NIH Clinical Research Studies Listed By Institute of the Principal Investigator

National Institute of Child Health and Human Development (NICHD)

75 Protocols (57 Active Accrual of new subjects, 18 Follow-up of previously enrolled subjects)

Active Accrual, Protocols Recruiting New Patients 
* 09-CH-0213:
Malaria Transmission-Blocking Pfs25-Pfs25 Conjugate Vaccine

* 09-CH-0203:
Cholesterol in Autism Spectrum Disorder (ASD): Characterization and Treatment

* 09-CH-0185:
Biomarker Validation for Niemann-Pick Disease, Type C: Safety and Efficacy of N-Acetyl Cysteine

* 09-CH-0180:
Non-Invasive Non-Ionizing Polarized Imaging System to Assess Structure of Cervix

* 09-CH-0085:
Global Study of Women's Health

* 09-CH-0063:
Pilot Study of MRI-Guided High Intensity Focused Ultrasound Ablation of Uterine Fibroids

* 09-CH-0059:
Molecular Bases of Response to Copper Treatment in Menkes Disease, Related Phenotypes, and Unexplained Copper Deficiency

* 08-CH-0213:
WAGR Syndrome and Other 11p Contiguous Gene Deletions: Clinical Characterization and Correlation with Genotype

* 08-CH-0203:
A Pilot Study to Assess the Feasibility of PTH 1-34 Therapy via Pump in the Management of Chronic Hypoparathyroidism

* 08-CH-0170:
Establishment of a Fibroid Tissue Bank

* 08-CH-0139:
Preventing Excessive Weight Gain in Adolescent Girls at High-Risk for Adult Obesity

* 08-CH-0085:
Eating Behavior in Adolescents

* 08-CH-0022:
Treatment of Menorrhagia in Women with Thrombocytopenia: Comparison of Platelet Transfusion Alone to Platelet Transfusion with Continuous Oral Contraceptive Pills

* 08-CH-0001:
Calibration of Non-Invasive Non-Ionizing Imaging Techniques to Study Vasculature of Healthy Volunteers

* 07-CH-0192:
Detection and Treatment of Endocrine Abnormalities in Childhood Cancer Survivors

* 07-CH-0126:
Pilot Study of the Metabolic Effects of Betahistine Hydrochloride (Obecure) in Overweight Women

* 07-CH-0008:
Prospective, Open-Label, Multicenter, International Study of Mifepristone for Symptomatic Treatment of Cushing's Syndrome Caused by Ectopic Adrenal Corticotrophin Hormone (ACTH) Secretion

* 06-CH-0223:
Biobehavioral Study of Recently Adopted Children

* 06-CH-0186:
Evaluation of Biochemical Markers and Clinical Investigation of Niemann-Pick Disease, Type C

* 06-CH-0038:
Body Heat Content and Dissipation in Obese and Normal Weight Adults

* 06-CH-0011:
Natural History Study of Patients with Excess Androgen

* 06-CH-0010:
Remodeling of Chromatin-Based Epigenetic Structures in Development and Aging

* 05-CH-0013:
Adrenal Function in Critical Illness

* 04-CH-0250:
Event Related Potentials in Infants and Adults

* 04-CH-0077:
Screening and Diagnosis of Patients with Connective Tissue Disorders

* 04-CH-0056:
The Neural Immune Mechanisms and Genetic Influences on Chronic Pelvic Pain in Women with Endometriosis

* 04-CH-0050:
Eating Behavior in Children

* 03-CH-0225:
Investigation of Simvastatin Therapy in Smith-Lemli-Opitz Syndrome

* 03-CH-0069:
Early Learning and Development Project

* 03-CH-0060:
Virtual Functional Anatomy (VFA)

* 02-CH-0311:
Investigations into Inborn Errors of Cholesterol Synthesis and Related Disorders

* 02-CH-0195:
Human MATER and Idiopathic Infertility

* 02-CH-0023:
Studies of Pediatric Patients with Metabolic or Other Genetic Disorders

* 01-CH-0086:
A Combination Therapy with Cystagon and N-Acetylcysteine for INCL Patients

* 00-CH-0219:
Turner Syndrome: Genotype and Phenotype

* 00-CH-0189:
FSH-Stimulated Inhibin B as a Marker for Early Ovarian Insufficiency

* 00-CH-0180:
Endocrine Studies in Health and Disease

* 00-CH-0160:
Clinical and Molecular Analysis of ACTH-Independent Steroid Hormone Production in Adrenocortical Tissue

* 00-CH-0136:
A Trial of Pamidronate in Children with Osteogenesis Imperfecta

* 00-CH-0127:
Evaluation of Patients with Endocrine-Related Conditions

* 00-CH-0093:
Diagnosis, Pathophysiology, and Molecular Biology of Pheochromocytoma and Paraganglioma

