Protocol Number: 98-CC-0019

Title:

Normal Volunteer Scanning on MR

Number:

98-CC-0019

Summary:

Magnetic resonance is an imaging technique that uses magnetic fields and radio waves to create images of the body. The technology used in magnetic resonance imaging continues to improve. Advancements in magnetic resonance imaging (MRI) requires researchers to study new techniques in normal volunteers in order to understand how to use them in patients with diseases.

In this study researchers plan to do a variety of diagnostic tests including magnetic resonance imaging on normal volunteers. The studies may involve injections of contrast media, substances injected into the blood of participant that improves the image created by the MRI scanner. The study is not expected to benefit the participants. However, information gathered from the study may be used to improve diagnostic techniques and develop new research studies.

Sponsoring Institute:

National Institutes of Health Clinical Center (CC)

Recruitment Detail

Type: Participants currently recruited/enrolled

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): Children

Eligibility Criteria:

INCLUSION CRITERIA:

Any normal volunteer above the age of 18 who is capable of giving informed consent.

EXCLUSION CRITERIA:

A subject will be excluded if he/she has a contraindication to MR scanning implanted metal clips or wires of the type which may concentrate radiofrequency fields or cause tissue damage from twisting in a magnetic field. Examples include: aneurysm clip, implanted neural stimulator, implanted cardiac pacemaker or autodefibrillator, cochlear implant, ocular foreign body (e.g., metal shavings), any implanted device (pumps, infusion devices, etc), shrapnel injuries.

For studies involving the use or Optison (microbubble contrast agent), subjects will be excluded if they have severe liver or lung disease, congenital heart defects, history of pulmonary emboli, or known or suspected hyper-sensitivity (allergic reaction) to blood, blood products or albumin.

For studies involving the injection of Gadolinium based contrast a serum Creatinine obtained within one week of the MRI examination. All subjects with a calculated eGFR less than 60 will be excluded from having a contrast enhanced MRI, but will not be excluded from the protocol for non contrasted MRI studies.

Subjects will be excluded if it is deemed that they have a condition which would preclude their use for technical development (e.g., paralyzed hemidiaphragm, morbid obesity, claustrophobia, etc.) or present unnecessary risks (e.g. pregnancy, surgery of uncertain type, symptoms of pheochromocytoma or insulinoma, etc.) Lactating women and subjects with hemoglobinopathies, asthma, or renal or hepatic disease will be excluded from studies involving the administration of contrast agents.

Special Instructions:

Currently Not Provided

Keywords:

Magnetic Resonance Imaging

Gadolinium

Magnetic Resonance Angiography

Recruitment Keyword(s):

Normal Volunteer

Condition(s):

Healthy

Investigational Drug(s):

None

Investigational Device(s):

None

Intervention(s):

None

Supporting Site:

Warren G. Magnuson Clinical Center

Contact(s):

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citation(s):

Renal Cancer: pre-operative evaluation with dual phase three dimensional MR angiography

Tolerance data of Gd-DTPA: a review

Measurement of relative cerebral blood volume changes with visual stimulation by 'double-dose' gadopentate-dimeglumine-enhanced dynamic magnetic resonance imaging

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department of Clinical Research Informatics, CC.

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National Institutes of Health Clinical Center Bethesda, Maryland 20892. Last update: 11/25/2009