Protocol Details

Assessment and Treatment of People with Alcohol Drinking Problems

This study is currently recruiting participants.

Summary | Eligibility | Citations | Contacts

Summary

Number	05-AA-0121
Sponsoring Institute	National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruitment Detail	Type: Participants currently recruited/enrolled Gender: Male & Female Min Age: 18 Max Age: 65
Referral Letter Required	No
Population Exclusion(s)	Children
Special Instructions	Currently Not Provided
Keywords	Dependence; CIWA; Addiction Severity Index; CPRS-S-A; Combined Behavioral Intervention; Medical Management
Recruitment Keyword(s)	Alcohol Dependence; Alcoholism; Alcohol Drinking Related Problems
Condition(s)	Alcoholism; Alcohol Dependence; Alcohol Drinking Related Problems
Investigational Drug(s)	None
Investigational Device(s)	None
Intervention(s)	None
Supporting Site	National Institute on Alcohol Abuse and Alcoholism

The purpose of this study is to gather information about people's drinking histories and to evaluate them for other research studies being conducted at the National Institute on Alcohol Abuse and Alcoholism (NIAAA). The evaluation will include a physical examination, blood tests, an MRI scan of the brain and completion of various questionnaires about alcohol use and mood. The information gathered from all of these tests will be used by researchers to gain a better understanding of the disease of alcoholism and determine eligibility for other NIAAA studies. This is an inpatient study so participants will stay at the NIH hospital for at least three weeks and up to six weeks if a person is found to be eligible for other NIAAA research studies.

The study is open to people age 18 and older whose alcohol drinking has caused significant problems in their lives, and who desire alcoholism treatment. Detoxification will be provided if needed, and each person may participate in our alcoholism treatment program. The treatment includes group and individual counseling sessions as well as self-help meetings such as AA. Family counseling and recreational opportunities are also an important part of the treatment experience. The doctors, nurses, social workers and all of our other staff are committed to helping participants design an aftercare program that will help them leave the hospital and remain sober. Participants may also be able to attend a 12-week aftercare program in the NIAAA outpatient clinic.

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Eligibility

INCLUSION CRITERIA:

Age greater than 18 years old.

Are seeking help for alcohol drinking-related problems.

EXCLUSION CRITERIA:

People who present with complicated medical problems requiring intensive medical or diagnostic management, such as:

Hypertensive emergency;

Serious GI bleeding;

Major organ or body system dysfunction such as decompensated liver disease, renal failure, myocardial ischemia, congestive heart failure or cerebrovascular disease, major endocrine problems such as uncontrolled diabetes, pancreatic or thyroid disease.

People who are infected with the Human Immunodeficiency Virus (HIV).

Serious neuro-psychiatric conditions which impair judgment or cognitive function to an extent that precludes them from providing informed consent, such as acute psychosis or severe dementia (incompetent individuals).

People who are unlikely or unable to complete the treatment program because they become or are likely to be incarcerated while on the protocol.

People who are required to receive treatment by a court of law or who are involuntarily committed to treatment.

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Citations:

O'Connor PG, Schottenfeld RS. Patients with alcohol problems. N Engl J Med. 1998 Feb 26;338(9):592-602.

COMBINE Study Research Group. Testing combined pharmacotherapies and behavioral interventions in alcohol dependence: rationale and methods. Alcohol Clin Exp Res. 2003 Jul;27(7):1107-22.

O'Brien CP. Treatment of alcoholism as a chronic disorder. Alcohol. 1994 Nov-Dec;11(6):433-7.

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Contacts:

Principal Investigator	Referral Contact	For more information:
David T. George, M.D. National Institute on Alcohol Abuse and Alcoholism (NIAAA) National Institutes of Health 10 CENTER DR BG 10-CRC RM 2-2352 MSC 1540 BETHESDA MD 20892-1540 (301) 435-9385 tedg@mail.nih.gov	Debra Hill National Institute on Alcohol Abuse and Alcoholism (NIAAA) National Institutes of Health Building 10 Room1-5300 SE 10 Center Drive Bethesda, Maryland 20892 (301) 402-2721 debbyh@mail.nih.gov	Patient Recruitment and Public Liaison Office Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 prpl@mail.cc.nih.gov

Clinical Trials Number:

NCT00106093

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