2a and Tenofovir DF versus Tenofovir DF Monotherapy in HBeAg-Positive and HBeAg-Negative Chronic Hepatitis B

* 13-DK-0090:
Identifying Risk for Diabetes and Heart Disease in Women: A Study of African-American, African and White Federal Employees and Contractors

* 13-DK-0057:
Short Term Effects of Leptin Withdrawal or Initiation in Lipodystrophy Independent of Energy Intake

* 13-DK-0002:
Treatment for Non-Alcoholic Fatty Liver with Different Doses of Vitamin E

* 12-DK-0154:
Evaluation of Patients with Gastrointestinal Disease

* 12-DK-0097:
Energy Expenditure Responses to Different Temperatures

* 12-DK-0071:
Combination Entecavir and Peginterferon Therapy in HBeAG-Postive Immune-Tolerant Adults with Chronic Hepatitis B

* 12-DK-0046:
Treatment of Chronic Delta Hepatitis with Lonafarnib

* 11-DK-0168:
Magnetic Resonance of Body, Arterial Wall and Angiography Imaging for Non-Invasive Assessment of Arterial Distensibility, Endothelial Dysfunction and Atherosclerotic Disease Using 1.5T High Field (3T) MRI: A Technical Development Study of Cardiac and Bod

* 11-DK-0151:
Withdrawal of Therapy After Long-Term Oral Nucleos(t)ide Analogue Treatment in Patients with Chronic Hepatitis B

* 11-DK-0114:
A Pilot Trial of YF476, A Gastrin Antagonist, in Patients with Type II Gastric Carcinoids Associated with Zollinger-Ellison Syndrome

* 11-DK-0108:
Observational Study of Persons with Hepatitis B Virus Infection in North America (Cohort Study)

* 11-DK-0023:
The Nephrotic Syndrome Study Network (NEPTUNE)

* 10-DK-0163:
Metabolic Effects of Non-Nutritive Sweeteners

* 10-DK-0135:
Role of Donor Genetics and Recipient Genetics in Kidney Transplant Outcomes

* 09-DK-0223:
Rituximab Plus Cyclosporine in Idiopathic Membranous Nephropathy

* 09-DK-0140:
Natural History of Autoimmune Diabetes and Its Complications

* 09-DK-0097:
Vitamin E Pharmacokinetics and Biomarkers in Women

* 08-DK-0173:
A Trial of Segmental Stiffening Wires to Improve the Efficiency and Patient Tolerability of Colonoscopy

* 08-DK-0138:
A New Method for Determining Gastric Acid Output Using a Wireless Capsule

* 08-DK-0098:
Natural History of Familial Carcinoid Tumor

* 08-DK-0004:
High Throughput Screening of Compound Libraries to Discover a Drug for the Treatment of Sickle Cell Disease

* 07-DK-0212:
Prospective Evaluation of Albuminuria in HIV Positive Patients

* 07-DK-0207:
Tenofovir Disoproxil Fumarate Alone Versus its Combination with Emtricitabine for Treatment of Chronic Hepatitis B

* 07-DK-0202:
Thyroid Hormones Homeostasis and Energy Metabolism Changes During Exposure to Cold Temperature in Humans

* 07-DK-0115:
Natural History of Type 2 Diabetes Mellitus in Children and Young Adults

* 07-DK-0077:
Study of the Phenotype of Overweight and Obese Adults

* 06-DK-0142:
Peripheral Blood Collection of Adult Stem Cells

* 06-DK-0020:
Kidney Disease Biomarkers

* 05-DK-0085:
Clinical and Laboratory Investigation of Humans with Informative Iron or Erythroid Phenotypes

* 05-DK-0015:
Retinoids for Podocyte Disease

* 04-DK-0021:
Urinary Vitamin C Loss in Subjects with and without Diabetes

* 03-DK-0257:
Effect of Leptin Therapy in the Treatment of Severe Insulin Resistance

* 03-DK-0256:
Inhibition of Intestinal Glucose Absorption by the Bioflavonoid Quercetin in the Obese and in Obese Type 2 Diabetics

* 03-DK-0098:
Study of Thyrotropin Releasing Hormone in Patients with Thyroid or Pituitary Abnormalities

* 01-DK-0062:
Genetic Analysis of Familial Keloids

* 00-DK-0221:
Evaluation of the Immune Response in Humans After Exposure to Hepatitis C Virus

* 00-DK-0107:
Search for Novel Methods to Detect Acute Renal Failure

* 99-DK-0002:
Diabetes and Heart Disease Risk in Blacks

* 94-DK-0133:
Genetic Markers for Focal Segmental Glomerulosclerosis

* 94-DK-0127:
Pathogenesis of Glomerulosclerosis

* 93-DK-0127:
Family Studies in Metabolic Diseases and Mineral Metabolism

* 92-DK-0156:
Studies of Immunologically-Mediated Kidney Diseases

* 92-DK-0033:
Pharmacokinetics and Biodistribution of Ascorbic Acid in Healthy Human Subjects

* 91-DK-0214:
Evaluation of Patients with Liver Disease

* 91-DK-0085:
Studies of Hyperparathyroidism and Related Disorders

* 91-DK-0066:
Fasting Hypoglycemia: Diagnosis and Treatment

* 89-DK-0173:
Studies of States with Resistance to Vitamin D and Parathyroid Hormone

