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Connectivity Analysis for Investigation of Auditory Impairment in Epilepsy
This study is currently recruiting participants.
Summary | Eligibility | Citations | Contacts
Summary
Number |
10-DC-0211 |
Sponsoring Institute |
National Institute on Deafness and Other Communication Disorders (NIDCD) |
Recruitment Detail |
Type: Participants currently recruited/enrolled |
Referral Letter Required |
Yes |
Population Exclusion(s) |
Children |
Special Instructions |
Currently Not Provided |
Keywords |
MEG; |
Recruitment Keyword(s) |
Epilepsy; |
Condition(s) |
Brain Mapping; |
Investigational Drug(s) |
None |
Investigational Device(s) |
None |
Intervention(s) |
None |
Supporting Site |
|
- People with epilepsy often have auditory processing disorders that affect their ability to hear clearly and may cause problems with understanding speech and other kinds of verbal communication. Researchers are interested in developing better ways of studying what parts of the brain are affected by hearing disorders and epilepsy, and they need better clinical tests to measure how individuals process sound. These tests will allow researchers to examine and evaluate the effects of epilepsy and related disorders on speech and communication.
- A procedure called a magnetoencephalography (MEG) can be used to measure the electrical currents involved in brain activity. Researchers are interested in learning whether MEG can be used to detect differences in the processing of simple sounds in patients with epilepsy, both with and without hearing impairments.
Objectives:
- To measure brain activity in hearing impaired persons with epilepsy and compare the results with those from people with normal hearing and epilepsy as well as people with normal hearing and no epilepsy. This research is performed in collaboration with Johns Hopkins Hospital and epilepsy patients must be candidates for surgery at Johns Hopkins.
Eligibility:
- Individuals between 18 to 55 years of age who (1) have epilepsy and have hearing impairments, (2) have epilepsy but do not have hearing impairments, or (3) are healthy volunteers who have neither epilepsy nor hearing impairments.
- Participants with epilepsy must have developed seizures after 10 years of age, and must be candidates for grid implantation surgery at Johns Hopkins Hospital..
Design:
- This study will require one visit of approximately 4 to 6 hours.
- Participants will be screened with a full physical examination and medical history, along with a basic hearing test.
- Participants will have a magnetic resonance imaging (MRI) scan of the brain, followed by a MEG scan to record magnetic field changes produced by brain activity.
- During MEG recording, participants will be asked to listen to various sounds and make simple responses (pressing a button, moving your hand or speaking) in response to sounds heard through earphones. The MEG procedure should take between 1 and 2 hours.
- Treatment at NIH is not provided as part of this protocol.
Eligibility
INCLUSION CRITERIA:
Normal peripheral hearing: pure tone air conduction thresholds less than or equal to 20 dB HL at octave frequencies between 250-8000 Hz for each ear; word recognition scores in quiet greater than or equal to 88% for each ear; normal 226 Hz tympanometry (middle ear peak pressure at 0 plus/minus 100 daPa and peak compensated static compliance of 0.3-1.5 mmho); no history of chronic otitis media, PE tubes, or hearing loss
For those participants with epilepsy - seizure onset age > 10 years
Normal cognitive function (Full-Scale IQ > 84)
Absence of any co-morbid neurological disorder
Absence of highly magnetizable metallic implants, including highly magnetizable dental work
A negative urine pregnancy test
For participants with epilepsy - scheduled or to-be-scheduled for grid implantation surgery at Johns Hopkins Hospital
EXCLUSION CRITERIA:
Evidence of neurological or psychiatric disorder that would interfere with data interpretation, including cognitive impairment
Presence of a lesion on a previous MRI, except for the following: mesotemporal sclerosis, cortical dysplasia, and dysembryoplastic neuroepithelial tumor.
Presence of highly magnetizable metallic implants, such as pacemakers, aneurysm clips, cochlear implants and shrapnel fragments, including highly magnetizable dental work, or any significant history of exposure to small metallic objects which may have become lodged in the head or neck.
For controls (healthy volunteers) only: history of speech-language disorder
Citations:
Contacts:
Principal Investigator |
Referral Contact |
For more information: |
| Barry Horwitz, Ph.D. National Institute on Deafness and Other Communication Disorders (NIDCD) National Institutes of Health Building 10 Room 8S235-B 10 Center Drive Bethesda, Maryland 20892 (301) 594-7755 horwitzb@mail.nih.gov |
Arpan Banerjee, Ph.D. National Institute on Deafness and Other Communication Disorders (NIDCD) National Institutes of Health Building 10 Room 8S235D 10 Center Drive Bethesda, Maryland 20892 (301) 594-7758 banerjeea2@mail.nih.gov |
Patient Recruitment and Public Liaison Office Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 prpl@mail.cc.nih.gov |
Clinical Trials Number:
NCT01212068
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