NIH Clinical Research Studies Listed By Institute of the Principal Investigator

National Eye Institute (NEI)

45 Protocols (40 Active Accrual of new subjects, 5 Follow-up of previously enrolled subjects)


Active Accrual, Protocols Recruiting New Patients 
* 14-EI-0173:
An Investigation of Retinal Findings in Patients with Signs and Symptoms of Alzheimer's Disease Enrolled in 09-M-0198

* 14-EI-0171:
The Focal Electro-Oculogram in Macular Disease

* 14-EI-0108:
Pilot Study to Evaluate Oral Minocycline in the Treatment of Cystoid Macular Edema Associated with Retinitis Pigmentosa

* 14-EI-0078:
A Phase 2 Multicenter Randomized Clinical Trial of Ciliary Neurotrophic Factor (CNTF) for Macular Telangiectasia Type 2 (MacTel)

* 14-EI-0064:
Whole Exome and Whole Genome Sequencing for Genotyping of Inherited and Congenital Eye Conditions

* 13-EI-0206:
A Randomized, Controlled, Double-Masked, Clinical Trial of Autologous Serum Eye Drops for Severe Ocular Chronic Graft-versus-Host Disease (GVHD) in Hematopoietic Stem Cell Transplant (HSCT) Patients

* 13-EI-0154:
Color Vision as an Outcome Measure for Clinical Trials of Inherited Retinal Degenerations

* 13-EI-0124:
A Pilot Study of Nitisinone in the Treatment of Oculocutaneous Albinism, Type 1B

* 13-EI-0102:
Gevokizumab Treatment for Active Scleritis By IL-1 Inhibition (GATSBY)

* 13-EI-0072:
Microbiome and Ocular Inflammatory Disease

* 13-EI-0049:
Genetics of Uveal Coloboma

* 13-EI-0027:
AMD Phenotype and Genotype Study (APGS)

* 12-EI-0203:
Natural History of ABCA4-Related Retinopathies

* 12-EI-0042:
NEI Intramural Biorepository for Retinal Diseases

* 11-EI-0264:
A Pilot Study for the Evaluation of Minocycline as a Microglia Inhibitor in the Treatment of Central Retinal Vein Occlusions

* 11-EI-0263:
A Pilot Study for the Evaluation of Minocycline as a Microglia Inhibitor in the Treatment of Branch Retinal Vein Occlusions

* 11-EI-0245:
Generation of Induced Pluripotent Stem (iPS) Cell Lines from Somatic Cells of Participants with Eye Diseases and from Somatic Cells of Matched Controls

* 11-EI-0173:
The Natural History of Ocular Graft-Versus Host Disease

* 11-EI-0147:
Longitudinal Investigation of Dark Adaptation in Participants with Age-Related Macular Degeneration

* 10-EI-0140:
Genotype-Phenotype Study of Patients with Plaquenil -Induced Retinal Toxicity, with Evaluation of the ABCA4 Gene

* 10-EI-0093:
Immunogenetic Mechanisms in Behcet's Disease

* 10-EI-0016:
Internal Monitoring of Eye Movement in Schizophrenia

* 08-EI-0169:
Evaluation and Treatment Protocol for Potential Research Participants with Ocular Diseases

* 08-EI-0102:
Screening Study for the Evaluation and Diagnosis of Potential Research Participants

* 08-EI-0099:
Epigenetics, Molecular Genetics, and Biomarkers of Degenerative and Inflammatory Ocular Diseases

* 08-EI-0043:
Age-Related Eye Disease Study (AREDS) and AREDS2 Follow-Up

* 08-EI-0031:
Visual Motor Coordination

* 07-EI-0145:
Ocular Impact of X Chromosome Karyotype and Sex Hormones in Turner Syndrome

* 06-EI-0236:
National Ophthalmic Genotyping and Phenotyping Network, Stage 1 - Creation of DNA Repository for Inherited Ophthalmic Diseases

* 06-EI-0068:
The Vitreous Proteome and Inflammatory Mediators in Ocular Inflammatory Disease

* 06-EI-0059:
Clinical and Molecular Studies in Families with Glaucoma and Related Diseases

* 06-EI-0058:
Clinical and Molecular Studies in Families with Myopia and Related Diseases

* 05-EI-0143:
Molecular Genetics of Retinal Degenerations

* 05-EI-0096:
Natural History and Genetic Studies of Usher Syndrome

* 04-EI-0008:
Clinical and Molecular Studies in Families with Corneal Dystrophy or Other Inherited Corneal Diseases

* 03-EI-0155:
Evaluation of Single Nucleotide Polymorphism (SNP) in Patients with and Subjects without Age-Related Macular Degeneration (AMD)

* 03-EI-0123:
Clinical and Molecular Studies in Families with Congenital or Hereditary Cataracts

* 03-EI-0122:
Evaluation of Immune Responses to Different Antigens in Non Infectious Ocular Inflammatory Diseases

* 03-EI-0033:
X-Linked Juvenile Retinoschisis - Clinical and Molecular Studies

* 92-EI-0113:
Immunopathology and Molecular Pathology of Ocular Diseases in Humans

Active Follow-up, Protocols NOT Recruiting New Patients 

* 12-EI-0167:
A Phase I/II Study of the NT-501 Intraocular Implant Releasing Ciliary Neurotrophic Factor (CNTF) in Participants with CNGB3 Achromatopsia

* 12-EI-0134:
A Phase II Randomized Study to Compare Anti-VEGF Agents in the Treatment of Diabetic Macular Edema (CADME)

* 11-EI-0244:
A Pilot Phase I/II Study for the Evaluation of Dextromethorphan as a Microglia Inhibitor in the Treatment of Diabetic Macular Edema (MiDME2)

* 07-EI-0213:
Laboratory of Immunology/National Eye Institute Repository

* 06-EI-0050:
Multicenter Uveitis Steroid Treatment (MUST) Trial Protocol

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