* 89-DK-0152:
Determination of Glomerular Filtration Rate, Effective Renal Plasma Flow and Glomerular Capillary Wall Permselectivity

* 87-DK-0029:
Diagnosis and Treatment of Patients with Cystic Fibrosis and Other Disorders of the Respiratory System and Pancreas

* 85-DK-0082:
Acromegaly Treatment and Natural History

* 77-DK-0096:
Studies on Thyroid Nodules and Thyroid Cancer

* 77-DK-0002:
Evaluation of Patients with Thyroid Function Disorders

* 76-DK-0006:
Studies of Molecular Genetics of Insulin Secretion, Insulin Action, and Diabetes Mellitus

Active Follow-up, Protocols NOT Recruiting New Patients 

* 14-DK-0154:
Metabolic and Neural Adaptations to Weight Loss, Plateau, and Regain

* 14-DK-0012:
Expanded-Access Single Named-Patient Guidance Document for the Use Of BMS 650032 (Asunaprevir; ASV) in Combination with Daclatasvir for the Treatment of a Patient with Recurrent Hepatitis C Virus (HCV) Infection

* 13-DK-0136:
A Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Multiple Dose, 2-Period Crossover Study to Evaluate the Effect of RM-493 on Energy Expenditure in Obese Subjects

* 13-DK-0013:
Impact of Chronic Cold Exposure on Energy Metabolism in Humans

* 11-DK-0256:
Pharmacokinetic and Pharmacodynamic Studies of Liothyronine. A Study on the Metabolic Effects of Thyroid Hormone

* 10-DK-0187:
Duration of Long-Term Immunity After Hepatitis B Virus Immunization

* 10-DK-0064:
Effects of Caloric Restriction Alone versus Postoperative Caloric Restriction Following Bariatric Surgery on Glucose Metabolism in Patients with Diabetes Mellitus

* 10-DK-0002:
Partners for Better Health in Adolescent Type 2 Diabetes: The Buddy Study

* 09-DK-0081:
Selective Reduction of Dietary Carbohydrate Versus Fat: Effects on Metabolism, Endocrine Physiology, Brain Activity and Reward Circuitry

* 09-DK-0055:
Assessment of the Effects of a DPP-4 Inhibitor (Sitagliptin) Januvia on Immune Function in Healthy Individuals

* 08-DK-0165:
Thyroid Hormones Homeostasis and Energy Metabolism Changes During Stimulation of Endogenously Secreted Bile Acids (BAs)

* 08-DK-0149:
High Dose Ribavirin in Combination with Peginterferon for Patients with Chronic Hepatitis C Genotype 1 Infection Who Have Failed to Respond or Relapsed after Standard Therapy

* 08-DK-0106:
Hepatitis C Eradication and Progression of Atherosclerosis

* 07-DK-0219:
A Nutrigenomics Intervention for the Study of the Role of Dietary Sitosterol on Lipid, Glucose and Energy Metabolism

* 07-DK-0163:
The Effect of Diet on Vascular Disease: A Study of African American and Caucasian Women

* 06-DK-0183:
Gene Expression and Release of Inflammatory Mediators in Overweight Subjects Before and After Weight Loss

* 06-DK-0025:
The Effects of Lithium Carbonate on Low Dose Radioiodine Ablation in Early Thyroid Cancer Treatment

* 05-DK-0119:
Peripheral Thyroid Hormone Conversion and Glucose and Energy Metabolism

* 03-DK-0245:
Effect of AC 2993 (Synthetic Exendin-4) - Administered Alone or in Combination with Daclizumab - on Islet Function in Patients with Type I Diabetes

* 03-DK-0226:
Pulse Dexamethasone Over 48 Weeks for Podocyte Disease

* 03-DK-0071:
Sirolimus Therapy in Idiopathic and Lupus Membranous Nephropathy

* 02-DK-0022:
Long-Term Efficacy of Leptin Replacement in Treatment of Lipodystrophy

* 01-DK-0249:
Ingested Interferon-Alpha: Prolongation or Permanence of the "Honeymoon" Phase in Newly Diagnosed Diabetes Mellitus

* 01-DK-0247:
Treatment of Chronic Delta Hepatitis with Pegylated Interferon

* 01-DK-0246:
Combination of Lamivudine and Adefovir Dipivoxil for Treatment of Chronic Hepatitis B

* 01-DK-0053:
Permeability Factor in Focal Segmental Glomerulosclerosis

* 01-DK-0036:
Solitary Islet Transplantation for Type 1 Diabetes Mellitus Using Steroid Sparing Immunosuppression

* 00-DK-0186:
The Hep C Antiviral Long-Term Tx Against Cirrhosis (HALT-C) Trial: A Randomized Controlled Trial to Evaluate the Safety & Efficacy of Long-Term Peginterferon Alpha2A for Tx of Chronic Hep C in Patients Who Failed to Respond to Previous Interferon Therap

* 00-DK-0042:
Pirfenidone in Focal Segmental Glomerulosclerosis:Phase II Study

* 90-DK-0137:
Evaluation of the Gastrinoma in Patients with Zollinger-Ellison Syndrome

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