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Functional Neuroanatomy of Positive and Negative Affect in Alcoholics and Non-Alcoholics
This study is currently recruiting participants.
Summary | Eligibility | Citations | Contacts
Summary
Number |
98-AA-0056 |
Sponsoring Institute |
National Institute on Alcohol Abuse and Alcoholism (NIAAA) |
Recruitment Detail |
Type: Participants currently recruited/enrolled |
Referral Letter Required |
No |
Population Exclusion(s) |
None |
Special Instructions |
Currently Not Provided |
Keywords |
Brain Imaging; |
Recruitment Keyword(s) |
Normal Volunteer |
Condition(s) |
Alcoholism; |
Investigational Drug(s) |
None |
Investigational Device(s) |
None |
Intervention(s) |
None |
Supporting Site |
|
Patients who would like to participate in this study will first undergo a screening process to see if they will be eligible for the study. Patients eligible to participate in the study will go through two sessions.
During session one, researchers will attempt to evoke positive and negative emotions by showing patients slides of different emotion-arousing stimuli (pictures of pleasant and unpleasant scenes). While patients are viewing these slides, researchers will be measuring patient's heart rate, sweating, and eye-blinking.
During session two, patients will undergo an MRI of the brain while seeing similar emotion-arousing pictures as in session one. In addition, patients may be asked to play a simple computer game for a reward of money while researchers use the MRI to measure brain activity.
Researchers hope to develop methods to evoke positive and negative emotions and simultaneously (at the same time) see brain activation in normal volunteers, alcoholics, and recovered alcoholics.
Eligibility
INPATIENT ALCOHOLICS:
We will study up to 150 male and 150 female individuals who meet criteria for alcohol use disorders and are between the age of 18 and 65 years. Inpatient alcoholics will be recruited from the NIAAA protocol 05-AA-0121, Assessment and treatment of people with alcohol drinking problems.
INCLUSION CRITERIA:
Are physically healthy.
Are between 18-65 years of age.
Have 20/40 vision or corrected to 20/40
Are right handed.
EXCLUSION CRITERIA:
Have no ferromagnetic objects in their bodies which might be adversely affected by MRI (e.g. surgical clips; metal fragments in or near brain; eye or blood vessels; cardiac or neurological pacemaker; cochlear or eye implant - any doubt about presence of these objects will result in exclusion from this study).
Test HIV negative (since AIDS-related dementia compromises brain function).
Have any organic brain syndrome.
Have active homicidal or suicidal ideation, or active symptoms of post-traumatic stress disorder.
Are not currently receiving psychotropic medication for emotional distress.
Are not pregnant or lactating.
Have any symptoms of alcohol withdrawal at the time of scan.
RECOVERING ALCOHOLICS:
We will study up to 50 male and 50 female individuals who in the pasy have met criteria for alcohol use disorders and are between the age of 18 and 65 years. Recovering alcoholics must be at least 3 month without alcohol use, and will be recruited from the NIAAA protocol 05-AA-0121, Assessment and treatment of people with alcohol drinking problems.
INCLUSION CRITERIA AND EXCLUSION CRITERIA:
Same as inpatient alcoholics.
HEALTHY NON-ALCOHOLICS:
We will study up to 150 male and 150 female who have never met criteria for an alcohol use disorder and are between the age of 18 and 65 years and will be recruited from the NIAAA protocol 98-AA-0009, Screening Evaluation for NIAAA Protocols.
INCLUSION CRITERIA AND EXCLUSION CRITERIA:
Same as inpatient alcoholics.
CHILDREN OF ALCOHOLICS
INCLUSION CRITERIA AND EXCLUSION CRITERIA:
Same as inpatient alcoholics except age range is between 12 and 18.
CHILDREN OF NON-ALCOHOLICS
INCLUSION CRITERIA AND EXCLUSION CRITERIA:
Same as inpatient alcoholics except age range is between 12 and 18.
PARENTS OF CHILDREN WHO HAVE AT LEAST ONE PARENT WITH A HISTORY OF ALCOHOL DEPENDENCE
INCLUSION CRITERIA:
Legally able to consent for child
PARENTS OF CHILDREN WITH NO FAMILY HISTORY OF ALCOHOL DEPENDENCE
INCLUSION CRITERIA:
Legally able to consent for child
Citations:
Contacts:
Principal Investigator |
Referral Contact |
For more information: |
| Reza Momenan, Ph.D. National Institute on Alcohol Abuse and Alcoholism (NIAAA) National Institutes of Health Building 10 Room 3C112 10 Center Drive Bethesda, Maryland 20892 (301) 496-6540 rezam@mail.nih.gov |
Reza Momenan, Ph.D. National Institute on Alcohol Abuse and Alcoholism (NIAAA) National Institutes of Health Building 10 Room 3C112 10 Center Drive Bethesda, Maryland 20892 (301) 496-6540 rezam@mail.nih.gov |
Patient Recruitment and Public Liaison Office Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 prpl@mail.cc.nih.gov |
Clinical Trials Number:
NCT00001675
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