* 00-CH-0035:
The Development of Categorization

* 99-CH-0103:
Evaluation of Women with Endocrine and Reproductive-Related Conditions

* 99-CH-0055:
New Imaging Modalities in the Evaluation of Patients with Ectopic Cushing's Syndrome

* 98-CH-0155:
Categorization Based on Motion-Carried Information in Infancy

* 98-CH-0081:
Clinical and Basic Investigations into Smith-Lemli-Opitz Syndrome

* 97-CH-0076:
A Clinical and Genetic Investigation of Pituitary Tumors and Related Hypothalmic Disorders

* 97-CH-0064:
Evaluation and Intervention for Ambulation, Basilar Invagination, and Secondary Effects of Osteogenesis Imperfecta

* 96-CH-0101:
Population Differences in the Insulin Sensitivity, Resting Energy Expenditure, and Body Composition of Overweight Children and Children of Overweight Parents

* 95-CH-0110:
Endometrial Mediators of Gonadal Steroid Action

* 95-CH-0059:
Definition of the Genotype and Clinical Phenotype of Primary Pigmented Nodular Adrenocortical Disease (PPNAD), Carney Complex, Peutz-Jeghers Syndrome and Related Conditions

* 92-CH-0223:
Autoimmune Premature Ovarian Failure: A Controlled Trial of Alternate-Day Prednisone Therapy

* 92-CH-0034:
Studies of Growth Deficiency and Growth Hormone Treatment in Children with Osteogenesis Imperfecta Types III and IV

* 92-CH-0011:
Treatment of Hypoparathyroidism with Synthetic Human Parathyroid Hormone 1-34

* 91-CH-0127:
Ovarian Follicle Function in Patients with Premature Ovarian Failure

* 90-CH-0149:
Early Copper Histidine Therapy in Menkes Disease

* 84-CH-0169:
Endocrine Studies of Healthy Children

Active Follow-up, Protocols NOT Recruiting New Patients 

* 07-CH-0193:
Use of the GnRH Agonist Leuprolide Acetate (Lupron(Registered Trademark)) to Preserve Ovarian Function in Women Undergoing Chemotherapy

* 07-CH-0169:
Noninvasive Optical Imaging of the Effects of External Spectral Filters on Macular Autofluorescence in Pseudophakic Eyes

* 06-CH-0201:
Effect of Transdermal Estradiol Replacement Therapy on Ovulation Rate in Women with Premature Ovarian Failure: A Randomized, Placebo-Controlled Trial

* 06-CH-0119:
Breast Cancer and Insulin Resistance: Implications for Preventive Counseling in Familial and Sporadic Cases

* 06-CH-0090:
Evaluation of Whether the Selective Progesterone Receptor Modulator CDB-2914 Can Shrink Leiomyomata

* 06-CH-0039:
Pilot Program for Targeted Prevention of Adolescent Weight Gain

* 05-CH-0037:
The Effects of Hydrocortisone, Melatonin, and Placebo on Symptoms of Jet Lag

* 04-CH-0283:
Anthrax Vaccine Clinical Trials

* 02-CH-0309:
The Diagnostic Performance of Screening Tests for the Diagnosis of Cushing's Syndrome

* 02-CH-0287:
Treatment of Leiomyomata with the Selective Progesterone Receptor Modulator CDB-2914

* 02-CH-0278:
Dyadic Interactions in Depressed and Non-Depressed Mothers with Their Infants

* 02-CH-0100:
Supplemental Calcium in Overweight Out-Patients

* 01-CH-0096:
Catecholamine Reserve and Exercise Tolerance in Subjects with Congenital Adrenal Hyperplasia and in Healthy Controls

* 00-CH-0134:
Effects of Metformin on Energy Intake, Energy Expenditure, and Body Weight in Overweight Children with Insulin Resistance

* 98-CH-0111:
Safety and Efficacy of Orlistat (Xenical, Hoffmann LaRoche) in African American and Caucasian Children and Adolescents with Obesity-Related Comorbid Conditions

* 96-CH-0033:
An Open, Randomized, Long-Term Clinical Trial of Flutamide, Testolactone, and Reduced Hydrocortisone Dose vs. Conventional Treatment of Children with Congenital Adrenal Hyperplasia

* 95-CH-0104:
Internal Jugular Vein Sampling for ACTH Levels for the Differential Diagnosis of Cushing Syndrome

* 88-CH-0032:
Specificity of Mother-Infant Interaction: The Influence of Maternal Age, Employment Status, and Parenthood Status

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